Development Level

Tbio 845 | 11,445
Tchem 267 | 1,598
Tclin 117 | 613
Tdark 40 | 6,588

Collection

Kinase: IDG Consortium (Target... 6 | 125
GPCR: IDG Consortium (Targets) 5 | 126
Kinase: IDG Consortium (Comple... 4 | 37
Ion Channel: IDG Consortium (T... 3 | 99
GPCR: IDG Consortium (Complete... 2 | 25

IMPC Phenotype

preweaning lethality, complete... 106 | 979
preweaning lethality, incomple... 60 | 499
abnormal behavior 33 | 298
abnormal kidney morphology 32 | 65
enlarged heart 30 | 210
decreased vertical activity 29 | 208
embryonic lethality prior to t... 28 | 278
decreased total body fat amoun... 27 | 207
hypoactivity 25 | 132
abnormal bone structure 24 | 187
abnormal embryo size 23 | 220
abnormal seminal vesicle morph... 23 | 114
increased total body fat amoun... 22 | 134
abnormal heart morphology 21 | 162
increased circulating alkaline... 21 | 122
increased lean body mass 20 | 172
decreased lymphocyte cell numb... 19 | 83
embryonic lethality prior to o... 19 | 239
decreased body weight 18 | 161
short tibia 17 | 97
decreased lean body mass 16 | 135
decreased mean corpuscular vol... 16 | 79
increased bone mineral content 16 | 108
decreased bone mineral density 15 | 126
decreased circulating glucose ... 15 | 126
hyperactivity 15 | 148
increased circulating HDL chol... 15 | 80
increased startle reflex 15 | 112
decreased circulating serum al... 14 | 82
edema 14 | 59
decreased bone mineral content 13 | 151
increased neutrophil cell numb... 13 | 46
abnormal eye morphology 12 | 68
decreased body length 12 | 101
decreased circulating choleste... 12 | 93
decreased grip strength 12 | 116
decreased leukocyte cell numbe... 12 | 73
improved glucose tolerance 12 | 79
increased blood urea nitrogen ... 12 | 48
small kidney 12 | 16
small superior vagus ganglion 12 | 74
decreased circulating HDL chol... 11 | 68
decreased hemoglobin content 11 | 68
decreased prepulse inhibition 11 | 82
embryonic growth retardation 11 | 106
increased or absent threshold ... 11 | 101
abnormal epididymis morphology 10 | 42
abnormal retina morphology 10 | 71
decreased circulating insulin ... 10 | 76
decreased circulating total pr... 10 | 49
decreased erythrocyte cell num... 10 | 62
decreased startle reflex 10 | 75
impaired glucose tolerance 10 | 75
increased bone mineral density 10 | 72
increased circulating potassiu... 10 | 29
increased fasted circulating g... 10 | 76
increased hemoglobin content 10 | 45
increased monocyte cell number 10 | 63
thrombocytopenia 10 | 56
abnormal lens morphology 9 | 81
decreased circulating triglyce... 9 | 79
increased circulating calcium ... 9 | 34
increased circulating choleste... 9 | 66
increased heart weight 9 | 62
polycystic kidney 9 | 15
abnormal cranium morphology 8 | 36
abnormal lung morphology 8 | 26
cataract 8 | 92
decreased mean corpuscular hem... 8 | 50
enlarged kidney 8 | 14
increased mean corpuscular hem... 8 | 96
increased mean corpuscular vol... 8 | 92
male infertility 8 | 123
abnormal coat-hair pigmentatio... 7 | 64
abnormal tooth morphology 7 | 24
decreased circulating LDL chol... 7 | 38
decreased circulating alkaline... 7 | 46
decreased circulating phosphat... 7 | 27
decreased fasted circulating g... 7 | 65
enlarged lymph nodes 7 | 37
increased circulating creatini... 7 | 38
increased circulating total pr... 7 | 28
increased erythrocyte cell num... 7 | 39
increased hematocrit 7 | 46
small testis 7 | 58
abnormal behavioral response t... 6 | 66
abnormal bone mineralization 6 | 38
abnormal gait 6 | 69
abnormal spleen morphology 6 | 55
abnormal vibrissa morphology 6 | 25
absent startle reflex 6 | 24
decreased circulating calcium ... 6 | 36
decreased hematocrit 6 | 46
decreased neutrophil cell numb... 6 | 42
enlarged spleen 6 | 41
increased circulating triglyce... 6 | 42
limb grasping 6 | 41
pallor 6 | 34
prenatal lethality prior to he... 6 | 87
thrombocytosis 6 | 27

Disease

Carcinoma 905 | 11,493
ovarian cancer 714 | 8,520
osteosarcoma 626 | 7,950
psoriasis 601 | 6,694
glioblastoma 516 | 5,792
medulloblastoma, large-cell 504 | 6,241
lung cancer 476 | 4,740
Cancer 461 | 2,499
atypical teratoid / rhabdoid tumor 414 | 5,112
ependymoma 387 | 4,679
Breast cancer 384 | 3,578
malignant mesothelioma 345 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 315 | 3,291
group 3 medulloblastoma 311 | 4,104
adult high grade glioma 308 | 3,801
intraductal papillary-mucinous adenoma (IPMA) 301 | 2,955
invasive ductal carcinoma 298 | 2,951
Astrocytoma, Pilocytic 292 | 3,081
lung carcinoma 291 | 2,843
Autosomal recessive predisposition 289 | 1,442
non-small cell lung cancer 289 | 2,890
pancreatic cancer 286 | 2,398
lung adenocarcinoma 282 | 2,716
Kidney cancer 281 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 278 | 2,989
interstitial cystitis 250 | 2,312
primitive neuroectodermal tumor 239 | 3,035
oligodendroglioma 233 | 2,850
diabetes mellitus 220 | 1,728
pituitary cancer 220 | 1,972
tuberculosis 219 | 2,010
cystic fibrosis 217 | 1,696
subependymal giant cell astrocytoma 217 | 2,287
ulcerative colitis 213 | 1,819
astrocytic glioma 210 | 2,597
pancreatic ductal adenocarcinoma liver metastasis 197 | 1,962
breast carcinoma 193 | 1,638
colon cancer 193 | 1,478
ductal carcinoma in situ 188 | 1,745
group 4 medulloblastoma 176 | 1,855
Kidney disease 174 | 430
Schizophrenia 170 | 1,160
Intellectual disability 168 | 1,016
adrenocortical carcinoma 160 | 1,428
Pick disease 154 | 1,894
primary pancreatic ductal adenocarcinoma 145 | 1,109
cutaneous lupus erythematosus 141 | 1,057
astrocytoma 140 | 1,146
Rheumatoid arthritis 139 | 1,191
Obesity 138 | 678
Dull intelligence 136 | 645
Low intelligence 136 | 645
Mental Retardation 136 | 645
Mental deficiency 136 | 645
Poor school performance 136 | 645
Epilepsy 130 | 792
Hypertension 127 | 396
Liver Cirrhosis, Experimental 127 | 769
acute quadriplegic myopathy 125 | 1,158
Hypertensive disease 123 | 292
Seizures 123 | 596
Short stature 122 | 531
juvenile dermatomyositis 118 | 1,187
spina bifida 109 | 1,074
Cognitive delay 108 | 608
Global developmental delay 108 | 608
Mental and motor retardation 108 | 608
Multiple myeloma 108 | 1,332
Bipolar Disorder 107 | 666
pediatric high grade glioma 107 | 1,064
Muscle hypotonia 106 | 571
Melanoma 103 | 711
gastric carcinoma 103 | 807
Atopic dermatitis 101 | 952
Breast Neoplasms 100 | 445
Prostatic Neoplasms 98 | 495
Mammary Neoplasms 96 | 425
nasopharyngeal carcinoma 95 | 1,058
Osteoporosis 94 | 363
dermatomyositis 94 | 966
Endometriosis 93 | 540
active Crohn's disease 93 | 922
Liver cancer 91 | 604
Alzheimer's disease 89 | 658
Failure to gain weight 89 | 365
Pediatric failure to thrive 89 | 365
Depressive disorder 88 | 409
Hepatomegaly 88 | 285
active ulcerative colitis 88 | 764
Anemia 85 | 365
Asthma 82 | 385
Down syndrome 82 | 499
autosomal dominant Emery-Dreifuss muscular dystrophy 82 | 510
esophageal adenocarcinoma 82 | 737
primary Sjogren syndrome 81 | 735
Atherosclerosis 80 | 291
Diarrhea 78 | 253
aldosterone-producing adenoma 78 | 665
Arthritis 77 | 290
Heart disease 77 | 306

Tissue

Endocrine System 1,239 | 18,159
Digestive Tract 1,236 | 17,369
Skin and soft tissues 1,220 | 17,230
Female tissues 1,218 | 17,400
Urinary Tract 1,215 | 16,678
Male tissues 1,213 | 17,142
Liver and Pancreas 1,195 | 16,750
Nervous System 1,189 | 16,725
Blood and immune system 1,185 | 16,909
Respiratory system 1,171 | 16,393
Cardiovascular System 1,092 | 15,192

Target Family

Non-IDG 605 | 12,091
Enzyme 284 | 4,145
Transcription Factor 116 | 1,400
Kinase 82 | 634
Transporter 68 | 473
GPCR 48 | 408
Ion Channel 34 | 344
Epigenetic 17 | 242
Nuclear Receptor 12 | 48
TF/Epigenetic 3 | 38

MGI Phenotype

renal-urinary system phenotype 1,269 | 1,269
mortality-aging 5,018 | 5,018
homeostasis-metabolism phenoty... 4,747 | 4,747
growth-size-body region phenot... 4,157 | 4,157
cellular phenotype 3,637 | 3,637
immune system phenotype 3,461 | 3,461
nervous system phenotype 3,447 | 3,447
behavior-neurological phenotyp... 3,401 | 3,401
hematopoietic system phenotype 3,383 | 3,383
cardiovascular system phenotyp... 2,660 | 2,660
endocrine-exocrine gland pheno... 2,293 | 2,293
skeleton phenotype 2,222 | 2,222
normal phenotype 1,999 | 1,999
reproductive system phenotype 1,999 | 1,999
integument phenotype 1,874 | 1,874
embryo phenotype 1,827 | 1,827
vision-eye phenotype 1,622 | 1,622
muscle phenotype 1,479 | 1,479
digestive-alimentary phenotype 1,398 | 1,398
respiratory system phenotype 1,390 | 1,390
liver-biliary system phenotype 1,300 | 1,300
craniofacial phenotype 1,182 | 1,182
limbs-digits-tail phenotype 1,071 | 1,071
adipose tissue phenotype 992 | 992
neoplasm 975 | 975
hearing-vestibular-ear phenoty... 767 | 767
pigmentation phenotype 506 | 506
taste-olfaction phenotype 147 | 147
no phenotypic analysis 5 | 5

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Neuroendocrine convertase 2 PCSK2 Tchem Enzyme -2.00248 109.8 132
Growth/differentiation factor 15 GDF15 Tbio Non-IDG -2.84344 761.3 702
Ras association domain-containing protein 5 RASSF5 Tbio Non-IDG -1.81149 71.3 155
DNA topoisomerase 3-beta-1 TOP3B Tbio Enzyme -1.06981 9.54 153
Bardet-Biedl syndrome 4 protein BBS4 Tbio Non-IDG -1.53435 31.5 200
Electrogenic sodium bicarbonate cotransporter 1 SLC4A4 Tbio Transporter -2.63743 436.2 124
ATPase family AAA domain-containing protein 2B ATAD2B Tchem Epigenetic 0.27 1.01 18
Extracellular matrix protein FRAS1 FRAS1 Tbio Non-IDG -1.51346 36.5 22
Isobutyryl-CoA dehydrogenase, mitochondrial ACAD8 Tbio Enzyme -1.14784 13.9 150
Relaxin receptor 2 RXFP2 Tbio GPCR -1.97913 85.3 207