Development Level

Tbio 995 | 11,651
Tchem 214 | 1,388
Tclin 127 | 612
Tdark 54 | 6,593

Collection

RFA-RM-18-021 17 | 328
Kinase: IDG Consortium (Target... 10 | 125
GPCR: IDG Consortium (Targets) 4 | 126
Ion Channel: IDG Consortium (T... 3 | 99
GPCR: IDG Consortium (Complete... 2 | 25
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 130 | 979
preweaning lethality, incomple... 60 | 499
abnormal embryo size 31 | 220
abnormal behavior 28 | 298
embryonic lethality prior to t... 25 | 278
abnormal bone structure 24 | 187
enlarged heart 21 | 210
decreased total body fat amoun... 19 | 207
decreased vertical activity 19 | 208
increased circulating alkaline... 19 | 122
hypoactivity 18 | 132
increased startle reflex 18 | 112
increased total body fat amoun... 18 | 134
short tibia 17 | 97
decreased body weight 16 | 161
decreased bone mineral content 16 | 151
increased lean body mass 16 | 172
decreased lean body mass 15 | 135
decreased prepulse inhibition 15 | 82
impaired glucose tolerance 15 | 75
decreased circulating HDL chol... 14 | 68
decreased circulating choleste... 14 | 93
edema 14 | 59
abnormal heart morphology 13 | 162
decreased bone mineral density 13 | 126
embryonic lethality prior to o... 13 | 239
abnormal lung morphology 12 | 26
hyperactivity 12 | 148
prenatal lethality prior to he... 12 | 87
abnormal retina morphology 11 | 71
cataract 11 | 92
decreased circulating alkaline... 11 | 46
decreased circulating glucose ... 11 | 126
decreased lymphocyte cell numb... 11 | 83
abnormal eye morphology 10 | 68
decreased erythrocyte cell num... 10 | 62
decreased hemoglobin content 10 | 68
decreased mean corpuscular vol... 10 | 79
increased bone mineral content 10 | 108
increased circulating HDL chol... 10 | 80
increased circulating choleste... 10 | 66
increased neutrophil cell numb... 10 | 46
male infertility 10 | 123
tremors 10 | 39
abnormal craniofacial morpholo... 9 | 33
abnormal gait 9 | 69
abnormal lens morphology 9 | 81
abnormal neural tube closure 9 | 46
embryonic growth retardation 9 | 106
improved glucose tolerance 9 | 79
increased bone mineral density 9 | 72
increased circulating creatini... 9 | 38
increased heart weight 9 | 62
increased mean corpuscular hem... 9 | 96
prenatal lethality 9 | 28
small superior vagus ganglion 9 | 74
anophthalmia 8 | 33
decreased body length 8 | 101
decreased circulating serum al... 8 | 82
decreased circulating triglyce... 8 | 79
decreased grip strength 8 | 116
decreased neutrophil cell numb... 8 | 42
increased blood urea nitrogen ... 8 | 48
increased circulating chloride... 8 | 41
increased leukocyte cell numbe... 8 | 47
increased monocyte cell number 8 | 63
pallor 8 | 34
abnormal seminal vesicle morph... 7 | 114
decreased circulating alanine ... 7 | 47
decreased startle reflex 7 | 75
increased circulating phosphat... 7 | 26
increased circulating total pr... 7 | 28
increased mean corpuscular vol... 7 | 92
pale yolk sac 7 | 25
small testis 7 | 58
thrombocytopenia 7 | 56
abnormal kidney morphology 6 | 65
abnormal tooth morphology 6 | 24
cyanosis 6 | 7
decreased circulating insulin ... 6 | 76
decreased fasted circulating g... 6 | 65
decreased heart left ventricle... 6 | 28
decreased hematocrit 6 | 46
enlarged lymph nodes 6 | 37
increased fasted circulating g... 6 | 76
increased or absent threshold ... 6 | 101
limb grasping 6 | 41
abnormal cranium morphology 5 | 36
abnormal locomotor behavior 5 | 24
abnormal sleep behavior 5 | 70
abnormal vertebrae morphology 5 | 18
decreased caudal vertebrae num... 5 | 53
decreased circulating amylase ... 5 | 28
decreased circulating creatini... 5 | 39
decreased spleen weight 5 | 10
increased circulating calcium ... 5 | 34
increased circulating sodium l... 5 | 71
increased circulating triglyce... 5 | 42
increased hemoglobin content 5 | 45
small thymus 5 | 16

Disease

Carcinoma 980 | 11,493
ovarian cancer 781 | 8,520
osteosarcoma 661 | 7,950
psoriasis 650 | 6,694
glioblastoma 606 | 5,792
medulloblastoma, large-cell 580 | 6,241
lung cancer 559 | 4,740
atypical teratoid / rhabdoid tumor 510 | 5,112
Cancer 490 | 2,499
ependymoma 488 | 4,679
Breast cancer 449 | 3,578
malignant mesothelioma 375 | 3,232
group 3 medulloblastoma 373 | 4,104
adult high grade glioma 363 | 3,801
lung carcinoma 356 | 2,843
Astrocytoma, Pilocytic 343 | 3,081
invasive ductal carcinoma 343 | 2,951
non-small cell lung cancer 342 | 2,890
intraductal papillary-mucinous adenoma (IPMA) 340 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 336 | 3,291
Kidney cancer 335 | 2,613
pancreatic cancer 335 | 2,398
intraductal papillary-mucinous carcinoma (IPMC) 327 | 2,989
lung adenocarcinoma 326 | 2,716
interstitial cystitis 288 | 2,312
oligodendroglioma 287 | 2,850
primitive neuroectodermal tumor 276 | 3,035
pituitary cancer 257 | 1,972
subependymal giant cell astrocytoma 256 | 2,287
astrocytic glioma 248 | 2,597
Autosomal recessive predisposition 247 | 1,442
ulcerative colitis 245 | 1,819
tuberculosis 232 | 2,010
cystic fibrosis 228 | 1,696
breast carcinoma 223 | 1,638
Schizophrenia 217 | 1,160
ductal carcinoma in situ 215 | 1,745
colon cancer 202 | 1,478
diabetes mellitus 196 | 1,728
group 4 medulloblastoma 183 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 180 | 1,962
Pick disease 178 | 1,894
Intellectual disability 173 | 1,016
adrenocortical carcinoma 166 | 1,428
primary pancreatic ductal adenocarcinoma 157 | 1,109
Rheumatoid arthritis 156 | 1,191
astrocytoma 146 | 1,146
Short stature 139 | 531
Epilepsy 137 | 792
juvenile dermatomyositis 136 | 1,187
acute quadriplegic myopathy 135 | 1,158
Obesity 132 | 678
cutaneous lupus erythematosus 132 | 1,057
nasopharyngeal carcinoma 132 | 1,058
Dull intelligence 131 | 645
Low intelligence 131 | 645
Mental Retardation 131 | 645
Mental deficiency 131 | 645
Poor school performance 131 | 645
pediatric high grade glioma 130 | 1,064
Liver Cirrhosis, Experimental 127 | 769
gastric carcinoma 123 | 807
Seizures 121 | 596
Cognitive delay 119 | 608
Global developmental delay 119 | 608
Mental and motor retardation 119 | 608
dermatomyositis 119 | 966
Melanoma 118 | 711
spina bifida 118 | 1,074
Atopic dermatitis 117 | 952
Liver cancer 117 | 604
Asthma 113 | 385
Bipolar Disorder 113 | 666
Breast Neoplasms 111 | 445
Muscle hypotonia 111 | 571
Kidney disease 110 | 430
Mammary Neoplasms 109 | 425
Hypertension 105 | 396
Alzheimer's disease 103 | 658
Cleft Palate 98 | 271
Hypoplastic mandible condyle 98 | 275
Mandibular hypoplasia 98 | 275
Micrognathism 98 | 275
Multiple myeloma 98 | 1,332
esophageal adenocarcinoma 98 | 737
Duchenne muscular dystrophy 97 | 601
Prostatic Neoplasms 95 | 495
autosomal dominant Emery-Dreifuss muscular dystrophy 95 | 510
active Crohn's disease 94 | 922
non primary Sjogren syndrome sicca 94 | 891
Arthritis 93 | 290
Hypertensive disease 91 | 292
active ulcerative colitis 91 | 764
Orbital separation excessive 88 | 244
Skin cancer 88 | 469
Endometriosis 87 | 540
Vascular disease 87 | 319
Cryptorchidism 86 | 296
Depressive disorder 86 | 409
Autistic Disorder 85 | 364

Tissue

Endocrine System 1,352 | 18,159
Digestive Tract 1,337 | 17,369
Skin and soft tissues 1,329 | 17,230
Female tissues 1,316 | 17,400
Male tissues 1,313 | 17,142
Urinary Tract 1,298 | 16,678
Blood and immune system 1,295 | 16,909
Liver and Pancreas 1,291 | 16,750
Nervous System 1,284 | 16,725
Respiratory system 1,269 | 16,393
Cardiovascular System 1,185 | 15,192

Target Family

Non-IDG 651 | 12,091
Enzyme 260 | 4,145
Transcription Factor 212 | 1,400
Kinase 94 | 634
GPCR 58 | 408
Ion Channel 40 | 344
Epigenetic 29 | 242
Transporter 24 | 473
Nuclear Receptor 10 | 48
TF/Epigenetic 8 | 38
oGPCR 4 | 421

MGI Phenotype

respiratory system phenotype 1,390 | 1,390
mortality-aging 5,018 | 5,018
homeostasis-metabolism phenoty... 4,747 | 4,747
growth-size-body region phenot... 4,157 | 4,157
cellular phenotype 3,637 | 3,637
immune system phenotype 3,461 | 3,461
nervous system phenotype 3,447 | 3,447
behavior-neurological phenotyp... 3,401 | 3,401
hematopoietic system phenotype 3,383 | 3,383
cardiovascular system phenotyp... 2,660 | 2,660
endocrine-exocrine gland pheno... 2,293 | 2,293
skeleton phenotype 2,222 | 2,222
normal phenotype 1,999 | 1,999
reproductive system phenotype 1,999 | 1,999
integument phenotype 1,874 | 1,874
embryo phenotype 1,827 | 1,827
vision-eye phenotype 1,622 | 1,622
muscle phenotype 1,479 | 1,479
digestive-alimentary phenotype 1,398 | 1,398
liver-biliary system phenotype 1,300 | 1,300
renal-urinary system phenotype 1,269 | 1,269
craniofacial phenotype 1,182 | 1,182
limbs-digits-tail phenotype 1,071 | 1,071
adipose tissue phenotype 992 | 992
neoplasm 975 | 975
hearing-vestibular-ear phenoty... 767 | 767
pigmentation phenotype 506 | 506
taste-olfaction phenotype 147 | 147
no phenotypic analysis 5 | 5

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Paired mesoderm homeobox protein 1 PRRX1 Tbio Transcription Factor -1.58479 38.8 304
43 kDa receptor-associated protein of the synapse RAPSN Tbio Non-IDG -2.09902 132.1 134
ATP-binding cassette sub-family A member 1 ABCA1 Tclin Transporter -3.15111 1451.8 388
Neuroendocrine secretory protein 55 GNAS Tbio Non-IDG -2.63356 1389.7 509
Transcription factor HES-1 HES1 Tbio Transcription Factor -1.77409 55.5 444
Tyrosine-protein kinase ZAP-70 ZAP70 Tchem Kinase -2.91589 798.2 1515
Proprotein convertase subtilisin/kexin type 6 PCSK6 Tchem Enzyme -2.33983 216.4 239
Leukotriene B4 receptor 1 LTB4R Tchem GPCR -2.74171 557.6 365