Development Level

Tbio 9,119 | 11,445
Tdark 3,263 | 6,588
Tchem 1,359 | 1,598
Tclin 511 | 613

Collection

RFA-RM-18-021 239 | 328
Kinase: IDG Consortium (Target... 100 | 125
Ion Channel: IDG Consortium (T... 75 | 99
GPCR: IDG Consortium (Targets) 74 | 126
Kinase: IDG Consortium (Comple... 29 | 37
GPCR: IDG Consortium (Complete... 20 | 25

IMPC Phenotype

preweaning lethality, complete... 880 | 979
preweaning lethality, incomple... 432 | 499
embryonic lethality prior to t... 254 | 278
abnormal behavior 246 | 298
embryonic lethality prior to o... 219 | 239
abnormal embryo size 198 | 220
decreased total body fat amoun... 182 | 207
enlarged heart 182 | 210
decreased vertical activity 171 | 208
abnormal bone structure 156 | 187
increased lean body mass 149 | 172
decreased body weight 142 | 161
abnormal heart morphology 139 | 162
decreased bone mineral content 129 | 151
decreased lean body mass 122 | 135
increased total body fat amoun... 118 | 134
hyperactivity 115 | 148
hypoactivity 113 | 132
decreased bone mineral density 112 | 126
increased circulating alkaline... 110 | 122
male infertility 109 | 123
decreased circulating glucose ... 107 | 126
decreased grip strength 101 | 116
embryonic growth retardation 99 | 106
abnormal seminal vesicle morph... 93 | 114
increased bone mineral content 89 | 108
increased startle reflex 89 | 112
decreased body length 88 | 101
short tibia 88 | 97
increased or absent threshold ... 86 | 101
increased mean corpuscular hem... 85 | 96
cataract 80 | 92
decreased circulating choleste... 79 | 93
increased mean corpuscular vol... 78 | 92
decreased lymphocyte cell numb... 77 | 83
prenatal lethality prior to he... 76 | 87
decreased prepulse inhibition 71 | 82
increased circulating HDL chol... 71 | 80
decreased circulating serum al... 68 | 82
decreased circulating triglyce... 67 | 79
decreased mean corpuscular vol... 67 | 79
abnormal lens morphology 66 | 81
improved glucose tolerance 66 | 79
decreased startle reflex 65 | 75
abnormal retina morphology 64 | 71
decreased leukocyte cell numbe... 64 | 73
increased fasted circulating g... 64 | 76
impaired glucose tolerance 63 | 75
small superior vagus ganglion 63 | 74
decreased circulating insulin ... 62 | 76
increased bone mineral density 62 | 72
abnormal gait 61 | 69
decreased fasted circulating g... 60 | 65
decreased circulating HDL chol... 58 | 68
abnormal eye morphology 57 | 68
decreased hemoglobin content 57 | 68
increased circulating choleste... 57 | 66
increased circulating sodium l... 57 | 71
abnormal coat-hair pigmentatio... 56 | 64
abnormal sleep behavior 56 | 70
decreased erythrocyte cell num... 56 | 62
increased monocyte cell number 56 | 63
increased heart weight 55 | 62
abnormal behavioral response t... 54 | 66
abnormal kidney morphology 53 | 65
edema 52 | 59
female infertility 50 | 60
small testis 48 | 58
thrombocytopenia 47 | 56
decreased circulating total pr... 46 | 49
decreased mean corpuscular hem... 46 | 50
abnormal spleen morphology 45 | 55
hydrometra 45 | 53
decreased caudal vertebrae num... 44 | 53
decreased circulating alkaline... 44 | 46
abnormal neural tube closure 43 | 46
abnormal skin morphology 43 | 50
decreased circulating alanine ... 43 | 47
increased leukocyte cell numbe... 42 | 47
decreased blood urea nitrogen ... 41 | 51
increased hematocrit 41 | 46
increased blood urea nitrogen ... 40 | 48
decreased hematocrit 39 | 46
increased mean platelet volume 39 | 45
increased neutrophil cell numb... 39 | 46
increased circulating chloride... 37 | 41
increased hemoglobin content 37 | 45
tremors 37 | 39
decreased red blood cell distr... 36 | 41
increased grip strength 36 | 41
abnormal epididymis morphology 35 | 42
decreased neutrophil cell numb... 35 | 42
increased circulating triglyce... 35 | 42
increased erythrocyte cell num... 35 | 39
limb grasping 35 | 41
prolonged QT interval 35 | 38
decreased circulating LDL chol... 34 | 38
prolonged ST segment 34 | 36
cardiovascular system phenotyp... 33 | 36
pallor 33 | 34

Disease

Carcinoma 9,157 | 11,493
ovarian cancer 7,097 | 8,520
osteosarcoma 6,435 | 7,950
medulloblastoma, large-cell 5,135 | 6,241
psoriasis 5,129 | 6,694
glioblastoma 4,781 | 5,792
atypical teratoid / rhabdoid tumor 4,193 | 5,112
lung cancer 3,932 | 4,740
ependymoma 3,845 | 4,679
group 3 medulloblastoma 3,369 | 4,104
adult high grade glioma 3,096 | 3,801
Breast cancer 2,946 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 2,716 | 3,291
malignant mesothelioma 2,678 | 3,232
Astrocytoma, Pilocytic 2,518 | 3,081
primitive neuroectodermal tumor 2,509 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,471 | 2,989
invasive ductal carcinoma 2,463 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,426 | 2,955
non-small cell lung cancer 2,414 | 2,890
oligodendroglioma 2,349 | 2,850
lung carcinoma 2,333 | 2,843
lung adenocarcinoma 2,208 | 2,716
Kidney cancer 2,136 | 2,613
astrocytic glioma 2,131 | 2,597
pancreatic cancer 1,961 | 2,398
Cancer 1,957 | 2,499
interstitial cystitis 1,892 | 2,312
subependymal giant cell astrocytoma 1,883 | 2,287
pancreatic ductal adenocarcinoma liver metastasis 1,620 | 1,962
tuberculosis 1,612 | 2,010
Pick disease 1,609 | 1,894
pituitary cancer 1,595 | 1,972
ulcerative colitis 1,513 | 1,819
group 4 medulloblastoma 1,504 | 1,855
ductal carcinoma in situ 1,450 | 1,745
cystic fibrosis 1,354 | 1,696
breast carcinoma 1,312 | 1,638
Autosomal recessive predisposition 1,292 | 1,442
diabetes mellitus 1,282 | 1,728
colon cancer 1,224 | 1,478
adrenocortical carcinoma 1,181 | 1,428
Multiple myeloma 1,161 | 1,332
juvenile dermatomyositis 1,001 | 1,187
acute quadriplegic myopathy 985 | 1,158
astrocytoma 953 | 1,146
primary pancreatic ductal adenocarcinoma 945 | 1,109
Rheumatoid arthritis 939 | 1,191
Schizophrenia 925 | 1,160
spina bifida 892 | 1,074
pediatric high grade glioma 886 | 1,064
Intellectual disability 877 | 1,016
nasopharyngeal carcinoma 877 | 1,058
cutaneous lupus erythematosus 836 | 1,057
dermatomyositis 817 | 966
Atopic dermatitis 768 | 952
active Crohn's disease 753 | 922
non primary Sjogren syndrome sicca 720 | 891
Epilepsy 693 | 792
Waldenstrons macroglobulinemia 674 | 765
gastric carcinoma 674 | 807
Liver Cirrhosis, Experimental 670 | 769
primary Sjogren syndrome 624 | 735
acute myeloid leukemia 623 | 783
active ulcerative colitis 619 | 764
esophageal adenocarcinoma 598 | 737
medulloblastoma 592 | 720
Melanoma 572 | 711
Obesity 568 | 678
Dull intelligence 566 | 645
Low intelligence 566 | 645
Mental Retardation 566 | 645
Mental deficiency 566 | 645
Poor school performance 566 | 645
progressive supranuclear palsy 565 | 676
aldosterone-producing adenoma 550 | 665
Alzheimer's disease 548 | 658
Bipolar Disorder 542 | 666
Cognitive delay 542 | 608
Global developmental delay 542 | 608
Mental and motor retardation 542 | 608
Seizures 525 | 596
Muscle hypotonia 515 | 571
Duchenne muscular dystrophy 506 | 601
Liver cancer 460 | 604
Short stature 460 | 531
pancreatic carcinoma 449 | 562
Endometriosis 446 | 540
autosomal dominant Emery-Dreifuss muscular dystrophy 444 | 510
hepatocellular carcinoma 442 | 547
fibroadenoma 432 | 559
Prostatic Neoplasms 420 | 495
chronic rhinosinusitis 418 | 512
Down syndrome 407 | 499
posterior fossa group A ependymoma 392 | 468
Multiple Sclerosis 388 | 540
Amyotrophic lateral sclerosis 384 | 451
mucosa-associated lymphoid tissue lymphoma 383 | 484
sonic hedgehog group medulloblastoma 383 | 467
Skin cancer 382 | 469

Tissue

Endocrine System 13,899 | 18,159
Digestive Tract 13,562 | 17,369
Female tissues 13,538 | 17,400
Skin and soft tissues 13,463 | 17,230
Male tissues 13,393 | 17,142
Blood and immune system 13,236 | 16,909
Liver and Pancreas 13,197 | 16,750
Urinary Tract 13,178 | 16,678
Nervous System 13,174 | 16,725
Respiratory system 12,947 | 16,393
Cardiovascular System 12,205 | 15,192

Target Family

Non-IDG 8,073 | 12,091
Enzyme 3,346 | 4,145
Transcription Factor 891 | 1,400
Kinase 539 | 634
Transporter 406 | 473
GPCR 283 | 408
Ion Channel 274 | 344
Epigenetic 200 | 242
oGPCR 170 | 421
Nuclear Receptor 44 | 48
TF/Epigenetic 26 | 38

Ortholog Species

Horse 14,252 | 14,252
Mouse 16,570 | 16,570
Cow 15,320 | 15,320
Rat 15,117 | 15,117
Dog 15,073 | 15,073
Chimp 14,140 | 14,140
Macaque 12,761 | 12,761
Opossum 12,230 | 12,230
Anole lizard 10,588 | 10,588
Xenopus 10,468 | 10,468
Pig 10,168 | 10,168
Zebrafish 9,726 | 9,726
Chicken 7,827 | 7,827
Platypus 5,703 | 5,703
C. elegans 3,179 | 3,179
Fruitfly 3,050 | 3,050
S.cerevisiae 1,799 | 1,799

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Glutaredoxin domain-containing cysteine-rich protein 2 GRXCR2 Tbio Non-IDG 0.00000 1.00 14
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93