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Target Filters...

Development Level

Tbio 9,609 | 11,445
Tdark 3,515 | 6,588
Tchem 1,426 | 1,598
Tclin 562 | 613

Collection

Kinase: IDG Consortium (Target... 107 | 125
GPCR: IDG Consortium (Targets) 94 | 126
Ion Channel: IDG Consortium (T... 91 | 99
Kinase: IDG Consortium (Comple... 32 | 37
GPCR: IDG Consortium (Complete... 23 | 25

IMPC Phenotype

preweaning lethality, complete... 913 | 979
preweaning lethality, incomple... 448 | 499
abnormal behavior 266 | 298
embryonic lethality prior to t... 257 | 278
embryonic lethality prior to o... 223 | 239
abnormal embryo size 201 | 220
enlarged heart 193 | 210
decreased total body fat amoun... 188 | 207
decreased vertical activity 178 | 208
abnormal bone structure 162 | 187
increased lean body mass 155 | 172
decreased body weight 151 | 161
abnormal heart morphology 150 | 162
decreased bone mineral content 134 | 151
hyperactivity 131 | 148
hypoactivity 121 | 132
decreased lean body mass 120 | 135
increased total body fat amoun... 119 | 134
decreased bone mineral density 116 | 126
decreased circulating glucose ... 116 | 126
increased circulating alkaline... 110 | 122
male infertility 109 | 123
abnormal seminal vesicle morph... 108 | 114
decreased grip strength 103 | 116
embryonic growth retardation 99 | 106
increased startle reflex 99 | 112
increased bone mineral content 97 | 108
decreased body length 89 | 101
increased mean corpuscular hem... 89 | 96
increased or absent threshold ... 88 | 101
short tibia 86 | 97
increased mean corpuscular vol... 85 | 92
cataract 83 | 92
decreased circulating choleste... 83 | 93
prenatal lethality prior to he... 81 | 87
decreased lymphocyte cell numb... 77 | 83
decreased prepulse inhibition 77 | 82
increased circulating HDL chol... 76 | 80
decreased circulating triglyce... 72 | 79
decreased circulating serum al... 71 | 82
improved glucose tolerance 71 | 79
abnormal lens morphology 70 | 81
decreased mean corpuscular vol... 70 | 79
decreased startle reflex 69 | 75
increased fasted circulating g... 69 | 76
increased circulating sodium l... 68 | 71
decreased circulating insulin ... 67 | 76
impaired glucose tolerance 67 | 75
small superior vagus ganglion 67 | 74
abnormal retina morphology 65 | 71
abnormal eye morphology 64 | 68
abnormal gait 63 | 69
abnormal sleep behavior 63 | 70
decreased leukocyte cell numbe... 63 | 73
decreased hemoglobin content 62 | 68
increased circulating choleste... 62 | 66
decreased fasted circulating g... 60 | 65
increased bone mineral density 60 | 72
abnormal behavioral response t... 59 | 66
decreased circulating HDL chol... 59 | 68
decreased erythrocyte cell num... 59 | 62
increased monocyte cell number 59 | 63
abnormal kidney morphology 58 | 65
increased heart weight 56 | 62
abnormal coat-hair pigmentatio... 55 | 64
edema 55 | 59
small testis 55 | 58
thrombocytopenia 55 | 56
female infertility 54 | 60
abnormal spleen morphology 52 | 55
hydrometra 50 | 53
decreased caudal vertebrae num... 49 | 53
decreased circulating total pr... 47 | 49
decreased blood urea nitrogen ... 46 | 51
decreased mean corpuscular hem... 46 | 50
decreased circulating alanine ... 44 | 47
abnormal skin morphology 43 | 50
decreased circulating alkaline... 43 | 46
increased leukocyte cell numbe... 43 | 47
increased neutrophil cell numb... 43 | 46
abnormal neural tube closure 42 | 46
abnormal testis morphology 42 | 43
decreased hematocrit 42 | 46
increased mean platelet volume 42 | 45
increased blood urea nitrogen ... 41 | 48
abnormal epididymis morphology 39 | 42
decreased neutrophil cell numb... 39 | 42
decreased red blood cell distr... 39 | 41
increased grip strength 39 | 41
increased hematocrit 39 | 46
increased circulating triglyce... 38 | 42
limb grasping 38 | 41
increased hemoglobin content 37 | 45
prolonged QT interval 37 | 38
decreased circulating LDL chol... 36 | 38
decreased circulating calcium ... 36 | 36
decreased circulating creatini... 36 | 39
enlarged spleen 36 | 41
increased circulating chloride... 36 | 41
prolonged ST segment 36 | 36

Disease

Carcinoma 9,361 | 11,493
ovarian cancer 7,290 | 8,520
osteosarcoma 6,639 | 7,950
psoriasis 5,415 | 6,694
medulloblastoma, large-cell 5,334 | 6,241
glioblastoma 4,981 | 5,792
atypical teratoid / rhabdoid tumor 4,374 | 5,112
ependymoma 3,996 | 4,679
lung cancer 3,996 | 4,740
group 3 medulloblastoma 3,476 | 4,104
adult high grade glioma 3,232 | 3,801
Breast cancer 3,030 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 2,791 | 3,291
malignant mesothelioma 2,769 | 3,232
Astrocytoma, Pilocytic 2,658 | 3,081
invasive ductal carcinoma 2,595 | 2,951
primitive neuroectodermal tumor 2,571 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,559 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,524 | 2,955
non-small cell lung cancer 2,494 | 2,890
oligodendroglioma 2,480 | 2,850
lung carcinoma 2,387 | 2,843
lung adenocarcinoma 2,324 | 2,716
astrocytic glioma 2,255 | 2,597
Kidney cancer 2,146 | 2,613
Cancer 2,116 | 2,499
pancreatic cancer 2,044 | 2,398
subependymal giant cell astrocytoma 1,972 | 2,287
interstitial cystitis 1,968 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,724 | 1,962
pituitary cancer 1,704 | 1,972
tuberculosis 1,702 | 2,010
Pick disease 1,648 | 1,894
group 4 medulloblastoma 1,571 | 1,855
ulcerative colitis 1,564 | 1,819
ductal carcinoma in situ 1,527 | 1,745
breast carcinoma 1,421 | 1,638
cystic fibrosis 1,418 | 1,696
diabetes mellitus 1,355 | 1,728
Autosomal recessive predisposition 1,296 | 1,442
colon cancer 1,249 | 1,478
adrenocortical carcinoma 1,214 | 1,428
Multiple myeloma 1,165 | 1,332
juvenile dermatomyositis 1,029 | 1,187
Schizophrenia 1,009 | 1,160
astrocytoma 1,009 | 1,146
acute quadriplegic myopathy 1,002 | 1,158
Rheumatoid arthritis 998 | 1,191
primary pancreatic ductal adenocarcinoma 964 | 1,109
pediatric high grade glioma 925 | 1,064
spina bifida 910 | 1,074
Intellectual disability 897 | 1,016
nasopharyngeal carcinoma 875 | 1,058
cutaneous lupus erythematosus 861 | 1,057
dermatomyositis 821 | 966
Atopic dermatitis 782 | 952
active Crohn's disease 768 | 922
non primary Sjogren syndrome sicca 737 | 891
Epilepsy 715 | 792
gastric carcinoma 708 | 807
Liver Cirrhosis, Experimental 695 | 769
Waldenstrons macroglobulinemia 669 | 765
acute myeloid leukemia 667 | 783
active ulcerative colitis 638 | 764
esophageal adenocarcinoma 633 | 737
primary Sjogren syndrome 617 | 735
medulloblastoma 611 | 720
Obesity 600 | 678
aldosterone-producing adenoma 581 | 665
Bipolar Disorder 580 | 666
Dull intelligence 578 | 645
Low intelligence 578 | 645
Mental Retardation 578 | 645
Mental deficiency 578 | 645
Poor school performance 578 | 645
progressive supranuclear palsy 568 | 676
Alzheimer's disease 561 | 658
Melanoma 561 | 711
Cognitive delay 555 | 608
Global developmental delay 555 | 608
Mental and motor retardation 555 | 608
Seizures 549 | 596
Muscle hypotonia 533 | 571
Duchenne muscular dystrophy 528 | 601
fibroadenoma 486 | 559
pancreatic carcinoma 484 | 562
Endometriosis 478 | 540
Liver cancer 475 | 604
Short stature 469 | 531
Multiple Sclerosis 452 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 450 | 510
Down syndrome 448 | 499
hepatocellular carcinoma 448 | 547
Prostatic Neoplasms 444 | 495
chronic rhinosinusitis 427 | 512
posterior fossa group A ependymoma 412 | 468
Breast Neoplasms 405 | 445
Amyotrophic lateral sclerosis 395 | 451
mucosa-associated lymphoid tissue lymphoma 392 | 484
sonic hedgehog group medulloblastoma 390 | 467

Tissue

Endocrine System 14,643 | 18,159
Digestive Tract 14,204 | 17,369
Female tissues 14,188 | 17,400
Skin and soft tissues 14,103 | 17,230
Male tissues 14,031 | 17,142
Blood and immune system 13,859 | 16,909
Nervous System 13,813 | 16,725
Liver and Pancreas 13,789 | 16,750
Urinary Tract 13,761 | 16,678
Respiratory system 13,501 | 16,393
Cardiovascular System 12,670 | 15,192

Target Family

Non-IDG 8,604 | 12,091
Enzyme 3,451 | 4,145
Transcription Factor 943 | 1,400
Kinase 561 | 634
Transporter 419 | 473
GPCR 339 | 408
Ion Channel 314 | 344
oGPCR 210 | 421
Epigenetic 198 | 242
Nuclear Receptor 43 | 48
TF/Epigenetic 30 | 38

Ortholog Species

Rat 15,112 | 15,112
Mouse 16,567 | 16,567
Cow 15,316 | 15,316
Dog 15,069 | 15,069
Horse 14,249 | 14,249
Chimp 14,136 | 14,136
Macaque 12,758 | 12,758
Opossum 12,223 | 12,223
Anole lizard 10,585 | 10,585
Xenopus 10,463 | 10,463
Pig 10,164 | 10,164
Zebrafish 9,725 | 9,725
Chicken 7,823 | 7,823
Platypus 5,699 | 5,699
C. elegans 3,178 | 3,178
Fruitfly 3,048 | 3,048
S.cerevisiae 1,798 | 1,798

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Trafficking protein particle complex subunit 2-like protein TRAPPC2L Tdark Non-IDG -0.18066 0.74 35
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418
Uncharacterized protein ZSWIM9 ZSWIM9 Tdark Non-IDG 0.00000 12
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123
Suppressor of tumorigenicity 14 protein ST14 Tchem Non-IDG -2.50215 338.3 309
Peroxisomal membrane protein PEX16 PEX16 Tbio Non-IDG -1.43594 27.8 78
T-box transcription factor TBX21 TBX21 Tbio Transcription Factor -2.95359 868.5 480
Urotensin-2 receptor UTS2R Tchem GPCR -1.95094 62.5 182
T-complex protein 1 subunit zeta CCT6A Tbio Non-IDG -1.39880 26.2 90