Development Level

Tbio 1 | 11,651

Disease

Almond-shaped eyes 1 | 23
Arsenic Poisoning 1 | 62
Arteriosclerosis 1 | 11
Arthralgia 1 | 90
Ascites 1 | 22
Atrophic condition of skin 1 | 25
Basal cell carcinoma 1 | 54
Basal cell nevi 1 | 23
Biliary atresia 1 | 12
Bladder Neoplasm 1 | 112
Bone marrow hypocellularity 1 | 20
Cachexia 1 | 50
Chromosome Breakage 1 | 36
Cockayne Syndrome, Type I 1 | 3
Conduct disorder 1 | 33
Congenital deafness 1 | 185
Conjunctival telangiectasis 1 | 14
Deafness 1 | 198
Decreased platelet count 1 | 111
Defective DNA repair after ultraviolet radiation damage 1 | 7
Defective enamel matrix 1 | 35
Dental Enamel Hypoplasia 1 | 43
Dental abnormalities 1 | 60
Dry skin 1 | 75
Dwarfism 1 | 37
Dysplasia of tooth enamel 1 | 35
Elevated hepatic transaminases 1 | 81
Enophthalmos 1 | 75
Erythema 1 | 58
Esophageal atresia 1 | 43
Esophageal atresia with or without tracheoesophageal fistula 1 | 21
FANCONI ANEMIA, COMPLEMENTATION GROUP Q 1 | 1
Fanconi anemia 1 | 56
Fatigue 1 | 182
Fever 1 | 138
Flushing 1 | 60
Freckles 1 | 33
Genetic Predisposition to Disease 1 | 27
Hardened artery wall 1 | 6
Hearing Loss, Partial 1 | 185
High pitched voice 1 | 23
Highly variable phenotype and severity 1 | 150
Highly variable phenotype, even within families 1 | 150
Hyperkeratosis 1 | 50
Hyperpigmented macules 1 | 42
Impaired cognition 1 | 96
Increased chromosomal breakage 1 | 27
Infantile onset 1 | 238
Irregular hyperpigmentation 1 | 33
Keratitis 1 | 62
Lack of subcutaneous fatty tissue 1 | 2
Leukopenia 1 | 72
Low Vision 1 | 174
Mental impairment 1 | 95
Micronuclei, Chromosome-Defective 1 | 25
Mild Mental Retardation 1 | 70
Neoplasm Metastasis 1 | 168
Neoplasms, Germ Cell and Embryonal 1 | 15
Numerous pigmented freckles 1 | 4
Papilloma 1 | 44
Papule 1 | 43
Peripheral Nervous System Diseases 1 | 52
Peripheral Neuropathy 1 | 134
Peripheral demyelinating neuropathy 1 | 7
Photosensitivity of skin 1 | 51
Poikiloderma 1 | 14
Poor coordination 1 | 11
Precociously senile appearance 1 | 18
Progressive mental retardation 1 | 37
Pyridoxine-responsive sideroblastic anemia 1 | 17
Radial aplasia/hypoplasia 1 | 29
Retinal Diseases 1 | 55
Sensorineural Hearing Loss (disorder) 1 | 284
Short palpebral fissure 1 | 38
Squamous cell carcinoma of skin 1 | 11
Subclinical abnormal liver function tests 1 | 81
Sunken eyes 1 | 63
Telangiectasia of the skin 1 | 39
Testicular Neoplasms 1 | 6
Thin dental enamel 1 | 35
Thin skin 1 | 47
Thrombocytopenia 1 | 197
Thumb aplasia 1 | 16
Tooth Abnormalities 1 | 69
Tracheoesophageal Fistula 1 | 36
Urinary Bladder Neoplasms 1 | 114
Visual Impairment 1 | 174
XFE progeroid syndrome 1 | 3
Xeroderma Pigmentosum, Complementation Group F 1 | 1
Xeroderma pigmentosum 1 | 43
Xeroderma pigmentosum group B 1 | 20
Xeroderma pigmentosum group D 1 | 33
Xeroderma pigmentosum group F 1 | 22
Xeroderma pigmentosum group G 1 | 16
Xeroderma pigmentosum, group F 1 | 1
Xeroderma pigmentosum-Cockayne syndrome complex 1 | 4
Xerosis 1 | 75
esophageal atresia/tracheoesophageal fistula 1 | 22
hearing impairment 1 | 199
hypopigmented skin patch 1 | 59

Tissue

Blood and immune system 1 | 16,909
Cardiovascular System 1 | 15,192
Digestive Tract 1 | 17,369
Endocrine System 1 | 18,159
Female tissues 1 | 17,400
Liver and Pancreas 1 | 16,750
Male tissues 1 | 17,142
Nervous System 1 | 16,725
Respiratory system 1 | 16,393
Skin and soft tissues 1 | 17,230
Urinary Tract 1 | 16,678

Target Family

Enzyme 1 | 4,145

OMIM Phenotype

?XFE progeroid syndrome 1 | 1
Abacavir hypersensitivity, sus... 35 | 35
Phenotype: {Spondyloarthropath... 35 | 35
Stevens-Johnson syndrome, susc... 35 | 35
Synovitis, chronic, susceptibi... 35 | 35
Toxic epidermal necrolysis, su... 35 | 35
Phenotype: {Hypersensitivity s... 21 | 21
HIV-1 viremia, susceptibility ... 14 | 14
Phenotype: {Psoriasis suscepti... 14 | 14
Multiple sclerosis, susceptibi... 13 | 13
Phenotype: {Sarcoidosis, susce... 13 | 13
Colorectal cancer, somatic 8 | 8
Gastric cancer, somatic 6 | 6
Diabetes mellitus, noninsulin-... 5 | 5
Pheochromocytoma 5 | 5
ACTH-independent macronodular ... 4 | 4
Alzheimer disease, susceptibil... 4 | 4
Malaria, resistance to 4 | 4
McCune-Albright syndrome, soma... 4 | 4
Mycobacterium tuberculosis, su... 4 | 4
Osseous heteroplasia, progress... 4 | 4
Phenotype: Colorectal cancer, ... 4 | 4
Phenotype: Pseudohypoparathyro... 4 | 4
Phenotype: [Blood group 4 | 4
Phenotype: {Myocardial infarct... 4 | 4
Phenotype: {Schizophrenia, sus... 4 | 4
Pituitary adenoma 3, multiple ... 4 | 4
Pseudohypoparathyroidism Ib 4 | 4
Pseudohypoparathyroidism Ic 4 | 4
Pseudopseudohypoparathyroidism 4 | 4
Renal tubular dysgenesis 4 | 4
Tetralogy of Fallot 4 | 4
Afibrinogenemia, congenital 3 | 3
Aplastic anemia 3 | 3
Bladder cancer, somatic 3 | 3
COACH syndrome 3 | 3
Central hypoventilation syndro... 3 | 3
Dejerine-Sottas disease 3 | 3
Diabetes mellitus, permanent n... 3 | 3
LADD syndrome 3 | 3
Leukemia, acute myeloid 3 | 3
Lung cancer, susceptibility to 3 | 3
Mismatch repair cancer syndrom... 3 | 3
Multiple pterygium syndrome, l... 3 | 3
Myocardial infarction, suscept... 3 | 3
Neuropathy, distal hereditary ... 3 | 3
Omenn syndrome 3 | 3
Paraganglioma and gastric stro... 3 | 3
Parkinson disease, susceptibil... 3 | 3
Phenotype: Anterior segment dy... 3 | 3
Phenotype: Bethlem myopathy 1 3 | 3
Phenotype: Dysfibrinogenemia, ... 3 | 3
Phenotype: Epilepsy, progressi... 3 | 3
Phenotype: Leigh syndrome due ... 3 | 3
Phenotype: Orthostatic intoler... 3 | 3
Phenotype: {Breast cancer, sus... 3 | 3
Prostate cancer, susceptibilit... 3 | 3
Retinitis punctata albescens 3 | 3
Roussy-Levy syndrome 3 | 3
Schimmelpenning-Feuerstein-Mim... 3 | 3
Schizencephaly 3 | 3
Ullrich congenital muscular dy... 3 | 3
Arthrogryposis, distal, type 2... 2 | 2
Asthma, susceptibility to 2 | 2
Brachydactyly, type A2 2 | 2
Cerebrooculofacioskeletal synd... 2 | 2
De Sanctis-Cacchione syndrome 2 | 2
Epidermolysis bullosa simplex,... 2 | 2
Epidermolysis bullosa simplex,... 2 | 2
Epidermolysis bullosa simplex,... 2 | 2
Hypercholesterolemia, familial... 2 | 2
Hypofibrinogenemia, congenital 2 | 2
Ichthyosis, cyclic, with epide... 2 | 2
Jackson-Weiss syndrome 2 | 2
Leukemia, acute lymphoblastic,... 2 | 2
Leukemia, acute myeloid, somat... 2 | 2
Macular degeneration, age-rela... 2 | 2
Melanoma, cutaneous malignant,... 2 | 2
Microvascular complications of... 2 | 2
Ovarian cancer, somatic 2 | 2
Phenotype: Cockayne syndrome, ... 2 | 2
Phenotype: Epidermodysplasia v... 2 | 2
Phenotype: Epidermolysis bullo... 2 | 2
Phenotype: Epidermolytic hyper... 2 | 2
Phenotype: Hemochromatosis 2 | 2
Phenotype: Lacticacidemia due ... 2 | 2
Phenotype: Meesmann corneal dy... 2 | 2
Phenotype: Obesity, severe 2 | 2
Phenotype: Paroxysmal nonkines... 2 | 2
Phenotype: T-cell immunodefici... 2 | 2
Phenotype: Vitreoretinopathy, ... 2 | 2
Phenotype: {Alcohol dependence... 2 | 2
Phenotype: {Diabetes mellitus,... 2 | 2
Phenotype: {Nephrolithiasis, u... 2 | 2
Pick disease 2 | 2
Porphyria cutanea tarda, susce... 2 | 2
Porphyria variegata, susceptib... 2 | 2
Premature ovarian failure 11 2 | 2
Restrictive dermopathy, lethal 2 | 2
UV-sensitive syndrome 1 2 | 2
[Transferrin serum level QTL2] 2 | 2

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA repair endonuclease XPF ERCC4 Tbio Enzyme -1.91482 69.2 286