Development Level

Tbio 7,057 | 11,445
Tdark 2,085 | 6,588
Tchem 1,061 | 1,598
Tclin 382 | 613

Collection

Kinase: IDG Consortium (Target... 91 | 125
Ion Channel: IDG Consortium (T... 60 | 99
GPCR: IDG Consortium (Targets) 43 | 126
Kinase: IDG Consortium (Comple... 23 | 37
GPCR: IDG Consortium (Complete... 14 | 25

IMPC Phenotype

preweaning lethality, complete... 748 | 979
preweaning lethality, incomple... 358 | 499
embryonic lethality prior to t... 211 | 278
abnormal behavior 201 | 298
embryonic lethality prior to o... 178 | 239
abnormal embryo size 164 | 220
enlarged heart 137 | 210
decreased total body fat amoun... 135 | 207
abnormal bone structure 130 | 187
decreased vertical activity 130 | 208
increased lean body mass 124 | 172
decreased body weight 116 | 161
decreased bone mineral content 101 | 151
abnormal heart morphology 97 | 162
increased total body fat amoun... 96 | 134
hyperactivity 93 | 148
decreased lean body mass 90 | 135
increased circulating alkaline... 87 | 122
male infertility 87 | 123
decreased circulating glucose ... 86 | 126
decreased bone mineral density 81 | 126
abnormal seminal vesicle morph... 79 | 114
embryonic growth retardation 79 | 106
hypoactivity 79 | 132
increased startle reflex 78 | 112
decreased grip strength 76 | 116
increased bone mineral content 76 | 108
decreased body length 75 | 101
increased or absent threshold ... 70 | 101
short tibia 67 | 97
prenatal lethality prior to he... 63 | 87
increased mean corpuscular hem... 62 | 96
decreased circulating choleste... 61 | 93
decreased lymphocyte cell numb... 61 | 83
cataract 60 | 92
decreased circulating triglyce... 59 | 79
decreased prepulse inhibition 59 | 82
increased circulating HDL chol... 58 | 80
increased mean corpuscular vol... 57 | 92
decreased startle reflex 55 | 75
abnormal lens morphology 54 | 81
decreased circulating serum al... 53 | 82
decreased mean corpuscular vol... 53 | 79
abnormal retina morphology 51 | 71
decreased circulating insulin ... 51 | 76
increased bone mineral density 51 | 72
decreased leukocyte cell numbe... 50 | 73
improved glucose tolerance 50 | 79
small superior vagus ganglion 50 | 74
edema 48 | 59
impaired glucose tolerance 48 | 75
increased fasted circulating g... 48 | 76
abnormal kidney morphology 47 | 65
increased circulating choleste... 47 | 66
abnormal gait 46 | 69
abnormal sleep behavior 46 | 70
abnormal coat-hair pigmentatio... 45 | 64
decreased fasted circulating g... 45 | 65
decreased hemoglobin content 45 | 68
increased monocyte cell number 45 | 63
abnormal behavioral response t... 43 | 66
abnormal eye morphology 43 | 68
decreased circulating HDL chol... 43 | 68
decreased erythrocyte cell num... 43 | 62
increased heart weight 43 | 62
thrombocytopenia 42 | 56
small testis 41 | 58
increased circulating sodium l... 40 | 71
abnormal spleen morphology 39 | 55
decreased circulating total pr... 38 | 49
female infertility 38 | 60
decreased circulating alanine ... 37 | 47
decreased mean corpuscular hem... 36 | 50
hydrometra 36 | 53
decreased caudal vertebrae num... 35 | 53
decreased circulating alkaline... 34 | 46
abnormal neural tube closure 33 | 46
decreased red blood cell distr... 33 | 41
increased blood urea nitrogen ... 33 | 48
abnormal epididymis morphology 32 | 42
abnormal testis morphology 32 | 43
decreased hematocrit 32 | 46
increased neutrophil cell numb... 32 | 46
abnormal skin morphology 31 | 50
decreased blood urea nitrogen ... 31 | 51
increased leukocyte cell numbe... 31 | 47
increased mean platelet volume 31 | 45
increased circulating triglyce... 30 | 42
tremors 30 | 39
abnormal bone mineralization 29 | 38
increased grip strength 29 | 41
increased hematocrit 29 | 46
decreased circulating LDL chol... 28 | 38
increased erythrocyte cell num... 28 | 39
decreased neutrophil cell numb... 27 | 42
enlarged lymph nodes 27 | 37
prolonged QT interval 27 | 38
enlarged spleen 26 | 41
increased hemoglobin content 26 | 45
limb grasping 26 | 41

Disease

Carcinoma 6,918 | 11,493
ovarian cancer 5,751 | 8,520
osteosarcoma 5,032 | 7,950
medulloblastoma, large-cell 4,046 | 6,241
psoriasis 3,853 | 6,694
glioblastoma 3,811 | 5,792
atypical teratoid / rhabdoid tumor 3,371 | 5,112
ependymoma 3,112 | 4,679
lung cancer 3,084 | 4,740
group 3 medulloblastoma 2,716 | 4,104
adult high grade glioma 2,410 | 3,801
Breast cancer 2,373 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 2,140 | 3,291
malignant mesothelioma 2,130 | 3,232
primitive neuroectodermal tumor 2,029 | 3,035
Astrocytoma, Pilocytic 1,974 | 3,081
invasive ductal carcinoma 1,962 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 1,941 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 1,929 | 2,955
oligodendroglioma 1,919 | 2,850
non-small cell lung cancer 1,854 | 2,890
astrocytic glioma 1,754 | 2,597
lung carcinoma 1,722 | 2,843
lung adenocarcinoma 1,716 | 2,716
Kidney cancer 1,671 | 2,613
pancreatic cancer 1,546 | 2,398
subependymal giant cell astrocytoma 1,502 | 2,287
Cancer 1,485 | 2,499
interstitial cystitis 1,343 | 2,312
Pick disease 1,342 | 1,894
pancreatic ductal adenocarcinoma liver metastasis 1,330 | 1,962
pituitary cancer 1,309 | 1,972
tuberculosis 1,225 | 2,010
group 4 medulloblastoma 1,194 | 1,855
ulcerative colitis 1,142 | 1,819
ductal carcinoma in situ 1,133 | 1,745
cystic fibrosis 1,063 | 1,696
breast carcinoma 1,048 | 1,638
Autosomal recessive predisposition 1,018 | 1,442
Multiple myeloma 985 | 1,332
adrenocortical carcinoma 966 | 1,428
diabetes mellitus 947 | 1,728
colon cancer 944 | 1,478
acute quadriplegic myopathy 835 | 1,158
juvenile dermatomyositis 816 | 1,187
astrocytoma 800 | 1,146
Rheumatoid arthritis 761 | 1,191
primary pancreatic ductal adenocarcinoma 760 | 1,109
Intellectual disability 741 | 1,016
Schizophrenia 716 | 1,160
pediatric high grade glioma 708 | 1,064
spina bifida 684 | 1,074
dermatomyositis 656 | 966
nasopharyngeal carcinoma 645 | 1,058
Epilepsy 573 | 792
cutaneous lupus erythematosus 565 | 1,057
active Crohn's disease 563 | 922
Waldenstrons macroglobulinemia 561 | 765
Atopic dermatitis 551 | 952
acute myeloid leukemia 547 | 783
non primary Sjogren syndrome sicca 547 | 891
gastric carcinoma 530 | 807
medulloblastoma 496 | 720
Liver Cirrhosis, Experimental 486 | 769
progressive supranuclear palsy 486 | 676
Dull intelligence 485 | 645
Low intelligence 485 | 645
Mental Retardation 485 | 645
Mental deficiency 485 | 645
Poor school performance 485 | 645
Cognitive delay 457 | 608
Global developmental delay 457 | 608
Mental and motor retardation 457 | 608
aldosterone-producing adenoma 456 | 665
Seizures 441 | 596
active ulcerative colitis 439 | 764
primary Sjogren syndrome 439 | 735
Muscle hypotonia 435 | 571
Bipolar Disorder 434 | 666
esophageal adenocarcinoma 427 | 737
Alzheimer's disease 425 | 658
Obesity 425 | 678
Melanoma 407 | 711
Duchenne muscular dystrophy 397 | 601
Short stature 382 | 531
pancreatic carcinoma 374 | 562
autosomal dominant Emery-Dreifuss muscular dystrophy 365 | 510
Liver cancer 358 | 604
hepatocellular carcinoma 353 | 547
Down syndrome 346 | 499
fibroadenoma 345 | 559
chronic rhinosinusitis 340 | 512
Endometriosis 329 | 540
Prostatic Neoplasms 323 | 495
sonic hedgehog group medulloblastoma 317 | 467
Amyotrophic lateral sclerosis 316 | 451
Neurodegenerative disease 301 | 414
posterior fossa group A ependymoma 295 | 468
tuberculosis and treatment for 6 months 293 | 409
gastric cancer 292 | 459

Tissue

Endocrine System 10,460 | 18,159
Digestive Tract 10,280 | 17,369
Female tissues 10,258 | 17,400
Skin and soft tissues 10,242 | 17,230
Male tissues 10,199 | 17,142
Nervous System 10,149 | 16,725
Blood and immune system 10,081 | 16,909
Liver and Pancreas 10,080 | 16,750
Urinary Tract 10,077 | 16,678
Respiratory system 9,932 | 16,393
Cardiovascular System 9,496 | 15,192

Target Family

Non-IDG 5,942 | 12,091
Enzyme 2,623 | 4,145
Transcription Factor 574 | 1,400
Kinase 457 | 634
Transporter 302 | 473
GPCR 223 | 408
Ion Channel 216 | 344
Epigenetic 178 | 242
Nuclear Receptor 34 | 48
TF/Epigenetic 28 | 38
oGPCR 8 | 421

Ortholog Species

Anole lizard 10,585 | 10,585
Mouse 16,567 | 16,567
Cow 15,316 | 15,316
Rat 15,112 | 15,112
Dog 15,069 | 15,069
Horse 14,249 | 14,249
Chimp 14,136 | 14,136
Macaque 12,758 | 12,758
Opossum 12,223 | 12,223
Xenopus 10,463 | 10,463
Pig 10,164 | 10,164
Zebrafish 9,725 | 9,725
Chicken 7,823 | 7,823
Platypus 5,699 | 5,699
C. elegans 3,178 | 3,178
Fruitfly 3,048 | 3,048
S.cerevisiae 1,798 | 1,798

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Beta-secretase 2 BACE2 Tchem Enzyme -2.09709 114.0 418
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123
Suppressor of tumorigenicity 14 protein ST14 Tchem Non-IDG -2.50215 338.3 309
Peroxisomal membrane protein PEX16 PEX16 Tbio Non-IDG -1.43594 27.8 78
T-box transcription factor TBX21 TBX21 Tbio Transcription Factor -2.95359 868.5 480
Urotensin-2 receptor UTS2R Tchem GPCR -1.95094 62.5 182
Zinc finger protein Helios IKZF2 Tbio Transcription Factor -1.26324 15.8 221
Ras-related protein Rab-21 RAB21 Tbio Enzyme -1.33715 23.1 275
Beta-1,3-galactosyltransferase 1 B3GALT1 Tbio Enzyme -0.68296 3.85 66
Paraspeckle component 1 PSPC1 Tbio Non-IDG -1.75415 48.3 19