Development Level

Tbio 8,212 | 11,445
Tdark 2,822 | 6,588
Tchem 1,268 | 1,598
Tclin 459 | 613

Collection

RFA-RM-18-021 230 | 328
Kinase: IDG Consortium (Target... 102 | 125
Ion Channel: IDG Consortium (T... 73 | 99
GPCR: IDG Consortium (Targets) 60 | 126
Kinase: IDG Consortium (Comple... 28 | 37
GPCR: IDG Consortium (Complete... 16 | 25

IMPC Phenotype

preweaning lethality, complete... 788 | 979
preweaning lethality, incomple... 371 | 499
abnormal behavior 227 | 298
embryonic lethality prior to t... 223 | 278
embryonic lethality prior to o... 196 | 239
abnormal embryo size 180 | 220
enlarged heart 161 | 210
decreased total body fat amoun... 155 | 207
abnormal bone structure 148 | 187
decreased vertical activity 146 | 208
decreased body weight 137 | 161
increased lean body mass 129 | 172
decreased bone mineral content 121 | 151
abnormal heart morphology 119 | 162
hyperactivity 112 | 148
increased total body fat amoun... 103 | 134
decreased lean body mass 102 | 135
hypoactivity 101 | 132
decreased circulating glucose ... 99 | 126
increased circulating alkaline... 98 | 122
decreased bone mineral density 96 | 126
male infertility 96 | 123
increased startle reflex 92 | 112
embryonic growth retardation 91 | 106
decreased grip strength 87 | 116
increased or absent threshold ... 85 | 101
abnormal seminal vesicle morph... 82 | 114
increased bone mineral content 82 | 108
short tibia 80 | 97
decreased body length 77 | 101
decreased circulating choleste... 75 | 93
decreased lymphocyte cell numb... 73 | 83
increased mean corpuscular vol... 70 | 92
cataract 69 | 92
prenatal lethality prior to he... 67 | 87
increased mean corpuscular hem... 66 | 96
decreased prepulse inhibition 65 | 82
decreased circulating triglyce... 64 | 79
decreased leukocyte cell numbe... 63 | 73
improved glucose tolerance 63 | 79
increased circulating HDL chol... 63 | 80
abnormal lens morphology 61 | 81
decreased hemoglobin content 59 | 68
decreased startle reflex 59 | 75
decreased circulating serum al... 58 | 82
decreased mean corpuscular vol... 58 | 79
abnormal eye morphology 56 | 68
decreased circulating HDL chol... 56 | 68
abnormal retina morphology 55 | 71
decreased erythrocyte cell num... 55 | 62
small superior vagus ganglion 55 | 74
increased bone mineral density 54 | 72
impaired glucose tolerance 53 | 75
increased fasted circulating g... 53 | 76
increased monocyte cell number 53 | 63
abnormal gait 52 | 69
increased circulating choleste... 52 | 66
increased circulating sodium l... 52 | 71
decreased circulating insulin ... 51 | 76
increased heart weight 51 | 62
abnormal sleep behavior 50 | 70
small testis 50 | 58
abnormal coat-hair pigmentatio... 48 | 64
abnormal behavioral response t... 46 | 66
abnormal kidney morphology 46 | 65
female infertility 46 | 60
thrombocytopenia 46 | 56
edema 45 | 59
decreased fasted circulating g... 43 | 65
hydrometra 41 | 53
increased blood urea nitrogen ... 41 | 48
decreased caudal vertebrae num... 40 | 53
decreased hematocrit 40 | 46
abnormal neural tube closure 39 | 46
decreased mean corpuscular hem... 39 | 50
increased neutrophil cell numb... 38 | 46
abnormal spleen morphology 37 | 55
increased circulating triglyce... 37 | 42
decreased blood urea nitrogen ... 36 | 51
decreased circulating alanine ... 36 | 47
decreased circulating alkaline... 36 | 46
decreased circulating total pr... 36 | 49
abnormal skin morphology 35 | 50
tremors 35 | 39
decreased red blood cell distr... 33 | 41
increased circulating creatini... 33 | 38
increased leukocyte cell numbe... 33 | 47
abnormal epididymis morphology 32 | 42
decreased circulating LDL chol... 32 | 38
decreased circulating creatini... 32 | 39
increased circulating chloride... 32 | 41
increased hematocrit 32 | 46
increased hemoglobin content 32 | 45
increased mean platelet volume 32 | 45
limb grasping 32 | 41
abnormal testis morphology 31 | 43
cardiovascular system phenotyp... 31 | 36
enlarged spleen 30 | 41
increased circulating calcium ... 30 | 34
increased erythrocyte cell num... 30 | 39

Disease

Carcinoma 8,399 | 11,493
ovarian cancer 6,426 | 8,520
osteosarcoma 5,887 | 7,950
medulloblastoma, large-cell 4,673 | 6,241
psoriasis 4,655 | 6,694
glioblastoma 4,335 | 5,792
atypical teratoid / rhabdoid tumor 3,825 | 5,112
lung cancer 3,592 | 4,740
ependymoma 3,465 | 4,679
group 3 medulloblastoma 3,065 | 4,104
adult high grade glioma 2,829 | 3,801
Breast cancer 2,667 | 3,578
malignant mesothelioma 2,474 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 2,470 | 3,291
Astrocytoma, Pilocytic 2,291 | 3,081
primitive neuroectodermal tumor 2,289 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,260 | 2,989
invasive ductal carcinoma 2,209 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,207 | 2,955
non-small cell lung cancer 2,155 | 2,890
oligodendroglioma 2,144 | 2,850
lung carcinoma 2,109 | 2,843
Kidney cancer 2,014 | 2,613
lung adenocarcinoma 2,013 | 2,716
astrocytic glioma 1,926 | 2,597
Cancer 1,805 | 2,499
pancreatic cancer 1,752 | 2,398
subependymal giant cell astrocytoma 1,704 | 2,287
interstitial cystitis 1,682 | 2,312
tuberculosis 1,503 | 2,010
Pick disease 1,487 | 1,894
pancreatic ductal adenocarcinoma liver metastasis 1,484 | 1,962
pituitary cancer 1,428 | 1,972
group 4 medulloblastoma 1,384 | 1,855
ulcerative colitis 1,358 | 1,819
ductal carcinoma in situ 1,310 | 1,745
cystic fibrosis 1,239 | 1,696
breast carcinoma 1,195 | 1,638
diabetes mellitus 1,146 | 1,728
Autosomal recessive predisposition 1,129 | 1,442
colon cancer 1,115 | 1,478
adrenocortical carcinoma 1,079 | 1,428
Multiple myeloma 1,025 | 1,332
juvenile dermatomyositis 910 | 1,187
Schizophrenia 886 | 1,160
astrocytoma 886 | 1,146
acute quadriplegic myopathy 885 | 1,158
Rheumatoid arthritis 869 | 1,191
primary pancreatic ductal adenocarcinoma 834 | 1,109
Intellectual disability 802 | 1,016
pediatric high grade glioma 793 | 1,064
spina bifida 791 | 1,074
nasopharyngeal carcinoma 775 | 1,058
cutaneous lupus erythematosus 768 | 1,057
dermatomyositis 746 | 966
Atopic dermatitis 698 | 952
active Crohn's disease 673 | 922
non primary Sjogren syndrome sicca 649 | 891
Epilepsy 631 | 792
Waldenstrons macroglobulinemia 621 | 765
gastric carcinoma 617 | 807
acute myeloid leukemia 602 | 783
Liver Cirrhosis, Experimental 596 | 769
primary Sjogren syndrome 576 | 735
active ulcerative colitis 556 | 764
medulloblastoma 554 | 720
esophageal adenocarcinoma 541 | 737
progressive supranuclear palsy 530 | 676
Alzheimer's disease 523 | 658
Melanoma 523 | 711
Dull intelligence 518 | 645
Low intelligence 518 | 645
Mental Retardation 518 | 645
Mental deficiency 518 | 645
Poor school performance 518 | 645
aldosterone-producing adenoma 516 | 665
Obesity 507 | 678
Bipolar Disorder 499 | 666
Cognitive delay 486 | 608
Global developmental delay 486 | 608
Mental and motor retardation 486 | 608
Seizures 484 | 596
Duchenne muscular dystrophy 468 | 601
Muscle hypotonia 460 | 571
pancreatic carcinoma 425 | 562
Short stature 415 | 531
Liver cancer 408 | 604
Endometriosis 403 | 540
Multiple Sclerosis 401 | 540
Prostatic Neoplasms 395 | 495
autosomal dominant Emery-Dreifuss muscular dystrophy 395 | 510
fibroadenoma 393 | 559
hepatocellular carcinoma 389 | 547
Down syndrome 388 | 499
chronic rhinosinusitis 376 | 512
posterior fossa group A ependymoma 361 | 468
Amyotrophic lateral sclerosis 352 | 451
Breast Neoplasms 342 | 445
Skin cancer 340 | 469
mucosa-associated lymphoid tissue lymphoma 338 | 484

Tissue

Endocrine System 12,480 | 18,159
Digestive Tract 12,152 | 17,369
Female tissues 12,152 | 17,400
Skin and soft tissues 12,058 | 17,230
Male tissues 12,016 | 17,142
Blood and immune system 11,866 | 16,909
Nervous System 11,831 | 16,725
Liver and Pancreas 11,829 | 16,750
Urinary Tract 11,801 | 16,678
Respiratory system 11,597 | 16,393
Cardiovascular System 10,943 | 15,192

Target Family

Non-IDG 7,179 | 12,091
Enzyme 2,989 | 4,145
Transcription Factor 867 | 1,400
Kinase 518 | 634
Transporter 367 | 473
GPCR 261 | 408
Ion Channel 249 | 344
Epigenetic 193 | 242
oGPCR 74 | 421
Nuclear Receptor 43 | 48
TF/Epigenetic 21 | 38

Ortholog Species

Macaque 12,761 | 12,761
Mouse 16,570 | 16,570
Cow 15,320 | 15,320
Rat 15,117 | 15,117
Dog 15,073 | 15,073
Horse 14,252 | 14,252
Chimp 14,140 | 14,140
Opossum 12,230 | 12,230
Anole lizard 10,588 | 10,588
Xenopus 10,468 | 10,468
Pig 10,168 | 10,168
Zebrafish 9,726 | 9,726
Chicken 7,827 | 7,827
Platypus 5,703 | 5,703
C. elegans 3,179 | 3,179
Fruitfly 3,050 | 3,050
S.cerevisiae 1,799 | 1,799

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
Glutaredoxin domain-containing cysteine-rich protein 2 GRXCR2 Tbio Non-IDG 0.00000 1.00 14
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.53750 4.06 29
Probable global transcription activator SNF2L1 SMARCA1 Tbio Non-IDG -2.20560 145.6 116