Development Level

Tbio 7,060 | 11,445
Tdark 2,085 | 6,588
Tchem 1,061 | 1,598
Tclin 382 | 613

Collection

RFA-RM-18-021 192 | 328
Kinase: IDG Consortium (Target... 91 | 125
Ion Channel: IDG Consortium (T... 60 | 99
GPCR: IDG Consortium (Targets) 43 | 126
Kinase: IDG Consortium (Comple... 23 | 37
GPCR: IDG Consortium (Complete... 14 | 25

IMPC Phenotype

preweaning lethality, complete... 748 | 979
preweaning lethality, incomple... 358 | 499
embryonic lethality prior to t... 211 | 278
abnormal behavior 201 | 298
embryonic lethality prior to o... 178 | 239
abnormal embryo size 164 | 220
enlarged heart 137 | 210
decreased total body fat amoun... 135 | 207
abnormal bone structure 130 | 187
decreased vertical activity 130 | 208
increased lean body mass 124 | 172
decreased body weight 116 | 161
decreased bone mineral content 101 | 151
abnormal heart morphology 97 | 162
increased total body fat amoun... 96 | 134
hyperactivity 93 | 148
decreased lean body mass 90 | 135
increased circulating alkaline... 87 | 122
male infertility 87 | 123
decreased circulating glucose ... 86 | 126
decreased bone mineral density 81 | 126
abnormal seminal vesicle morph... 79 | 114
embryonic growth retardation 79 | 106
hypoactivity 79 | 132
increased startle reflex 78 | 112
decreased grip strength 76 | 116
increased bone mineral content 76 | 108
decreased body length 75 | 101
increased or absent threshold ... 70 | 101
short tibia 67 | 97
prenatal lethality prior to he... 63 | 87
increased mean corpuscular hem... 62 | 96
decreased circulating choleste... 61 | 93
decreased lymphocyte cell numb... 61 | 83
cataract 60 | 92
decreased circulating triglyce... 59 | 79
decreased prepulse inhibition 59 | 82
increased circulating HDL chol... 58 | 80
increased mean corpuscular vol... 57 | 92
decreased startle reflex 55 | 75
abnormal lens morphology 54 | 81
decreased circulating serum al... 53 | 82
decreased mean corpuscular vol... 53 | 79
abnormal retina morphology 51 | 71
decreased circulating insulin ... 51 | 76
increased bone mineral density 51 | 72
decreased leukocyte cell numbe... 50 | 73
improved glucose tolerance 50 | 79
small superior vagus ganglion 50 | 74
edema 48 | 59
impaired glucose tolerance 48 | 75
increased fasted circulating g... 48 | 76
abnormal kidney morphology 47 | 65
increased circulating choleste... 47 | 66
abnormal gait 46 | 69
abnormal sleep behavior 46 | 70
abnormal coat-hair pigmentatio... 45 | 64
decreased fasted circulating g... 45 | 65
decreased hemoglobin content 45 | 68
increased monocyte cell number 45 | 63
abnormal behavioral response t... 43 | 66
abnormal eye morphology 43 | 68
decreased circulating HDL chol... 43 | 68
decreased erythrocyte cell num... 43 | 62
increased heart weight 43 | 62
thrombocytopenia 42 | 56
small testis 41 | 58
increased circulating sodium l... 40 | 71
abnormal spleen morphology 39 | 55
decreased circulating total pr... 38 | 49
female infertility 38 | 60
decreased circulating alanine ... 37 | 47
decreased mean corpuscular hem... 36 | 50
hydrometra 36 | 53
decreased caudal vertebrae num... 35 | 53
decreased circulating alkaline... 34 | 46
abnormal neural tube closure 33 | 46
decreased red blood cell distr... 33 | 41
increased blood urea nitrogen ... 33 | 48
abnormal epididymis morphology 32 | 42
abnormal testis morphology 32 | 43
decreased hematocrit 32 | 46
increased neutrophil cell numb... 32 | 46
abnormal skin morphology 31 | 50
decreased blood urea nitrogen ... 31 | 51
increased leukocyte cell numbe... 31 | 47
increased mean platelet volume 31 | 45
increased circulating triglyce... 30 | 42
tremors 30 | 39
abnormal bone mineralization 29 | 38
increased grip strength 29 | 41
decreased circulating LDL chol... 28 | 38
increased erythrocyte cell num... 28 | 39
increased hematocrit 28 | 46
decreased neutrophil cell numb... 27 | 42
enlarged lymph nodes 27 | 37
prolonged QT interval 27 | 38
enlarged spleen 26 | 41
increased hemoglobin content 26 | 45
limb grasping 26 | 41

Disease

Carcinoma 6,920 | 11,493
ovarian cancer 5,753 | 8,520
osteosarcoma 5,032 | 7,950
medulloblastoma, large-cell 4,047 | 6,241
psoriasis 3,855 | 6,694
glioblastoma 3,813 | 5,792
atypical teratoid / rhabdoid tumor 3,371 | 5,112
ependymoma 3,114 | 4,679
lung cancer 3,088 | 4,740
group 3 medulloblastoma 2,717 | 4,104
adult high grade glioma 2,412 | 3,801
Breast cancer 2,377 | 3,578
intraductal papillary-mucinous neoplasm (IPMN) 2,143 | 3,291
malignant mesothelioma 2,132 | 3,232
primitive neuroectodermal tumor 2,030 | 3,035
Astrocytoma, Pilocytic 1,976 | 3,081
invasive ductal carcinoma 1,964 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 1,944 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 1,930 | 2,955
oligodendroglioma 1,920 | 2,850
non-small cell lung cancer 1,855 | 2,890
astrocytic glioma 1,755 | 2,597
lung carcinoma 1,723 | 2,843
lung adenocarcinoma 1,717 | 2,716
Kidney cancer 1,672 | 2,613
pancreatic cancer 1,548 | 2,398
subependymal giant cell astrocytoma 1,501 | 2,287
Cancer 1,487 | 2,499
interstitial cystitis 1,346 | 2,312
Pick disease 1,341 | 1,894
pancreatic ductal adenocarcinoma liver metastasis 1,332 | 1,962
pituitary cancer 1,310 | 1,972
tuberculosis 1,225 | 2,010
group 4 medulloblastoma 1,195 | 1,855
ulcerative colitis 1,144 | 1,819
ductal carcinoma in situ 1,135 | 1,745
cystic fibrosis 1,066 | 1,696
breast carcinoma 1,049 | 1,638
Autosomal recessive predisposition 1,018 | 1,442
Multiple myeloma 985 | 1,332
adrenocortical carcinoma 966 | 1,428
diabetes mellitus 947 | 1,728
colon cancer 945 | 1,478
acute quadriplegic myopathy 836 | 1,158
juvenile dermatomyositis 815 | 1,187
astrocytoma 801 | 1,146
Rheumatoid arthritis 761 | 1,191
primary pancreatic ductal adenocarcinoma 760 | 1,109
Intellectual disability 741 | 1,016
Schizophrenia 717 | 1,160
pediatric high grade glioma 708 | 1,064
spina bifida 685 | 1,074
dermatomyositis 656 | 966
nasopharyngeal carcinoma 647 | 1,058
Epilepsy 573 | 792
cutaneous lupus erythematosus 565 | 1,057
active Crohn's disease 563 | 922
Waldenstrons macroglobulinemia 561 | 765
Atopic dermatitis 552 | 952
acute myeloid leukemia 547 | 783
non primary Sjogren syndrome sicca 546 | 891
gastric carcinoma 530 | 807
medulloblastoma 496 | 720
Liver Cirrhosis, Experimental 486 | 769
progressive supranuclear palsy 486 | 676
Dull intelligence 485 | 645
Low intelligence 485 | 645
Mental Retardation 485 | 645
Mental deficiency 485 | 645
Poor school performance 485 | 645
Cognitive delay 457 | 608
Global developmental delay 457 | 608
Mental and motor retardation 457 | 608
aldosterone-producing adenoma 457 | 665
Seizures 441 | 596
active ulcerative colitis 440 | 764
primary Sjogren syndrome 439 | 735
Muscle hypotonia 435 | 571
Bipolar Disorder 434 | 666
esophageal adenocarcinoma 428 | 737
Alzheimer's disease 425 | 658
Obesity 425 | 678
Melanoma 407 | 711
Duchenne muscular dystrophy 397 | 601
Short stature 382 | 531
pancreatic carcinoma 374 | 562
autosomal dominant Emery-Dreifuss muscular dystrophy 366 | 510
Liver cancer 358 | 604
hepatocellular carcinoma 353 | 547
Down syndrome 346 | 499
fibroadenoma 346 | 559
chronic rhinosinusitis 340 | 512
Endometriosis 329 | 540
Prostatic Neoplasms 323 | 495
Amyotrophic lateral sclerosis 317 | 451
sonic hedgehog group medulloblastoma 317 | 467
Neurodegenerative disease 301 | 414
posterior fossa group A ependymoma 295 | 468
tuberculosis and treatment for 6 months 293 | 409
gastric cancer 292 | 459

Tissue

Endocrine System 10,463 | 18,159
Digestive Tract 10,283 | 17,369
Female tissues 10,261 | 17,400
Skin and soft tissues 10,245 | 17,230
Male tissues 10,202 | 17,142
Nervous System 10,152 | 16,725
Blood and immune system 10,084 | 16,909
Liver and Pancreas 10,083 | 16,750
Urinary Tract 10,080 | 16,678
Respiratory system 9,935 | 16,393
Cardiovascular System 9,499 | 15,192

Target Family

Non-IDG 5,943 | 12,091
Enzyme 2,625 | 4,145
Transcription Factor 574 | 1,400
Kinase 457 | 634
Transporter 302 | 473
GPCR 223 | 408
Ion Channel 216 | 344
Epigenetic 178 | 242
Nuclear Receptor 34 | 48
TF/Epigenetic 28 | 38
oGPCR 8 | 421

Ortholog Species

Anole lizard 10,588 | 10,588
Mouse 16,570 | 16,570
Cow 15,320 | 15,320
Rat 15,117 | 15,117
Dog 15,073 | 15,073
Horse 14,252 | 14,252
Chimp 14,140 | 14,140
Macaque 12,761 | 12,761
Opossum 12,230 | 12,230
Xenopus 10,468 | 10,468
Pig 10,168 | 10,168
Zebrafish 9,726 | 9,726
Chicken 7,827 | 7,827
Platypus 5,703 | 5,703
C. elegans 3,179 | 3,179
Fruitfly 3,050 | 3,050
S.cerevisiae 1,799 | 1,799

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
RWD domain-containing protein 3 RWDD3 Tbio Non-IDG -1.02793 10.9 98
Glutaredoxin domain-containing cysteine-rich protein 2 GRXCR2 Tbio Non-IDG 0.00000 1.00 14
Serine incorporator 5 SERINC5 Tbio Non-IDG -1.50535 34.0 11
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
UPF0606 protein KIAA1549 KIAA1549 Tbio Non-IDG -1.67668 47.8 19
WD repeat domain phosphoinositide-interacting protein 4 WDR45 Tbio Non-IDG -1.29355 17.4 93
Probable global transcription activator SNF2L1 SMARCA1 Tbio Non-IDG -2.20560 145.6 116
Post-GPI attachment to proteins factor 6 TMEM8A Tdark Non-IDG -0.56820 3.55 16
Protein unc-13 homolog D UNC13D Tbio Non-IDG -1.93790 85.1 158
60S ribosomal protein L3 RPL3 Tbio Non-IDG -2.02901 103.9 190