Development Level

Tbio 6,538 | 11,445
Tdark 2,236 | 6,588
Tchem 1,008 | 1,598
Tclin 382 | 613

Collection

Kinase: IDG Consortium (Target... 73 | 125
Ion Channel: IDG Consortium (T... 61 | 99
GPCR: IDG Consortium (Targets) 53 | 126
Kinase: IDG Consortium (Comple... 22 | 37
GPCR: IDG Consortium (Complete... 10 | 25

IMPC Phenotype

preweaning lethality, complete... 629 | 979
preweaning lethality, incomple... 316 | 499
abnormal behavior 193 | 298
embryonic lethality prior to t... 182 | 278
embryonic lethality prior to o... 161 | 239
abnormal embryo size 136 | 220
enlarged heart 131 | 210
decreased vertical activity 130 | 208
decreased total body fat amoun... 123 | 207
abnormal bone structure 114 | 187
decreased body weight 113 | 161
abnormal heart morphology 108 | 162
increased lean body mass 98 | 172
hyperactivity 97 | 148
increased total body fat amoun... 95 | 134
decreased bone mineral content 88 | 151
hypoactivity 86 | 132
decreased lean body mass 83 | 135
male infertility 81 | 123
increased startle reflex 80 | 112
increased circulating alkaline... 76 | 122
decreased bone mineral density 74 | 126
decreased circulating glucose ... 72 | 126
increased or absent threshold ... 68 | 101
abnormal seminal vesicle morph... 66 | 114
decreased grip strength 64 | 116
increased bone mineral content 64 | 108
decreased circulating choleste... 61 | 93
embryonic growth retardation 60 | 106
short tibia 60 | 97
decreased lymphocyte cell numb... 57 | 83
increased mean corpuscular vol... 57 | 92
decreased body length 56 | 101
decreased prepulse inhibition 56 | 82
increased mean corpuscular hem... 56 | 96
decreased startle reflex 55 | 75
cataract 52 | 92
decreased leukocyte cell numbe... 52 | 73
increased circulating HDL chol... 52 | 80
prenatal lethality prior to he... 51 | 87
small superior vagus ganglion 50 | 74
decreased circulating triglyce... 49 | 79
increased bone mineral density 48 | 72
decreased hemoglobin content 46 | 68
abnormal gait 45 | 69
decreased mean corpuscular vol... 45 | 79
increased circulating sodium l... 45 | 71
abnormal retina morphology 44 | 71
increased monocyte cell number 44 | 63
abnormal coat-hair pigmentatio... 43 | 64
decreased circulating serum al... 43 | 82
increased circulating choleste... 43 | 66
increased fasted circulating g... 43 | 76
abnormal lens morphology 42 | 81
abnormal sleep behavior 42 | 70
decreased erythrocyte cell num... 42 | 62
abnormal behavioral response t... 41 | 66
impaired glucose tolerance 41 | 75
abnormal eye morphology 40 | 68
edema 40 | 59
abnormal kidney morphology 39 | 65
hydrometra 38 | 53
improved glucose tolerance 38 | 79
abnormal neural tube closure 37 | 46
decreased circulating HDL chol... 37 | 68
decreased circulating insulin ... 37 | 76
decreased fasted circulating g... 37 | 65
female infertility 37 | 60
small testis 36 | 58
increased heart weight 35 | 62
thrombocytopenia 35 | 56
decreased blood urea nitrogen ... 34 | 51
decreased hematocrit 33 | 46
decreased circulating total pr... 32 | 49
decreased mean corpuscular hem... 32 | 50
abnormal skin morphology 31 | 50
abnormal spleen morphology 31 | 55
increased grip strength 30 | 41
increased neutrophil cell numb... 30 | 46
abnormal testis morphology 29 | 43
decreased caudal vertebrae num... 29 | 53
decreased neutrophil cell numb... 29 | 42
increased blood urea nitrogen ... 29 | 48
abnormal cranium morphology 27 | 36
abnormal epididymis morphology 27 | 42
enlarged lymph nodes 27 | 37
increased circulating triglyce... 27 | 42
limb grasping 27 | 41
tremors 27 | 39
abnormal bone mineralization 26 | 38
decreased circulating alanine ... 26 | 47
decreased red blood cell distr... 26 | 41
increased leukocyte cell numbe... 26 | 47
decreased circulating LDL chol... 25 | 38
increased mean platelet volume 25 | 45
decreased circulating alkaline... 24 | 46
enlarged spleen 24 | 41
increased circulating calcium ... 24 | 34
increased hematocrit 24 | 46
increased hemoglobin content 24 | 45

Disease

Carcinoma 6,627 | 11,493
ovarian cancer 5,046 | 8,520
osteosarcoma 4,596 | 7,950
psoriasis 3,647 | 6,694
medulloblastoma, large-cell 3,609 | 6,241
glioblastoma 3,405 | 5,792
atypical teratoid / rhabdoid tumor 2,976 | 5,112
lung cancer 2,810 | 4,740
ependymoma 2,688 | 4,679
group 3 medulloblastoma 2,396 | 4,104
adult high grade glioma 2,212 | 3,801
Breast cancer 2,057 | 3,578
malignant mesothelioma 1,942 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 1,914 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 1,768 | 2,989
Astrocytoma, Pilocytic 1,755 | 3,081
primitive neuroectodermal tumor 1,748 | 3,035
invasive ductal carcinoma 1,735 | 2,951
non-small cell lung cancer 1,730 | 2,890
intraductal papillary-mucinous adenoma (IPMA) 1,726 | 2,955
oligodendroglioma 1,641 | 2,850
lung carcinoma 1,616 | 2,843
lung adenocarcinoma 1,597 | 2,716
astrocytic glioma 1,518 | 2,597
Kidney cancer 1,474 | 2,613
Cancer 1,448 | 2,499
pancreatic cancer 1,387 | 2,398
interstitial cystitis 1,357 | 2,312
subependymal giant cell astrocytoma 1,342 | 2,287
pancreatic ductal adenocarcinoma liver metastasis 1,203 | 1,962
tuberculosis 1,133 | 2,010
Pick disease 1,132 | 1,894
pituitary cancer 1,098 | 1,972
ulcerative colitis 1,077 | 1,819
group 4 medulloblastoma 1,061 | 1,855
ductal carcinoma in situ 1,030 | 1,745
cystic fibrosis 966 | 1,696
Autosomal recessive predisposition 927 | 1,442
breast carcinoma 920 | 1,638
diabetes mellitus 908 | 1,728
colon cancer 878 | 1,478
Multiple myeloma 855 | 1,332
adrenocortical carcinoma 832 | 1,428
acute quadriplegic myopathy 696 | 1,158
Rheumatoid arthritis 691 | 1,191
astrocytoma 688 | 1,146
juvenile dermatomyositis 684 | 1,187
primary pancreatic ductal adenocarcinoma 660 | 1,109
Schizophrenia 657 | 1,160
nasopharyngeal carcinoma 646 | 1,058
pediatric high grade glioma 618 | 1,064
Intellectual disability 616 | 1,016
spina bifida 611 | 1,074
dermatomyositis 588 | 966
cutaneous lupus erythematosus 577 | 1,057
Atopic dermatitis 554 | 952
active Crohn's disease 550 | 922
Waldenstrons macroglobulinemia 504 | 765
non primary Sjogren syndrome sicca 499 | 891
Epilepsy 495 | 792
gastric carcinoma 492 | 807
acute myeloid leukemia 469 | 783
Liver Cirrhosis, Experimental 446 | 769
active ulcerative colitis 435 | 764
esophageal adenocarcinoma 434 | 737
medulloblastoma 426 | 720
primary Sjogren syndrome 426 | 735
Obesity 420 | 678
progressive supranuclear palsy 420 | 676
Dull intelligence 402 | 645
Low intelligence 402 | 645
Mental Retardation 402 | 645
Mental deficiency 402 | 645
Poor school performance 402 | 645
Alzheimer's disease 395 | 658
Melanoma 395 | 711
Seizures 390 | 596
aldosterone-producing adenoma 389 | 665
Cognitive delay 379 | 608
Global developmental delay 379 | 608
Mental and motor retardation 379 | 608
Bipolar Disorder 374 | 666
Muscle hypotonia 369 | 571
Endometriosis 343 | 540
Duchenne muscular dystrophy 332 | 601
Short stature 329 | 531
pancreatic carcinoma 314 | 562
chronic rhinosinusitis 311 | 512
fibroadenoma 311 | 559
Multiple Sclerosis 309 | 540
hepatocellular carcinoma 305 | 547
Prostatic Neoplasms 296 | 495
autosomal dominant Emery-Dreifuss muscular dystrophy 291 | 510
Down syndrome 281 | 499
posterior fossa group A ependymoma 279 | 468
mucosa-associated lymphoid tissue lymphoma 278 | 484
Breast Neoplasms 276 | 445
Liver cancer 276 | 604
Neurodegenerative disease 274 | 414
Mammary Neoplasms 267 | 425

Tissue

Endocrine System 9,950 | 18,159
Digestive Tract 9,696 | 17,369
Female tissues 9,683 | 17,400
Skin and soft tissues 9,629 | 17,230
Male tissues 9,584 | 17,142
Blood and immune system 9,490 | 16,909
Liver and Pancreas 9,437 | 16,750
Nervous System 9,434 | 16,725
Urinary Tract 9,417 | 16,678
Respiratory system 9,261 | 16,393
Cardiovascular System 8,729 | 15,192

Target Family

Non-IDG 5,733 | 12,091
Enzyme 2,462 | 4,145
Transcription Factor 636 | 1,400
Kinase 378 | 634
Transporter 280 | 473
GPCR 203 | 408
Ion Channel 193 | 344
Epigenetic 150 | 242
oGPCR 74 | 421
Nuclear Receptor 32 | 48
TF/Epigenetic 23 | 38

Ortholog Species

Pig 10,164 | 10,164
Mouse 16,567 | 16,567
Cow 15,316 | 15,316
Rat 15,112 | 15,112
Dog 15,069 | 15,069
Horse 14,249 | 14,249
Chimp 14,136 | 14,136
Macaque 12,758 | 12,758
Opossum 12,223 | 12,223
Anole lizard 10,585 | 10,585
Xenopus 10,463 | 10,463
Zebrafish 9,725 | 9,725
Chicken 7,823 | 7,823
Platypus 5,699 | 5,699
C. elegans 3,178 | 3,178
Fruitfly 3,048 | 3,048
S.cerevisiae 1,798 | 1,798

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Trafficking protein particle complex subunit 2-like protein TRAPPC2L Tdark Non-IDG -0.18066 0.74 35
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123
Suppressor of tumorigenicity 14 protein ST14 Tchem Non-IDG -2.50215 338.3 309
Peroxisomal membrane protein PEX16 PEX16 Tbio Non-IDG -1.43594 27.8 78
T-box transcription factor TBX21 TBX21 Tbio Transcription Factor -2.95359 868.5 480
T-complex protein 1 subunit zeta CCT6A Tbio Non-IDG -1.39880 26.2 90
Thrombopoietin THPO Tbio Non-IDG -3.23551 1632.3 440
Zinc finger protein Helios IKZF2 Tbio Transcription Factor -1.26324 15.8 221