Development Level

Tbio 1,234 | 10,625
Tchem 358 | 1,890
Tdark 150 | 7,003
Tclin 131 | 602

Collection

Eligible Kinase Proteins 15 | 134
Eligible Ion Channel Proteins 10 | 117
Eligible non-olfactory GPCR Proteins 5 | 143

IMPC Term

preweaning lethality, complete... 76 | 633
preweaning lethality, incomple... 55 | 260
male infertility 53 | 62
decreased lean body mass 40 | 195
abnormal behavior 39 | 226
decreased bone mineral content 33 | 157
decreased body weight 32 | 174
enlarged heart 31 | 111
female infertility 29 | 34
abnormal seminal vesicle morph... 28 | 47
decreased body length 25 | 108
embryonic lethality prior to t... 25 | 187
decreased bone mineral density 24 | 126
decreased total body fat amoun... 24 | 186
small testis 23 | 37
abnormal embryo size 22 | 112
decreased circulating glucose ... 21 | 121
decreased grip strength 21 | 123
hypoactivity 21 | 89
increased or absent threshold ... 21 | 128
abnormal bone structure 20 | 131
abnormal testis morphology 20 | 30
abnormal heart morphology 19 | 51
abnormal epididymis morphology 18 | 31
increased circulating alkaline... 18 | 119
enlarged epididymis 17 | 27
hyperactivity 17 | 108
increased mean corpuscular hem... 17 | 93
increased grip strength 16 | 83
decreased circulating HDL chol... 15 | 77
decreased circulating insulin ... 15 | 75
increased mean corpuscular vol... 15 | 91
thrombocytopenia 15 | 46
decreased circulating choleste... 14 | 85
decreased circulating triglyce... 13 | 83
short tibia 13 | 82
abnormal retina morphology 12 | 100
decreased circulating serum al... 12 | 79
decreased heart weight 12 | 44
hydrops fetalis 12 | 22
increased blood urea nitrogen ... 12 | 44
increased lean body mass 12 | 107
increased total body fat amoun... 12 | 57
abnormal behavioral response t... 11 | 52
abnormal lens morphology 11 | 73
abnormal retinal pigmentation 11 | 61
embryonic lethality prior to o... 11 | 148
abnormal eye morphology 10 | 38
decreased hemoglobin content 10 | 53
decreased prepulse inhibition 10 | 52
decreased startle reflex 10 | 48
impaired glucose tolerance 10 | 52
increased bone mineral content 10 | 92
increased circulating HDL chol... 10 | 63
abnormal bone mineralization 9 | 55
abnormal kidney morphology 9 | 30
abnormal sleep behavior 9 | 63
hydrometra 9 | 13
increased circulating choleste... 9 | 53
abnormal gait 8 | 51
decreased circulating total pr... 8 | 41
decreased lumbar vertebrae num... 8 | 62
decreased rib number 8 | 59
increased body weight 8 | 42
increased fasted circulating g... 8 | 68
limb grasping 8 | 35
abnormal hindbrain development 7 | 24
abnormal neural tube closure 7 | 37
cataract 7 | 26
decreased caudal vertebrae num... 7 | 49
decreased circulating alanine ... 7 | 53
decreased circulating alkaline... 7 | 41
decreased erythrocyte cell num... 7 | 43
decreased vertical activity 7 | 22
increased circulating sodium l... 7 | 71
increased hematocrit 7 | 36
increased sacral vertebrae num... 7 | 62
tremors 7 | 34
abnormal cranium morphology 6 | 32
abnormal forebrain development 6 | 18
abnormal midbrain development 6 | 22
abnormal skin morphology 6 | 23
abnormal snout morphology 6 | 18
abnormal spleen morphology 6 | 36
abnormal tooth morphology 6 | 24
abnormal vibrissa morphology 6 | 17
cardiovascular system phenotyp... 6 | 35
decreased circulating amylase ... 6 | 24
decreased circulating fructosa... 6 | 31
decreased eosinophil cell numb... 6 | 41
decreased leukocyte cell numbe... 6 | 54
improved glucose tolerance 6 | 56
increased circulating chloride... 6 | 43
increased circulating creatini... 6 | 29
abnormal coat/hair pigmentatio... 5 | 54
decreased NK T cell number 5 | 28
decreased circulating LDL chol... 5 | 37
increased circulating total pr... 5 | 20
increased exploration in new e... 5 | 56
increased hemoglobin content 5 | 45

Disease

ovarian cancer 981 | 8,484
osteosarcoma 856 | 7,933
psoriasis 831 | 6,685
medulloblastoma, large-cell 773 | 6,234
glioblastoma 672 | 5,572
lung cancer 623 | 4,466
Cancer 568 | 2,346
atypical teratoid / rhabdoid tumor 540 | 4,369
Breast cancer 468 | 3,094
malignant mesothelioma 449 | 3,162
intraductal papillary-mucinous neoplasm (IPMN) 433 | 3,289
invasive ductal carcinoma 406 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 398 | 2,956
pilocytic astrocytoma 394 | 3,086
intraductal papillary-mucinous carcinoma (IPMC) 386 | 2,988
primitive neuroectodermal tumor 385 | 3,031
lung adenocarcinoma 368 | 2,713
non-small cell lung cancer 367 | 2,798
lung carcinoma 355 | 2,844
Carcinoma 351 | 2,147
pediatric high grade glioma 351 | 2,712
oligodendroglioma 342 | 2,849
pancreatic cancer 342 | 2,300
interstitial cystitis 320 | 2,299
subependymal giant cell astrocytoma 294 | 2,287
ependymoma 291 | 2,514
ulcerative colitis 288 | 2,087
pituitary cancer 285 | 1,972
ductal carcinoma in situ 271 | 1,745
astrocytic glioma 265 | 2,241
group 4 medulloblastoma 263 | 1,875
group 3 medulloblastoma 253 | 2,254
colon cancer 249 | 1,475
cystic fibrosis 244 | 1,665
adult high grade glioma 240 | 2,148
breast carcinoma 236 | 1,614
posterior fossa group A ependymoma 231 | 1,511
diabetes mellitus 220 | 1,663
Pick disease 216 | 1,893
adrenocortical carcinoma 213 | 1,427
astrocytoma 207 | 1,493
tuberculosis 205 | 1,557
primary pancreatic ductal adenocarcinoma 198 | 1,271
medulloblastoma 182 | 1,524
sonic hedgehog group medulloblastoma 181 | 1,482
pancreatic ductal adenocarcinoma liver metastasis 177 | 1,795
acute quadriplegic myopathy 176 | 1,157
posterior fossa group B ependymoma 169 | 1,530
Rheumatoid Arthritis 168 | 1,160
juvenile dermatomyositis 160 | 1,189
Obesity 147 | 616
Multiple myeloma 146 | 1,327
spina bifida 145 | 1,064
Endometriosis 144 | 535
cutaneous lupus erythematosus 141 | 1,056
nasopharyngeal carcinoma 141 | 1,056
Prostatic Neoplasms 139 | 471
gastric carcinoma 134 | 832
atypical teratoid/rhabdoid tumor 133 | 1,095
Mammary Neoplasms 132 | 410
Atopic dermatitis 131 | 944
dermatomyositis 126 | 933
Alzheimer's disease 121 | 644
Intellectual disability 118 | 573
active Crohn's disease 117 | 918
Down syndrome 114 | 548
esophageal adenocarcinoma 111 | 737
Infertility 109 | 163
Male infertility 109 | 170
autosomal dominant Emery-Dreifuss muscular dystrophy 106 | 499
aldosterone-producing adenoma 104 | 664
Duchenne muscular dystrophy 103 | 602
Kidney disease 100 | 396
primary Sjogren syndrome 96 | 789
Schizophrenia 91 | 501
Waldenstrons macroglobulinemia 90 | 765
non primary Sjogren syndrome sicca 88 | 840
Neurodegenerative disease 86 | 383
Amyotrophic Lateral Sclerosis 82 | 431
Autistic Disorder 82 | 320
Stomach Neoplasms 81 | 282
Asthma 77 | 349
Atherosclerosis 76 | 275
fibroadenoma 76 | 557
pancreatic carcinoma 76 | 567
progressive supranuclear palsy 75 | 674
Liver carcinoma 74 | 217
acute myeloid leukemia 74 | 780
chronic rhinosinusitis 74 | 512
Hypertension 73 | 287
Multiple Sclerosis 73 | 498
Colorectal Neoplasms 71 | 217
Lung Neoplasms 71 | 171
Polycystic Ovary Syndrome 69 | 332
tuberculosis and treatment for 6 months 69 | 686
Adenoma 68 | 165
Parkinson's disease 67 | 364
non-small cell lung carcinoma 67 | 413
Epilepsy 66 | 346
mucosa-associated lymphoid tissue lymphoma 66 | 480

Tissue

Endocrine System 1,855 | 18,512
Female tissues 1,854 | 18,647
Nervous System 1,850 | 18,561
Digestive Tract 1,849 | 18,473
Urinary Tract 1,847 | 18,444
Liver and Pancreas 1,831 | 18,136
Male tissues 1,826 | 17,969
Skin and soft tissues 1,826 | 18,115
Cardiovascular System 1,821 | 17,958
Blood and immune system 1,812 | 17,995
Respiratory system 1,768 | 17,484

Target Family

Non-IDG 898 | 11,971
Enzyme 394 | 4,146
Transcription Factor 208 | 1,400
Kinase 127 | 634
Epigenetic 66 | 242
GPCR 57 | 406
Ion Channel 45 | 341
Transporter 40 | 473
Nuclear Receptor 29 | 48
TF/Epigenetic 9 | 38

MGI Term

reproductive system phenotype 1,873 | 1,873
mortality/aging 4,850 | 4,850
homeostasis/metabolism phenoty... 4,454 | 4,454
growth/size/body region phenot... 3,915 | 3,915
cellular phenotype 3,348 | 3,348
nervous system phenotype 3,201 | 3,201
behavior/neurological phenotyp... 3,192 | 3,192
immune system phenotype 3,148 | 3,148
hematopoietic system phenotype 3,145 | 3,145
cardiovascular system phenotyp... 2,448 | 2,448
endocrine/exocrine gland pheno... 2,084 | 2,084
skeleton phenotype 2,058 | 2,058
normal phenotype 1,916 | 1,916
integument phenotype 1,748 | 1,748
embryo phenotype 1,674 | 1,674
vision/eye phenotype 1,478 | 1,478
muscle phenotype 1,385 | 1,385
digestive/alimentary phenotype 1,292 | 1,292
respiratory system phenotype 1,291 | 1,291
liver/biliary system phenotype 1,160 | 1,160
renal/urinary system phenotype 1,157 | 1,157
craniofacial phenotype 1,077 | 1,077
limbs/digits/tail phenotype 1,011 | 1,011
neoplasm 918 | 918
adipose tissue phenotype 901 | 901
hearing/vestibular/ear phenoty... 692 | 692
pigmentation phenotype 459 | 459
taste/olfaction phenotype 142 | 142
obsolete other phenotype 69 | 69

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
F-box only protein 47 FBXO47 Tdark Non-IDG 0.08 0.95 47
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Glial cell line-derived neurotrophic factor GDNF Tbio Non-IDG -3.30206 2301.5 303
Muellerian-inhibiting factor AMH Tbio Non-IDG -3.34520 2413.2 212
Insulin receptor-related protein INSRR Tchem Kinase -1.96888 93.2 241
Taste receptor type 1 member 1 TAS1R1 Tbio GPCR -1.71516 50.8 165