Development Level

Tbio 2,200 | 11,445
Tdark 544 | 6,588
Tchem 250 | 1,598
Tclin 56 | 613

Collection

RFA-RM-18-021 20 | 328
Kinase: IDG Consortium (Target... 16 | 125
Ion Channel: IDG Consortium (T... 4 | 99
Kinase: IDG Consortium (Comple... 2 | 37

IMPC Phenotype

preweaning lethality, complete... 395 | 979
embryonic lethality prior to o... 123 | 239
embryonic lethality prior to t... 112 | 278
preweaning lethality, incomple... 94 | 499
abnormal embryo size 69 | 220
abnormal behavior 58 | 298
decreased body weight 47 | 161
embryonic growth retardation 43 | 106
abnormal bone structure 42 | 187
decreased total body fat amoun... 37 | 207
enlarged heart 36 | 210
abnormal heart morphology 34 | 162
decreased lean body mass 34 | 135
increased lean body mass 32 | 172
prenatal lethality prior to he... 31 | 87
decreased body length 30 | 101
decreased bone mineral content 29 | 151
increased total body fat amoun... 29 | 134
decreased circulating glucose ... 28 | 126
decreased bone mineral density 27 | 126
hyperactivity 25 | 148
male infertility 25 | 123
hypoactivity 24 | 132
increased mean corpuscular hem... 24 | 96
cataract 21 | 92
decreased grip strength 21 | 116
decreased vertical activity 21 | 208
increased or absent threshold ... 21 | 101
increased startle reflex 21 | 112
decreased circulating choleste... 20 | 93
increased circulating alkaline... 20 | 122
short tibia 20 | 97
decreased circulating serum al... 19 | 82
increased circulating HDL chol... 19 | 80
decreased lymphocyte cell numb... 18 | 83
increased circulating choleste... 18 | 66
increased circulating sodium l... 18 | 71
increased fasted circulating g... 18 | 76
abnormal lens morphology 17 | 81
decreased caudal vertebrae num... 17 | 53
abnormal behavioral response t... 16 | 66
decreased fasted circulating g... 16 | 65
abnormal eye morphology 15 | 68
abnormal seminal vesicle morph... 15 | 114
decreased circulating triglyce... 15 | 79
decreased erythrocyte cell num... 15 | 62
increased mean corpuscular vol... 15 | 92
abnormal kidney morphology 14 | 65
decreased circulating HDL chol... 14 | 68
decreased startle reflex 14 | 75
abnormal coat-hair pigmentatio... 13 | 64
abnormal retina morphology 13 | 71
decreased leukocyte cell numbe... 13 | 73
decreased mean corpuscular vol... 13 | 79
increased bone mineral density 13 | 72
small superior vagus ganglion 13 | 74
abnormal cranium morphology 12 | 36
abnormal neural tube closure 12 | 46
hydrometra 12 | 53
increased bone mineral content 12 | 108
abnormal pericardium morpholog... 11 | 26
decreased red blood cell distr... 11 | 41
edema 11 | 59
increased heart weight 11 | 62
increased monocyte cell number 11 | 63
thrombocytopenia 11 | 56
abnormal embryo turning 10 | 31
abnormal gait 10 | 69
abnormal spleen morphology 10 | 55
decreased circulating alanine ... 10 | 47
decreased circulating alkaline... 10 | 46
decreased circulating aspartat... 10 | 34
decreased circulating insulin ... 10 | 76
decreased circulating total pr... 10 | 49
impaired glucose tolerance 10 | 75
increased grip strength 10 | 41
increased neutrophil cell numb... 10 | 46
abnormal retinal blood vessel ... 9 | 26
abnormal sleep behavior 9 | 70
absent pinna reflex 9 | 23
decreased neutrophil cell numb... 9 | 42
increased circulating free fat... 9 | 20
long tibia 9 | 25
prenatal lethality 9 | 28
tremors 9 | 39
abnormal tail morphology 8 | 25
decreased hemoglobin content 8 | 68
decreased prepulse inhibition 8 | 82
increased circulating chloride... 8 | 41
increased circulating creatini... 8 | 38
increased circulating iron lev... 8 | 30
increased circulating potassiu... 8 | 29
increased leukocyte cell numbe... 8 | 47
pallor 8 | 34
prolonged QT interval 8 | 38
prolonged ST segment 8 | 36
small testis 8 | 58
vertebral fusion 8 | 23
decreased circulating LDL chol... 7 | 38
pale yolk sac 7 | 25

Disease

Carcinoma 1,819 | 11,493
ovarian cancer 1,810 | 8,520
osteosarcoma 1,479 | 7,950
medulloblastoma, large-cell 1,037 | 6,241
psoriasis 964 | 6,694
glioblastoma 955 | 5,792
lung cancer 922 | 4,740
atypical teratoid / rhabdoid tumor 814 | 5,112
group 3 medulloblastoma 734 | 4,104
ependymoma 712 | 4,679
Breast cancer 574 | 3,578
adult high grade glioma 528 | 3,801
malignant mesothelioma 526 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 520 | 3,291
primitive neuroectodermal tumor 481 | 3,035
Multiple myeloma 453 | 1,332
astrocytic glioma 430 | 2,597
oligodendroglioma 430 | 2,850
intraductal papillary-mucinous carcinoma (IPMC) 429 | 2,989
pancreatic ductal adenocarcinoma liver metastasis 415 | 1,962
Kidney cancer 407 | 2,613
invasive ductal carcinoma 400 | 2,951
non-small cell lung cancer 400 | 2,890
intraductal papillary-mucinous adenoma (IPMA) 389 | 2,955
Pick disease 372 | 1,894
lung adenocarcinoma 359 | 2,716
Autosomal recessive predisposition 350 | 1,442
Cancer 347 | 2,499
Astrocytoma, Pilocytic 339 | 3,081
subependymal giant cell astrocytoma 336 | 2,287
pancreatic cancer 310 | 2,398
diabetes mellitus 302 | 1,728
group 4 medulloblastoma 293 | 1,855
tuberculosis 290 | 2,010
Intellectual disability 264 | 1,016
lung carcinoma 260 | 2,843
acute quadriplegic myopathy 247 | 1,158
Waldenstrons macroglobulinemia 243 | 765
colon cancer 228 | 1,478
pituitary cancer 224 | 1,972
dermatomyositis 223 | 966
astrocytoma 220 | 1,146
breast carcinoma 215 | 1,638
adrenocortical carcinoma 205 | 1,428
ductal carcinoma in situ 203 | 1,745
Cognitive delay 196 | 608
Global developmental delay 196 | 608
Mental and motor retardation 196 | 608
ulcerative colitis 190 | 1,819
Epilepsy 189 | 792
pediatric high grade glioma 188 | 1,064
juvenile dermatomyositis 187 | 1,187
Muscle hypotonia 184 | 571
interstitial cystitis 181 | 2,312
Rheumatoid arthritis 172 | 1,191
Dull intelligence 170 | 645
Low intelligence 170 | 645
Mental Retardation 170 | 645
Mental deficiency 170 | 645
Poor school performance 170 | 645
acute myeloid leukemia 162 | 783
Seizures 160 | 596
non primary Sjogren syndrome sicca 159 | 891
primary pancreatic ductal adenocarcinoma 157 | 1,109
Schizophrenia 154 | 1,160
cystic fibrosis 152 | 1,696
nasopharyngeal carcinoma 150 | 1,058
medulloblastoma 136 | 720
spina bifida 135 | 1,074
progressive supranuclear palsy 131 | 676
Short stature 128 | 531
Small head 123 | 374
Alzheimer's disease 115 | 658
Cerebellar Ataxia 114 | 304
hepatocellular carcinoma 112 | 547
active Crohn's disease 111 | 922
pancreatic carcinoma 107 | 562
aldosterone-producing adenoma 103 | 665
Atopic dermatitis 98 | 952
gastric cancer 95 | 459
Failure to gain weight 92 | 365
Obesity 92 | 678
Pediatric failure to thrive 92 | 365
tuberculosis and treatment for 6 months 90 | 409
Neurodegenerative disease 89 | 414
Nystagmus 88 | 317
active ulcerative colitis 88 | 764
gastric carcinoma 86 | 807
Bipolar Disorder 85 | 666
sonic hedgehog group medulloblastoma 85 | 467
hereditary spastic paraplegia 84 | 318
Hypoplastic mandible condyle 82 | 275
Mandibular hypoplasia 82 | 275
Micrognathism 82 | 275
Parkinson's disease 81 | 392
primary Sjogren syndrome 81 | 735
Hepatomegaly 80 | 285
Cryptorchidism 78 | 296
Melanoma 78 | 711
Optic Atrophy 78 | 242

Tissue

Endocrine System 3,037 | 18,159
Digestive Tract 3,019 | 17,369
Female tissues 3,019 | 17,400
Skin and soft tissues 3,015 | 17,230
Male tissues 3,013 | 17,142
Nervous System 3,009 | 16,725
Liver and Pancreas 3,005 | 16,750
Urinary Tract 2,998 | 16,678
Blood and immune system 2,992 | 16,909
Respiratory system 2,988 | 16,393
Cardiovascular System 2,935 | 15,192

Target Family

Non-IDG 1,752 | 12,091
Enzyme 1,000 | 4,145
Kinase 104 | 634
Transcription Factor 63 | 1,400
Transporter 48 | 473
Epigenetic 46 | 242
Ion Channel 16 | 344
GPCR 11 | 408
TF/Epigenetic 7 | 38
Nuclear Receptor 3 | 48

Ortholog Species

Fruitfly 3,050 | 3,050
Mouse 16,570 | 16,570
Cow 15,320 | 15,320
Rat 15,117 | 15,117
Dog 15,073 | 15,073
Horse 14,252 | 14,252
Chimp 14,140 | 14,140
Macaque 12,761 | 12,761
Opossum 12,230 | 12,230
Anole lizard 10,588 | 10,588
Xenopus 10,468 | 10,468
Pig 10,168 | 10,168
Zebrafish 9,726 | 9,726
Chicken 7,827 | 7,827
Platypus 5,703 | 5,703
C. elegans 3,179 | 3,179
S.cerevisiae 1,799 | 1,799

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
GPI mannosyltransferase 4 PIGZ Tdark Enzyme -1.18571 13.8 39
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.53750 4.06 29
Probable global transcription activator SNF2L1 SMARCA1 Tbio Non-IDG -2.20560 145.6 116
Dephospho-CoA kinase domain-containing protein DCAKD Tdark Enzyme 0.95 0.08 141
Non-lysosomal glucosylceramidase GBA2 Tchem Enzyme -1.62330 43.1 59
Pre-mRNA-splicing factor CWC22 homolog CWC22 Tbio Non-IDG -3.08456 1172.8 103
Septin-11 SEPT11 Tbio Non-IDG -1.47747 32.4 127
60S ribosomal protein L36 RPL36 Tbio Non-IDG -1.62928 39.9 123