Development Level

Tchem 2 | 1,598

IMPC Phenotype

decreased mean corpuscular vol... 1 | 79
decreased vertical activity 1 | 208

Disease

Autosomal recessive predisposition 2 | 1,442
Bronchioloalveolar Adenocarcinoma 2 | 14
Cancer 2 | 2,499
Carcinoma 2 | 11,493
Lung Neoplasms 2 | 232
Rheumatoid arthritis 2 | 1,191
lung cancer 2 | 4,740
ovarian cancer 2 | 8,520
psoriasis 2 | 6,694
APLASIA CUTIS CONGENITA WITH EPIBULBAR DERMOIDS 1 | 1
Abnormal dermatoglyphic pattern 1 | 24
Abnormal hair quantity 1 | 16
Abnormal platelet function 1 | 12
Abnormality of dental color 1 | 5
Abnormality of head shape 1 | 5
Abnormality of the spleen 1 | 13
Abnormality of the ulna 1 | 10
Absent eyebrow 1 | 13
Adenocarcinoma in situ 1 | 15
Agenesis of eyebrows 1 | 13
Aplasia of eyebrows 1 | 13
Aplasia/Hypoplasia of the abdominal wall musculature 1 | 17
Asymmetry of head 1 | 5
Asymmetry of the posterior cranium 1 | 20
Atrial septal aneurysm 1 | 2
Autoimmune lymphoproliferative syndrome 1 | 11
Brittle hair 1 | 25
CARDIOFACIOCUTANEOUS SYNDROME 2 1 | 1
Cafe au lait spots, multiple 1 | 17
Carcinogenesis 1 | 8
Cardio-facio-cutaneous syndrome 1 | 6
Cardiofaciocutaneous syndrome 1 | 15
Cardiofaciocutaneous syndrome 1 1 | 4
Cecal Neoplasms 1 | 4
Congenital pectus carinatum 1 | 52
Connective tissue cancer 1 | 10
Costello Syndrome 1 | 17
Costello syndrome (disorder) 1 | 6
Cranial asymmetry 1 | 5
Curly hair (finding) 1 | 14
Deep palmar crease 1 | 8
Dystrophic fingernails 1 | 18
Enlarged thorax 1 | 18
Exanthem 1 | 37
Excess nuchal skin 1 | 30
Excessive wrinkled skin 1 | 16
Facial asymmetry 1 | 32
Fibrous skin tumor of tuberous sclerosis 1 | 18
Finger abnormalities 1 | 3
Flattening of cranial vault 1 | 20
Flattening of head 1 | 20
Follicular thyroid carcinoma 1 | 14
Fractured hair 1 | 25
Fragile hair 1 | 25
Gallbladder Neoplasms 1 | 10
Gastric Cancer, Hereditary Diffuse 1 | 12
Gastritis, Atrophic 1 | 4
Gastrointestinal Hemorrhage 1 | 52
Generalized hyperpigmentation 1 | 22
Genu recurvatum 1 | 12
Hemimegalencephaly 1 | 5
Hepatitis 1 | 67
Hereditary Nonpolyposis Colorectal Cancer 1 | 11
Hypophosphatemic Rickets 1 | 11
Irritation - emotion 1 | 68
Leukocytosis 1 | 17
Long palpebral fissure 1 | 17
Lung adenoma 1 | 8
Madarosis of eyebrow 1 | 13
Malformation of cranial vault shape 1 | 5
Malformation of cranium shape 1 | 5
Malformation of head shape 1 | 5
Malignant skin fibrous histiocytoma 1 | 2
Multiple lentigines 1 | 10
NOONAN SYNDROME 3 1 | 1
Neoplasm of stomach 1 | 11
Neoplasms 1 | 63
Neoplasms, Experimental 1 | 40
Nevus sebaceous 1 | 3
Noonan syndrome 1 | 34
Partial to total absence of eyelashes 1 | 7
Plagiocephaly 1 | 20
Plagiocephaly, Nonsynostotic 1 | 20
Porencephaly 1 | 20
RAS-ASSOCIATED AUTOIMMUNE LEUKOPROLIFERATIVE DISORDER 1 | 2
Rectal Neoplasms 1 | 18
Reduced tensile strength of hair 1 | 25
Rhomboid shaped head 1 | 20
Senile lentigo 1 | 10
Slow-growing hair 1 | 19
Small intestine cancer 1 | 12
Somatic mosaicism 1 | 6
Sparse or absent eyelashes 1 | 7
Sparse to absent eyelashes 1 | 7
Stomach Carcinoma 1 | 11
Thickened helices 1 | 15
Toe abnormalities 1 | 4
Uterine Neoplasms 1 | 9
Wide spaced nipples 1 | 46
pre-malignant neoplasm 1 | 2

Tissue

Blood and immune system 2 | 16,909
Cardiovascular System 2 | 15,192
Digestive Tract 2 | 17,369
Endocrine System 2 | 18,159
Female tissues 2 | 17,400
Liver and Pancreas 2 | 16,750
Male tissues 2 | 17,142
Nervous System 2 | 16,725
Respiratory system 2 | 16,393
Skin and soft tissues 2 | 17,230
Urinary Tract 2 | 16,678

Target Family

Enzyme 1 | 4,145
Kinase 1 | 634

OMIM Phenotype

Phenotype: Lung cancer, somati... 2 | 2
Abacavir hypersensitivity, sus... 35 | 35
Phenotype: {Spondyloarthropath... 35 | 35
Stevens-Johnson syndrome, susc... 35 | 35
Synovitis, chronic, susceptibi... 35 | 35
Toxic epidermal necrolysis, su... 35 | 35
Phenotype: {Hypersensitivity s... 21 | 21
HIV-1 viremia, susceptibility ... 14 | 14
Phenotype: {Psoriasis suscepti... 14 | 14
Multiple sclerosis, susceptibi... 13 | 13
Phenotype: {Sarcoidosis, susce... 13 | 13
Colorectal cancer, somatic 8 | 8
Gastric cancer, somatic 6 | 6
Diabetes mellitus, noninsulin-... 5 | 5
Pheochromocytoma 5 | 5
ACTH-independent macronodular ... 4 | 4
Alzheimer disease, susceptibil... 4 | 4
Malaria, resistance to 4 | 4
McCune-Albright syndrome, soma... 4 | 4
Mycobacterium tuberculosis, su... 4 | 4
Osseous heteroplasia, progress... 4 | 4
Phenotype: Colorectal cancer, ... 4 | 4
Phenotype: Pseudohypoparathyro... 4 | 4
Phenotype: [Blood group 4 | 4
Phenotype: {Myocardial infarct... 4 | 4
Phenotype: {Schizophrenia, sus... 4 | 4
Pituitary adenoma 3, multiple ... 4 | 4
Pseudohypoparathyroidism Ib 4 | 4
Pseudohypoparathyroidism Ic 4 | 4
Pseudopseudohypoparathyroidism 4 | 4
Renal tubular dysgenesis 4 | 4
Tetralogy of Fallot 4 | 4
Afibrinogenemia, congenital 3 | 3
Aplastic anemia 3 | 3
Bladder cancer, somatic 3 | 3
COACH syndrome 3 | 3
Central hypoventilation syndro... 3 | 3
Dejerine-Sottas disease 3 | 3
Diabetes mellitus, permanent n... 3 | 3
LADD syndrome 3 | 3
Leukemia, acute myeloid 3 | 3
Lung cancer, susceptibility to 3 | 3
Mismatch repair cancer syndrom... 3 | 3
Multiple pterygium syndrome, l... 3 | 3
Myocardial infarction, suscept... 3 | 3
Neuropathy, distal hereditary ... 3 | 3
Omenn syndrome 3 | 3
Paraganglioma and gastric stro... 3 | 3
Parkinson disease, susceptibil... 3 | 3
Phenotype: Anterior segment dy... 3 | 3
Phenotype: Bethlem myopathy 1 3 | 3
Phenotype: Dysfibrinogenemia, ... 3 | 3
Phenotype: Epilepsy, progressi... 3 | 3
Phenotype: Leigh syndrome due ... 3 | 3
Phenotype: Orthostatic intoler... 3 | 3
Phenotype: {Breast cancer, sus... 3 | 3
Prostate cancer, susceptibilit... 3 | 3
Retinitis punctata albescens 3 | 3
Roussy-Levy syndrome 3 | 3
Schimmelpenning-Feuerstein-Mim... 3 | 3
Schizencephaly 3 | 3
Ullrich congenital muscular dy... 3 | 3
Arthrogryposis, distal, type 2... 2 | 2
Asthma, susceptibility to 2 | 2
Brachydactyly, type A2 2 | 2
Cerebrooculofacioskeletal synd... 2 | 2
De Sanctis-Cacchione syndrome 2 | 2
Epidermolysis bullosa simplex,... 2 | 2
Epidermolysis bullosa simplex,... 2 | 2
Epidermolysis bullosa simplex,... 2 | 2
Hypercholesterolemia, familial... 2 | 2
Hypofibrinogenemia, congenital 2 | 2
Ichthyosis, cyclic, with epide... 2 | 2
Jackson-Weiss syndrome 2 | 2
Leukemia, acute lymphoblastic,... 2 | 2
Leukemia, acute myeloid, somat... 2 | 2
Macular degeneration, age-rela... 2 | 2
Melanoma, cutaneous malignant,... 2 | 2
Microvascular complications of... 2 | 2
Ovarian cancer, somatic 2 | 2
Phenotype: Cockayne syndrome, ... 2 | 2
Phenotype: Epidermodysplasia v... 2 | 2
Phenotype: Epidermolysis bullo... 2 | 2
Phenotype: Epidermolytic hyper... 2 | 2
Phenotype: Hemochromatosis 2 | 2
Phenotype: Lacticacidemia due ... 2 | 2
Phenotype: Meesmann corneal dy... 2 | 2
Phenotype: Obesity, severe 2 | 2
Phenotype: Paroxysmal nonkines... 2 | 2
Phenotype: T-cell immunodefici... 2 | 2
Phenotype: Vitreoretinopathy, ... 2 | 2
Phenotype: {Alcohol dependence... 2 | 2
Phenotype: {Diabetes mellitus,... 2 | 2
Phenotype: {Nephrolithiasis, u... 2 | 2
Pick disease 2 | 2
Porphyria cutanea tarda, susce... 2 | 2
Porphyria variegata, susceptib... 2 | 2
Premature ovarian failure 11 2 | 2
Restrictive dermopathy, lethal 2 | 2
UV-sensitive syndrome 1 2 | 2

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
Mitogen-activated protein kinase kinase kinase 8 MAP3K8 Tchem Kinase -2.09230 154.3 433