Development Level

Tbio 3,772 | 11,445
Tdark 1,133 | 6,588
Tchem 565 | 1,598
Tclin 229 | 613

Collection

Kinase: IDG Consortium (Target... 47 | 125
Ion Channel: IDG Consortium (T... 37 | 99
GPCR: IDG Consortium (Targets) 34 | 126
Kinase: IDG Consortium (Comple... 13 | 37
GPCR: IDG Consortium (Complete... 10 | 25

IMPC Phenotype

preweaning lethality, complete... 391 | 979
preweaning lethality, incomple... 182 | 499
embryonic lethality prior to t... 115 | 278
embryonic lethality prior to o... 101 | 239
abnormal behavior 98 | 298
enlarged heart 82 | 210
abnormal embryo size 78 | 220
decreased total body fat amoun... 72 | 207
decreased vertical activity 69 | 208
decreased body weight 68 | 161
abnormal bone structure 66 | 187
abnormal heart morphology 56 | 162
increased lean body mass 55 | 172
decreased bone mineral content 50 | 151
hypoactivity 48 | 132
decreased lean body mass 46 | 135
hyperactivity 45 | 148
increased or absent threshold ... 45 | 101
increased startle reflex 45 | 112
decreased grip strength 44 | 116
decreased body length 43 | 101
decreased bone mineral density 43 | 126
decreased circulating glucose ... 42 | 126
increased total body fat amoun... 42 | 134
embryonic growth retardation 40 | 106
increased circulating alkaline... 39 | 122
prenatal lethality prior to he... 39 | 87
abnormal seminal vesicle morph... 38 | 114
increased mean corpuscular vol... 38 | 92
male infertility 38 | 123
cataract 37 | 92
decreased lymphocyte cell numb... 35 | 83
increased circulating HDL chol... 35 | 80
decreased circulating choleste... 34 | 93
decreased circulating triglyce... 34 | 79
increased bone mineral content 33 | 108
decreased prepulse inhibition 31 | 82
decreased startle reflex 31 | 75
impaired glucose tolerance 31 | 75
increased circulating choleste... 31 | 66
increased mean corpuscular hem... 31 | 96
abnormal lens morphology 30 | 81
decreased circulating serum al... 30 | 82
decreased leukocyte cell numbe... 28 | 73
abnormal gait 27 | 69
abnormal retina morphology 27 | 71
decreased circulating insulin ... 27 | 76
increased monocyte cell number 27 | 63
edema 26 | 59
increased bone mineral density 26 | 72
increased circulating sodium l... 26 | 71
decreased erythrocyte cell num... 25 | 62
decreased mean corpuscular vol... 25 | 79
increased fasted circulating g... 25 | 76
increased heart weight 25 | 62
small testis 25 | 58
abnormal coat-hair pigmentatio... 24 | 64
thrombocytopenia 24 | 56
abnormal eye morphology 23 | 68
decreased fasted circulating g... 23 | 65
decreased hematocrit 22 | 46
decreased hemoglobin content 22 | 68
short tibia 22 | 97
abnormal kidney morphology 21 | 65
decreased blood urea nitrogen ... 21 | 51
decreased circulating HDL chol... 21 | 68
increased hematocrit 21 | 46
decreased caudal vertebrae num... 20 | 53
decreased neutrophil cell numb... 20 | 42
small superior vagus ganglion 20 | 74
tremors 20 | 39
increased mean platelet volume 19 | 45
abnormal testis morphology 18 | 43
increased blood urea nitrogen ... 18 | 48
increased hemoglobin content 18 | 45
limb grasping 18 | 41
abnormal behavioral response t... 17 | 66
abnormal bone mineralization 17 | 38
abnormal epididymis morphology 17 | 42
abnormal skin morphology 17 | 50
abnormal sleep behavior 17 | 70
decreased circulating total pr... 17 | 49
improved glucose tolerance 17 | 79
increased circulating triglyce... 17 | 42
increased neutrophil cell numb... 17 | 46
decreased circulating alanine ... 16 | 47
enlarged lymph nodes 16 | 37
female infertility 16 | 60
hydrometra 16 | 53
increased leukocyte cell numbe... 16 | 47
abnormal cranium morphology 15 | 36
abnormal neural tube closure 15 | 46
absent startle reflex 15 | 24
decreased circulating LDL chol... 15 | 38
decreased circulating iron lev... 15 | 32
increased circulating calcium ... 15 | 34
increased circulating chloride... 15 | 41
increased circulating phosphat... 15 | 26
increased erythrocyte cell num... 15 | 39
increased grip strength 15 | 41

Disease

Carcinoma 3,721 | 11,493
ovarian cancer 3,231 | 8,520
osteosarcoma 2,667 | 7,950
medulloblastoma, large-cell 2,237 | 6,241
psoriasis 2,165 | 6,694
glioblastoma 2,115 | 5,792
atypical teratoid / rhabdoid tumor 1,866 | 5,112
lung cancer 1,751 | 4,740
ependymoma 1,710 | 4,679
group 3 medulloblastoma 1,473 | 4,104
Breast cancer 1,355 | 3,578
adult high grade glioma 1,323 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 1,221 | 3,291
malignant mesothelioma 1,178 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 1,130 | 2,989
primitive neuroectodermal tumor 1,122 | 3,035
invasive ductal carcinoma 1,108 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 1,092 | 2,955
Astrocytoma, Pilocytic 1,087 | 3,081
oligodendroglioma 1,079 | 2,850
non-small cell lung cancer 1,055 | 2,890
astrocytic glioma 984 | 2,597
lung carcinoma 974 | 2,843
lung adenocarcinoma 945 | 2,716
pancreatic cancer 888 | 2,398
Kidney cancer 866 | 2,613
Cancer 835 | 2,499
interstitial cystitis 788 | 2,312
subependymal giant cell astrocytoma 787 | 2,287
Pick disease 759 | 1,894
pancreatic ductal adenocarcinoma liver metastasis 756 | 1,962
pituitary cancer 738 | 1,972
tuberculosis 722 | 2,010
group 4 medulloblastoma 670 | 1,855
ductal carcinoma in situ 663 | 1,745
cystic fibrosis 659 | 1,696
ulcerative colitis 649 | 1,819
Multiple myeloma 594 | 1,332
breast carcinoma 577 | 1,638
colon cancer 569 | 1,478
adrenocortical carcinoma 551 | 1,428
diabetes mellitus 550 | 1,728
Autosomal recessive predisposition 525 | 1,442
acute quadriplegic myopathy 510 | 1,158
juvenile dermatomyositis 496 | 1,187
Rheumatoid arthritis 435 | 1,191
spina bifida 431 | 1,074
primary pancreatic ductal adenocarcinoma 421 | 1,109
nasopharyngeal carcinoma 413 | 1,058
astrocytoma 409 | 1,146
dermatomyositis 403 | 966
pediatric high grade glioma 394 | 1,064
Schizophrenia 383 | 1,160
Atopic dermatitis 362 | 952
Intellectual disability 361 | 1,016
Waldenstrons macroglobulinemia 348 | 765
acute myeloid leukemia 331 | 783
active Crohn's disease 329 | 922
cutaneous lupus erythematosus 326 | 1,057
gastric carcinoma 293 | 807
primary Sjogren syndrome 293 | 735
non primary Sjogren syndrome sicca 291 | 891
Epilepsy 290 | 792
aldosterone-producing adenoma 285 | 665
progressive supranuclear palsy 281 | 676
esophageal adenocarcinoma 277 | 737
Liver Cirrhosis, Experimental 272 | 769
active ulcerative colitis 267 | 764
medulloblastoma 261 | 720
Obesity 259 | 678
Bipolar Disorder 243 | 666
Alzheimer's disease 241 | 658
Dull intelligence 239 | 645
Low intelligence 239 | 645
Mental Retardation 239 | 645
Mental deficiency 239 | 645
Poor school performance 239 | 645
Duchenne muscular dystrophy 238 | 601
Melanoma 238 | 711
Seizures 226 | 596
hepatocellular carcinoma 226 | 547
autosomal dominant Emery-Dreifuss muscular dystrophy 225 | 510
pancreatic carcinoma 225 | 562
Cognitive delay 224 | 608
Global developmental delay 224 | 608
Mental and motor retardation 224 | 608
Muscle hypotonia 217 | 571
Endometriosis 209 | 540
Down syndrome 208 | 499
Liver cancer 195 | 604
chronic rhinosinusitis 194 | 512
Amyotrophic lateral sclerosis 188 | 451
Short stature 186 | 531
sonic hedgehog group medulloblastoma 186 | 467
gastric cancer 184 | 459
tuberculosis and treatment for 6 months 182 | 409
fibroadenoma 179 | 559
Breast Neoplasms 174 | 445
Prostatic Neoplasms 174 | 495
mucosa-associated lymphoid tissue lymphoma 166 | 484

Tissue

Endocrine System 5,607 | 18,159
Digestive Tract 5,488 | 17,369
Female tissues 5,480 | 17,400
Skin and soft tissues 5,466 | 17,230
Male tissues 5,434 | 17,142
Nervous System 5,383 | 16,725
Blood and immune system 5,366 | 16,909
Liver and Pancreas 5,351 | 16,750
Urinary Tract 5,344 | 16,678
Respiratory system 5,262 | 16,393
Cardiovascular System 5,004 | 15,192

Target Family

Non-IDG 3,166 | 12,091
Enzyme 1,421 | 4,145
Transcription Factor 321 | 1,400
Kinase 231 | 634
Transporter 149 | 473
GPCR 147 | 408
Ion Channel 132 | 344
Epigenetic 78 | 242
Nuclear Receptor 22 | 48
oGPCR 21 | 421
TF/Epigenetic 11 | 38

Ortholog Species

Platypus 5,699 | 5,699
Mouse 16,567 | 16,567
Cow 15,316 | 15,316
Rat 15,112 | 15,112
Dog 15,069 | 15,069
Horse 14,249 | 14,249
Chimp 14,136 | 14,136
Macaque 12,758 | 12,758
Opossum 12,223 | 12,223
Anole lizard 10,585 | 10,585
Xenopus 10,463 | 10,463
Pig 10,164 | 10,164
Zebrafish 9,725 | 9,725
Chicken 7,823 | 7,823
C. elegans 3,178 | 3,178
Fruitfly 3,048 | 3,048
S.cerevisiae 1,798 | 1,798

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123
Suppressor of tumorigenicity 14 protein ST14 Tchem Non-IDG -2.50215 338.3 309
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Beta-1,3-galactosyltransferase 1 B3GALT1 Tbio Enzyme -0.68296 3.85 66
Disintegrin and metalloproteinase domain-containing protein 28 ADAM28 Tbio Enzyme -1.87527 79.6 110
Probable ergosterol biosynthetic protein 28 ERG28 Tdark Non-IDG -1.25331 16.7 40
Paired mesoderm homeobox protein 1 PRRX1 Tbio Transcription Factor -1.58479 38.8 304
Atlastin-1 ATL1 Tbio Non-IDG -2.07795 119.7 164