Development Level

Tbio 10,485 | 11,445
Tdark 3,983 | 6,588
Tchem 1,516 | 1,598
Tclin 586 | 613

Collection

RFA-RM-18-021 299 | 328
Kinase: IDG Consortium (Target... 119 | 125
GPCR: IDG Consortium (Targets) 103 | 126
Ion Channel: IDG Consortium (T... 91 | 99
Kinase: IDG Consortium (Comple... 35 | 37
GPCR: IDG Consortium (Complete... 24 | 25

IMPC Phenotype

preweaning lethality, complete... 969 | 979
preweaning lethality, incomple... 486 | 499
abnormal behavior 296 | 298
embryonic lethality prior to t... 276 | 278
embryonic lethality prior to o... 234 | 239
abnormal embryo size 217 | 220
enlarged heart 208 | 210
decreased total body fat amoun... 206 | 207
decreased vertical activity 202 | 208
abnormal bone structure 183 | 187
increased lean body mass 168 | 172
abnormal heart morphology 161 | 162
decreased body weight 160 | 161
decreased bone mineral content 148 | 151
hyperactivity 142 | 148
decreased lean body mass 133 | 135
increased total body fat amoun... 132 | 134
hypoactivity 128 | 132
decreased bone mineral density 125 | 126
decreased circulating glucose ... 124 | 126
increased circulating alkaline... 122 | 122
male infertility 119 | 123
decreased grip strength 115 | 116
abnormal seminal vesicle morph... 113 | 114
increased startle reflex 110 | 112
increased bone mineral content 107 | 108
embryonic growth retardation 104 | 106
decreased body length 101 | 101
increased or absent threshold ... 101 | 101
short tibia 96 | 97
increased mean corpuscular hem... 92 | 96
decreased circulating choleste... 91 | 93
cataract 89 | 92
increased mean corpuscular vol... 89 | 92
decreased lymphocyte cell numb... 83 | 83
prenatal lethality prior to he... 83 | 87
decreased circulating serum al... 82 | 82
decreased prepulse inhibition 82 | 82
decreased circulating triglyce... 79 | 79
improved glucose tolerance 78 | 79
increased circulating HDL chol... 78 | 80
abnormal lens morphology 77 | 81
decreased mean corpuscular vol... 76 | 79
increased fasted circulating g... 76 | 76
decreased circulating insulin ... 75 | 76
decreased startle reflex 75 | 75
small superior vagus ganglion 74 | 74
decreased leukocyte cell numbe... 73 | 73
impaired glucose tolerance 73 | 75
increased bone mineral density 71 | 72
increased circulating sodium l... 71 | 71
abnormal sleep behavior 69 | 70
abnormal eye morphology 68 | 68
abnormal retina morphology 68 | 71
decreased hemoglobin content 68 | 68
abnormal gait 67 | 69
decreased circulating HDL chol... 66 | 68
abnormal behavioral response t... 65 | 66
increased circulating choleste... 65 | 66
decreased fasted circulating g... 64 | 65
abnormal kidney morphology 63 | 65
increased monocyte cell number 63 | 63
abnormal coat-hair pigmentatio... 62 | 64
decreased erythrocyte cell num... 62 | 62
increased heart weight 62 | 62
edema 58 | 59
female infertility 58 | 60
small testis 57 | 58
thrombocytopenia 56 | 56
abnormal spleen morphology 55 | 55
hydrometra 53 | 53
decreased blood urea nitrogen ... 51 | 51
decreased caudal vertebrae num... 51 | 53
abnormal skin morphology 50 | 50
decreased circulating total pr... 49 | 49
decreased mean corpuscular hem... 49 | 50
increased blood urea nitrogen ... 48 | 48
decreased circulating alanine ... 47 | 47
abnormal neural tube closure 46 | 46
decreased circulating alkaline... 46 | 46
decreased hematocrit 46 | 46
increased neutrophil cell numb... 46 | 46
increased leukocyte cell numbe... 45 | 47
increased mean platelet volume 45 | 45
abnormal testis morphology 43 | 43
increased hematocrit 43 | 46
decreased neutrophil cell numb... 42 | 42
abnormal epididymis morphology 41 | 42
decreased red blood cell distr... 41 | 41
enlarged spleen 41 | 41
increased circulating chloride... 41 | 41
increased circulating triglyce... 41 | 42
increased grip strength 41 | 41
increased hemoglobin content 41 | 45
limb grasping 41 | 41
decreased circulating LDL chol... 38 | 38
decreased circulating creatini... 38 | 39
increased erythrocyte cell num... 38 | 39
prolonged QT interval 38 | 38
tremors 38 | 39

Disease

Carcinoma 10,261 | 11,493
ovarian cancer 7,976 | 8,520
osteosarcoma 7,256 | 7,950
psoriasis 5,932 | 6,694
medulloblastoma, large-cell 5,846 | 6,241
glioblastoma 5,473 | 5,792
atypical teratoid / rhabdoid tumor 4,835 | 5,112
ependymoma 4,413 | 4,679
lung cancer 4,364 | 4,740
group 3 medulloblastoma 3,853 | 4,104
adult high grade glioma 3,567 | 3,801
Breast cancer 3,355 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 3,060 | 3,291
malignant mesothelioma 3,023 | 3,232
Astrocytoma, Pilocytic 2,909 | 3,081
primitive neuroectodermal tumor 2,859 | 3,035
invasive ductal carcinoma 2,811 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 2,801 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,773 | 2,955
non-small cell lung cancer 2,711 | 2,890
oligodendroglioma 2,705 | 2,850
lung carcinoma 2,633 | 2,843
lung adenocarcinoma 2,535 | 2,716
astrocytic glioma 2,469 | 2,597
Kidney cancer 2,409 | 2,613
pancreatic cancer 2,238 | 2,398
Cancer 2,225 | 2,499
subependymal giant cell astrocytoma 2,168 | 2,287
interstitial cystitis 2,129 | 2,312
pituitary cancer 1,865 | 1,972
pancreatic ductal adenocarcinoma liver metastasis 1,855 | 1,962
tuberculosis 1,827 | 2,010
Pick disease 1,802 | 1,894
group 4 medulloblastoma 1,736 | 1,855
ulcerative colitis 1,696 | 1,819
ductal carcinoma in situ 1,667 | 1,745
cystic fibrosis 1,563 | 1,696
breast carcinoma 1,539 | 1,638
diabetes mellitus 1,444 | 1,728
Autosomal recessive predisposition 1,411 | 1,442
colon cancer 1,361 | 1,478
adrenocortical carcinoma 1,325 | 1,428
Multiple myeloma 1,265 | 1,332
juvenile dermatomyositis 1,118 | 1,187
acute quadriplegic myopathy 1,107 | 1,158
Rheumatoid arthritis 1,092 | 1,191
astrocytoma 1,090 | 1,146
Schizophrenia 1,086 | 1,160
primary pancreatic ductal adenocarcinoma 1,050 | 1,109
pediatric high grade glioma 1,000 | 1,064
spina bifida 999 | 1,074
Intellectual disability 986 | 1,016
nasopharyngeal carcinoma 973 | 1,058
cutaneous lupus erythematosus 936 | 1,057
dermatomyositis 885 | 966
Atopic dermatitis 873 | 952
active Crohn's disease 834 | 922
non primary Sjogren syndrome sicca 810 | 891
Epilepsy 773 | 792
gastric carcinoma 771 | 807
Liver Cirrhosis, Experimental 737 | 769
acute myeloid leukemia 726 | 783
Waldenstrons macroglobulinemia 724 | 765
active ulcerative colitis 699 | 764
esophageal adenocarcinoma 682 | 737
medulloblastoma 669 | 720
primary Sjogren syndrome 665 | 735
Obesity 651 | 678
Melanoma 643 | 711
aldosterone-producing adenoma 636 | 665
Dull intelligence 632 | 645
Low intelligence 632 | 645
Mental Retardation 632 | 645
Mental deficiency 632 | 645
Poor school performance 632 | 645
Bipolar Disorder 631 | 666
progressive supranuclear palsy 628 | 676
Alzheimer's disease 615 | 658
Cognitive delay 598 | 608
Global developmental delay 598 | 608
Mental and motor retardation 598 | 608
Seizures 588 | 596
Duchenne muscular dystrophy 568 | 601
Muscle hypotonia 565 | 571
Liver cancer 557 | 604
fibroadenoma 532 | 559
pancreatic carcinoma 523 | 562
Short stature 513 | 531
Endometriosis 503 | 540
hepatocellular carcinoma 497 | 547
autosomal dominant Emery-Dreifuss muscular dystrophy 489 | 510
chronic rhinosinusitis 479 | 512
Down syndrome 473 | 499
Prostatic Neoplasms 473 | 495
Multiple Sclerosis 462 | 540
posterior fossa group A ependymoma 440 | 468
sonic hedgehog group medulloblastoma 436 | 467
Amyotrophic lateral sclerosis 430 | 451
mucosa-associated lymphoid tissue lymphoma 425 | 484
Breast Neoplasms 422 | 445

Tissue

Endocrine System 16,053 | 18,159
Digestive Tract 15,572 | 17,369
Female tissues 15,555 | 17,400
Skin and soft tissues 15,455 | 17,230
Male tissues 15,385 | 17,142
Blood and immune system 15,188 | 16,909
Nervous System 15,127 | 16,725
Liver and Pancreas 15,097 | 16,750
Urinary Tract 15,067 | 16,678
Respiratory system 14,798 | 16,393
Cardiovascular System 13,852 | 15,192

Target Family

Non-IDG 9,471 | 12,091
Enzyme 3,765 | 4,145
Transcription Factor 1,043 | 1,400
Kinase 606 | 634
Transporter 445 | 473
GPCR 364 | 408
Ion Channel 329 | 344
oGPCR 237 | 421
Epigenetic 228 | 242
Nuclear Receptor 48 | 48
TF/Epigenetic 34 | 38

Ortholog Species

Mouse 16,570 | 16,570
Cow 15,320 | 15,320
Rat 15,117 | 15,117
Dog 15,073 | 15,073
Horse 14,252 | 14,252
Chimp 14,140 | 14,140
Macaque 12,761 | 12,761
Opossum 12,230 | 12,230
Anole lizard 10,588 | 10,588
Xenopus 10,468 | 10,468
Pig 10,168 | 10,168
Zebrafish 9,726 | 9,726
Chicken 7,827 | 7,827
Platypus 5,703 | 5,703
C. elegans 3,179 | 3,179
Fruitfly 3,050 | 3,050
S.cerevisiae 1,799 | 1,799

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Glutaredoxin domain-containing cysteine-rich protein 2 GRXCR2 Tbio Non-IDG 0.00000 1.00 14
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.53750 4.06 29