Development Level

Tbio 9,724 | 11,445
Tdark 3,623 | 6,588
Tchem 1,427 | 1,598
Tclin 542 | 613

Collection

Kinase: IDG Consortium (Target... 110 | 125
Ion Channel: IDG Consortium (T... 88 | 99
GPCR: IDG Consortium (Targets) 84 | 126
Kinase: IDG Consortium (Comple... 30 | 37
GPCR: IDG Consortium (Complete... 19 | 25

IMPC Phenotype

preweaning lethality, complete... 922 | 979
preweaning lethality, incomple... 451 | 499
abnormal behavior 276 | 298
embryonic lethality prior to t... 265 | 278
embryonic lethality prior to o... 224 | 239
abnormal embryo size 204 | 220
enlarged heart 192 | 210
decreased vertical activity 186 | 208
decreased total body fat amoun... 185 | 207
abnormal bone structure 161 | 187
increased lean body mass 151 | 172
decreased body weight 148 | 161
abnormal heart morphology 145 | 162
decreased bone mineral content 137 | 151
hyperactivity 130 | 148
increased total body fat amoun... 123 | 134
decreased lean body mass 122 | 135
hypoactivity 120 | 132
decreased circulating glucose ... 116 | 126
male infertility 115 | 123
decreased bone mineral density 113 | 126
increased circulating alkaline... 111 | 122
abnormal seminal vesicle morph... 107 | 114
decreased grip strength 105 | 116
increased bone mineral content 100 | 108
embryonic growth retardation 99 | 106
increased startle reflex 98 | 112
decreased body length 92 | 101
increased or absent threshold ... 89 | 101
increased mean corpuscular hem... 85 | 96
increased mean corpuscular vol... 84 | 92
short tibia 84 | 97
decreased circulating choleste... 83 | 93
cataract 80 | 92
prenatal lethality prior to he... 80 | 87
decreased lymphocyte cell numb... 76 | 83
decreased circulating serum al... 73 | 82
decreased prepulse inhibition 73 | 82
decreased circulating triglyce... 72 | 79
small superior vagus ganglion 71 | 74
decreased mean corpuscular vol... 70 | 79
increased circulating HDL chol... 70 | 80
abnormal lens morphology 69 | 81
decreased circulating insulin ... 68 | 76
increased fasted circulating g... 68 | 76
decreased leukocyte cell numbe... 66 | 73
decreased startle reflex 66 | 75
improved glucose tolerance 66 | 79
increased bone mineral density 66 | 72
abnormal gait 65 | 69
increased circulating sodium l... 65 | 71
abnormal eye morphology 64 | 68
abnormal retina morphology 63 | 71
abnormal sleep behavior 63 | 70
decreased hemoglobin content 63 | 68
impaired glucose tolerance 63 | 75
abnormal behavioral response t... 60 | 66
decreased fasted circulating g... 60 | 65
increased circulating choleste... 60 | 66
decreased erythrocyte cell num... 59 | 62
increased monocyte cell number 59 | 63
abnormal coat-hair pigmentatio... 58 | 64
abnormal kidney morphology 58 | 65
decreased circulating HDL chol... 58 | 68
edema 56 | 59
female infertility 56 | 60
increased heart weight 55 | 62
thrombocytopenia 54 | 56
hydrometra 52 | 53
small testis 52 | 58
abnormal spleen morphology 51 | 55
decreased blood urea nitrogen ... 48 | 51
decreased circulating total pr... 48 | 49
abnormal skin morphology 47 | 50
decreased mean corpuscular hem... 47 | 50
decreased caudal vertebrae num... 45 | 53
decreased hematocrit 44 | 46
increased blood urea nitrogen ... 44 | 48
abnormal neural tube closure 43 | 46
increased leukocyte cell numbe... 43 | 47
decreased circulating alanine ... 42 | 47
increased hematocrit 41 | 46
increased mean platelet volume 41 | 45
increased neutrophil cell numb... 41 | 46
abnormal testis morphology 40 | 43
decreased circulating alkaline... 40 | 46
limb grasping 40 | 41
abnormal epididymis morphology 39 | 42
decreased neutrophil cell numb... 39 | 42
increased circulating triglyce... 39 | 42
enlarged spleen 38 | 41
decreased red blood cell distr... 37 | 41
increased hemoglobin content 37 | 45
increased erythrocyte cell num... 36 | 39
tremors 36 | 39
cardiovascular system phenotyp... 35 | 36
decreased circulating LDL chol... 35 | 38
increased circulating chloride... 35 | 41
increased grip strength 35 | 41
prolonged QT interval 35 | 38

Disease

Carcinoma 9,498 | 11,493
ovarian cancer 7,489 | 8,520
osteosarcoma 6,801 | 7,950
psoriasis 5,493 | 6,694
medulloblastoma, large-cell 5,395 | 6,241
glioblastoma 5,027 | 5,792
atypical teratoid / rhabdoid tumor 4,426 | 5,112
lung cancer 4,076 | 4,740
ependymoma 4,058 | 4,679
group 3 medulloblastoma 3,543 | 4,104
adult high grade glioma 3,263 | 3,801
Breast cancer 3,094 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 2,853 | 3,291
malignant mesothelioma 2,833 | 3,232
Astrocytoma, Pilocytic 2,658 | 3,081
primitive neuroectodermal tumor 2,612 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,588 | 2,989
invasive ductal carcinoma 2,575 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,549 | 2,955
non-small cell lung cancer 2,510 | 2,890
oligodendroglioma 2,471 | 2,850
lung carcinoma 2,396 | 2,843
lung adenocarcinoma 2,331 | 2,716
astrocytic glioma 2,240 | 2,597
Kidney cancer 2,121 | 2,613
Cancer 2,094 | 2,499
pancreatic cancer 2,060 | 2,398
subependymal giant cell astrocytoma 1,973 | 2,287
interstitial cystitis 1,963 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,735 | 1,962
tuberculosis 1,708 | 2,010
pituitary cancer 1,693 | 1,972
Pick disease 1,671 | 1,894
group 4 medulloblastoma 1,613 | 1,855
ulcerative colitis 1,550 | 1,819
ductal carcinoma in situ 1,527 | 1,745
cystic fibrosis 1,429 | 1,696
breast carcinoma 1,401 | 1,638
Autosomal recessive predisposition 1,341 | 1,442
diabetes mellitus 1,325 | 1,728
colon cancer 1,260 | 1,478
adrenocortical carcinoma 1,232 | 1,428
Multiple myeloma 1,225 | 1,332
juvenile dermatomyositis 1,040 | 1,187
acute quadriplegic myopathy 1,028 | 1,158
astrocytoma 1,028 | 1,146
Rheumatoid arthritis 1,009 | 1,191
primary pancreatic ductal adenocarcinoma 984 | 1,109
Schizophrenia 967 | 1,160
spina bifida 945 | 1,074
Intellectual disability 926 | 1,016
nasopharyngeal carcinoma 918 | 1,058
pediatric high grade glioma 918 | 1,064
cutaneous lupus erythematosus 862 | 1,057
dermatomyositis 839 | 966
Atopic dermatitis 799 | 952
active Crohn's disease 774 | 922
non primary Sjogren syndrome sicca 763 | 891
Epilepsy 721 | 792
gastric carcinoma 708 | 807
Waldenstrons macroglobulinemia 699 | 765
Liver Cirrhosis, Experimental 696 | 769
acute myeloid leukemia 685 | 783
active ulcerative colitis 652 | 764
esophageal adenocarcinoma 631 | 737
primary Sjogren syndrome 620 | 735
medulloblastoma 617 | 720
Dull intelligence 601 | 645
Low intelligence 601 | 645
Mental Retardation 601 | 645
Mental deficiency 601 | 645
Poor school performance 601 | 645
Obesity 597 | 678
progressive supranuclear palsy 591 | 676
aldosterone-producing adenoma 589 | 665
Melanoma 573 | 711
Alzheimer's disease 565 | 658
Cognitive delay 563 | 608
Global developmental delay 563 | 608
Mental and motor retardation 563 | 608
Seizures 563 | 596
Bipolar Disorder 562 | 666
Muscle hypotonia 536 | 571
Duchenne muscular dystrophy 527 | 601
Short stature 490 | 531
pancreatic carcinoma 486 | 562
fibroadenoma 476 | 559
hepatocellular carcinoma 464 | 547
Endometriosis 462 | 540
Liver cancer 458 | 604
autosomal dominant Emery-Dreifuss muscular dystrophy 454 | 510
Prostatic Neoplasms 447 | 495
Down syndrome 439 | 499
chronic rhinosinusitis 434 | 512
Multiple Sclerosis 426 | 540
mucosa-associated lymphoid tissue lymphoma 406 | 484
posterior fossa group A ependymoma 400 | 468
Breast Neoplasms 398 | 445
sonic hedgehog group medulloblastoma 396 | 467
gastric cancer 395 | 459

Tissue

Endocrine System 14,911 | 18,159
Digestive Tract 14,499 | 17,369
Female tissues 14,483 | 17,400
Skin and soft tissues 14,401 | 17,230
Male tissues 14,307 | 17,142
Blood and immune system 14,174 | 16,909
Nervous System 14,100 | 16,725
Liver and Pancreas 14,091 | 16,750
Urinary Tract 14,051 | 16,678
Respiratory system 13,807 | 16,393
Cardiovascular System 12,983 | 15,192

Target Family

Non-IDG 8,706 | 12,091
Enzyme 3,525 | 4,145
Transcription Factor 989 | 1,400
Kinase 563 | 634
Transporter 424 | 473
GPCR 321 | 408
Ion Channel 302 | 344
Epigenetic 213 | 242
oGPCR 199 | 421
Nuclear Receptor 46 | 48
TF/Epigenetic 28 | 38

Ortholog Species

Cow 15,316 | 15,316
Mouse 16,567 | 16,567
Rat 15,112 | 15,112
Dog 15,069 | 15,069
Horse 14,249 | 14,249
Chimp 14,136 | 14,136
Macaque 12,758 | 12,758
Opossum 12,223 | 12,223
Anole lizard 10,585 | 10,585
Xenopus 10,463 | 10,463
Pig 10,164 | 10,164
Zebrafish 9,725 | 9,725
Chicken 7,823 | 7,823
Platypus 5,699 | 5,699
C. elegans 3,178 | 3,178
Fruitfly 3,048 | 3,048
S.cerevisiae 1,798 | 1,798

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Trafficking protein particle complex subunit 2-like protein TRAPPC2L Tdark Non-IDG -0.18066 0.74 35
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418
Uncharacterized protein ZSWIM9 ZSWIM9 Tdark Non-IDG 0.00000 12
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123
Suppressor of tumorigenicity 14 protein ST14 Tchem Non-IDG -2.50215 338.3 309
Peroxisomal membrane protein PEX16 PEX16 Tbio Non-IDG -1.43594 27.8 78
T-box transcription factor TBX21 TBX21 Tbio Transcription Factor -2.95359 868.5 480
Urotensin-2 receptor UTS2R Tchem GPCR -1.95094 62.5 182
Paraneoplastic antigen Ma2 PNMA2 Tbio Non-IDG -2.92781 822.4 113