Development Level

Tbio 5,261 | 11,445
Tdark 1,479 | 6,588
Tchem 797 | 1,598
Tclin 290 | 613

Collection

RFA-RM-18-021 127 | 328
Kinase: IDG Consortium (Target... 48 | 125
Ion Channel: IDG Consortium (T... 45 | 99
GPCR: IDG Consortium (Targets) 36 | 126
Kinase: IDG Consortium (Comple... 19 | 37
GPCR: IDG Consortium (Complete... 9 | 25

IMPC Phenotype

preweaning lethality, complete... 591 | 979
preweaning lethality, incomple... 262 | 499
embryonic lethality prior to t... 173 | 278
abnormal behavior 149 | 298
embryonic lethality prior to o... 148 | 239
abnormal embryo size 121 | 220
decreased total body fat amoun... 108 | 207
enlarged heart 108 | 210
decreased vertical activity 102 | 208
decreased body weight 98 | 161
increased lean body mass 93 | 172
abnormal bone structure 92 | 187
abnormal heart morphology 87 | 162
decreased bone mineral content 81 | 151
decreased lean body mass 79 | 135
increased total body fat amoun... 75 | 134
hypoactivity 74 | 132
decreased circulating glucose ... 70 | 126
embryonic growth retardation 69 | 106
decreased bone mineral density 64 | 126
hyperactivity 64 | 148
increased circulating alkaline... 64 | 122
increased bone mineral content 63 | 108
abnormal seminal vesicle morph... 60 | 114
decreased grip strength 59 | 116
increased startle reflex 57 | 112
decreased lymphocyte cell numb... 56 | 83
decreased body length 55 | 101
male infertility 55 | 123
short tibia 55 | 97
increased mean corpuscular hem... 52 | 96
increased mean corpuscular vol... 51 | 92
prenatal lethality prior to he... 51 | 87
increased or absent threshold ... 49 | 101
cataract 48 | 92
decreased circulating choleste... 47 | 93
decreased circulating triglyce... 46 | 79
abnormal lens morphology 44 | 81
increased circulating HDL chol... 43 | 80
impaired glucose tolerance 42 | 75
increased bone mineral density 42 | 72
abnormal gait 41 | 69
decreased circulating insulin ... 41 | 76
decreased startle reflex 41 | 75
increased fasted circulating g... 40 | 76
abnormal retina morphology 39 | 71
decreased fasted circulating g... 39 | 65
decreased mean corpuscular vol... 39 | 79
decreased circulating serum al... 38 | 82
decreased leukocyte cell numbe... 38 | 73
improved glucose tolerance 38 | 79
decreased prepulse inhibition 37 | 82
increased monocyte cell number 37 | 63
decreased hemoglobin content 36 | 68
increased circulating choleste... 36 | 66
small superior vagus ganglion 36 | 74
abnormal eye morphology 35 | 68
decreased erythrocyte cell num... 35 | 62
abnormal coat-hair pigmentatio... 34 | 64
small testis 34 | 58
increased heart weight 33 | 62
thrombocytopenia 33 | 56
decreased circulating HDL chol... 32 | 68
increased circulating sodium l... 32 | 71
abnormal behavioral response t... 31 | 66
abnormal sleep behavior 30 | 70
decreased circulating alkaline... 30 | 46
edema 30 | 59
abnormal spleen morphology 29 | 55
decreased caudal vertebrae num... 29 | 53
hydrometra 29 | 53
tremors 29 | 39
abnormal skin morphology 28 | 50
abnormal kidney morphology 27 | 65
decreased circulating total pr... 27 | 49
abnormal epididymis morphology 26 | 42
abnormal neural tube closure 26 | 46
increased hematocrit 26 | 46
abnormal bone mineralization 25 | 38
abnormal testis morphology 25 | 43
decreased circulating LDL chol... 25 | 38
decreased hematocrit 25 | 46
increased blood urea nitrogen ... 25 | 48
increased circulating triglyce... 25 | 42
increased neutrophil cell numb... 25 | 46
decreased circulating alanine ... 24 | 47
decreased mean corpuscular hem... 24 | 50
enlarged lymph nodes 24 | 37
increased hemoglobin content 24 | 45
increased mean platelet volume 24 | 45
abnormal embryo turning 23 | 31
decreased blood urea nitrogen ... 23 | 51
decreased neutrophil cell numb... 23 | 42
abnormal cranium morphology 22 | 36
decreased circulating creatini... 22 | 39
decreased red blood cell distr... 22 | 41
increased grip strength 22 | 41
prolonged QT interval 22 | 38
increased mean corpuscular hem... 21 | 36
pallor 21 | 34

Disease

Carcinoma 5,178 | 11,493
ovarian cancer 4,437 | 8,520
osteosarcoma 3,755 | 7,950
medulloblastoma, large-cell 3,115 | 6,241
glioblastoma 2,929 | 5,792
psoriasis 2,900 | 6,694
atypical teratoid / rhabdoid tumor 2,585 | 5,112
lung cancer 2,377 | 4,740
ependymoma 2,363 | 4,679
group 3 medulloblastoma 2,072 | 4,104
Breast cancer 1,883 | 3,578
adult high grade glioma 1,839 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 1,691 | 3,291
malignant mesothelioma 1,579 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 1,554 | 2,989
primitive neuroectodermal tumor 1,545 | 3,035
intraductal papillary-mucinous adenoma (IPMA) 1,523 | 2,955
Astrocytoma, Pilocytic 1,522 | 3,081
invasive ductal carcinoma 1,490 | 2,951
oligodendroglioma 1,459 | 2,850
non-small cell lung cancer 1,421 | 2,890
astrocytic glioma 1,377 | 2,597
lung carcinoma 1,349 | 2,843
lung adenocarcinoma 1,299 | 2,716
Kidney cancer 1,284 | 2,613
pancreatic cancer 1,210 | 2,398
subependymal giant cell astrocytoma 1,127 | 2,287
Cancer 1,104 | 2,499
Pick disease 1,064 | 1,894
interstitial cystitis 1,056 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 1,028 | 1,962
pituitary cancer 1,001 | 1,972
group 4 medulloblastoma 952 | 1,855
tuberculosis 940 | 2,010
ulcerative colitis 875 | 1,819
ductal carcinoma in situ 874 | 1,745
cystic fibrosis 834 | 1,696
breast carcinoma 791 | 1,638
Autosomal recessive predisposition 778 | 1,442
colon cancer 752 | 1,478
Multiple myeloma 736 | 1,332
adrenocortical carcinoma 721 | 1,428
diabetes mellitus 691 | 1,728
acute quadriplegic myopathy 635 | 1,158
juvenile dermatomyositis 627 | 1,187
primary pancreatic ductal adenocarcinoma 594 | 1,109
Schizophrenia 586 | 1,160
Rheumatoid arthritis 577 | 1,191
astrocytoma 555 | 1,146
Intellectual disability 548 | 1,016
dermatomyositis 547 | 966
pediatric high grade glioma 524 | 1,064
spina bifida 523 | 1,074
nasopharyngeal carcinoma 504 | 1,058
active Crohn's disease 455 | 922
Atopic dermatitis 449 | 952
Waldenstrons macroglobulinemia 441 | 765
cutaneous lupus erythematosus 426 | 1,057
Epilepsy 425 | 792
gastric carcinoma 414 | 807
acute myeloid leukemia 396 | 783
progressive supranuclear palsy 382 | 676
non primary Sjogren syndrome sicca 380 | 891
aldosterone-producing adenoma 379 | 665
Liver Cirrhosis, Experimental 378 | 769
active ulcerative colitis 365 | 764
primary Sjogren syndrome 362 | 735
Dull intelligence 359 | 645
Low intelligence 359 | 645
Mental Retardation 359 | 645
Mental deficiency 359 | 645
Poor school performance 359 | 645
Bipolar Disorder 356 | 666
Alzheimer's disease 348 | 658
Cognitive delay 346 | 608
Global developmental delay 346 | 608
Mental and motor retardation 346 | 608
Obesity 342 | 678
medulloblastoma 339 | 720
Seizures 336 | 596
esophageal adenocarcinoma 328 | 737
Melanoma 324 | 711
Muscle hypotonia 316 | 571
Duchenne muscular dystrophy 306 | 601
Short stature 293 | 531
pancreatic carcinoma 290 | 562
Liver cancer 280 | 604
Endometriosis 274 | 540
Down syndrome 272 | 499
hepatocellular carcinoma 268 | 547
autosomal dominant Emery-Dreifuss muscular dystrophy 267 | 510
fibroadenoma 262 | 559
Prostatic Neoplasms 251 | 495
Amyotrophic lateral sclerosis 247 | 451
tuberculosis and treatment for 6 months 245 | 409
chronic rhinosinusitis 242 | 512
gastric cancer 242 | 459
sonic hedgehog group medulloblastoma 230 | 467
Breast Neoplasms 224 | 445
Small head 223 | 374

Tissue

Endocrine System 7,738 | 18,159
Digestive Tract 7,621 | 17,369
Female tissues 7,609 | 17,400
Skin and soft tissues 7,572 | 17,230
Male tissues 7,556 | 17,142
Nervous System 7,517 | 16,725
Urinary Tract 7,492 | 16,678
Liver and Pancreas 7,477 | 16,750
Blood and immune system 7,462 | 16,909
Respiratory system 7,354 | 16,393
Cardiovascular System 7,056 | 15,192

Target Family

Non-IDG 4,449 | 12,091
Enzyme 1,976 | 4,145
Transcription Factor 344 | 1,400
Kinase 328 | 634
Transporter 235 | 473
Ion Channel 175 | 344
GPCR 161 | 408
Epigenetic 117 | 242
Nuclear Receptor 25 | 48
TF/Epigenetic 16 | 38
oGPCR 1 | 421

Ortholog Species

Chicken 7,827 | 7,827
Mouse 16,570 | 16,570
Cow 15,320 | 15,320
Rat 15,117 | 15,117
Dog 15,073 | 15,073
Horse 14,252 | 14,252
Chimp 14,140 | 14,140
Macaque 12,761 | 12,761
Opossum 12,230 | 12,230
Anole lizard 10,588 | 10,588
Xenopus 10,468 | 10,468
Pig 10,168 | 10,168
Zebrafish 9,726 | 9,726
Platypus 5,703 | 5,703
C. elegans 3,179 | 3,179
Fruitfly 3,050 | 3,050
S.cerevisiae 1,799 | 1,799

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DmX-like protein 1 DMXL1 Tdark Non-IDG -2.50063 311.1 13
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
Mitochondrial coenzyme A transporter SLC25A42 SLC25A42 Tbio Transporter -0.53750 4.06 29
Probable global transcription activator SNF2L1 SMARCA1 Tbio Non-IDG -2.20560 145.6 116
Mitochondrial uncoupling protein 3 UCP3 Tbio Non-IDG -2.74050 585.4 181
Protein unc-13 homolog D UNC13D Tbio Non-IDG -1.93790 85.1 158
60S ribosomal protein L3 RPL3 Tbio Non-IDG -2.02901 103.9 190
Dephospho-CoA kinase domain-containing protein DCAKD Tdark Enzyme 0.95 0.08 141
Non-lysosomal glucosylceramidase GBA2 Tchem Enzyme -1.62330 43.1 59