Development Level

Tbio 1,418 | 11,651
Tchem 291 | 1,388
Tdark 154 | 6,593
Tclin 136 | 612

Collection

Kinase: IDG Consortium (Target... 15 | 125
Ion Channel: IDG Consortium (T... 9 | 99
GPCR: IDG Consortium (Targets) 5 | 126
Kinase: IDG Consortium (Comple... 3 | 37
GPCR: IDG Consortium (Complete... 2 | 25

IMPC Phenotype

preweaning lethality, complete... 115 | 979
preweaning lethality, incomple... 103 | 499
male infertility 81 | 123
decreased vertical activity 70 | 208
abnormal seminal vesicle morph... 62 | 114
enlarged heart 61 | 210
abnormal behavior 51 | 298
embryonic lethality prior to t... 43 | 278
abnormal heart morphology 42 | 162
female infertility 40 | 60
small testis 38 | 58
abnormal bone structure 36 | 187
decreased bone mineral content 36 | 151
decreased body weight 32 | 161
decreased total body fat amoun... 32 | 207
abnormal embryo size 31 | 220
abnormal epididymis morphology 31 | 42
abnormal testis morphology 29 | 43
decreased bone mineral density 29 | 126
increased total body fat amoun... 29 | 134
decreased lean body mass 28 | 135
hypoactivity 28 | 132
increased lean body mass 27 | 172
embryonic lethality prior to o... 26 | 239
enlarged epididymis 23 | 31
increased circulating alkaline... 23 | 122
decreased circulating glucose ... 22 | 126
hyperactivity 22 | 148
abnormal kidney morphology 21 | 65
increased bone mineral content 20 | 108
decreased body length 19 | 101
decreased circulating choleste... 19 | 93
hydrometra 19 | 53
decreased circulating insulin ... 18 | 76
edema 18 | 59
small superior vagus ganglion 18 | 74
decreased prepulse inhibition 17 | 82
impaired glucose tolerance 17 | 75
improved glucose tolerance 17 | 79
increased or absent threshold ... 17 | 101
increased mean corpuscular vol... 16 | 92
increased startle reflex 16 | 112
abnormal eye morphology 15 | 68
decreased lymphocyte cell numb... 15 | 83
increased mean corpuscular hem... 15 | 96
short tibia 15 | 97
decreased circulating serum al... 14 | 82
decreased mean corpuscular vol... 14 | 79
increased circulating choleste... 14 | 66
limb grasping 14 | 41
abnormal skin morphology 13 | 50
cataract 13 | 92
thrombocytopenia 13 | 56
abnormal lens morphology 12 | 81
abnormal retina morphology 12 | 71
abnormal spleen morphology 12 | 55
decreased grip strength 12 | 116
embryonic growth retardation 12 | 106
increased circulating HDL chol... 12 | 80
increased fasted circulating g... 12 | 76
abnormal sleep behavior 11 | 70
decreased circulating HDL chol... 11 | 68
decreased fasted circulating g... 11 | 65
decreased startle reflex 11 | 75
abnormal behavioral response t... 10 | 66
decreased circulating calcium ... 10 | 36
decreased circulating total pr... 10 | 49
decreased circulating triglyce... 10 | 79
decreased hemoglobin content 10 | 68
decreased leukocyte cell numbe... 10 | 73
increased blood urea nitrogen ... 10 | 48
increased bone mineral density 10 | 72
increased monocyte cell number 10 | 63
prenatal lethality prior to he... 10 | 87
abnormal gait 9 | 69
decreased erythrocyte cell num... 9 | 62
decreased heart left ventricle... 9 | 28
abnormal coat-hair pigmentatio... 8 | 64
abnormal locomotor behavior 8 | 24
decreased circulating alanine ... 8 | 47
decreased circulating alkaline... 8 | 46
decreased circulating iron lev... 8 | 32
enlarged spleen 8 | 41
increased leukocyte cell numbe... 8 | 47
increased mean platelet volume 8 | 45
thin ventricular wall 8 | 24
abnormal bone mineralization 7 | 38
abnormal craniofacial morpholo... 7 | 33
abnormal neural tube closure 7 | 46
abnormal snout morphology 7 | 23
anophthalmia 7 | 33
decreased circulating fructosa... 7 | 30
decreased heart weight 7 | 27
increased circulating creatini... 7 | 38
increased circulating total pr... 7 | 28
increased grip strength 7 | 41
increased hemoglobin content 7 | 45
increased neutrophil cell numb... 7 | 46
small spleen 7 | 19
tremors 7 | 39

Disease

Carcinoma 1,397 | 11,493
ovarian cancer 1,047 | 8,520
osteosarcoma 927 | 7,950
psoriasis 882 | 6,694
medulloblastoma, large-cell 830 | 6,241
glioblastoma 753 | 5,792
lung cancer 693 | 4,740
atypical teratoid / rhabdoid tumor 668 | 5,112
Cancer 617 | 2,499
ependymoma 602 | 4,679
Breast cancer 567 | 3,578
group 3 medulloblastoma 529 | 4,104
adult high grade glioma 482 | 3,801
malignant mesothelioma 482 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 457 | 3,291
invasive ductal carcinoma 430 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 419 | 2,955
Astrocytoma, Pilocytic 414 | 3,081
primitive neuroectodermal tumor 408 | 3,035
Kidney cancer 406 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 402 | 2,989
non-small cell lung cancer 399 | 2,890
lung adenocarcinoma 392 | 2,716
lung carcinoma 378 | 2,843
pancreatic cancer 377 | 2,398
oligodendroglioma 364 | 2,850
astrocytic glioma 341 | 2,597
interstitial cystitis 335 | 2,312
Autosomal recessive predisposition 329 | 1,442
subependymal giant cell astrocytoma 309 | 2,287
pituitary cancer 302 | 1,972
ductal carcinoma in situ 281 | 1,745
tuberculosis 269 | 2,010
ulcerative colitis 268 | 1,819
breast carcinoma 260 | 1,638
cystic fibrosis 260 | 1,696
Schizophrenia 258 | 1,160
colon cancer 258 | 1,478
group 4 medulloblastoma 251 | 1,855
diabetes mellitus 249 | 1,728
Intellectual disability 243 | 1,016
Pick disease 236 | 1,894
adrenocortical carcinoma 229 | 1,428
pancreatic ductal adenocarcinoma liver metastasis 217 | 1,962
Rheumatoid arthritis 189 | 1,191
acute quadriplegic myopathy 182 | 1,158
primary pancreatic ductal adenocarcinoma 182 | 1,109
Dull intelligence 179 | 645
Low intelligence 179 | 645
Mental Retardation 179 | 645
Mental deficiency 179 | 645
Poor school performance 179 | 645
Obesity 175 | 678
Epilepsy 171 | 792
Short stature 169 | 531
juvenile dermatomyositis 168 | 1,187
astrocytoma 163 | 1,146
Cognitive delay 161 | 608
Global developmental delay 161 | 608
Mental and motor retardation 161 | 608
spina bifida 161 | 1,074
Prostatic Neoplasms 157 | 495
Multiple myeloma 155 | 1,332
Bipolar Disorder 150 | 666
Seizures 148 | 596
Endometriosis 147 | 540
nasopharyngeal carcinoma 147 | 1,058
cutaneous lupus erythematosus 146 | 1,057
pediatric high grade glioma 145 | 1,064
Breast Neoplasms 144 | 445
Mammary Neoplasms 142 | 425
Atopic dermatitis 141 | 952
Liver Cirrhosis, Experimental 141 | 769
Muscle hypotonia 134 | 571
gastric carcinoma 132 | 807
Alzheimer's disease 131 | 658
Melanoma 131 | 711
dermatomyositis 131 | 966
Liver cancer 127 | 604
Male infertility 125 | 206
active Crohn's disease 124 | 922
Infertility 122 | 188
Depressive disorder 121 | 409
Down syndrome 117 | 499
Osteoporosis 114 | 363
esophageal adenocarcinoma 113 | 737
Small head 111 | 374
aldosterone-producing adenoma 110 | 665
autosomal dominant Emery-Dreifuss muscular dystrophy 110 | 510
Cryptorchidism 109 | 296
Duchenne muscular dystrophy 107 | 601
non primary Sjogren syndrome sicca 105 | 891
Kidney disease 104 | 430
Autistic Disorder 102 | 364
medulloblastoma 100 | 720
Hypertension 98 | 396
active ulcerative colitis 97 | 764
Neurodegenerative disease 94 | 414
Stomach Neoplasms 93 | 300
primary Sjogren syndrome 93 | 735

Tissue

Endocrine System 1,968 | 18,159
Digestive Tract 1,876 | 17,369
Female tissues 1,876 | 17,400
Male tissues 1,863 | 17,142
Skin and soft tissues 1,862 | 17,230
Nervous System 1,822 | 16,725
Blood and immune system 1,819 | 16,909
Urinary Tract 1,809 | 16,678
Liver and Pancreas 1,802 | 16,750
Respiratory system 1,782 | 16,393
Cardiovascular System 1,632 | 15,192

Target Family

Non-IDG 973 | 12,091
Enzyme 424 | 4,145
Transcription Factor 215 | 1,400
Kinase 131 | 634
Epigenetic 66 | 242
GPCR 59 | 408
Ion Channel 51 | 344
Transporter 42 | 473
Nuclear Receptor 29 | 48
TF/Epigenetic 9 | 38

MGI Phenotype

reproductive system phenotype 1,999 | 1,999
mortality-aging 5,018 | 5,018
homeostasis-metabolism phenoty... 4,747 | 4,747
growth-size-body region phenot... 4,157 | 4,157
cellular phenotype 3,637 | 3,637
immune system phenotype 3,461 | 3,461
nervous system phenotype 3,447 | 3,447
behavior-neurological phenotyp... 3,401 | 3,401
hematopoietic system phenotype 3,383 | 3,383
cardiovascular system phenotyp... 2,660 | 2,660
endocrine-exocrine gland pheno... 2,293 | 2,293
skeleton phenotype 2,222 | 2,222
normal phenotype 1,999 | 1,999
integument phenotype 1,874 | 1,874
embryo phenotype 1,827 | 1,827
vision-eye phenotype 1,622 | 1,622
muscle phenotype 1,479 | 1,479
digestive-alimentary phenotype 1,398 | 1,398
respiratory system phenotype 1,390 | 1,390
liver-biliary system phenotype 1,300 | 1,300
renal-urinary system phenotype 1,269 | 1,269
craniofacial phenotype 1,182 | 1,182
limbs-digits-tail phenotype 1,071 | 1,071
adipose tissue phenotype 992 | 992
neoplasm 975 | 975
hearing-vestibular-ear phenoty... 767 | 767
pigmentation phenotype 506 | 506
taste-olfaction phenotype 147 | 147
no phenotypic analysis 5 | 5

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Signal transducer and activator of transcription 3 STAT3 Tchem Transcription Factor -3.81500 6459.7 1749
Cellular tumor antigen p53 TP53 Tchem Transcription Factor -4.74112 54026.3 6298
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN PTEN Tbio Enzyme -3.70874 5099.6 916