Development Level

Tbio 8,015 | 11,445
Tdark 2,577 | 6,588
Tchem 1,175 | 1,598
Tclin 463 | 613

Collection

RFA-RM-18-021 228 | 328
Kinase: IDG Consortium (Target... 95 | 125
Ion Channel: IDG Consortium (T... 74 | 99
GPCR: IDG Consortium (Targets) 67 | 126
Kinase: IDG Consortium (Comple... 26 | 37
GPCR: IDG Consortium (Complete... 17 | 25

IMPC Phenotype

preweaning lethality, complete... 803 | 979
preweaning lethality, incomple... 386 | 499
embryonic lethality prior to t... 236 | 278
abnormal behavior 221 | 298
embryonic lethality prior to o... 204 | 239
abnormal embryo size 175 | 220
decreased total body fat amoun... 160 | 207
enlarged heart 160 | 210
decreased vertical activity 146 | 208
abnormal bone structure 133 | 187
increased lean body mass 133 | 172
decreased body weight 130 | 161
abnormal heart morphology 124 | 162
decreased bone mineral content 111 | 151
hyperactivity 110 | 148
increased total body fat amoun... 104 | 134
hypoactivity 100 | 132
decreased circulating glucose ... 99 | 126
decreased lean body mass 94 | 135
decreased bone mineral density 92 | 126
increased circulating alkaline... 92 | 122
increased startle reflex 91 | 112
decreased grip strength 85 | 116
embryonic growth retardation 85 | 106
increased bone mineral content 85 | 108
male infertility 85 | 123
increased or absent threshold ... 82 | 101
decreased body length 80 | 101
abnormal seminal vesicle morph... 79 | 114
short tibia 75 | 97
cataract 73 | 92
increased mean corpuscular vol... 72 | 92
decreased prepulse inhibition 70 | 82
prenatal lethality prior to he... 69 | 87
decreased circulating choleste... 67 | 93
increased circulating HDL chol... 67 | 80
increased mean corpuscular hem... 66 | 96
abnormal lens morphology 64 | 81
decreased lymphocyte cell numb... 64 | 83
decreased circulating serum al... 63 | 82
decreased circulating triglyce... 62 | 79
decreased startle reflex 61 | 75
abnormal retina morphology 59 | 71
decreased mean corpuscular vol... 58 | 79
decreased leukocyte cell numbe... 57 | 73
small superior vagus ganglion 56 | 74
decreased circulating insulin ... 55 | 76
increased circulating choleste... 55 | 66
improved glucose tolerance 54 | 79
abnormal eye morphology 52 | 68
abnormal gait 52 | 69
decreased circulating HDL chol... 52 | 68
impaired glucose tolerance 52 | 75
increased circulating sodium l... 52 | 71
abnormal sleep behavior 51 | 70
decreased fasted circulating g... 50 | 65
abnormal behavioral response t... 49 | 66
increased bone mineral density 49 | 72
increased fasted circulating g... 49 | 76
abnormal coat-hair pigmentatio... 48 | 64
abnormal kidney morphology 48 | 65
decreased hemoglobin content 48 | 68
decreased erythrocyte cell num... 47 | 62
increased heart weight 46 | 62
edema 45 | 59
increased monocyte cell number 45 | 63
small testis 45 | 58
thrombocytopenia 44 | 56
abnormal spleen morphology 43 | 55
female infertility 41 | 60
hydrometra 41 | 53
decreased circulating total pr... 40 | 49
abnormal neural tube closure 38 | 46
decreased blood urea nitrogen ... 38 | 51
decreased mean corpuscular hem... 38 | 50
abnormal skin morphology 37 | 50
decreased caudal vertebrae num... 37 | 53
decreased circulating alanine ... 36 | 47
decreased hematocrit 36 | 46
increased blood urea nitrogen ... 36 | 48
decreased circulating alkaline... 35 | 46
increased circulating triglyce... 35 | 42
increased neutrophil cell numb... 35 | 46
abnormal testis morphology 34 | 43
increased hemoglobin content 34 | 45
increased mean platelet volume 34 | 45
limb grasping 34 | 41
increased circulating chloride... 33 | 41
increased hematocrit 32 | 46
abnormal epididymis morphology 31 | 42
decreased neutrophil cell numb... 31 | 42
enlarged lymph nodes 31 | 37
increased circulating calcium ... 31 | 34
increased circulating creatini... 31 | 38
enlarged spleen 30 | 41
tremors 30 | 39
abnormal bone mineralization 29 | 38
decreased circulating aspartat... 29 | 34
increased erythrocyte cell num... 29 | 39
increased grip strength 29 | 41

Disease

Carcinoma 7,937 | 11,493
ovarian cancer 6,310 | 8,520
osteosarcoma 5,630 | 7,950
medulloblastoma, large-cell 4,520 | 6,241
psoriasis 4,459 | 6,694
glioblastoma 4,257 | 5,792
atypical teratoid / rhabdoid tumor 3,751 | 5,112
lung cancer 3,455 | 4,740
ependymoma 3,449 | 4,679
group 3 medulloblastoma 3,035 | 4,104
adult high grade glioma 2,741 | 3,801
Breast cancer 2,624 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 2,393 | 3,291
malignant mesothelioma 2,324 | 3,232
Astrocytoma, Pilocytic 2,238 | 3,081
primitive neuroectodermal tumor 2,227 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,210 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,188 | 2,955
invasive ductal carcinoma 2,165 | 2,951
oligodendroglioma 2,115 | 2,850
non-small cell lung cancer 2,065 | 2,890
lung carcinoma 2,018 | 2,843
lung adenocarcinoma 1,936 | 2,716
astrocytic glioma 1,929 | 2,597
Kidney cancer 1,900 | 2,613
pancreatic cancer 1,732 | 2,398
Cancer 1,704 | 2,499
subependymal giant cell astrocytoma 1,695 | 2,287
interstitial cystitis 1,609 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,499 | 1,962
pituitary cancer 1,489 | 1,972
Pick disease 1,453 | 1,894
tuberculosis 1,402 | 2,010
group 4 medulloblastoma 1,342 | 1,855
ulcerative colitis 1,319 | 1,819
ductal carcinoma in situ 1,271 | 1,745
cystic fibrosis 1,225 | 1,696
breast carcinoma 1,156 | 1,638
Autosomal recessive predisposition 1,143 | 1,442
diabetes mellitus 1,104 | 1,728
colon cancer 1,073 | 1,478
adrenocortical carcinoma 1,022 | 1,428
Multiple myeloma 1,006 | 1,332
acute quadriplegic myopathy 892 | 1,158
juvenile dermatomyositis 891 | 1,187
astrocytoma 868 | 1,146
Rheumatoid arthritis 860 | 1,191
primary pancreatic ductal adenocarcinoma 849 | 1,109
Schizophrenia 839 | 1,160
Intellectual disability 811 | 1,016
pediatric high grade glioma 795 | 1,064
spina bifida 780 | 1,074
nasopharyngeal carcinoma 759 | 1,058
dermatomyositis 711 | 966
cutaneous lupus erythematosus 681 | 1,057
Atopic dermatitis 651 | 952
active Crohn's disease 650 | 922
Epilepsy 633 | 792
non primary Sjogren syndrome sicca 616 | 891
gastric carcinoma 607 | 807
Waldenstrons macroglobulinemia 596 | 765
Liver Cirrhosis, Experimental 578 | 769
acute myeloid leukemia 576 | 783
active ulcerative colitis 537 | 764
medulloblastoma 537 | 720
primary Sjogren syndrome 519 | 735
Dull intelligence 517 | 645
Low intelligence 517 | 645
Mental Retardation 517 | 645
Mental deficiency 517 | 645
Poor school performance 517 | 645
esophageal adenocarcinoma 513 | 737
progressive supranuclear palsy 513 | 676
Obesity 510 | 678
aldosterone-producing adenoma 508 | 665
Cognitive delay 494 | 608
Global developmental delay 494 | 608
Melanoma 494 | 711
Mental and motor retardation 494 | 608
Bipolar Disorder 492 | 666
Seizures 487 | 596
Alzheimer's disease 483 | 658
Muscle hypotonia 465 | 571
Duchenne muscular dystrophy 448 | 601
Liver cancer 431 | 604
Short stature 412 | 531
Endometriosis 393 | 540
pancreatic carcinoma 392 | 562
autosomal dominant Emery-Dreifuss muscular dystrophy 390 | 510
fibroadenoma 382 | 559
Down syndrome 381 | 499
hepatocellular carcinoma 375 | 547
chronic rhinosinusitis 366 | 512
Prostatic Neoplasms 356 | 495
Breast Neoplasms 345 | 445
posterior fossa group A ependymoma 344 | 468
Amyotrophic lateral sclerosis 343 | 451
sonic hedgehog group medulloblastoma 339 | 467
Multiple Sclerosis 333 | 540
Skin cancer 331 | 469

Tissue

Endocrine System 11,968 | 18,159
Digestive Tract 11,728 | 17,369
Female tissues 11,699 | 17,400
Skin and soft tissues 11,660 | 17,230
Male tissues 11,559 | 17,142
Nervous System 11,456 | 16,725
Blood and immune system 11,431 | 16,909
Liver and Pancreas 11,416 | 16,750
Urinary Tract 11,409 | 16,678
Respiratory system 11,217 | 16,393
Cardiovascular System 10,609 | 15,192

Target Family

Non-IDG 6,829 | 12,091
Enzyme 2,928 | 4,145
Transcription Factor 734 | 1,400
Kinase 483 | 634
Transporter 358 | 473
GPCR 275 | 408
Ion Channel 260 | 344
Epigenetic 184 | 242
oGPCR 113 | 421
Nuclear Receptor 39 | 48
TF/Epigenetic 27 | 38

Ortholog Species

Opossum 12,230 | 12,230
Mouse 16,570 | 16,570
Cow 15,320 | 15,320
Rat 15,117 | 15,117
Dog 15,073 | 15,073
Horse 14,252 | 14,252
Chimp 14,140 | 14,140
Macaque 12,761 | 12,761
Anole lizard 10,588 | 10,588
Xenopus 10,468 | 10,468
Pig 10,168 | 10,168
Zebrafish 9,726 | 9,726
Chicken 7,827 | 7,827
Platypus 5,703 | 5,703
C. elegans 3,179 | 3,179
Fruitfly 3,050 | 3,050
S.cerevisiae 1,799 | 1,799

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.53750 4.06 29
Probable global transcription activator SNF2L1 SMARCA1 Tbio Non-IDG -2.20560 145.6 116
Mitochondrial uncoupling protein 3 UCP3 Tbio Non-IDG -2.74050 585.4 181