Development Level

Tbio 1,350 | 11,445
Tdark 223 | 6,588
Tchem 193 | 1,598
Tclin 33 | 613

Collection

RFA-RM-18-021 18 | 328
Kinase: IDG Consortium (Target... 15 | 125
Ion Channel: IDG Consortium (T... 3 | 99
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 254 | 979
embryonic lethality prior to o... 81 | 239
embryonic lethality prior to t... 64 | 278
preweaning lethality, incomple... 49 | 499
abnormal embryo size 37 | 220
abnormal behavior 28 | 298
decreased body weight 25 | 161
decreased total body fat amoun... 20 | 207
embryonic growth retardation 19 | 106
abnormal lens morphology 18 | 81
cataract 18 | 92
enlarged heart 18 | 210
decreased bone mineral content 17 | 151
increased lean body mass 17 | 172
decreased circulating glucose ... 16 | 126
abnormal heart morphology 15 | 162
increased total body fat amoun... 15 | 134
prenatal lethality prior to he... 15 | 87
decreased lean body mass 14 | 135
abnormal bone structure 13 | 187
decreased circulating triglyce... 13 | 79
increased circulating choleste... 13 | 66
increased mean corpuscular vol... 13 | 92
decreased circulating choleste... 12 | 93
increased circulating HDL chol... 12 | 80
increased circulating sodium l... 12 | 71
abnormal neural tube closure 11 | 46
decreased body length 11 | 101
decreased fasted circulating g... 11 | 65
hypoactivity 11 | 132
increased bone mineral content 11 | 108
abnormal coat-hair pigmentatio... 10 | 64
abnormal kidney morphology 10 | 65
decreased bone mineral density 10 | 126
decreased grip strength 10 | 116
hyperactivity 10 | 148
increased circulating alkaline... 10 | 122
increased mean corpuscular hem... 10 | 96
abnormal embryo turning 9 | 31
decreased circulating HDL chol... 9 | 68
decreased circulating alkaline... 9 | 46
decreased lymphocyte cell numb... 9 | 83
increased startle reflex 9 | 112
small testis 9 | 58
abnormal behavioral response t... 8 | 66
abnormal seminal vesicle morph... 8 | 114
decreased erythrocyte cell num... 8 | 62
decreased mean corpuscular vol... 8 | 79
male infertility 8 | 123
short tibia 8 | 97
syndactyly 8 | 23
abnormal retina morphology 7 | 71
brachydactyly 7 | 19
decreased caudal vertebrae num... 7 | 53
decreased circulating aspartat... 7 | 34
decreased circulating insulin ... 7 | 76
decreased circulating serum al... 7 | 82
decreased hemoglobin content 7 | 68
decreased vertical activity 7 | 208
edema 7 | 59
impaired glucose tolerance 7 | 75
increased fasted circulating g... 7 | 76
long tibia 7 | 25
abnormal eye morphology 6 | 68
abnormal retinal vasculature m... 6 | 27
abnormal testis morphology 6 | 43
decreased circulating LDL chol... 6 | 38
decreased circulating alanine ... 6 | 47
hydrometra 6 | 53
increased erythrocyte cell num... 6 | 39
increased heart weight 6 | 62
increased monocyte cell number 6 | 63
increased red blood cell distr... 6 | 34
limb grasping 6 | 41
abnormal coat appearance 5 | 31
abnormal craniofacial morpholo... 5 | 33
abnormal gait 5 | 69
abnormal joint morphology 5 | 23
abnormal pericardium morpholog... 5 | 26
abnormal retinal blood vessel ... 5 | 26
abnormal sleep behavior 5 | 70
anophthalmia 5 | 33
decreased circulating free fat... 5 | 31
decreased circulating total pr... 5 | 49
decreased mean corpuscular hem... 5 | 50
decreased prepulse inhibition 5 | 82
enlarged lymph nodes 5 | 37
female infertility 5 | 60
increased bone mineral density 5 | 72
increased circulating chloride... 5 | 41
increased circulating potassiu... 5 | 29
increased leukocyte cell numbe... 5 | 47
increased neutrophil cell numb... 5 | 46
microphthalmia 5 | 26
decreased startle reflex 4 | 75
increased circulating bilirubi... 4 | 16
increased mean platelet volume 4 | 45
increased or absent threshold ... 4 | 101
increased prepulse inhibition 4 | 32
pallor 4 | 34

Disease

ovarian cancer 1,109 | 8,520
Carcinoma 1,012 | 11,493
osteosarcoma 843 | 7,950
medulloblastoma, large-cell 623 | 6,241
psoriasis 615 | 6,694
lung cancer 586 | 4,740
glioblastoma 526 | 5,792
atypical teratoid / rhabdoid tumor 441 | 5,112
group 3 medulloblastoma 401 | 4,104
Multiple myeloma 365 | 1,332
ependymoma 358 | 4,679
Breast cancer 328 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 323 | 3,291
malignant mesothelioma 301 | 3,232
pancreatic ductal adenocarcinoma liver metastasis 280 | 1,962
adult high grade glioma 276 | 3,801
non-small cell lung cancer 269 | 2,890
primitive neuroectodermal tumor 261 | 3,035
invasive ductal carcinoma 257 | 2,951
Autosomal recessive predisposition 254 | 1,442
astrocytic glioma 231 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 231 | 2,989
oligodendroglioma 229 | 2,850
intraductal papillary-mucinous adenoma (IPMA) 224 | 2,955
lung adenocarcinoma 209 | 2,716
Cancer 206 | 2,499
diabetes mellitus 199 | 1,728
Pick disease 189 | 1,894
Waldenstrons macroglobulinemia 189 | 765
pancreatic cancer 189 | 2,398
Kidney cancer 180 | 2,613
tuberculosis 170 | 2,010
Intellectual disability 164 | 1,016
acute quadriplegic myopathy 164 | 1,158
colon cancer 164 | 1,478
Astrocytoma, Pilocytic 160 | 3,081
subependymal giant cell astrocytoma 159 | 2,287
group 4 medulloblastoma 157 | 1,855
dermatomyositis 149 | 966
Epilepsy 142 | 792
Cognitive delay 133 | 608
Global developmental delay 133 | 608
Mental and motor retardation 133 | 608
Seizures 130 | 596
ductal carcinoma in situ 130 | 1,745
adrenocortical carcinoma 128 | 1,428
Muscle hypotonia 126 | 571
astrocytoma 122 | 1,146
breast carcinoma 122 | 1,638
interstitial cystitis 119 | 2,312
lung carcinoma 119 | 2,843
Dull intelligence 117 | 645
Low intelligence 117 | 645
Mental Retardation 117 | 645
Mental deficiency 117 | 645
Poor school performance 117 | 645
pituitary cancer 109 | 1,972
pediatric high grade glioma 108 | 1,064
ulcerative colitis 108 | 1,819
acute myeloid leukemia 104 | 783
Rheumatoid arthritis 100 | 1,191
juvenile dermatomyositis 99 | 1,187
non primary Sjogren syndrome sicca 98 | 891
nasopharyngeal carcinoma 92 | 1,058
Small head 87 | 374
Failure to gain weight 82 | 365
Pediatric failure to thrive 82 | 365
Schizophrenia 81 | 1,160
cystic fibrosis 81 | 1,696
Cerebellar Ataxia 78 | 304
primary pancreatic ductal adenocarcinoma 76 | 1,109
Short stature 74 | 531
active Crohn's disease 73 | 922
spina bifida 72 | 1,074
Atopic dermatitis 69 | 952
medulloblastoma 68 | 720
pancreatic carcinoma 68 | 562
progressive supranuclear palsy 67 | 676
Neurodegenerative disease 66 | 414
aldosterone-producing adenoma 63 | 665
Hepatomegaly 61 | 285
hepatocellular carcinoma 61 | 547
Obesity 59 | 678
Optic Atrophy 59 | 242
Anemia 57 | 365
Nystagmus 56 | 317
Sensorineural Hearing Loss (disorder) 56 | 284
hereditary spastic paraplegia 56 | 318
Alzheimer's disease 55 | 658
gastric cancer 53 | 459
Liver Cirrhosis, Experimental 52 | 769
Strabismus 52 | 270
esophageal adenocarcinoma 52 | 737
Cataract 51 | 297
Stomach Neoplasms 51 | 300
active ulcerative colitis 50 | 764
gastric carcinoma 50 | 807
Muscle Spasticity 49 | 195
cutaneous lupus erythematosus 48 | 1,057
sonic hedgehog group medulloblastoma 48 | 467

Tissue

Endocrine System 1,790 | 18,159
Digestive Tract 1,775 | 17,369
Male tissues 1,775 | 17,142
Skin and soft tissues 1,774 | 17,230
Female tissues 1,773 | 17,400
Blood and immune system 1,770 | 16,909
Urinary Tract 1,769 | 16,678
Liver and Pancreas 1,768 | 16,750
Nervous System 1,765 | 16,725
Respiratory system 1,765 | 16,393
Cardiovascular System 1,744 | 15,192

Target Family

Non-IDG 845 | 12,091
Enzyme 793 | 4,145
Transporter 69 | 473
Kinase 64 | 634
Epigenetic 17 | 242
Transcription Factor 7 | 1,400
Ion Channel 4 | 344

Ortholog Species

S.cerevisiae 1,799 | 1,799
Mouse 16,570 | 16,570
Cow 15,320 | 15,320
Rat 15,117 | 15,117
Dog 15,073 | 15,073
Horse 14,252 | 14,252
Chimp 14,140 | 14,140
Macaque 12,761 | 12,761
Opossum 12,230 | 12,230
Anole lizard 10,588 | 10,588
Xenopus 10,468 | 10,468
Pig 10,168 | 10,168
Zebrafish 9,726 | 9,726
Chicken 7,827 | 7,827
Platypus 5,703 | 5,703
C. elegans 3,179 | 3,179
Fruitfly 3,050 | 3,050

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39
Probable global transcription activator SNF2L1 SMARCA1 Tbio Non-IDG -2.20560 145.6 116
Dephospho-CoA kinase domain-containing protein DCAKD Tdark Enzyme 0.95 0.08 141
40S ribosomal protein S19 RPS19 Tbio Non-IDG -3.14746 1380.8 267
Pre-mRNA-splicing factor CWC22 homolog CWC22 Tbio Non-IDG -3.08456 1172.8 103
60S ribosomal protein L36 RPL36 Tbio Non-IDG -1.62928 39.9 123
Pyruvate kinase PKLR PKLR Tbio Kinase -2.37549 231.1 391
Cell division cycle protein 23 homolog CDC23 Tbio Non-IDG -1.50528 30.4 191
RNA polymerase II subunit A C-terminal domain phosphatase CTDP1 Tbio Enzyme -1.88697 80.7 113
Anaphase-promoting complex subunit 2 ANAPC2 Tbio Enzyme -0.45557 2.44 166