Development Level

Tbio 1 | 11,651
Tchem 1 | 1,388

Disease

Autosomal recessive predisposition 2 | 1,442
Carcinoma 2 | 11,493
Cognitive delay 2 | 608
Epilepsy 2 | 792
Global developmental delay 2 | 608
Mental and motor retardation 2 | 608
Seizures 2 | 596
Acidosis, Lactic 1 | 97
Acquired immunodeficiency syndrome 1 | 197
Arteritis 1 | 3
Biotin deficiency 1 | 10
Biotinidase deficiency 1 | 14
Blood protein disease 1 | 11
Burkitt Lymphoma 1 | 20
Clonus 1 | 18
Congenital neurologic anomalies 1 | 20
Congenital thrombotic disease, due to Protein C deficiency 1 | 1
Cutaneous porphyria 1 | 6
Deep Vein Thrombosis 1 | 8
Disorder of eye 1 | 27
Disseminated intravascular coagulation 1 | 38
Dull intelligence 1 | 645
Eye Abnormalities 1 | 35
Hepatomegaly 1 | 285
Hereditary thrombophilia due to congenital protein C deficiency 1 | 1
Highly variable severity 1 | 157
Holocarboxylase synthetase deficiency 1 | 6
Hyper-beta-alaninemia 1 | 9
Hyperlysinemia 1 | 6
Hypertension 1 | 396
Hypertensive disease 1 | 292
Hypoglycemia 1 | 152
Increased blood alanine 1 | 9
Increased serum alanine 1 | 9
Increased serum lactate 1 | 60
Increased serum pyruvate 1 | 9
Intellectual disability 1 | 1,016
Kidney cancer 1 | 2,613
Lactic acidemia 1 | 95
Lactic acidosis 1 | 51
Leukomalacia, Periventricular 1 | 1
Liver Cirrhosis, Experimental 1 | 769
Low intelligence 1 | 645
Marantic endocarditis 1 | 2
Mental Retardation 1 | 645
Mental deficiency 1 | 645
Muscle hypotonia 1 | 571
Neuronal loss in the cerebral cortex 1 | 1
Poor school performance 1 | 645
Prenatal onset 1 | 139
Primary cutaneous amyloidosis 1 | 29
Protein C deficiency 1 | 19
Pulmonary embolism 1 | 55
Purpura 1 | 43
Purpura fulminans 1 | 9
Pyruvate carboxylase deficiency 1 | 1
Pyruvate carboxylase deficiency disease 1 | 1
Pyruvate decarboxylase deficiency 1 | 16
Radial neuropathy 1 | 3
Renal Tubular Acidosis, Type II 1 | 4
Renal tubular acidosis 1 | 24
Sepsis 1 | 24
Superficial thrombophlebitis 1 | 2
Susceptibility to viral and mycobacterial infections 1 | 11
THROMBOPHILIA DUE TO PROTEIN C DEFICIENCY, AUTOSOMAL RECESSIVE 1 | 1
Thin skin 1 | 47
Thromboembolism 1 | 15
Thrombophilia 1 | 38
Thrombophilia, Hereditary, Due To Protein C Deficiency, Autosomal Dominant 1 | 1
Thrombophilia, hereditary, due to protein C deficiency, autosomal recessive 1 | 1
Thrombosis 1 | 46
Thrombosis of cerebral veins 1 | 6
Variable expressivity 1 | 157
Vascular disease 1 | 319
Venous Thromboembolism 1 | 8
Venous Thrombosis 1 | 47
Vitreous Hemorrhage 1 | 6
Warfarin-induced skin necrosis 1 | 2
adrenocortical carcinoma 1 | 1,428
adult high grade glioma 1 | 3,801
atypical teratoid / rhabdoid tumor 1 | 5,112
breast carcinoma 1 | 1,638
chronic kidney disease 1 | 90
ductal carcinoma in situ 1 | 1,745
group 3 medulloblastoma 1 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 1 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 1 | 2,989
invasive ductal carcinoma 1 | 2,951
lung adenocarcinoma 1 | 2,716
lung carcinoma 1 | 2,843
medulloblastoma, large-cell 1 | 6,241
non-small cell lung cancer 1 | 2,890
ovarian cancer 1 | 8,520
pancreatic ductal adenocarcinoma liver metastasis 1 | 1,962
primary Sjogren syndrome 1 | 735
primitive neuroectodermal tumor 1 | 3,035
psoriasis 1 | 6,694

Tissue

Blood and immune system 2 | 16,909
Digestive Tract 2 | 17,369
Endocrine System 2 | 18,159
Female tissues 2 | 17,400
Liver and Pancreas 2 | 16,750
Male tissues 2 | 17,142
Nervous System 2 | 16,725
Respiratory system 2 | 16,393
Skin and soft tissues 2 | 17,230
Urinary Tract 2 | 16,678
Cardiovascular System 1 | 15,192

Target Family

Enzyme 2 | 4,145

OMIM Phenotype

Thrombophilia due to protein C... 2 | 2
Abacavir hypersensitivity, sus... 35 | 35
Phenotype: {Spondyloarthropath... 35 | 35
Stevens-Johnson syndrome, susc... 35 | 35
Synovitis, chronic, susceptibi... 35 | 35
Toxic epidermal necrolysis, su... 35 | 35
Phenotype: {Hypersensitivity s... 21 | 21
HIV-1 viremia, susceptibility ... 14 | 14
Phenotype: {Psoriasis suscepti... 14 | 14
Multiple sclerosis, susceptibi... 13 | 13
Phenotype: {Sarcoidosis, susce... 13 | 13
Colorectal cancer, somatic 8 | 8
Gastric cancer, somatic 6 | 6
Diabetes mellitus, noninsulin-... 5 | 5
Pheochromocytoma 5 | 5
ACTH-independent macronodular ... 4 | 4
Alzheimer disease, susceptibil... 4 | 4
Malaria, resistance to 4 | 4
McCune-Albright syndrome, soma... 4 | 4
Mycobacterium tuberculosis, su... 4 | 4
Osseous heteroplasia, progress... 4 | 4
Phenotype: Colorectal cancer, ... 4 | 4
Phenotype: Pseudohypoparathyro... 4 | 4
Phenotype: [Blood group 4 | 4
Phenotype: {Myocardial infarct... 4 | 4
Phenotype: {Schizophrenia, sus... 4 | 4
Pituitary adenoma 3, multiple ... 4 | 4
Pseudohypoparathyroidism Ib 4 | 4
Pseudohypoparathyroidism Ic 4 | 4
Pseudopseudohypoparathyroidism 4 | 4
Renal tubular dysgenesis 4 | 4
Tetralogy of Fallot 4 | 4
Afibrinogenemia, congenital 3 | 3
Aplastic anemia 3 | 3
Bladder cancer, somatic 3 | 3
COACH syndrome 3 | 3
Central hypoventilation syndro... 3 | 3
Dejerine-Sottas disease 3 | 3
Diabetes mellitus, permanent n... 3 | 3
LADD syndrome 3 | 3
Leukemia, acute myeloid 3 | 3
Lung cancer, susceptibility to 3 | 3
Mismatch repair cancer syndrom... 3 | 3
Multiple pterygium syndrome, l... 3 | 3
Myocardial infarction, suscept... 3 | 3
Neuropathy, distal hereditary ... 3 | 3
Omenn syndrome 3 | 3
Paraganglioma and gastric stro... 3 | 3
Parkinson disease, susceptibil... 3 | 3
Phenotype: Anterior segment dy... 3 | 3
Phenotype: Bethlem myopathy 1 3 | 3
Phenotype: Dysfibrinogenemia, ... 3 | 3
Phenotype: Epilepsy, progressi... 3 | 3
Phenotype: Leigh syndrome due ... 3 | 3
Phenotype: Orthostatic intoler... 3 | 3
Phenotype: {Breast cancer, sus... 3 | 3
Prostate cancer, susceptibilit... 3 | 3
Retinitis punctata albescens 3 | 3
Roussy-Levy syndrome 3 | 3
Schimmelpenning-Feuerstein-Mim... 3 | 3
Schizencephaly 3 | 3
Ullrich congenital muscular dy... 3 | 3
Arthrogryposis, distal, type 2... 2 | 2
Asthma, susceptibility to 2 | 2
Brachydactyly, type A2 2 | 2
Cerebrooculofacioskeletal synd... 2 | 2
De Sanctis-Cacchione syndrome 2 | 2
Epidermolysis bullosa simplex,... 2 | 2
Epidermolysis bullosa simplex,... 2 | 2
Epidermolysis bullosa simplex,... 2 | 2
Hypercholesterolemia, familial... 2 | 2
Hypofibrinogenemia, congenital 2 | 2
Ichthyosis, cyclic, with epide... 2 | 2
Jackson-Weiss syndrome 2 | 2
Leukemia, acute lymphoblastic,... 2 | 2
Leukemia, acute myeloid, somat... 2 | 2
Macular degeneration, age-rela... 2 | 2
Melanoma, cutaneous malignant,... 2 | 2
Microvascular complications of... 2 | 2
Ovarian cancer, somatic 2 | 2
Phenotype: Cockayne syndrome, ... 2 | 2
Phenotype: Epidermodysplasia v... 2 | 2
Phenotype: Epidermolysis bullo... 2 | 2
Phenotype: Epidermolytic hyper... 2 | 2
Phenotype: Hemochromatosis 2 | 2
Phenotype: Lacticacidemia due ... 2 | 2
Phenotype: Meesmann corneal dy... 2 | 2
Phenotype: Obesity, severe 2 | 2
Phenotype: Paroxysmal nonkines... 2 | 2
Phenotype: T-cell immunodefici... 2 | 2
Phenotype: Vitreoretinopathy, ... 2 | 2
Phenotype: {Alcohol dependence... 2 | 2
Phenotype: {Diabetes mellitus,... 2 | 2
Phenotype: {Nephrolithiasis, u... 2 | 2
Pick disease 2 | 2
Porphyria cutanea tarda, susce... 2 | 2
Porphyria variegata, susceptib... 2 | 2
Premature ovarian failure 11 2 | 2
Restrictive dermopathy, lethal 2 | 2
UV-sensitive syndrome 1 2 | 2

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Pyruvate carboxylase, mitochondrial PC Tbio Enzyme -2.57922 361.7 238
Vitamin K-dependent protein C PROC Tchem Enzyme -2.31320 183.3 417