Development Level

Tbio 857 | 10,625
Tchem 265 | 1,890
Tclin 121 | 602
Tdark 48 | 7,003

Collection

Eligible Kinase Proteins 10 | 134
Eligible Ion Channel Proteins 5 | 117
Eligible non-olfactory GPCR Proteins 5 | 143

IMPC Term

preweaning lethality, complete... 77 | 633
preweaning lethality, incomple... 32 | 260
abnormal behavior 25 | 226
decreased lean body mass 24 | 195
decreased bone mineral content 19 | 157
decreased bone mineral density 18 | 126
decreased total body fat amoun... 17 | 186
abnormal embryo size 16 | 112
embryonic lethality prior to t... 16 | 187
abnormal bone structure 15 | 131
decreased body weight 15 | 174
increased circulating alkaline... 14 | 119
short tibia 14 | 82
decreased circulating choleste... 13 | 85
decreased grip strength 13 | 123
decreased prepulse inhibition 13 | 52
enlarged heart 13 | 111
hypoactivity 13 | 89
abnormal bone mineralization 12 | 55
decreased body length 12 | 108
impaired glucose tolerance 11 | 52
increased grip strength 11 | 83
decreased circulating HDL chol... 10 | 77
decreased circulating glucose ... 10 | 121
increased or absent threshold ... 10 | 128
tremors 10 | 34
abnormal retina morphology 9 | 100
embryonic lethality prior to o... 9 | 148
hyperactivity 9 | 108
increased mean corpuscular hem... 9 | 93
increased mean corpuscular vol... 9 | 91
decreased circulating alkaline... 8 | 41
decreased circulating triglyce... 8 | 83
decreased hemoglobin content 8 | 53
increased blood urea nitrogen ... 8 | 44
increased body weight 8 | 42
increased bone mineral content 8 | 92
abnormal eye morphology 7 | 38
abnormal tooth morphology 7 | 24
decreased circulating alanine ... 7 | 53
decreased erythrocyte cell num... 7 | 43
increased heart weight 7 | 37
increased lean body mass 7 | 107
abnormal lung morphology 6 | 15
abnormal neural tube closure 6 | 37
abnormal retinal pigmentation 6 | 61
cataract 6 | 26
decreased circulating serum al... 6 | 79
decreased hematocrit 6 | 25
hydrops fetalis 6 | 22
improved glucose tolerance 6 | 56
increased circulating HDL chol... 6 | 63
increased circulating calcium ... 6 | 32
increased circulating choleste... 6 | 53
increased circulating creatini... 6 | 29
increased startle reflex 6 | 38
small testis 6 | 37
thrombocytopenia 6 | 46
abnormal behavioral response t... 5 | 52
abnormal gait 5 | 51
abnormal heart morphology 5 | 51
abnormal hindbrain development 5 | 24
abnormal lens morphology 5 | 73
abnormal midbrain development 5 | 22
abnormal testis morphology 5 | 30
anophthalmia 5 | 20
decreased circulating amylase ... 5 | 24
decreased lumbar vertebrae num... 5 | 62
decreased mean corpuscular vol... 5 | 50
increased bone mineral density 5 | 52
increased circulating phosphat... 5 | 24
increased circulating sodium l... 5 | 71
increased circulating total pr... 5 | 20
increased total body fat amoun... 5 | 57
abnormal forebrain development 4 | 18
abnormal locomotor activation 4 | 26
abnormal sleep behavior 4 | 63
abnormal spinal cord morpholog... 4 | 8
abnormal startle reflex 4 | 14
craniofacial phenotype 4 | 9
cyanosis 4 | 6
decreased circulating LDL chol... 4 | 37
decreased circulating insulin ... 4 | 75
decreased eosinophil cell numb... 4 | 41
decreased fasted circulating g... 4 | 49
decreased startle reflex 4 | 48
increased circulating LDL chol... 4 | 15
increased circulating chloride... 4 | 43
increased circulating free fat... 4 | 17
increased circulating serum al... 4 | 25
increased hemoglobin content 4 | 45
increased leukocyte cell numbe... 4 | 37
limb grasping 4 | 35
prenatal lethality prior to he... 4 | 64
thrombocytosis 4 | 23
abnormal epididymis morphology 3 | 31
decreased rib number 3 | 59
increased circulating aspartat... 3 | 17
increased circulating potassiu... 3 | 31
increased hematocrit 3 | 36

Disease

ovarian cancer 727 | 8,484
osteosarcoma 620 | 7,933
psoriasis 605 | 6,685
medulloblastoma, large-cell 542 | 6,234
glioblastoma 541 | 5,572
lung cancer 499 | 4,466
Cancer 440 | 2,346
atypical teratoid / rhabdoid tumor 407 | 4,369
Breast cancer 362 | 3,094
malignant mesothelioma 342 | 3,162
lung carcinoma 340 | 2,844
pilocytic astrocytoma 337 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 326 | 2,956
invasive ductal carcinoma 323 | 2,950
intraductal papillary-mucinous neoplasm (IPMN) 316 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 312 | 2,988
non-small cell lung cancer 312 | 2,798
lung adenocarcinoma 307 | 2,713
pancreatic cancer 292 | 2,300
Carcinoma 291 | 2,147
pediatric high grade glioma 280 | 2,712
interstitial cystitis 274 | 2,299
oligodendroglioma 267 | 2,849
primitive neuroectodermal tumor 259 | 3,031
ulcerative colitis 253 | 2,087
subependymal giant cell astrocytoma 242 | 2,287
pituitary cancer 235 | 1,972
ependymoma 223 | 2,514
cystic fibrosis 216 | 1,665
ductal carcinoma in situ 209 | 1,745
breast carcinoma 202 | 1,614
colon cancer 194 | 1,475
group 4 medulloblastoma 187 | 1,875
adult high grade glioma 184 | 2,148
astrocytic glioma 184 | 2,241
astrocytoma 182 | 1,493
posterior fossa group A ependymoma 175 | 1,511
primary pancreatic ductal adenocarcinoma 175 | 1,271
diabetes mellitus 174 | 1,663
group 3 medulloblastoma 172 | 2,254
tuberculosis 169 | 1,557
Pick disease 165 | 1,893
sonic hedgehog group medulloblastoma 155 | 1,482
adrenocortical carcinoma 154 | 1,427
posterior fossa group B ependymoma 144 | 1,530
Rheumatoid Arthritis 140 | 1,160
pancreatic ductal adenocarcinoma liver metastasis 139 | 1,795
juvenile dermatomyositis 132 | 1,189
cutaneous lupus erythematosus 128 | 1,056
medulloblastoma 128 | 1,524
acute quadriplegic myopathy 127 | 1,157
nasopharyngeal carcinoma 126 | 1,056
gastric carcinoma 124 | 832
dermatomyositis 111 | 933
Obesity 110 | 616
Atopic dermatitis 107 | 944
spina bifida 105 | 1,064
Kidney disease 101 | 396
atypical teratoid/rhabdoid tumor 101 | 1,095
Mammary Neoplasms 100 | 410
Asthma 98 | 349
Alzheimer's disease 96 | 644
esophageal adenocarcinoma 95 | 737
Duchenne muscular dystrophy 92 | 602
Multiple myeloma 90 | 1,327
Endometriosis 87 | 535
Intellectual disability 87 | 573
active Crohn's disease 87 | 918
autosomal dominant Emery-Dreifuss muscular dystrophy 87 | 499
primary Sjogren syndrome 84 | 789
Prostatic Neoplasms 83 | 471
Down syndrome 81 | 548
non primary Sjogren syndrome sicca 81 | 840
Arthritis 77 | 248
Multiple Sclerosis 76 | 498
Waldenstrons macroglobulinemia 75 | 765
Autistic Disorder 74 | 320
Schizophrenia 74 | 501
Vascular disease 73 | 281
aldosterone-producing adenoma 72 | 664
Hypertension 70 | 287
pancreatic carcinoma 67 | 567
Lung Neoplasms 66 | 171
Atherosclerosis 65 | 275
fibroadenoma 64 | 557
Craniofacial Abnormalities 62 | 147
Heart disease 62 | 279
acute myeloid leukemia 62 | 780
chronic rhinosinusitis 62 | 512
mucosa-associated lymphoid tissue lymphoma 62 | 480
non-small cell lung carcinoma 60 | 413
Amyotrophic Lateral Sclerosis 59 | 431
Cleft palate 58 | 125
Parkinson's disease 58 | 364
active ulcerative colitis 58 | 477
Hypertensive disease 57 | 193
Osteoporosis 57 | 257
hepatocellular carcinoma 57 | 532
Cerebrovascular disease 56 | 231
tuberculosis and treatment for 6 months 54 | 686

Tissue

Nervous System 1,278 | 18,561
Endocrine System 1,275 | 18,512
Female tissues 1,273 | 18,647
Digestive Tract 1,272 | 18,473
Urinary Tract 1,267 | 18,444
Liver and Pancreas 1,266 | 18,136
Male tissues 1,260 | 17,969
Skin and soft tissues 1,258 | 18,115
Cardiovascular System 1,254 | 17,958
Blood and immune system 1,252 | 17,995
Respiratory system 1,234 | 17,484

Target Family

Non-IDG 595 | 11,971
Enzyme 237 | 4,146
Transcription Factor 208 | 1,400
Kinase 89 | 634
GPCR 56 | 406
Ion Channel 37 | 341
Epigenetic 26 | 242
Transporter 21 | 473
Nuclear Receptor 10 | 48
TF/Epigenetic 8 | 38
oGPCR 4 | 421

MGI Term

respiratory system phenotype 1,291 | 1,291
mortality/aging 4,850 | 4,850
homeostasis/metabolism phenoty... 4,454 | 4,454
growth/size/body region phenot... 3,915 | 3,915
cellular phenotype 3,348 | 3,348
nervous system phenotype 3,201 | 3,201
behavior/neurological phenotyp... 3,192 | 3,192
immune system phenotype 3,148 | 3,148
hematopoietic system phenotype 3,145 | 3,145
cardiovascular system phenotyp... 2,448 | 2,448
endocrine/exocrine gland pheno... 2,084 | 2,084
skeleton phenotype 2,058 | 2,058
normal phenotype 1,916 | 1,916
reproductive system phenotype 1,873 | 1,873
integument phenotype 1,748 | 1,748
embryo phenotype 1,674 | 1,674
vision/eye phenotype 1,478 | 1,478
muscle phenotype 1,385 | 1,385
digestive/alimentary phenotype 1,292 | 1,292
liver/biliary system phenotype 1,160 | 1,160
renal/urinary system phenotype 1,157 | 1,157
craniofacial phenotype 1,077 | 1,077
limbs/digits/tail phenotype 1,011 | 1,011
neoplasm 918 | 918
adipose tissue phenotype 901 | 901
hearing/vestibular/ear phenoty... 692 | 692
pigmentation phenotype 459 | 459
taste/olfaction phenotype 142 | 142
obsolete other phenotype 69 | 69

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.39907 258.0 359
Erythropoietin EPO Tbio Non-IDG -3.90053 8755.8 628
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
Zinc finger protein 148 ZNF148 Tbio Transcription Factor -1.71996 60.7 178
V(D)J recombination-activating protein 1 RAG1 Tbio Non-IDG -3.00063 1061.1 65
Coagulation factor XI F11 Tchem Enzyme -2.65863 487.3 216
Glypican-3 GPC3 Tbio Non-IDG -2.85848 794.8 523