Targets

This is where graphics are reside..

Name	Gene	Development Level	Target Family	Log Novelty	Pubmed Score	Antibody Count
DmX-like protein 1	DMXL1	Tdark	Non-IDG	-2.50063	311.1	13
RWD domain-containing protein 3	RWDD3	Tbio	Non-IDG	-1.02793	10.9	98
Glutaredoxin domain-containing cysteine-rich protein 2	GRXCR2	Tbio	Non-IDG	0.00000	1.00	14
Serine incorporator 5	SERINC5	Tbio	Non-IDG	-1.50535	34.0	11
Potassium voltage-gated channel subfamily A member 2	KCNA2	Tclin	Ion Channel	-2.55550	343.3	205
UPF0606 protein KIAA1549	KIAA1549	Tbio	Non-IDG	-1.67668	47.8	19
Uncharacterized protein KIAA1551	KIAA1551	Tdark	Non-IDG	-0.49946	2.76	22
WD repeat domain phosphoinositide-interacting protein 4	WDR45	Tbio	Non-IDG	-1.29355	17.4	93
GPI mannosyltransferase 4	PIGZ	Tdark	Enzyme	-1.18571	13.8	39
Mitochondrial coenzyme A transporter SLC25A42	SLC25A42	Tbio	Transporter	-0.53750	4.06	29

	Tbio	9,614 \| 11,445
	Tdark	3,514 \| 6,588
	Tchem	1,427 \| 1,598
	Tclin	562 \| 613

	RFA-RM-18-021	277 \| 328
	Kinase: IDG Consortium (Target...	107 \| 125
	GPCR: IDG Consortium (Targets)	94 \| 126
	Ion Channel: IDG Consortium (T...	91 \| 99
	Kinase: IDG Consortium (Comple...	32 \| 37
	GPCR: IDG Consortium (Complete...	23 \| 25

	preweaning lethality, complete...	913 \| 979
	preweaning lethality, incomple...	448 \| 499
	abnormal behavior	266 \| 298
	embryonic lethality prior to t...	257 \| 278
	embryonic lethality prior to o...	223 \| 239
	abnormal embryo size	201 \| 220
	enlarged heart	193 \| 210
	decreased total body fat amoun...	188 \| 207
	decreased vertical activity	178 \| 208
	abnormal bone structure	162 \| 187
	increased lean body mass	155 \| 172
	decreased body weight	151 \| 161
	abnormal heart morphology	150 \| 162
	decreased bone mineral content	134 \| 151
	hyperactivity	131 \| 148
	hypoactivity	121 \| 132
	decreased lean body mass	120 \| 135
	increased total body fat amoun...	119 \| 134
	decreased bone mineral density	116 \| 126
	decreased circulating glucose ...	116 \| 126
	increased circulating alkaline...	110 \| 122
	male infertility	109 \| 123
	abnormal seminal vesicle morph...	108 \| 114
	decreased grip strength	104 \| 116
	embryonic growth retardation	99 \| 106
	increased startle reflex	99 \| 112
	increased bone mineral content	97 \| 108
	decreased body length	89 \| 101
	increased mean corpuscular hem...	89 \| 96
	increased or absent threshold ...	88 \| 101
	short tibia	86 \| 97
	increased mean corpuscular vol...	85 \| 92
	cataract	83 \| 92
	decreased circulating choleste...	83 \| 93
	prenatal lethality prior to he...	81 \| 87
	decreased lymphocyte cell numb...	77 \| 83
	decreased prepulse inhibition	77 \| 82
	increased circulating HDL chol...	76 \| 80
	decreased circulating triglyce...	72 \| 79
	decreased circulating serum al...	71 \| 82
	improved glucose tolerance	71 \| 79
	abnormal lens morphology	70 \| 81
	decreased mean corpuscular vol...	70 \| 79
	decreased startle reflex	69 \| 75
	increased fasted circulating g...	69 \| 76
	increased circulating sodium l...	68 \| 71
	decreased circulating insulin ...	67 \| 76
	impaired glucose tolerance	67 \| 75
	small superior vagus ganglion	67 \| 74
	abnormal retina morphology	65 \| 71
	abnormal eye morphology	64 \| 68
	abnormal gait	63 \| 69
	abnormal sleep behavior	63 \| 70
	decreased leukocyte cell numbe...	63 \| 73
	decreased hemoglobin content	62 \| 68
	increased circulating choleste...	62 \| 66
	decreased fasted circulating g...	60 \| 65
	increased bone mineral density	60 \| 72
	abnormal behavioral response t...	59 \| 66
	decreased circulating HDL chol...	59 \| 68
	decreased erythrocyte cell num...	59 \| 62
	increased monocyte cell number	59 \| 63
	abnormal kidney morphology	58 \| 65
	increased heart weight	56 \| 62
	abnormal coat-hair pigmentatio...	55 \| 64
	edema	55 \| 59
	small testis	55 \| 58
	thrombocytopenia	55 \| 56
	female infertility	54 \| 60
	abnormal spleen morphology	52 \| 55
	hydrometra	50 \| 53
	decreased caudal vertebrae num...	49 \| 53
	decreased circulating total pr...	47 \| 49
	decreased blood urea nitrogen ...	46 \| 51
	decreased mean corpuscular hem...	46 \| 50
	decreased circulating alanine ...	44 \| 47
	abnormal skin morphology	43 \| 50
	decreased circulating alkaline...	43 \| 46
	increased leukocyte cell numbe...	43 \| 47
	increased neutrophil cell numb...	43 \| 46
	abnormal neural tube closure	42 \| 46
	abnormal testis morphology	42 \| 43
	decreased hematocrit	42 \| 46
	increased mean platelet volume	42 \| 45
	increased blood urea nitrogen ...	41 \| 48
	abnormal epididymis morphology	39 \| 42
	decreased neutrophil cell numb...	39 \| 42
	decreased red blood cell distr...	39 \| 41
	increased grip strength	39 \| 41
	increased circulating triglyce...	38 \| 42
	increased hematocrit	38 \| 46
	limb grasping	38 \| 41
	increased hemoglobin content	37 \| 45
	prolonged QT interval	37 \| 38
	decreased circulating LDL chol...	36 \| 38
	decreased circulating calcium ...	36 \| 36
	decreased circulating creatini...	36 \| 39
	enlarged spleen	36 \| 41
	increased circulating chloride...	36 \| 41
	prolonged ST segment	36 \| 36

	Carcinoma	9,364 \| 11,493
	ovarian cancer	7,294 \| 8,520
	osteosarcoma	6,638 \| 7,950
	psoriasis	5,417 \| 6,694
	medulloblastoma, large-cell	5,336 \| 6,241
	glioblastoma	4,984 \| 5,792
	atypical teratoid / rhabdoid tumor	4,376 \| 5,112
	ependymoma	3,998 \| 4,679
	lung cancer	3,998 \| 4,740
	group 3 medulloblastoma	3,477 \| 4,104
	adult high grade glioma	3,234 \| 3,801
	Breast cancer	3,035 \| 3,578
	intraductal papillary-mucinous neoplasm (IPMN)	2,795 \| 3,291
	malignant mesothelioma	2,770 \| 3,232
	Astrocytoma, Pilocytic	2,661 \| 3,081
	invasive ductal carcinoma	2,597 \| 2,951
	primitive neuroectodermal tumor	2,572 \| 3,035
	intraductal papillary-mucinous carcinoma (IPMC)	2,562 \| 2,989
	intraductal papillary-mucinous adenoma (IPMA)	2,525 \| 2,955
	non-small cell lung cancer	2,496 \| 2,890
	oligodendroglioma	2,481 \| 2,850
	lung carcinoma	2,389 \| 2,843
	lung adenocarcinoma	2,324 \| 2,716
	astrocytic glioma	2,257 \| 2,597
	Kidney cancer	2,146 \| 2,613
	Cancer	2,118 \| 2,499
	pancreatic cancer	2,047 \| 2,398
	subependymal giant cell astrocytoma	1,972 \| 2,287
	interstitial cystitis	1,970 \| 2,312
	pancreatic ductal adenocarcinoma liver metastasis	1,725 \| 1,962
	pituitary cancer	1,705 \| 1,972
	tuberculosis	1,702 \| 2,010
	Pick disease	1,648 \| 1,894
	group 4 medulloblastoma	1,572 \| 1,855
	ulcerative colitis	1,566 \| 1,819
	ductal carcinoma in situ	1,529 \| 1,745
	breast carcinoma	1,422 \| 1,638
	cystic fibrosis	1,421 \| 1,696
	diabetes mellitus	1,356 \| 1,728
	Autosomal recessive predisposition	1,296 \| 1,442
	colon cancer	1,249 \| 1,478
	adrenocortical carcinoma	1,214 \| 1,428
	Multiple myeloma	1,166 \| 1,332
	juvenile dermatomyositis	1,028 \| 1,187
	Schizophrenia	1,011 \| 1,160
	astrocytoma	1,010 \| 1,146
	acute quadriplegic myopathy	1,004 \| 1,158
	Rheumatoid arthritis	998 \| 1,191
	primary pancreatic ductal adenocarcinoma	964 \| 1,109
	pediatric high grade glioma	925 \| 1,064
	spina bifida	910 \| 1,074
	Intellectual disability	897 \| 1,016
	nasopharyngeal carcinoma	878 \| 1,058
	cutaneous lupus erythematosus	861 \| 1,057
	dermatomyositis	821 \| 966
	Atopic dermatitis	783 \| 952
	active Crohn's disease	768 \| 922
	non primary Sjogren syndrome sicca	736 \| 891
	Epilepsy	715 \| 792
	gastric carcinoma	709 \| 807
	Liver Cirrhosis, Experimental	695 \| 769
	Waldenstrons macroglobulinemia	670 \| 765
	acute myeloid leukemia	668 \| 783
	active ulcerative colitis	639 \| 764
	esophageal adenocarcinoma	635 \| 737
	primary Sjogren syndrome	617 \| 735
	medulloblastoma	611 \| 720
	Obesity	601 \| 678
	aldosterone-producing adenoma	582 \| 665
	Bipolar Disorder	581 \| 666
	Dull intelligence	578 \| 645
	Low intelligence	578 \| 645
	Mental Retardation	578 \| 645
	Mental deficiency	578 \| 645
	Poor school performance	578 \| 645
	progressive supranuclear palsy	569 \| 676
	Alzheimer's disease	562 \| 658
	Melanoma	561 \| 711
	Cognitive delay	555 \| 608
	Global developmental delay	555 \| 608
	Mental and motor retardation	555 \| 608
	Seizures	549 \| 596
	Muscle hypotonia	533 \| 571
	Duchenne muscular dystrophy	529 \| 601
	fibroadenoma	486 \| 559
	pancreatic carcinoma	484 \| 562
	Endometriosis	478 \| 540
	Liver cancer	475 \| 604
	Short stature	469 \| 531
	Multiple Sclerosis	452 \| 540
	autosomal dominant Emery-Dreifuss muscular dystrophy	451 \| 510
	Down syndrome	448 \| 499
	hepatocellular carcinoma	448 \| 547
	Prostatic Neoplasms	444 \| 495
	chronic rhinosinusitis	427 \| 512
	posterior fossa group A ependymoma	412 \| 468
	Breast Neoplasms	406 \| 445
	Amyotrophic lateral sclerosis	396 \| 451
	mucosa-associated lymphoid tissue lymphoma	392 \| 484
	sonic hedgehog group medulloblastoma	390 \| 467

	Endocrine System	14,648 \| 18,159
	Digestive Tract	14,209 \| 17,369
	Female tissues	14,193 \| 17,400
	Skin and soft tissues	14,108 \| 17,230
	Male tissues	14,036 \| 17,142
	Blood and immune system	13,864 \| 16,909
	Nervous System	13,818 \| 16,725
	Liver and Pancreas	13,794 \| 16,750
	Urinary Tract	13,766 \| 16,678
	Respiratory system	13,506 \| 16,393
	Cardiovascular System	12,675 \| 15,192

Development Level

Collection

IMPC Phenotype

Disease

Tissue

Target Family

Ortholog Species

Drug Target Ontology

Target Development Level

Target Family

PANTHER Protein Ontology

Ligand

GTEx Tissue

HPA RNA Tissue

HPA Protein Tissue

HPM Tissue

JAX/MGI Phenotype

OMIM Phenotype

GWAS Trait

GO Component

UniProt Keywords

Data Source

	Non-IDG	8,607 \| 12,091
	Enzyme	3,452 \| 4,145
	Transcription Factor	943 \| 1,400
	Kinase	561 \| 634
	Transporter	419 \| 473
	GPCR	339 \| 408
	Ion Channel	315 \| 344
	oGPCR	210 \| 421
	Epigenetic	198 \| 242
	Nuclear Receptor	43 \| 48
	TF/Epigenetic	30 \| 38

	Rat	15,117 \| 15,117
	Mouse	16,570 \| 16,570
	Cow	15,320 \| 15,320
	Dog	15,073 \| 15,073
	Horse	14,252 \| 14,252
	Chimp	14,140 \| 14,140
	Macaque	12,761 \| 12,761
	Opossum	12,230 \| 12,230
	Anole lizard	10,588 \| 10,588
	Xenopus	10,468 \| 10,468
	Pig	10,168 \| 10,168
	Zebrafish	9,726 \| 9,726
	Chicken	7,827 \| 7,827
	Platypus	5,703 \| 5,703
	C. elegans	3,179 \| 3,179
	Fruitfly	3,050 \| 3,050
	S.cerevisiae	1,799 \| 1,799