Development Level

Tbio 8,874 | 11,445
Tdark 3,467 | 6,588
Tchem 1,306 | 1,598
Tclin 493 | 613

Collection

RFA-RM-18-021 241 | 328
Kinase: IDG Consortium (Target... 96 | 125
GPCR: IDG Consortium (Targets) 90 | 126
Ion Channel: IDG Consortium (T... 75 | 99
Kinase: IDG Consortium (Comple... 25 | 37
GPCR: IDG Consortium (Complete... 20 | 25

IMPC Phenotype

preweaning lethality, complete... 810 | 979
preweaning lethality, incomple... 399 | 499
abnormal behavior 243 | 298
embryonic lethality prior to t... 229 | 278
embryonic lethality prior to o... 200 | 239
decreased total body fat amoun... 177 | 207
enlarged heart 176 | 210
abnormal embryo size 174 | 220
decreased vertical activity 163 | 208
abnormal bone structure 150 | 187
increased lean body mass 144 | 172
abnormal heart morphology 136 | 162
decreased body weight 130 | 161
decreased bone mineral content 126 | 151
hyperactivity 121 | 148
hypoactivity 111 | 132
increased total body fat amoun... 107 | 134
decreased lean body mass 106 | 135
male infertility 105 | 123
decreased bone mineral density 102 | 126
decreased circulating glucose ... 102 | 126
increased circulating alkaline... 98 | 122
abnormal seminal vesicle morph... 92 | 114
decreased grip strength 89 | 116
embryonic growth retardation 86 | 106
increased bone mineral content 85 | 108
increased startle reflex 85 | 112
increased mean corpuscular hem... 82 | 96
cataract 77 | 92
decreased body length 77 | 101
decreased circulating choleste... 76 | 93
increased or absent threshold ... 76 | 101
short tibia 76 | 97
increased mean corpuscular vol... 73 | 92
decreased prepulse inhibition 72 | 82
decreased lymphocyte cell numb... 69 | 83
increased circulating HDL chol... 68 | 80
prenatal lethality prior to he... 68 | 87
decreased leukocyte cell numbe... 66 | 73
abnormal lens morphology 65 | 81
increased fasted circulating g... 65 | 76
decreased circulating serum al... 64 | 82
decreased circulating triglyce... 64 | 79
improved glucose tolerance 64 | 79
decreased mean corpuscular vol... 62 | 79
decreased startle reflex 62 | 75
small superior vagus ganglion 62 | 74
decreased circulating insulin ... 60 | 76
decreased hemoglobin content 58 | 68
abnormal gait 57 | 69
increased bone mineral density 57 | 72
increased circulating choleste... 57 | 66
increased circulating sodium l... 57 | 71
abnormal eye morphology 56 | 68
abnormal kidney morphology 56 | 65
decreased erythrocyte cell num... 56 | 62
abnormal sleep behavior 55 | 70
impaired glucose tolerance 55 | 75
increased monocyte cell number 54 | 63
decreased circulating HDL chol... 53 | 68
thrombocytopenia 53 | 56
female infertility 52 | 60
decreased fasted circulating g... 51 | 65
increased heart weight 51 | 62
abnormal retina morphology 50 | 71
abnormal behavioral response t... 49 | 66
abnormal coat-hair pigmentatio... 49 | 64
small testis 48 | 58
abnormal spleen morphology 47 | 55
hydrometra 47 | 53
decreased blood urea nitrogen ... 42 | 51
decreased mean corpuscular hem... 42 | 50
decreased caudal vertebrae num... 41 | 53
edema 41 | 59
decreased hematocrit 40 | 46
decreased circulating alkaline... 39 | 46
increased blood urea nitrogen ... 39 | 48
increased leukocyte cell numbe... 39 | 47
abnormal skin morphology 38 | 50
decreased circulating total pr... 38 | 49
increased neutrophil cell numb... 38 | 46
decreased circulating alanine ... 37 | 47
abnormal neural tube closure 36 | 46
enlarged spleen 36 | 41
decreased red blood cell distr... 35 | 41
increased circulating triglyce... 35 | 42
increased hemoglobin content 35 | 45
prolonged QT interval 35 | 38
decreased neutrophil cell numb... 34 | 42
prolonged ST segment 34 | 36
abnormal epididymis morphology 33 | 42
increased grip strength 33 | 41
increased hematocrit 33 | 46
increased mean platelet volume 33 | 45
limb grasping 33 | 41
abnormal testis morphology 32 | 43
decreased circulating calcium ... 31 | 36
increased erythrocyte cell num... 31 | 39
tremors 31 | 39
increased circulating chloride... 30 | 41

Disease

Carcinoma 9,030 | 11,493
ovarian cancer 6,797 | 8,520
osteosarcoma 6,180 | 7,950
psoriasis 5,060 | 6,694
medulloblastoma, large-cell 4,908 | 6,241
glioblastoma 4,622 | 5,792
atypical teratoid / rhabdoid tumor 4,035 | 5,112
lung cancer 3,760 | 4,740
ependymoma 3,714 | 4,679
group 3 medulloblastoma 3,240 | 4,104
adult high grade glioma 2,998 | 3,801
Breast cancer 2,832 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 2,611 | 3,291
malignant mesothelioma 2,574 | 3,232
Astrocytoma, Pilocytic 2,442 | 3,081
primitive neuroectodermal tumor 2,415 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 2,363 | 2,989
invasive ductal carcinoma 2,349 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 2,345 | 2,955
non-small cell lung cancer 2,293 | 2,890
lung carcinoma 2,286 | 2,843
oligodendroglioma 2,258 | 2,850
lung adenocarcinoma 2,139 | 2,716
Kidney cancer 2,116 | 2,613
astrocytic glioma 2,053 | 2,597
Cancer 1,947 | 2,499
pancreatic cancer 1,856 | 2,398
interstitial cystitis 1,799 | 2,312
subependymal giant cell astrocytoma 1,768 | 2,287
tuberculosis 1,587 | 2,010
pancreatic ductal adenocarcinoma liver metastasis 1,582 | 1,962
Pick disease 1,518 | 1,894
pituitary cancer 1,513 | 1,972
group 4 medulloblastoma 1,465 | 1,855
ulcerative colitis 1,435 | 1,819
ductal carcinoma in situ 1,404 | 1,745
cystic fibrosis 1,321 | 1,696
diabetes mellitus 1,297 | 1,728
breast carcinoma 1,262 | 1,638
Autosomal recessive predisposition 1,211 | 1,442
colon cancer 1,162 | 1,478
adrenocortical carcinoma 1,149 | 1,428
Multiple myeloma 1,104 | 1,332
juvenile dermatomyositis 938 | 1,187
Schizophrenia 922 | 1,160
acute quadriplegic myopathy 919 | 1,158
astrocytoma 911 | 1,146
Rheumatoid arthritis 899 | 1,191
primary pancreatic ductal adenocarcinoma 860 | 1,109
spina bifida 860 | 1,074
pediatric high grade glioma 853 | 1,064
nasopharyngeal carcinoma 850 | 1,058
cutaneous lupus erythematosus 808 | 1,057
Intellectual disability 799 | 1,016
dermatomyositis 760 | 966
Atopic dermatitis 750 | 952
active Crohn's disease 739 | 922
non primary Sjogren syndrome sicca 694 | 891
Waldenstrons macroglobulinemia 641 | 765
gastric carcinoma 639 | 807
Epilepsy 625 | 792
acute myeloid leukemia 621 | 783
Liver Cirrhosis, Experimental 611 | 769
active ulcerative colitis 601 | 764
primary Sjogren syndrome 596 | 735
esophageal adenocarcinoma 580 | 737
medulloblastoma 568 | 720
Melanoma 562 | 711
Obesity 553 | 678
progressive supranuclear palsy 537 | 676
aldosterone-producing adenoma 533 | 665
Dull intelligence 527 | 645
Low intelligence 527 | 645
Mental Retardation 527 | 645
Mental deficiency 527 | 645
Poor school performance 527 | 645
Bipolar Disorder 523 | 666
Alzheimer's disease 522 | 658
Cognitive delay 504 | 608
Global developmental delay 504 | 608
Mental and motor retardation 504 | 608
Seizures 485 | 596
Muscle hypotonia 473 | 571
Duchenne muscular dystrophy 464 | 601
Liver cancer 454 | 604
Endometriosis 436 | 540
fibroadenoma 433 | 559
pancreatic carcinoma 429 | 562
Short stature 422 | 531
Multiple Sclerosis 417 | 540
chronic rhinosinusitis 411 | 512
hepatocellular carcinoma 406 | 547
autosomal dominant Emery-Dreifuss muscular dystrophy 402 | 510
Prostatic Neoplasms 397 | 495
Down syndrome 395 | 499
Skin cancer 376 | 469
mucosa-associated lymphoid tissue lymphoma 375 | 484
posterior fossa group A ependymoma 372 | 468
Breast Neoplasms 370 | 445
sonic hedgehog group medulloblastoma 358 | 467

Tissue

Endocrine System 13,723 | 18,159
Female tissues 13,288 | 17,400
Digestive Tract 13,285 | 17,369
Skin and soft tissues 13,184 | 17,230
Male tissues 13,130 | 17,142
Blood and immune system 12,961 | 16,909
Liver and Pancreas 12,878 | 16,750
Nervous System 12,865 | 16,725
Urinary Tract 12,840 | 16,678
Respiratory system 12,606 | 16,393
Cardiovascular System 11,798 | 15,192

Target Family

Non-IDG 8,074 | 12,091
Enzyme 3,199 | 4,145
Transcription Factor 996 | 1,400
Kinase 517 | 634
Transporter 386 | 473
GPCR 294 | 408
Ion Channel 271 | 344
Epigenetic 187 | 242
oGPCR 149 | 421
Nuclear Receptor 38 | 48
TF/Epigenetic 29 | 38

Ortholog Species

Chimp 14,140 | 14,140
Mouse 16,570 | 16,570
Cow 15,320 | 15,320
Rat 15,117 | 15,117
Dog 15,073 | 15,073
Horse 14,252 | 14,252
Macaque 12,761 | 12,761
Opossum 12,230 | 12,230
Anole lizard 10,588 | 10,588
Xenopus 10,468 | 10,468
Pig 10,168 | 10,168
Zebrafish 9,726 | 9,726
Chicken 7,827 | 7,827
Platypus 5,703 | 5,703
C. elegans 3,179 | 3,179
Fruitfly 3,050 | 3,050
S.cerevisiae 1,799 | 1,799

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Carcinoembryonic antigen-related cell adhesion molecule 8 CEACAM8 Tbio Non-IDG -2.27709 182.9 314
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Zinc finger protein 175 ZNF175 Tbio Transcription Factor -0.86533 8.35 88
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Glutaredoxin domain-containing cysteine-rich protein 2 GRXCR2 Tbio Non-IDG 0.00000 1.00 14
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
Uncharacterized protein KIAA1551 KIAA1551 Tdark Non-IDG -0.49946 2.76 22
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.53750 4.06 29
Keratin-associated protein 9-1 KRTAP9-1 Tdark Non-IDG 0.00000 0
Mitochondrial uncoupling protein 3 UCP3 Tbio Non-IDG -2.74050 585.4 181