Development Level

Tbio 9,115 | 11,445
Tdark 3,264 | 6,588
Tchem 1,359 | 1,598
Tclin 511 | 613

Collection

Kinase: IDG Consortium (Target... 100 | 125
Ion Channel: IDG Consortium (T... 75 | 99
GPCR: IDG Consortium (Targets) 74 | 126
Kinase: IDG Consortium (Comple... 29 | 37
GPCR: IDG Consortium (Complete... 20 | 25

IMPC Phenotype

preweaning lethality, complete... 880 | 979
preweaning lethality, incomple... 432 | 499
embryonic lethality prior to t... 254 | 278
abnormal behavior 246 | 298
embryonic lethality prior to o... 219 | 239
abnormal embryo size 198 | 220
decreased total body fat amoun... 182 | 207
enlarged heart 182 | 210
decreased vertical activity 171 | 208
abnormal bone structure 156 | 187
increased lean body mass 149 | 172
decreased body weight 142 | 161
abnormal heart morphology 139 | 162
decreased bone mineral content 129 | 151
decreased lean body mass 122 | 135
increased total body fat amoun... 118 | 134
hyperactivity 115 | 148
hypoactivity 113 | 132
decreased bone mineral density 112 | 126
increased circulating alkaline... 110 | 122
male infertility 109 | 123
decreased circulating glucose ... 107 | 126
decreased grip strength 101 | 116
embryonic growth retardation 99 | 106
abnormal seminal vesicle morph... 93 | 114
increased bone mineral content 89 | 108
increased startle reflex 89 | 112
decreased body length 88 | 101
short tibia 88 | 97
increased or absent threshold ... 86 | 101
increased mean corpuscular hem... 85 | 96
cataract 80 | 92
decreased circulating choleste... 79 | 93
increased mean corpuscular vol... 78 | 92
decreased lymphocyte cell numb... 77 | 83
prenatal lethality prior to he... 76 | 87
decreased prepulse inhibition 71 | 82
increased circulating HDL chol... 71 | 80
decreased circulating serum al... 68 | 82
decreased circulating triglyce... 67 | 79
decreased mean corpuscular vol... 67 | 79
abnormal lens morphology 66 | 81
improved glucose tolerance 66 | 79
decreased startle reflex 65 | 75
abnormal retina morphology 64 | 71
decreased leukocyte cell numbe... 64 | 73
increased fasted circulating g... 64 | 76
impaired glucose tolerance 63 | 75
small superior vagus ganglion 63 | 74
decreased circulating insulin ... 62 | 76
increased bone mineral density 62 | 72
abnormal gait 61 | 69
decreased fasted circulating g... 60 | 65
decreased circulating HDL chol... 58 | 68
abnormal eye morphology 57 | 68
decreased hemoglobin content 57 | 68
increased circulating choleste... 57 | 66
increased circulating sodium l... 57 | 71
abnormal coat-hair pigmentatio... 56 | 64
abnormal sleep behavior 56 | 70
decreased erythrocyte cell num... 56 | 62
increased monocyte cell number 56 | 63
increased heart weight 55 | 62
abnormal behavioral response t... 54 | 66
abnormal kidney morphology 53 | 65
edema 52 | 59
female infertility 50 | 60
small testis 48 | 58
thrombocytopenia 47 | 56
decreased circulating total pr... 46 | 49
decreased mean corpuscular hem... 46 | 50
abnormal spleen morphology 45 | 55
hydrometra 45 | 53
decreased caudal vertebrae num... 44 | 53
decreased circulating alkaline... 44 | 46
abnormal neural tube closure 43 | 46
abnormal skin morphology 43 | 50
decreased circulating alanine ... 43 | 47
increased hematocrit 42 | 46
increased leukocyte cell numbe... 42 | 47
decreased blood urea nitrogen ... 41 | 51
increased blood urea nitrogen ... 40 | 48
decreased hematocrit 39 | 46
increased mean platelet volume 39 | 45
increased neutrophil cell numb... 39 | 46
increased circulating chloride... 37 | 41
increased hemoglobin content 37 | 45
tremors 37 | 39
decreased red blood cell distr... 36 | 41
increased grip strength 36 | 41
abnormal epididymis morphology 35 | 42
decreased neutrophil cell numb... 35 | 42
increased circulating triglyce... 35 | 42
increased erythrocyte cell num... 35 | 39
limb grasping 35 | 41
prolonged QT interval 35 | 38
decreased circulating LDL chol... 34 | 38
prolonged ST segment 34 | 36
cardiovascular system phenotyp... 33 | 36
pallor 33 | 34

Disease

Carcinoma 9,155 | 11,493
ovarian cancer 7,095 | 8,520
osteosarcoma 6,436 | 7,950
medulloblastoma, large-cell 5,134 | 6,241
psoriasis 5,129 | 6,694
glioblastoma 4,778 | 5,792
atypical teratoid / rhabdoid tumor 4,192 | 5,112
lung cancer 3,930 | 4,740
ependymoma 3,843 | 4,679
group 3 medulloblastoma 3,368 | 4,104
adult high grade glioma 3,094 | 3,801
Breast cancer 2,942 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 2,713 | 3,291
malignant mesothelioma 2,677 | 3,232
Astrocytoma, Pilocytic 2,516 | 3,081
primitive neuroectodermal tumor 2,508 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,468 | 2,989
invasive ductal carcinoma 2,462 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,425 | 2,955
non-small cell lung cancer 2,413 | 2,890
oligodendroglioma 2,348 | 2,850
lung carcinoma 2,332 | 2,843
lung adenocarcinoma 2,208 | 2,716
Kidney cancer 2,136 | 2,613
astrocytic glioma 2,130 | 2,597
pancreatic cancer 1,959 | 2,398
Cancer 1,956 | 2,499
interstitial cystitis 1,890 | 2,312
subependymal giant cell astrocytoma 1,883 | 2,287
pancreatic ductal adenocarcinoma liver metastasis 1,619 | 1,962
tuberculosis 1,612 | 2,010
Pick disease 1,610 | 1,894
pituitary cancer 1,594 | 1,972
ulcerative colitis 1,512 | 1,819
group 4 medulloblastoma 1,503 | 1,855
ductal carcinoma in situ 1,449 | 1,745
cystic fibrosis 1,351 | 1,696
breast carcinoma 1,311 | 1,638
Autosomal recessive predisposition 1,292 | 1,442
diabetes mellitus 1,281 | 1,728
colon cancer 1,224 | 1,478
adrenocortical carcinoma 1,181 | 1,428
Multiple myeloma 1,161 | 1,332
juvenile dermatomyositis 1,002 | 1,187
acute quadriplegic myopathy 984 | 1,158
astrocytoma 952 | 1,146
primary pancreatic ductal adenocarcinoma 945 | 1,109
Rheumatoid arthritis 939 | 1,191
Schizophrenia 924 | 1,160
spina bifida 892 | 1,074
pediatric high grade glioma 886 | 1,064
Intellectual disability 877 | 1,016
nasopharyngeal carcinoma 875 | 1,058
cutaneous lupus erythematosus 836 | 1,057
dermatomyositis 817 | 966
Atopic dermatitis 767 | 952
active Crohn's disease 753 | 922
non primary Sjogren syndrome sicca 721 | 891
Epilepsy 693 | 792
Waldenstrons macroglobulinemia 674 | 765
gastric carcinoma 674 | 807
Liver Cirrhosis, Experimental 670 | 769
primary Sjogren syndrome 624 | 735
acute myeloid leukemia 622 | 783
active ulcerative colitis 618 | 764
esophageal adenocarcinoma 597 | 737
medulloblastoma 592 | 720
Melanoma 572 | 711
Obesity 568 | 678
Dull intelligence 566 | 645
Low intelligence 566 | 645
Mental Retardation 566 | 645
Mental deficiency 566 | 645
Poor school performance 566 | 645
progressive supranuclear palsy 565 | 676
aldosterone-producing adenoma 549 | 665
Alzheimer's disease 548 | 658
Bipolar Disorder 542 | 666
Cognitive delay 542 | 608
Global developmental delay 542 | 608
Mental and motor retardation 542 | 608
Seizures 525 | 596
Muscle hypotonia 515 | 571
Duchenne muscular dystrophy 506 | 601
Liver cancer 460 | 604
Short stature 460 | 531
pancreatic carcinoma 449 | 562
Endometriosis 446 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 443 | 510
hepatocellular carcinoma 442 | 547
fibroadenoma 432 | 559
Prostatic Neoplasms 420 | 495
chronic rhinosinusitis 418 | 512
Down syndrome 407 | 499
posterior fossa group A ependymoma 392 | 468
Multiple Sclerosis 388 | 540
Amyotrophic lateral sclerosis 383 | 451
mucosa-associated lymphoid tissue lymphoma 383 | 484
sonic hedgehog group medulloblastoma 383 | 467
Skin cancer 382 | 469

Tissue

Endocrine System 13,896 | 18,159
Digestive Tract 13,559 | 17,369
Female tissues 13,535 | 17,400
Skin and soft tissues 13,460 | 17,230
Male tissues 13,390 | 17,142
Blood and immune system 13,233 | 16,909
Liver and Pancreas 13,194 | 16,750
Urinary Tract 13,175 | 16,678
Nervous System 13,171 | 16,725
Respiratory system 12,944 | 16,393
Cardiovascular System 12,202 | 15,192

Target Family

Non-IDG 8,071 | 12,091
Enzyme 3,345 | 4,145
Transcription Factor 891 | 1,400
Kinase 539 | 634
Transporter 406 | 473
GPCR 283 | 408
Ion Channel 274 | 344
Epigenetic 200 | 242
oGPCR 170 | 421
Nuclear Receptor 44 | 48
TF/Epigenetic 26 | 38

Ortholog Species

Horse 14,249 | 14,249
Mouse 16,567 | 16,567
Cow 15,316 | 15,316
Rat 15,112 | 15,112
Dog 15,069 | 15,069
Chimp 14,136 | 14,136
Macaque 12,758 | 12,758
Opossum 12,223 | 12,223
Anole lizard 10,585 | 10,585
Xenopus 10,463 | 10,463
Pig 10,164 | 10,164
Zebrafish 9,725 | 9,725
Chicken 7,823 | 7,823
Platypus 5,699 | 5,699
C. elegans 3,178 | 3,178
Fruitfly 3,048 | 3,048
S.cerevisiae 1,798 | 1,798

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Trafficking protein particle complex subunit 2-like protein TRAPPC2L Tdark Non-IDG -0.18066 0.74 35
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418
Uncharacterized protein ZSWIM9 ZSWIM9 Tdark Non-IDG 0.00000 12
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123
Suppressor of tumorigenicity 14 protein ST14 Tchem Non-IDG -2.50215 338.3 309
Peroxisomal membrane protein PEX16 PEX16 Tbio Non-IDG -1.43594 27.8 78
Urotensin-2 receptor UTS2R Tchem GPCR -1.95094 62.5 182
T-complex protein 1 subunit zeta CCT6A Tbio Non-IDG -1.39880 26.2 90
Paraneoplastic antigen Ma2 PNMA2 Tbio Non-IDG -2.92781 822.4 113