Development Level

Tbio 2,289 | 11,445
Tdark 486 | 6,588
Tchem 320 | 1,598
Tclin 84 | 613

Collection

RFA-RM-18-021 45 | 328
Kinase: IDG Consortium (Target... 31 | 125
Ion Channel: IDG Consortium (T... 12 | 99
Kinase: IDG Consortium (Comple... 5 | 37
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 357 | 979
preweaning lethality, incomple... 104 | 499
embryonic lethality prior to o... 99 | 239
embryonic lethality prior to t... 92 | 278
abnormal embryo size 62 | 220
abnormal behavior 59 | 298
abnormal bone structure 46 | 187
decreased body weight 44 | 161
decreased total body fat amoun... 42 | 207
decreased bone mineral content 40 | 151
increased lean body mass 35 | 172
increased total body fat amoun... 35 | 134
enlarged heart 34 | 210
decreased bone mineral density 31 | 126
decreased circulating glucose ... 30 | 126
embryonic growth retardation 29 | 106
increased circulating alkaline... 29 | 122
hypoactivity 28 | 132
decreased vertical activity 27 | 208
abnormal heart morphology 26 | 162
decreased lean body mass 26 | 135
decreased grip strength 25 | 116
increased mean corpuscular hem... 25 | 96
male infertility 25 | 123
increased startle reflex 23 | 112
short tibia 23 | 97
abnormal lens morphology 22 | 81
decreased fasted circulating g... 22 | 65
increased mean corpuscular vol... 22 | 92
increased or absent threshold ... 22 | 101
prenatal lethality prior to he... 22 | 87
cataract 21 | 92
decreased body length 21 | 101
increased fasted circulating g... 21 | 76
decreased circulating choleste... 20 | 93
hyperactivity 20 | 148
increased bone mineral content 20 | 108
abnormal behavioral response t... 17 | 66
decreased circulating triglyce... 17 | 79
increased bone mineral density 17 | 72
abnormal coat-hair pigmentatio... 16 | 64
abnormal eye morphology 16 | 68
decreased caudal vertebrae num... 16 | 53
decreased circulating insulin ... 16 | 76
decreased erythrocyte cell num... 16 | 62
decreased lymphocyte cell numb... 16 | 83
increased circulating choleste... 16 | 66
increased circulating sodium l... 16 | 71
abnormal seminal vesicle morph... 15 | 114
decreased circulating HDL chol... 15 | 68
edema 15 | 59
decreased hemoglobin content 14 | 68
impaired glucose tolerance 14 | 75
increased circulating chloride... 14 | 41
increased heart weight 14 | 62
thrombocytopenia 14 | 56
abnormal kidney morphology 13 | 65
abnormal retina morphology 13 | 71
decreased circulating alkaline... 13 | 46
decreased leukocyte cell numbe... 13 | 73
decreased prepulse inhibition 13 | 82
increased circulating HDL chol... 13 | 80
abnormal embryo turning 12 | 31
abnormal gait 12 | 69
abnormal neural tube closure 12 | 46
decreased circulating LDL chol... 12 | 38
decreased circulating alanine ... 12 | 47
decreased circulating serum al... 12 | 82
hydrometra 12 | 53
increased circulating iron lev... 12 | 30
decreased circulating iron lev... 11 | 32
increased grip strength 11 | 41
long tibia 11 | 25
small superior vagus ganglion 11 | 74
syndactyly 11 | 23
tremors 11 | 39
abnormal joint morphology 10 | 23
abnormal retinal vasculature m... 10 | 27
abnormal skin morphology 10 | 50
absent pinna reflex 10 | 23
decreased circulating aspartat... 10 | 34
decreased circulating total pr... 10 | 49
decreased mean corpuscular vol... 10 | 79
decreased startle reflex 10 | 75
increased hemoglobin content 10 | 45
increased monocyte cell number 10 | 63
abnormal bone mineralization 9 | 38
abnormal pericardium morpholog... 9 | 26
brachydactyly 9 | 19
decreased circulating fructosa... 9 | 30
female infertility 9 | 60
improved glucose tolerance 9 | 79
increased circulating calcium ... 9 | 34
increased erythrocyte cell num... 9 | 39
increased hematocrit 9 | 46
increased leukocyte cell numbe... 9 | 47
increased mean platelet volume 9 | 45
increased red blood cell distr... 9 | 34
small testis 9 | 58
pallor 8 | 34

Disease

Carcinoma 1,946 | 11,493
ovarian cancer 1,889 | 8,520
osteosarcoma 1,488 | 7,950
medulloblastoma, large-cell 1,160 | 6,241
glioblastoma 1,074 | 5,792
psoriasis 1,055 | 6,694
lung cancer 972 | 4,740
atypical teratoid / rhabdoid tumor 918 | 5,112
ependymoma 803 | 4,679
group 3 medulloblastoma 756 | 4,104
adult high grade glioma 620 | 3,801
Breast cancer 616 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 573 | 3,291
malignant mesothelioma 556 | 3,232
primitive neuroectodermal tumor 536 | 3,035
oligodendroglioma 512 | 2,850
Multiple myeloma 504 | 1,332
intraductal papillary-mucinous carcinoma (IPMC) 492 | 2,989
astrocytic glioma 482 | 2,597
pancreatic ductal adenocarcinoma liver metastasis 481 | 1,962
invasive ductal carcinoma 473 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 469 | 2,955
non-small cell lung cancer 456 | 2,890
Astrocytoma, Pilocytic 437 | 3,081
Kidney cancer 433 | 2,613
lung adenocarcinoma 410 | 2,716
Pick disease 402 | 1,894
Autosomal recessive predisposition 387 | 1,442
Cancer 376 | 2,499
subependymal giant cell astrocytoma 369 | 2,287
diabetes mellitus 345 | 1,728
lung carcinoma 340 | 2,843
pancreatic cancer 340 | 2,398
tuberculosis 320 | 2,010
group 4 medulloblastoma 298 | 1,855
Intellectual disability 277 | 1,016
Waldenstrons macroglobulinemia 272 | 765
acute quadriplegic myopathy 272 | 1,158
pituitary cancer 264 | 1,972
colon cancer 251 | 1,478
astrocytoma 246 | 1,146
ductal carcinoma in situ 244 | 1,745
dermatomyositis 239 | 966
interstitial cystitis 239 | 2,312
ulcerative colitis 231 | 1,819
breast carcinoma 229 | 1,638
Epilepsy 225 | 792
adrenocortical carcinoma 214 | 1,428
juvenile dermatomyositis 214 | 1,187
Cognitive delay 211 | 608
Global developmental delay 211 | 608
Mental and motor retardation 211 | 608
Muscle hypotonia 207 | 571
cystic fibrosis 207 | 1,696
pediatric high grade glioma 206 | 1,064
non primary Sjogren syndrome sicca 196 | 891
Rheumatoid arthritis 189 | 1,191
Dull intelligence 184 | 645
Low intelligence 184 | 645
Mental Retardation 184 | 645
Mental deficiency 184 | 645
Poor school performance 184 | 645
Seizures 183 | 596
Schizophrenia 171 | 1,160
acute myeloid leukemia 167 | 783
progressive supranuclear palsy 161 | 676
spina bifida 158 | 1,074
nasopharyngeal carcinoma 149 | 1,058
primary pancreatic ductal adenocarcinoma 148 | 1,109
Short stature 136 | 531
medulloblastoma 136 | 720
active Crohn's disease 125 | 922
Failure to gain weight 123 | 365
Pediatric failure to thrive 123 | 365
Neurodegenerative disease 121 | 414
Obesity 119 | 678
Cerebellar Ataxia 117 | 304
Small head 117 | 374
aldosterone-producing adenoma 117 | 665
Alzheimer's disease 116 | 658
Liver Cirrhosis, Experimental 113 | 769
cutaneous lupus erythematosus 109 | 1,057
hereditary spastic paraplegia 107 | 318
Atopic dermatitis 104 | 952
active ulcerative colitis 104 | 764
Nystagmus 103 | 317
pancreatic carcinoma 100 | 562
gastric carcinoma 97 | 807
hepatocellular carcinoma 97 | 547
sonic hedgehog group medulloblastoma 96 | 467
tuberculosis and treatment for 6 months 94 | 409
primary Sjogren syndrome 93 | 735
Bipolar Disorder 92 | 666
Anemia 87 | 365
Strabismus 87 | 270
Melanoma 86 | 711
esophageal adenocarcinoma 86 | 737
Sensorineural Hearing Loss (disorder) 85 | 284
Optic Atrophy 84 | 242
gastric cancer 84 | 459

Tissue

Endocrine System 3,155 | 18,159
Digestive Tract 3,127 | 17,369
Female tissues 3,118 | 17,400
Skin and soft tissues 3,117 | 17,230
Male tissues 3,112 | 17,142
Nervous System 3,108 | 16,725
Liver and Pancreas 3,103 | 16,750
Blood and immune system 3,096 | 16,909
Urinary Tract 3,094 | 16,678
Respiratory system 3,071 | 16,393
Cardiovascular System 3,000 | 15,192

Target Family

Non-IDG 1,643 | 12,091
Enzyme 1,151 | 4,145
Kinase 141 | 634
Transporter 99 | 473
Transcription Factor 43 | 1,400
Epigenetic 41 | 242
Ion Channel 39 | 344
GPCR 15 | 408
Nuclear Receptor 4 | 48
TF/Epigenetic 3 | 38

Ortholog Species

C. elegans 3,179 | 3,179
Mouse 16,570 | 16,570
Cow 15,320 | 15,320
Rat 15,117 | 15,117
Dog 15,073 | 15,073
Horse 14,252 | 14,252
Chimp 14,140 | 14,140
Macaque 12,761 | 12,761
Opossum 12,230 | 12,230
Anole lizard 10,588 | 10,588
Xenopus 10,468 | 10,468
Pig 10,168 | 10,168
Zebrafish 9,726 | 9,726
Chicken 7,827 | 7,827
Platypus 5,703 | 5,703
Fruitfly 3,050 | 3,050
S.cerevisiae 1,799 | 1,799

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
Protein unc-13 homolog D UNC13D Tbio Non-IDG -1.93790 85.1 158
Dephospho-CoA kinase domain-containing protein DCAKD Tdark Enzyme 0.95 0.08 141
40S ribosomal protein S19 RPS19 Tbio Non-IDG -3.14746 1380.8 267
Non-lysosomal glucosylceramidase GBA2 Tchem Enzyme -1.62330 43.1 59
Pre-mRNA-splicing factor CWC22 homolog CWC22 Tbio Non-IDG -3.08456 1172.8 103
Homeobox protein MSX-1 MSX1 Tbio Transcription Factor -2.59245 390.1 298
60S ribosomal protein L36 RPL36 Tbio Non-IDG -1.62928 39.9 123
Pyruvate kinase PKLR PKLR Tbio Kinase -2.37549 231.1 391
Metabotropic glutamate receptor 5 GRM5 Tchem GPCR -3.12353 1370.3 396