Development Level

Tbio 9,614 | 11,445
Tdark 3,511 | 6,588
Tchem 1,407 | 1,598
Tclin 541 | 613

Collection

RFA-RM-18-021 267 | 328
Kinase: IDG Consortium (Target... 115 | 125
Ion Channel: IDG Consortium (T... 84 | 99
GPCR: IDG Consortium (Targets) 79 | 126
Kinase: IDG Consortium (Comple... 30 | 37
GPCR: IDG Consortium (Complete... 20 | 25

IMPC Phenotype

preweaning lethality, complete... 910 | 979
preweaning lethality, incomple... 450 | 499
abnormal behavior 260 | 298
embryonic lethality prior to t... 257 | 278
embryonic lethality prior to o... 215 | 239
abnormal embryo size 208 | 220
enlarged heart 189 | 210
decreased vertical activity 180 | 208
decreased total body fat amoun... 178 | 207
abnormal bone structure 166 | 187
decreased body weight 147 | 161
increased lean body mass 147 | 172
abnormal heart morphology 144 | 162
decreased bone mineral content 134 | 151
hyperactivity 125 | 148
increased total body fat amoun... 119 | 134
decreased lean body mass 118 | 135
hypoactivity 113 | 132
male infertility 113 | 123
decreased bone mineral density 112 | 126
increased circulating alkaline... 111 | 122
decreased circulating glucose ... 109 | 126
abnormal seminal vesicle morph... 107 | 114
decreased grip strength 102 | 116
embryonic growth retardation 101 | 106
increased startle reflex 99 | 112
increased bone mineral content 95 | 108
decreased body length 90 | 101
short tibia 87 | 97
increased or absent threshold ... 86 | 101
increased mean corpuscular hem... 83 | 96
decreased circulating choleste... 82 | 93
cataract 81 | 92
prenatal lethality prior to he... 81 | 87
increased mean corpuscular vol... 80 | 92
decreased lymphocyte cell numb... 77 | 83
decreased circulating serum al... 76 | 82
decreased prepulse inhibition 76 | 82
decreased circulating triglyce... 75 | 79
increased circulating HDL chol... 74 | 80
abnormal lens morphology 70 | 81
small superior vagus ganglion 70 | 74
decreased leukocyte cell numbe... 69 | 73
decreased startle reflex 68 | 75
improved glucose tolerance 67 | 79
decreased mean corpuscular vol... 65 | 79
increased fasted circulating g... 65 | 76
decreased circulating insulin ... 64 | 76
abnormal gait 63 | 69
impaired glucose tolerance 63 | 75
increased circulating choleste... 63 | 66
abnormal retina morphology 62 | 71
abnormal eye morphology 61 | 68
abnormal sleep behavior 61 | 70
increased bone mineral density 61 | 72
abnormal kidney morphology 60 | 65
increased monocyte cell number 59 | 63
abnormal behavioral response t... 58 | 66
decreased circulating HDL chol... 58 | 68
decreased erythrocyte cell num... 58 | 62
decreased fasted circulating g... 57 | 65
decreased hemoglobin content 57 | 68
edema 56 | 59
increased circulating sodium l... 56 | 71
abnormal coat-hair pigmentatio... 55 | 64
female infertility 55 | 60
increased heart weight 54 | 62
small testis 54 | 58
thrombocytopenia 52 | 56
abnormal spleen morphology 50 | 55
hydrometra 50 | 53
abnormal neural tube closure 46 | 46
abnormal skin morphology 46 | 50
decreased blood urea nitrogen ... 46 | 51
decreased circulating total pr... 45 | 49
decreased mean corpuscular hem... 45 | 50
decreased caudal vertebrae num... 44 | 53
decreased circulating alanine ... 44 | 47
decreased hematocrit 44 | 46
decreased circulating alkaline... 43 | 46
abnormal testis morphology 41 | 43
increased blood urea nitrogen ... 41 | 48
increased circulating triglyce... 41 | 42
increased neutrophil cell numb... 41 | 46
abnormal epididymis morphology 40 | 42
increased leukocyte cell numbe... 40 | 47
limb grasping 40 | 41
enlarged spleen 39 | 41
increased mean platelet volume 39 | 45
decreased red blood cell distr... 38 | 41
increased grip strength 38 | 41
increased hematocrit 38 | 46
abnormal bone mineralization 37 | 38
decreased neutrophil cell numb... 37 | 42
increased hemoglobin content 37 | 45
cardiovascular system phenotyp... 36 | 36
decreased circulating LDL chol... 36 | 38
prolonged QT interval 35 | 38
tremors 35 | 39
increased erythrocyte cell num... 34 | 39

Disease

Carcinoma 9,601 | 11,493
ovarian cancer 7,427 | 8,520
osteosarcoma 6,772 | 7,950
psoriasis 5,438 | 6,694
medulloblastoma, large-cell 5,406 | 6,241
glioblastoma 5,066 | 5,792
atypical teratoid / rhabdoid tumor 4,485 | 5,112
ependymoma 4,122 | 4,679
lung cancer 4,042 | 4,740
group 3 medulloblastoma 3,573 | 4,104
adult high grade glioma 3,297 | 3,801
Breast cancer 3,097 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 2,839 | 3,291
malignant mesothelioma 2,811 | 3,232
Astrocytoma, Pilocytic 2,705 | 3,081
primitive neuroectodermal tumor 2,665 | 3,035
invasive ductal carcinoma 2,597 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 2,588 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,554 | 2,955
oligodendroglioma 2,509 | 2,850
non-small cell lung cancer 2,503 | 2,890
lung carcinoma 2,447 | 2,843
lung adenocarcinoma 2,329 | 2,716
Kidney cancer 2,281 | 2,613
astrocytic glioma 2,278 | 2,597
Cancer 2,056 | 2,499
pancreatic cancer 2,054 | 2,398
subependymal giant cell astrocytoma 2,010 | 2,287
interstitial cystitis 1,970 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,701 | 1,962
pituitary cancer 1,695 | 1,972
tuberculosis 1,695 | 2,010
Pick disease 1,691 | 1,894
group 4 medulloblastoma 1,613 | 1,855
ulcerative colitis 1,557 | 1,819
ductal carcinoma in situ 1,544 | 1,745
cystic fibrosis 1,435 | 1,696
breast carcinoma 1,408 | 1,638
Autosomal recessive predisposition 1,321 | 1,442
diabetes mellitus 1,320 | 1,728
colon cancer 1,271 | 1,478
adrenocortical carcinoma 1,237 | 1,428
Multiple myeloma 1,165 | 1,332
juvenile dermatomyositis 1,044 | 1,187
acute quadriplegic myopathy 1,033 | 1,158
astrocytoma 1,023 | 1,146
Rheumatoid arthritis 1,006 | 1,191
Schizophrenia 996 | 1,160
primary pancreatic ductal adenocarcinoma 978 | 1,109
spina bifida 936 | 1,074
Intellectual disability 929 | 1,016
pediatric high grade glioma 926 | 1,064
nasopharyngeal carcinoma 902 | 1,058
cutaneous lupus erythematosus 866 | 1,057
dermatomyositis 837 | 966
Atopic dermatitis 779 | 952
active Crohn's disease 771 | 922
non primary Sjogren syndrome sicca 760 | 891
Epilepsy 722 | 792
gastric carcinoma 701 | 807
Liver Cirrhosis, Experimental 682 | 769
Waldenstrons macroglobulinemia 676 | 765
acute myeloid leukemia 664 | 783
active ulcerative colitis 648 | 764
esophageal adenocarcinoma 636 | 737
primary Sjogren syndrome 631 | 735
medulloblastoma 628 | 720
Obesity 608 | 678
progressive supranuclear palsy 607 | 676
Melanoma 604 | 711
Dull intelligence 594 | 645
Low intelligence 594 | 645
Mental Retardation 594 | 645
Mental deficiency 594 | 645
Poor school performance 594 | 645
Bipolar Disorder 588 | 666
Alzheimer's disease 584 | 658
aldosterone-producing adenoma 584 | 665
Cognitive delay 566 | 608
Global developmental delay 566 | 608
Mental and motor retardation 566 | 608
Seizures 555 | 596
Duchenne muscular dystrophy 535 | 601
Muscle hypotonia 529 | 571
Liver cancer 517 | 604
Short stature 488 | 531
fibroadenoma 486 | 559
pancreatic carcinoma 480 | 562
autosomal dominant Emery-Dreifuss muscular dystrophy 471 | 510
Endometriosis 462 | 540
hepatocellular carcinoma 457 | 547
chronic rhinosinusitis 449 | 512
Down syndrome 442 | 499
Prostatic Neoplasms 428 | 495
Multiple Sclerosis 423 | 540
Amyotrophic lateral sclerosis 408 | 451
sonic hedgehog group medulloblastoma 407 | 467
Skin cancer 406 | 469
posterior fossa group A ependymoma 402 | 468
mucosa-associated lymphoid tissue lymphoma 391 | 484

Tissue

Endocrine System 14,722 | 18,159
Digestive Tract 14,313 | 17,369
Female tissues 14,301 | 17,400
Skin and soft tissues 14,210 | 17,230
Male tissues 14,152 | 17,142
Blood and immune system 13,977 | 16,909
Nervous System 13,948 | 16,725
Liver and Pancreas 13,907 | 16,750
Urinary Tract 13,899 | 16,678
Respiratory system 13,637 | 16,393
Cardiovascular System 12,824 | 15,192

Target Family

Non-IDG 8,597 | 12,091
Enzyme 3,425 | 4,145
Transcription Factor 1,020 | 1,400
Kinase 569 | 634
Transporter 425 | 473
GPCR 308 | 408
Ion Channel 305 | 344
Epigenetic 213 | 242
oGPCR 133 | 421
Nuclear Receptor 45 | 48
TF/Epigenetic 33 | 38

Ortholog Species

Dog 15,073 | 15,073
Mouse 16,570 | 16,570
Cow 15,320 | 15,320
Rat 15,117 | 15,117
Horse 14,252 | 14,252
Chimp 14,140 | 14,140
Macaque 12,761 | 12,761
Opossum 12,230 | 12,230
Anole lizard 10,588 | 10,588
Xenopus 10,468 | 10,468
Pig 10,168 | 10,168
Zebrafish 9,726 | 9,726
Chicken 7,827 | 7,827
Platypus 5,703 | 5,703
C. elegans 3,179 | 3,179
Fruitfly 3,050 | 3,050
S.cerevisiae 1,799 | 1,799

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Glutaredoxin domain-containing cysteine-rich protein 2 GRXCR2 Tbio Non-IDG 0.00000 1.00 14
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.53750 4.06 29