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Development Level

Tbio 1,624 | 11,651
Tchem 293 | 1,388
Tdark 165 | 6,593
Tclin 140 | 612

Collection

RFA-RM-18-021 27 | 328
Kinase: IDG Consortium (Target... 11 | 125
Ion Channel: IDG Consortium (T... 9 | 99
GPCR: IDG Consortium (Targets) 8 | 126
GPCR: IDG Consortium (Complete... 3 | 25
Kinase: IDG Consortium (Comple... 3 | 37

IMPC Phenotype

preweaning lethality, complete... 238 | 979
preweaning lethality, incomple... 151 | 499
abnormal bone structure 137 | 187
decreased bone mineral content 118 | 151
decreased total body fat amoun... 106 | 207
abnormal behavior 99 | 298
increased lean body mass 91 | 172
decreased body weight 87 | 161
decreased bone mineral density 85 | 126
decreased lean body mass 85 | 135
increased total body fat amoun... 81 | 134
increased circulating alkaline... 69 | 122
decreased body length 66 | 101
increased bone mineral content 64 | 108
short tibia 64 | 97
embryonic lethality prior to t... 59 | 278
abnormal embryo size 57 | 220
decreased circulating choleste... 48 | 93
decreased circulating glucose ... 47 | 126
enlarged heart 46 | 210
decreased vertical activity 44 | 208
embryonic lethality prior to o... 44 | 239
increased bone mineral density 44 | 72
hyperactivity 43 | 148
decreased circulating serum al... 40 | 82
hypoactivity 40 | 132
increased startle reflex 38 | 112
decreased caudal vertebrae num... 36 | 53
decreased grip strength 36 | 116
abnormal cranium morphology 35 | 36
decreased circulating HDL chol... 35 | 68
decreased circulating triglyce... 34 | 79
abnormal heart morphology 33 | 162
increased mean corpuscular hem... 33 | 96
male infertility 33 | 123
abnormal bone mineralization 32 | 38
abnormal gait 30 | 69
decreased circulating insulin ... 30 | 76
decreased hemoglobin content 30 | 68
increased heart weight 30 | 62
decreased prepulse inhibition 29 | 82
abnormal seminal vesicle morph... 28 | 114
decreased circulating total pr... 28 | 49
impaired glucose tolerance 28 | 75
increased circulating HDL chol... 28 | 80
increased circulating choleste... 27 | 66
increased mean corpuscular vol... 27 | 92
increased or absent threshold ... 27 | 101
decreased erythrocyte cell num... 26 | 62
thrombocytopenia 26 | 56
decreased circulating alkaline... 24 | 46
decreased leukocyte cell numbe... 24 | 73
abnormal tooth morphology 23 | 24
cataract 23 | 92
decreased lymphocyte cell numb... 23 | 83
decreased startle reflex 23 | 75
decreased circulating LDL chol... 22 | 38
prenatal lethality prior to he... 22 | 87
vertebral fusion 22 | 23
abnormal eye morphology 21 | 68
abnormal retina morphology 21 | 71
abnormal sleep behavior 21 | 70
corneal opacity 21 | 32
decreased circulating alanine ... 21 | 47
decreased mean corpuscular vol... 21 | 79
edema 21 | 59
improved glucose tolerance 21 | 79
increased blood urea nitrogen ... 21 | 48
increased hemoglobin content 21 | 45
abnormal coat-hair pigmentatio... 20 | 64
abnormal cornea morphology 20 | 31
abnormal lens morphology 20 | 81
abnormal snout morphology 20 | 23
decreased fasted circulating g... 20 | 65
increased circulating sodium l... 20 | 71
small superior vagus ganglion 20 | 74
decreased circulating calcium ... 19 | 36
increased grip strength 19 | 41
decreased blood urea nitrogen ... 18 | 51
decreased mean corpuscular hem... 18 | 50
increased circulating triglyce... 18 | 42
increased leukocyte cell numbe... 18 | 47
limb grasping 18 | 41
decreased circulating aspartat... 17 | 34
decreased hematocrit 17 | 46
increased circulating creatini... 17 | 38
increased circulating iron lev... 17 | 30
increased hematocrit 17 | 46
increased neutrophil cell numb... 17 | 46
tremors 17 | 39
abnormal maxilla morphology 16 | 17
abnormal spleen morphology 16 | 55
decreased circulating amylase ... 16 | 28
decreased circulating iron lev... 16 | 32
decreased heart weight 16 | 27
embryonic growth retardation 16 | 106
increased circulating chloride... 16 | 41
increased erythrocyte cell num... 16 | 39
increased fasted circulating g... 16 | 76
abnormal kidney morphology 15 | 65

Disease

Carcinoma 1,540 | 11,493
ovarian cancer 1,245 | 8,520
osteosarcoma 1,106 | 7,950
psoriasis 972 | 6,694
medulloblastoma, large-cell 913 | 6,241
glioblastoma 907 | 5,792
atypical teratoid / rhabdoid tumor 781 | 5,112
lung cancer 776 | 4,740
ependymoma 711 | 4,679
Cancer 655 | 2,499
Breast cancer 648 | 3,578
group 3 medulloblastoma 580 | 4,104
malignant mesothelioma 553 | 3,232
adult high grade glioma 535 | 3,801
Astrocytoma, Pilocytic 526 | 3,081
invasive ductal carcinoma 523 | 2,951
intraductal papillary-mucinous neoplasm (IPMN) 503 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 499 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 483 | 2,989
pancreatic cancer 477 | 2,398
Kidney cancer 474 | 2,613
non-small cell lung cancer 473 | 2,890
primitive neuroectodermal tumor 463 | 3,035
lung carcinoma 448 | 2,843
oligodendroglioma 434 | 2,850
lung adenocarcinoma 418 | 2,716
interstitial cystitis 393 | 2,312
astrocytic glioma 392 | 2,597
Autosomal recessive predisposition 378 | 1,442
ulcerative colitis 359 | 1,819
pituitary cancer 357 | 1,972
subependymal giant cell astrocytoma 339 | 2,287
tuberculosis 326 | 2,010
cystic fibrosis 311 | 1,696
breast carcinoma 299 | 1,638
diabetes mellitus 299 | 1,728
ductal carcinoma in situ 299 | 1,745
group 4 medulloblastoma 292 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 290 | 1,962
Pick disease 284 | 1,894
Intellectual disability 268 | 1,016
colon cancer 268 | 1,478
Schizophrenia 263 | 1,160
adrenocortical carcinoma 263 | 1,428
Rheumatoid arthritis 238 | 1,191
primary pancreatic ductal adenocarcinoma 231 | 1,109
Short stature 228 | 531
juvenile dermatomyositis 222 | 1,187
astrocytoma 216 | 1,146
acute quadriplegic myopathy 210 | 1,158
Dull intelligence 199 | 645
Low intelligence 199 | 645
Mental Retardation 199 | 645
Mental deficiency 199 | 645
Poor school performance 199 | 645
pediatric high grade glioma 196 | 1,064
Obesity 193 | 678
Epilepsy 188 | 792
cutaneous lupus erythematosus 182 | 1,057
Liver Cirrhosis, Experimental 178 | 769
spina bifida 177 | 1,074
Muscle hypotonia 173 | 571
Cognitive delay 172 | 608
Global developmental delay 172 | 608
Mental and motor retardation 172 | 608
Multiple myeloma 170 | 1,332
gastric carcinoma 170 | 807
Seizures 167 | 596
nasopharyngeal carcinoma 162 | 1,058
dermatomyositis 159 | 966
Atopic dermatitis 158 | 952
Breast Neoplasms 151 | 445
Osteoporosis 150 | 363
Duchenne muscular dystrophy 149 | 601
Melanoma 146 | 711
autosomal dominant Emery-Dreifuss muscular dystrophy 146 | 510
Mammary Neoplasms 145 | 425
Cleft Palate 143 | 271
Hypoplastic mandible condyle 143 | 275
Mandibular hypoplasia 143 | 275
Micrognathism 143 | 275
Liver cancer 142 | 604
esophageal adenocarcinoma 142 | 737
Bipolar Disorder 140 | 666
Prostatic Neoplasms 140 | 495
Kidney disease 139 | 430
active Crohn's disease 138 | 922
Alzheimer's disease 137 | 658
non primary Sjogren syndrome sicca 132 | 891
Acquired scoliosis 129 | 281
Curvature of spine 129 | 282
Down syndrome 129 | 499
active ulcerative colitis 128 | 764
medulloblastoma 126 | 720
Small head 125 | 374
Depressive disorder 124 | 409
acute myeloid leukemia 121 | 783
Orbital separation excessive 119 | 244
Cryptorchidism 118 | 296
Endometriosis 115 | 540

Tissue

Endocrine System 2,175 | 18,159
Digestive Tract 2,138 | 17,369
Female tissues 2,126 | 17,400
Male tissues 2,124 | 17,142
Skin and soft tissues 2,122 | 17,230
Urinary Tract 2,089 | 16,678
Blood and immune system 2,077 | 16,909
Liver and Pancreas 2,072 | 16,750
Nervous System 2,067 | 16,725
Respiratory system 2,042 | 16,393
Cardiovascular System 1,917 | 15,192

Target Family

Non-IDG 1,086 | 12,091
Enzyme 449 | 4,145
Transcription Factor 310 | 1,400
Kinase 128 | 634
Epigenetic 68 | 242
GPCR 64 | 408
Transporter 54 | 473
Ion Channel 35 | 344
Nuclear Receptor 19 | 48
TF/Epigenetic 9 | 38

MGI Phenotype

skeleton phenotype 2,222 | 2,222
mortality-aging 5,018 | 5,018
homeostasis-metabolism phenoty... 4,747 | 4,747
growth-size-body region phenot... 4,157 | 4,157
cellular phenotype 3,637 | 3,637
immune system phenotype 3,461 | 3,461
nervous system phenotype 3,447 | 3,447
behavior-neurological phenotyp... 3,401 | 3,401
hematopoietic system phenotype 3,383 | 3,383
cardiovascular system phenotyp... 2,660 | 2,660
endocrine-exocrine gland pheno... 2,293 | 2,293
normal phenotype 1,999 | 1,999
reproductive system phenotype 1,999 | 1,999
integument phenotype 1,874 | 1,874
embryo phenotype 1,827 | 1,827
vision-eye phenotype 1,622 | 1,622
muscle phenotype 1,479 | 1,479
digestive-alimentary phenotype 1,398 | 1,398
respiratory system phenotype 1,390 | 1,390
liver-biliary system phenotype 1,300 | 1,300
renal-urinary system phenotype 1,269 | 1,269
craniofacial phenotype 1,182 | 1,182
limbs-digits-tail phenotype 1,071 | 1,071
adipose tissue phenotype 992 | 992
neoplasm 975 | 975
hearing-vestibular-ear phenoty... 767 | 767
pigmentation phenotype 506 | 506
taste-olfaction phenotype 147 | 147
no phenotypic analysis 5 | 5

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Paired mesoderm homeobox protein 1 PRRX1 Tbio Transcription Factor -1.58479 38.8 304
Relaxin-3 RLN3 Tbio Non-IDG -1.88808 92.6 93
A disintegrin and metalloproteinase with thrombospondin motifs 6 ADAMTS6 Tdark Enzyme -0.67364 4.37 40
Integrin alpha-11 ITGA11 Tbio Non-IDG -1.13736 14.3 76
Tyrosine-protein phosphatase non-receptor type 5 PTPN5 Tchem Enzyme -1.85420 70.8 225
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Methylenetetrahydrofolate reductase MTHFR Tbio Enzyme -3.68447 5032.2 275