Development Level

Tbio 9,610 | 11,445
Tdark 3,512 | 6,588
Tchem 1,406 | 1,598
Tclin 541 | 613

Collection

Kinase: IDG Consortium (Target... 115 | 125
Ion Channel: IDG Consortium (T... 84 | 99
GPCR: IDG Consortium (Targets) 79 | 126
Kinase: IDG Consortium (Comple... 30 | 37
GPCR: IDG Consortium (Complete... 20 | 25

IMPC Phenotype

preweaning lethality, complete... 910 | 979
preweaning lethality, incomple... 450 | 499
abnormal behavior 260 | 298
embryonic lethality prior to t... 257 | 278
embryonic lethality prior to o... 215 | 239
abnormal embryo size 208 | 220
enlarged heart 189 | 210
decreased vertical activity 180 | 208
decreased total body fat amoun... 178 | 207
abnormal bone structure 166 | 187
decreased body weight 147 | 161
increased lean body mass 147 | 172
abnormal heart morphology 144 | 162
decreased bone mineral content 134 | 151
hyperactivity 125 | 148
increased total body fat amoun... 119 | 134
decreased lean body mass 118 | 135
hypoactivity 113 | 132
male infertility 113 | 123
decreased bone mineral density 112 | 126
increased circulating alkaline... 110 | 122
decreased circulating glucose ... 109 | 126
abnormal seminal vesicle morph... 107 | 114
decreased grip strength 101 | 116
embryonic growth retardation 101 | 106
increased startle reflex 98 | 112
increased bone mineral content 95 | 108
decreased body length 90 | 101
short tibia 87 | 97
increased or absent threshold ... 86 | 101
increased mean corpuscular hem... 83 | 96
decreased circulating choleste... 82 | 93
prenatal lethality prior to he... 81 | 87
cataract 80 | 92
increased mean corpuscular vol... 80 | 92
decreased lymphocyte cell numb... 77 | 83
decreased prepulse inhibition 76 | 82
decreased circulating serum al... 75 | 82
decreased circulating triglyce... 75 | 79
increased circulating HDL chol... 73 | 80
small superior vagus ganglion 70 | 74
abnormal lens morphology 69 | 81
decreased leukocyte cell numbe... 69 | 73
decreased startle reflex 68 | 75
improved glucose tolerance 67 | 79
increased fasted circulating g... 65 | 76
decreased circulating insulin ... 64 | 76
decreased mean corpuscular vol... 64 | 79
abnormal gait 63 | 69
impaired glucose tolerance 63 | 75
abnormal retina morphology 62 | 71
increased circulating choleste... 62 | 66
abnormal eye morphology 61 | 68
abnormal sleep behavior 61 | 70
increased bone mineral density 61 | 72
abnormal kidney morphology 60 | 65
increased monocyte cell number 59 | 63
abnormal behavioral response t... 58 | 66
decreased circulating HDL chol... 58 | 68
decreased erythrocyte cell num... 58 | 62
decreased fasted circulating g... 57 | 65
decreased hemoglobin content 57 | 68
edema 56 | 59
increased circulating sodium l... 56 | 71
abnormal coat-hair pigmentatio... 55 | 64
female infertility 55 | 60
increased heart weight 54 | 62
small testis 54 | 58
thrombocytopenia 52 | 56
abnormal spleen morphology 50 | 55
hydrometra 50 | 53
abnormal neural tube closure 46 | 46
abnormal skin morphology 46 | 50
decreased blood urea nitrogen ... 45 | 51
decreased circulating total pr... 45 | 49
decreased mean corpuscular hem... 45 | 50
decreased caudal vertebrae num... 44 | 53
decreased circulating alanine ... 44 | 47
decreased hematocrit 44 | 46
decreased circulating alkaline... 43 | 46
abnormal testis morphology 41 | 43
increased blood urea nitrogen ... 41 | 48
increased circulating triglyce... 41 | 42
increased neutrophil cell numb... 41 | 46
abnormal epididymis morphology 40 | 42
limb grasping 40 | 41
enlarged spleen 39 | 41
increased hematocrit 39 | 46
increased leukocyte cell numbe... 39 | 47
increased mean platelet volume 39 | 45
decreased red blood cell distr... 38 | 41
increased grip strength 38 | 41
abnormal bone mineralization 37 | 38
decreased neutrophil cell numb... 37 | 42
increased hemoglobin content 37 | 45
cardiovascular system phenotyp... 36 | 36
decreased circulating LDL chol... 36 | 38
prolonged QT interval 35 | 38
tremors 35 | 39
increased erythrocyte cell num... 34 | 39

Disease

Carcinoma 9,599 | 11,493
ovarian cancer 7,425 | 8,520
osteosarcoma 6,773 | 7,950
psoriasis 5,438 | 6,694
medulloblastoma, large-cell 5,406 | 6,241
glioblastoma 5,064 | 5,792
atypical teratoid / rhabdoid tumor 4,484 | 5,112
ependymoma 4,121 | 4,679
lung cancer 4,040 | 4,740
group 3 medulloblastoma 3,573 | 4,104
adult high grade glioma 3,296 | 3,801
Breast cancer 3,094 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 2,837 | 3,291
malignant mesothelioma 2,810 | 3,232
Astrocytoma, Pilocytic 2,704 | 3,081
primitive neuroectodermal tumor 2,664 | 3,035
invasive ductal carcinoma 2,596 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 2,586 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 2,554 | 2,955
oligodendroglioma 2,508 | 2,850
non-small cell lung cancer 2,502 | 2,890
lung carcinoma 2,447 | 2,843
lung adenocarcinoma 2,329 | 2,716
Kidney cancer 2,281 | 2,613
astrocytic glioma 2,277 | 2,597
Cancer 2,055 | 2,499
pancreatic cancer 2,053 | 2,398
subependymal giant cell astrocytoma 2,010 | 2,287
interstitial cystitis 1,969 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,700 | 1,962
tuberculosis 1,695 | 2,010
pituitary cancer 1,694 | 1,972
Pick disease 1,692 | 1,894
group 4 medulloblastoma 1,612 | 1,855
ulcerative colitis 1,557 | 1,819
ductal carcinoma in situ 1,543 | 1,745
cystic fibrosis 1,433 | 1,696
breast carcinoma 1,407 | 1,638
Autosomal recessive predisposition 1,321 | 1,442
diabetes mellitus 1,319 | 1,728
colon cancer 1,271 | 1,478
adrenocortical carcinoma 1,237 | 1,428
Multiple myeloma 1,165 | 1,332
juvenile dermatomyositis 1,045 | 1,187
acute quadriplegic myopathy 1,032 | 1,158
astrocytoma 1,023 | 1,146
Rheumatoid arthritis 1,006 | 1,191
Schizophrenia 994 | 1,160
primary pancreatic ductal adenocarcinoma 978 | 1,109
spina bifida 936 | 1,074
Intellectual disability 929 | 1,016
pediatric high grade glioma 926 | 1,064
nasopharyngeal carcinoma 901 | 1,058
cutaneous lupus erythematosus 866 | 1,057
dermatomyositis 837 | 966
Atopic dermatitis 779 | 952
active Crohn's disease 771 | 922
non primary Sjogren syndrome sicca 761 | 891
Epilepsy 722 | 792
gastric carcinoma 701 | 807
Liver Cirrhosis, Experimental 682 | 769
Waldenstrons macroglobulinemia 676 | 765
acute myeloid leukemia 663 | 783
active ulcerative colitis 647 | 764
esophageal adenocarcinoma 635 | 737
primary Sjogren syndrome 631 | 735
medulloblastoma 628 | 720
Obesity 607 | 678
progressive supranuclear palsy 607 | 676
Melanoma 604 | 711
Dull intelligence 594 | 645
Low intelligence 594 | 645
Mental Retardation 594 | 645
Mental deficiency 594 | 645
Poor school performance 594 | 645
Bipolar Disorder 587 | 666
Alzheimer's disease 584 | 658
aldosterone-producing adenoma 583 | 665
Cognitive delay 566 | 608
Global developmental delay 566 | 608
Mental and motor retardation 566 | 608
Seizures 555 | 596
Duchenne muscular dystrophy 535 | 601
Muscle hypotonia 529 | 571
Liver cancer 517 | 604
Short stature 488 | 531
fibroadenoma 486 | 559
pancreatic carcinoma 480 | 562
autosomal dominant Emery-Dreifuss muscular dystrophy 470 | 510
Endometriosis 462 | 540
hepatocellular carcinoma 457 | 547
chronic rhinosinusitis 449 | 512
Down syndrome 442 | 499
Prostatic Neoplasms 428 | 495
Multiple Sclerosis 423 | 540
Amyotrophic lateral sclerosis 407 | 451
sonic hedgehog group medulloblastoma 407 | 467
Skin cancer 406 | 469
posterior fossa group A ependymoma 402 | 468
mucosa-associated lymphoid tissue lymphoma 391 | 484

Tissue

Endocrine System 14,718 | 18,159
Digestive Tract 14,309 | 17,369
Female tissues 14,297 | 17,400
Skin and soft tissues 14,206 | 17,230
Male tissues 14,148 | 17,142
Blood and immune system 13,973 | 16,909
Nervous System 13,945 | 16,725
Liver and Pancreas 13,903 | 16,750
Urinary Tract 13,896 | 16,678
Respiratory system 13,634 | 16,393
Cardiovascular System 12,821 | 15,192

Target Family

Non-IDG 8,596 | 12,091
Enzyme 3,423 | 4,145
Transcription Factor 1,020 | 1,400
Kinase 569 | 634
Transporter 425 | 473
GPCR 308 | 408
Ion Channel 304 | 344
Epigenetic 213 | 242
oGPCR 133 | 421
Nuclear Receptor 45 | 48
TF/Epigenetic 33 | 38

Ortholog Species

Dog 15,069 | 15,069
Mouse 16,567 | 16,567
Cow 15,316 | 15,316
Rat 15,112 | 15,112
Horse 14,249 | 14,249
Chimp 14,136 | 14,136
Macaque 12,758 | 12,758
Opossum 12,223 | 12,223
Anole lizard 10,585 | 10,585
Xenopus 10,463 | 10,463
Pig 10,164 | 10,164
Zebrafish 9,725 | 9,725
Chicken 7,823 | 7,823
Platypus 5,699 | 5,699
C. elegans 3,178 | 3,178
Fruitfly 3,048 | 3,048
S.cerevisiae 1,798 | 1,798

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Trafficking protein particle complex subunit 2-like protein TRAPPC2L Tdark Non-IDG -0.18066 0.74 35
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418
Uncharacterized protein ZSWIM9 ZSWIM9 Tdark Non-IDG 0.00000 12
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123
Retinoic acid receptor responder protein 3 RARRES3 Tbio Non-IDG -1.84020 71.0 164
Suppressor of tumorigenicity 14 protein ST14 Tchem Non-IDG -2.50215 338.3 309
Peroxisomal membrane protein PEX16 PEX16 Tbio Non-IDG -1.43594 27.8 78
T-box transcription factor TBX21 TBX21 Tbio Transcription Factor -2.95359 868.5 480
Urotensin-2 receptor UTS2R Tchem GPCR -1.95094 62.5 182