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Target Filters...

Development Level

Tbio 1,396 | 10,625
Tchem 364 | 1,890
Tdark 161 | 7,003
Tclin 137 | 602

Collection

Eligible Kinase Proteins 13 | 134
Eligible Ion Channel Proteins 10 | 117
Eligible non-olfactory GPCR Proteins 7 | 145

IMPC Term

preweaning lethality, complete... 171 | 633
decreased bone mineral content 136 | 157
decreased lean body mass 126 | 195
abnormal bone structure 111 | 131
decreased bone mineral density 105 | 126
decreased total body fat amoun... 93 | 186
decreased body weight 88 | 174
abnormal behavior 80 | 226
decreased body length 70 | 108
preweaning lethality, incomple... 70 | 260
increased bone mineral content 68 | 92
short tibia 66 | 82
increased circulating alkaline... 61 | 119
decreased lumbar vertebrae num... 58 | 62
increased sacral vertebrae num... 58 | 62
decreased rib number 56 | 59
decreased grip strength 53 | 123
increased lean body mass 52 | 107
embryonic lethality prior to t... 50 | 187
abnormal bone mineralization 48 | 55
increased bone mineral density 46 | 52
decreased circulating choleste... 45 | 85
decreased circulating glucose ... 43 | 121
increased or absent threshold ... 43 | 128
decreased circulating serum al... 40 | 79
decreased caudal vertebrae num... 39 | 49
increased rib number 39 | 41
decreased circulating triglyce... 36 | 83
decreased circulating HDL chol... 35 | 77
hypoactivity 35 | 89
abnormal retina morphology 34 | 100
hyperactivity 33 | 108
increased grip strength 33 | 83
increased mean corpuscular vol... 31 | 91
abnormal embryo size 29 | 112
embryonic lethality prior to o... 29 | 148
enlarged heart 29 | 111
abnormal cranium morphology 28 | 32
increased mean corpuscular hem... 28 | 93
increased total body fat amoun... 28 | 57
abnormal gait 26 | 51
abnormal rib morphology 26 | 28
decreased circulating insulin ... 26 | 75
decreased heart weight 26 | 44
decreased hemoglobin content 26 | 53
abnormal tooth morphology 23 | 24
decreased circulating total pr... 23 | 41
decreased circulating LDL chol... 22 | 37
decreased erythrocyte cell num... 22 | 43
increased blood urea nitrogen ... 22 | 44
decreased circulating alanine ... 21 | 53
decreased prepulse inhibition 21 | 52
increased circulating HDL chol... 21 | 63
increased circulating choleste... 21 | 53
abnormal retinal pigmentation 19 | 61
decreased T cell number 19 | 31
decreased leukocyte cell numbe... 19 | 54
impaired glucose tolerance 19 | 52
increased circulating chloride... 19 | 43
increased hemoglobin content 19 | 45
thrombocytopenia 19 | 46
vertebral fusion 19 | 23
abnormal cornea morphology 18 | 24
abnormal lens morphology 18 | 73
decreased circulating alkaline... 18 | 41
increased heart weight 18 | 37
abnormal coat/hair pigmentatio... 17 | 54
decreased mean corpuscular vol... 17 | 50
prenatal lethality prior to he... 17 | 64
abnormal eye morphology 16 | 38
abnormal maxilla morphology 16 | 16
abnormal sleep behavior 16 | 63
abnormal snout morphology 16 | 18
increased circulating sodium l... 16 | 71
cataract 15 | 26
decreased CD8-positive, alpha-... 15 | 26
decreased mean corpuscular hem... 15 | 34
improved glucose tolerance 15 | 56
increased body weight 15 | 42
increased circulating iron lev... 15 | 25
increased monocyte cell number 15 | 27
limb grasping 15 | 35
male infertility 15 | 62
abnormal locomotor activation 14 | 26
corneal opacity 14 | 25
decreased circulating aspartat... 14 | 27
decreased circulating fructosa... 14 | 31
decreased circulating iron lev... 14 | 25
increased circulating creatini... 14 | 29
increased fasted circulating g... 14 | 68
abnormal femur morphology 13 | 14
abnormal heart morphology 13 | 51
abnormal joint morphology 13 | 14
abnormal thoracic vertebrae mo... 13 | 16
decreased circulating calcium ... 13 | 33
decreased fasted circulating g... 13 | 49
decreased hematocrit 13 | 25
decreased startle reflex 13 | 48
increased circulating calcium ... 13 | 32
tremors 13 | 34

Disease

ovarian cancer 1,136 | 8,492
osteosarcoma 1,027 | 7,933
psoriasis 907 | 6,685
medulloblastoma, large-cell 835 | 6,234
glioblastoma 797 | 5,572
lung cancer 695 | 4,473
atypical teratoid / rhabdoid tumor 613 | 4,369
Cancer 600 | 2,346
malignant mesothelioma 514 | 3,163
Breast cancer 513 | 3,099
pilocytic astrocytoma 498 | 3,086
invasive ductal carcinoma 489 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 470 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 470 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 457 | 2,988
non-small cell lung cancer 437 | 2,798
lung carcinoma 433 | 2,844
primitive neuroectodermal tumor 425 | 3,031
pancreatic cancer 423 | 2,300
oligodendroglioma 413 | 2,849
pediatric high grade glioma 397 | 2,712
lung adenocarcinoma 393 | 2,714
Carcinoma 390 | 2,147
ulcerative colitis 373 | 2,087
interstitial cystitis 366 | 2,299
ependymoma 337 | 2,514
pituitary cancer 332 | 1,972
subependymal giant cell astrocytoma 317 | 2,287
group 4 medulloblastoma 313 | 1,875
astrocytic glioma 292 | 2,241
ductal carcinoma in situ 290 | 1,745
cystic fibrosis 288 | 1,670
adult high grade glioma 279 | 2,148
breast carcinoma 277 | 1,614
astrocytoma 270 | 1,493
diabetes mellitus 266 | 1,663
group 3 medulloblastoma 263 | 2,254
posterior fossa group A ependymoma 263 | 1,511
Pick disease 259 | 1,893
colon cancer 258 | 1,475
primary pancreatic ductal adenocarcinoma 257 | 1,271
tuberculosis 251 | 1,563
adrenocortical carcinoma 250 | 1,427
pancreatic ductal adenocarcinoma liver metastasis 227 | 1,795
sonic hedgehog group medulloblastoma 224 | 1,482
Rheumatoid Arthritis 215 | 1,171
juvenile dermatomyositis 202 | 1,189
medulloblastoma 201 | 1,524
acute quadriplegic myopathy 197 | 1,157
posterior fossa group B ependymoma 196 | 1,530
cutaneous lupus erythematosus 170 | 1,056
gastric carcinoma 165 | 832
spina bifida 164 | 1,064
Obesity 160 | 616
atypical teratoid/rhabdoid tumor 157 | 1,095
nasopharyngeal carcinoma 157 | 1,056
Atopic dermatitis 150 | 944
dermatomyositis 150 | 967
Multiple myeloma 147 | 1,328
Duchenne muscular dystrophy 142 | 602
autosomal dominant Emery-Dreifuss muscular dystrophy 135 | 499
Mammary Neoplasms 133 | 410
esophageal adenocarcinoma 133 | 737
Alzheimer's disease 129 | 644
Kidney disease 127 | 397
Prostatic Neoplasms 127 | 471
Down syndrome 125 | 548
Intellectual disability 123 | 573
active Crohn's disease 123 | 918
Endometriosis 113 | 535
primary Sjogren syndrome 112 | 789
acute myeloid leukemia 111 | 785
non primary Sjogren syndrome sicca 109 | 840
Osteoporosis 105 | 259
aldosterone-producing adenoma 103 | 664
pancreatic carcinoma 102 | 567
Craniofacial Abnormalities 100 | 147
Amyotrophic Lateral Sclerosis 98 | 432
Multiple Sclerosis 98 | 498
Arthritis 95 | 248
fibroadenoma 95 | 557
Waldenstrons macroglobulinemia 94 | 765
Parkinson's disease 91 | 364
Neurodegenerative disease 87 | 383
progressive supranuclear palsy 87 | 674
hepatocellular carcinoma 86 | 550
Asthma 85 | 349
Atherosclerosis 84 | 275
mucosa-associated lymphoid tissue lymphoma 83 | 480
IGA Glomerulonephritis 81 | 454
Schizophrenia 81 | 503
Hypertension 80 | 293
active ulcerative colitis 80 | 477
chronic rhinosinusitis 78 | 512
Cleft palate 77 | 125
Vascular disease 76 | 281
Heart disease 74 | 279
Stomach Neoplasms 74 | 282
tuberculosis and treatment for 6 months 73 | 686
Autistic Disorder 72 | 320

Tissue

Nervous System 2,043 | 18,561
Digestive Tract 2,039 | 18,473
Endocrine System 2,038 | 18,512
Female tissues 2,038 | 18,647
Urinary Tract 2,029 | 18,444
Skin and soft tissues 2,015 | 18,115
Liver and Pancreas 2,014 | 18,136
Male tissues 2,006 | 17,969
Cardiovascular System 2,004 | 17,958
Blood and immune system 2,003 | 17,995
Respiratory system 1,976 | 17,484

Target Family

Non-IDG 984 | 11,969
Enzyme 411 | 4,146
Transcription Factor 298 | 1,400
Kinase 123 | 634
Epigenetic 64 | 242
GPCR 64 | 408
Transporter 52 | 473
Ion Channel 35 | 341
Nuclear Receptor 19 | 48
TF/Epigenetic 8 | 38

MGI Term

skeleton phenotype 2,058 | 2,058
mortality/aging 4,850 | 4,850
homeostasis/metabolism phenoty... 4,454 | 4,454
growth/size/body region phenot... 3,915 | 3,915
cellular phenotype 3,348 | 3,348
nervous system phenotype 3,201 | 3,201
behavior/neurological phenotyp... 3,192 | 3,192
immune system phenotype 3,148 | 3,148
hematopoietic system phenotype 3,145 | 3,145
cardiovascular system phenotyp... 2,448 | 2,448
endocrine/exocrine gland pheno... 2,084 | 2,084
normal phenotype 1,916 | 1,916
reproductive system phenotype 1,873 | 1,873
integument phenotype 1,748 | 1,748
embryo phenotype 1,674 | 1,674
vision/eye phenotype 1,478 | 1,478
muscle phenotype 1,385 | 1,385
digestive/alimentary phenotype 1,292 | 1,292
respiratory system phenotype 1,291 | 1,291
liver/biliary system phenotype 1,160 | 1,160
renal/urinary system phenotype 1,157 | 1,157
craniofacial phenotype 1,077 | 1,077
limbs/digits/tail phenotype 1,011 | 1,011
neoplasm 918 | 918
adipose tissue phenotype 901 | 901
hearing/vestibular/ear phenoty... 692 | 692
pigmentation phenotype 459 | 459
taste/olfaction phenotype 142 | 142
obsolete other phenotype 69 | 69

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
Metal-response element-binding transcription factor 2 MTF2 Tbio Epigenetic -1.74028 52.0 101
Equilibrative nucleoside transporter 1 SLC29A1 Tclin Transporter -2.59024 397.3 363
Homeobox protein Nkx-3.1 NKX3-1 Tbio Transcription Factor -2.10264 130.3 456
Homeobox protein Hox-D10 HOXD10 Tbio Transcription Factor -1.76497 45.4 166
5'-AMP-activated protein kinase subunit beta-1 PRKAB1 Tbio Kinase -1.47950 28.8 495
NACHT, LRR and PYD domains-containing protein 3 NLRP3 Tchem Non-IDG -3.22772 1655.7 459
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 PLOD1 Tbio Enzyme -2.08075 121.5 75
Fermitin family homolog 3 FERMT3 Tbio Non-IDG -1.81454 71.6 125
Lateral signaling target protein 2 homolog ZFYVE28 Tbio Non-IDG 0.38 0.33 63