Development Level

Tbio 8,870 | 11,445
Tdark 3,468 | 6,588
Tchem 1,305 | 1,598
Tclin 493 | 613

Collection

Kinase: IDG Consortium (Target... 96 | 125
GPCR: IDG Consortium (Targets) 90 | 126
Ion Channel: IDG Consortium (T... 75 | 99
Kinase: IDG Consortium (Comple... 25 | 37
GPCR: IDG Consortium (Complete... 20 | 25

IMPC Phenotype

preweaning lethality, complete... 810 | 979
preweaning lethality, incomple... 399 | 499
abnormal behavior 243 | 298
embryonic lethality prior to t... 229 | 278
embryonic lethality prior to o... 200 | 239
decreased total body fat amoun... 177 | 207
enlarged heart 176 | 210
abnormal embryo size 174 | 220
decreased vertical activity 163 | 208
abnormal bone structure 150 | 187
increased lean body mass 144 | 172
abnormal heart morphology 136 | 162
decreased body weight 130 | 161
decreased bone mineral content 126 | 151
hyperactivity 121 | 148
hypoactivity 111 | 132
increased total body fat amoun... 107 | 134
decreased lean body mass 106 | 135
male infertility 105 | 123
decreased bone mineral density 102 | 126
decreased circulating glucose ... 102 | 126
increased circulating alkaline... 98 | 122
abnormal seminal vesicle morph... 92 | 114
decreased grip strength 88 | 116
embryonic growth retardation 86 | 106
increased bone mineral content 85 | 108
increased startle reflex 85 | 112
increased mean corpuscular hem... 82 | 96
cataract 77 | 92
decreased body length 77 | 101
decreased circulating choleste... 76 | 93
increased or absent threshold ... 76 | 101
short tibia 76 | 97
increased mean corpuscular vol... 73 | 92
decreased prepulse inhibition 72 | 82
decreased lymphocyte cell numb... 69 | 83
increased circulating HDL chol... 68 | 80
prenatal lethality prior to he... 68 | 87
decreased leukocyte cell numbe... 66 | 73
abnormal lens morphology 65 | 81
increased fasted circulating g... 65 | 76
decreased circulating serum al... 64 | 82
decreased circulating triglyce... 64 | 79
improved glucose tolerance 64 | 79
decreased mean corpuscular vol... 62 | 79
decreased startle reflex 62 | 75
small superior vagus ganglion 62 | 74
decreased circulating insulin ... 60 | 76
decreased hemoglobin content 58 | 68
abnormal gait 57 | 69
increased bone mineral density 57 | 72
increased circulating choleste... 57 | 66
increased circulating sodium l... 57 | 71
abnormal eye morphology 56 | 68
abnormal kidney morphology 56 | 65
decreased erythrocyte cell num... 56 | 62
abnormal sleep behavior 55 | 70
impaired glucose tolerance 55 | 75
increased monocyte cell number 54 | 63
decreased circulating HDL chol... 53 | 68
thrombocytopenia 53 | 56
female infertility 52 | 60
decreased fasted circulating g... 51 | 65
increased heart weight 51 | 62
abnormal retina morphology 50 | 71
abnormal behavioral response t... 49 | 66
abnormal coat-hair pigmentatio... 49 | 64
small testis 48 | 58
abnormal spleen morphology 47 | 55
hydrometra 47 | 53
decreased blood urea nitrogen ... 42 | 51
decreased mean corpuscular hem... 42 | 50
decreased caudal vertebrae num... 41 | 53
edema 41 | 59
decreased hematocrit 40 | 46
decreased circulating alkaline... 39 | 46
increased blood urea nitrogen ... 39 | 48
increased leukocyte cell numbe... 39 | 47
abnormal skin morphology 38 | 50
decreased circulating total pr... 38 | 49
increased neutrophil cell numb... 38 | 46
decreased circulating alanine ... 37 | 47
abnormal neural tube closure 36 | 46
enlarged spleen 36 | 41
decreased red blood cell distr... 35 | 41
increased circulating triglyce... 35 | 42
increased hemoglobin content 35 | 45
prolonged QT interval 35 | 38
decreased neutrophil cell numb... 34 | 42
prolonged ST segment 34 | 36
abnormal epididymis morphology 33 | 42
increased grip strength 33 | 41
increased hematocrit 33 | 46
increased mean platelet volume 33 | 45
limb grasping 33 | 41
abnormal testis morphology 32 | 43
decreased circulating calcium ... 31 | 36
increased erythrocyte cell num... 31 | 39
tremors 31 | 39
increased circulating chloride... 30 | 41

Disease

Carcinoma 9,029 | 11,493
ovarian cancer 6,794 | 8,520
osteosarcoma 6,181 | 7,950
psoriasis 5,058 | 6,694
medulloblastoma, large-cell 4,907 | 6,241
glioblastoma 4,619 | 5,792
atypical teratoid / rhabdoid tumor 4,034 | 5,112
lung cancer 3,758 | 4,740
ependymoma 3,712 | 4,679
group 3 medulloblastoma 3,240 | 4,104
adult high grade glioma 2,995 | 3,801
Breast cancer 2,828 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 2,609 | 3,291
malignant mesothelioma 2,573 | 3,232
Astrocytoma, Pilocytic 2,439 | 3,081
primitive neuroectodermal tumor 2,414 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,361 | 2,989
invasive ductal carcinoma 2,348 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,344 | 2,955
non-small cell lung cancer 2,292 | 2,890
lung carcinoma 2,284 | 2,843
oligodendroglioma 2,256 | 2,850
lung adenocarcinoma 2,139 | 2,716
Kidney cancer 2,116 | 2,613
astrocytic glioma 2,052 | 2,597
Cancer 1,946 | 2,499
pancreatic cancer 1,854 | 2,398
interstitial cystitis 1,797 | 2,312
subependymal giant cell astrocytoma 1,768 | 2,287
tuberculosis 1,587 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,581 | 1,962
Pick disease 1,518 | 1,894
pituitary cancer 1,512 | 1,972
group 4 medulloblastoma 1,464 | 1,855
ulcerative colitis 1,434 | 1,819
ductal carcinoma in situ 1,403 | 1,745
cystic fibrosis 1,318 | 1,696
diabetes mellitus 1,296 | 1,728
breast carcinoma 1,261 | 1,638
Autosomal recessive predisposition 1,211 | 1,442
colon cancer 1,162 | 1,478
adrenocortical carcinoma 1,149 | 1,428
Multiple myeloma 1,104 | 1,332
juvenile dermatomyositis 939 | 1,187
Schizophrenia 920 | 1,160
acute quadriplegic myopathy 918 | 1,158
astrocytoma 909 | 1,146
Rheumatoid arthritis 899 | 1,191
primary pancreatic ductal adenocarcinoma 860 | 1,109
spina bifida 860 | 1,074
pediatric high grade glioma 853 | 1,064
nasopharyngeal carcinoma 848 | 1,058
cutaneous lupus erythematosus 808 | 1,057
Intellectual disability 799 | 1,016
dermatomyositis 759 | 966
Atopic dermatitis 749 | 952
active Crohn's disease 738 | 922
non primary Sjogren syndrome sicca 695 | 891
Waldenstrons macroglobulinemia 641 | 765
gastric carcinoma 639 | 807
Epilepsy 625 | 792
acute myeloid leukemia 620 | 783
Liver Cirrhosis, Experimental 611 | 769
active ulcerative colitis 600 | 764
primary Sjogren syndrome 596 | 735
esophageal adenocarcinoma 579 | 737
medulloblastoma 567 | 720
Melanoma 562 | 711
Obesity 553 | 678
progressive supranuclear palsy 537 | 676
aldosterone-producing adenoma 532 | 665
Dull intelligence 527 | 645
Low intelligence 527 | 645
Mental Retardation 527 | 645
Mental deficiency 527 | 645
Poor school performance 527 | 645
Alzheimer's disease 522 | 658
Bipolar Disorder 522 | 666
Cognitive delay 504 | 608
Global developmental delay 504 | 608
Mental and motor retardation 504 | 608
Seizures 485 | 596
Muscle hypotonia 473 | 571
Duchenne muscular dystrophy 464 | 601
Liver cancer 454 | 604
Endometriosis 436 | 540
fibroadenoma 433 | 559
pancreatic carcinoma 429 | 562
Short stature 422 | 531
Multiple Sclerosis 417 | 540
chronic rhinosinusitis 411 | 512
hepatocellular carcinoma 406 | 547
autosomal dominant Emery-Dreifuss muscular dystrophy 401 | 510
Prostatic Neoplasms 397 | 495
Down syndrome 395 | 499
Skin cancer 376 | 469
mucosa-associated lymphoid tissue lymphoma 375 | 484
posterior fossa group A ependymoma 372 | 468
Breast Neoplasms 370 | 445
sonic hedgehog group medulloblastoma 358 | 467

Tissue

Endocrine System 13,719 | 18,159
Female tissues 13,284 | 17,400
Digestive Tract 13,281 | 17,369
Skin and soft tissues 13,180 | 17,230
Male tissues 13,126 | 17,142
Blood and immune system 12,957 | 16,909
Liver and Pancreas 12,874 | 16,750
Nervous System 12,861 | 16,725
Urinary Tract 12,836 | 16,678
Respiratory system 12,602 | 16,393
Cardiovascular System 11,794 | 15,192

Target Family

Non-IDG 8,072 | 12,091
Enzyme 3,198 | 4,145
Transcription Factor 996 | 1,400
Kinase 517 | 634
Transporter 386 | 473
GPCR 294 | 408
Ion Channel 270 | 344
Epigenetic 187 | 242
oGPCR 149 | 421
Nuclear Receptor 38 | 48
TF/Epigenetic 29 | 38

Ortholog Species

Chimp 14,136 | 14,136
Mouse 16,567 | 16,567
Cow 15,316 | 15,316
Rat 15,112 | 15,112
Dog 15,069 | 15,069
Horse 14,249 | 14,249
Macaque 12,758 | 12,758
Opossum 12,223 | 12,223
Anole lizard 10,585 | 10,585
Xenopus 10,463 | 10,463
Pig 10,164 | 10,164
Zebrafish 9,725 | 9,725
Chicken 7,823 | 7,823
Platypus 5,699 | 5,699
C. elegans 3,178 | 3,178
Fruitfly 3,048 | 3,048
S.cerevisiae 1,798 | 1,798

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418
Retinoic acid receptor responder protein 3 RARRES3 Tbio Non-IDG -1.84020 71.0 164
Suppressor of tumorigenicity 14 protein ST14 Tchem Non-IDG -2.50215 338.3 309
Peroxisomal membrane protein PEX16 PEX16 Tbio Non-IDG -1.43594 27.8 78
T-box transcription factor TBX21 TBX21 Tbio Transcription Factor -2.95359 868.5 480
Urotensin-2 receptor UTS2R Tchem GPCR -1.95094 62.5 182
T-complex protein 1 subunit zeta CCT6A Tbio Non-IDG -1.39880 26.2 90
Paraneoplastic antigen Ma3 PNMA3 Tbio Non-IDG -1.88721 71.6 105
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275