Development Level

Tbio 734 | 10,625
Tchem 278 | 1,890
Tclin 114 | 602
Tdark 31 | 7,003

Collection

Eligible Ion Channel Proteins 5 | 117
Eligible Kinase Proteins 5 | 134
Eligible non-olfactory GPCR Proteins 4 | 143

IMPC Term

preweaning lethality, complete... 54 | 633
preweaning lethality, incomple... 30 | 260
abnormal behavior 25 | 226
decreased bone mineral density 23 | 126
decreased bone mineral content 20 | 157
decreased lean body mass 20 | 195
decreased total body fat amoun... 20 | 186
embryonic lethality prior to t... 20 | 187
abnormal bone structure 18 | 131
decreased body weight 17 | 174
enlarged heart 17 | 111
hypoactivity 16 | 89
increased circulating alkaline... 16 | 119
abnormal kidney morphology 15 | 30
abnormal bone mineralization 13 | 55
abnormal retina morphology 13 | 100
decreased body length 13 | 108
decreased circulating glucose ... 12 | 121
decreased circulating serum al... 12 | 79
decreased grip strength 12 | 123
increased bone mineral content 12 | 92
abnormal embryo size 11 | 112
decreased circulating triglyce... 11 | 83
embryonic lethality prior to o... 11 | 148
increased lean body mass 11 | 107
increased or absent threshold ... 11 | 128
decreased circulating choleste... 10 | 85
increased blood urea nitrogen ... 10 | 44
increased circulating HDL chol... 10 | 63
increased mean corpuscular hem... 10 | 93
short tibia 10 | 82
hyperactivity 9 | 108
increased bone mineral density 9 | 52
increased mean corpuscular vol... 9 | 91
increased total body fat amoun... 9 | 57
abnormal seminal vesicle morph... 8 | 47
abnormal tooth morphology 8 | 24
decreased circulating insulin ... 8 | 75
decreased heart weight 8 | 44
decreased hemoglobin content 8 | 53
decreased leukocyte cell numbe... 8 | 54
decreased prepulse inhibition 8 | 52
hydrops fetalis 8 | 22
increased body weight 8 | 42
increased hemoglobin content 8 | 45
thrombocytopenia 8 | 46
abnormal behavioral response t... 7 | 52
abnormal epididymis morphology 7 | 31
abnormal heart morphology 7 | 51
decreased circulating LDL chol... 7 | 37
decreased circulating alkaline... 7 | 41
decreased circulating total pr... 7 | 41
decreased erythrocyte cell num... 7 | 43
decreased kidney weight 7 | 7
decreased startle reflex 7 | 48
impaired glucose tolerance 7 | 52
increased circulating choleste... 7 | 53
increased grip strength 7 | 83
abnormal lens morphology 6 | 73
abnormal retinal pigmentation 6 | 61
decreased circulating HDL chol... 6 | 77
decreased circulating alanine ... 6 | 53
decreased mean corpuscular vol... 6 | 50
decreased rib number 6 | 59
enlarged lymph nodes 6 | 27
increased circulating calcium ... 6 | 32
increased circulating creatini... 6 | 29
increased circulating potassiu... 6 | 31
increased circulating triglyce... 6 | 24
increased fasted circulating g... 6 | 68
increased heart weight 6 | 37
abnormal coat/hair pigmentatio... 5 | 54
abnormal cranium morphology 5 | 32
abnormal gait 5 | 51
abnormal snout morphology 5 | 18
abnormal tail morphology 5 | 17
decreased circulating aspartat... 5 | 27
decreased circulating calcium ... 5 | 33
decreased circulating free fat... 5 | 39
decreased fasted circulating g... 5 | 49
decreased hematocrit 5 | 25
increased hematocrit 5 | 36
polycystic kidney 5 | 9
abnormal spleen morphology 4 | 36
absent startle reflex 4 | 15
decreased blood urea nitrogen ... 4 | 31
decreased lactate dehydrogenas... 4 | 14
decreased mean corpuscular hem... 4 | 34
enlarged spleen 4 | 26
female infertility 4 | 34
improved glucose tolerance 4 | 56
increased circulating aspartat... 4 | 17
increased circulating serum al... 4 | 25
increased circulating total pr... 4 | 20
increased mean corpuscular hem... 4 | 25
increased sacral vertebrae num... 4 | 62
male infertility 4 | 62
persistence of hyaloid vascula... 4 | 22
straub tail 4 | 26
thrombocytosis 4 | 23

Disease

ovarian cancer 658 | 8,484
osteosarcoma 565 | 7,933
psoriasis 552 | 6,685
medulloblastoma, large-cell 457 | 6,234
glioblastoma 444 | 5,572
lung cancer 431 | 4,466
Cancer 428 | 2,346
atypical teratoid / rhabdoid tumor 320 | 4,369
malignant mesothelioma 318 | 3,162
Breast cancer 306 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 288 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 285 | 2,956
invasive ductal carcinoma 280 | 2,950
lung carcinoma 273 | 2,844
pilocytic astrocytoma 269 | 3,086
lung adenocarcinoma 268 | 2,713
non-small cell lung cancer 261 | 2,798
intraductal papillary-mucinous carcinoma (IPMC) 259 | 2,988
pancreatic cancer 257 | 2,300
Carcinoma 252 | 2,147
interstitial cystitis 235 | 2,299
ulcerative colitis 226 | 2,087
pediatric high grade glioma 216 | 2,712
primitive neuroectodermal tumor 211 | 3,031
oligodendroglioma 209 | 2,849
cystic fibrosis 201 | 1,665
pituitary cancer 201 | 1,972
subependymal giant cell astrocytoma 201 | 2,287
diabetes mellitus 191 | 1,663
colon cancer 184 | 1,475
ependymoma 184 | 2,514
ductal carcinoma in situ 179 | 1,745
breast carcinoma 171 | 1,614
Kidney disease 165 | 396
tuberculosis 164 | 1,557
adult high grade glioma 162 | 2,148
group 4 medulloblastoma 162 | 1,875
astrocytoma 159 | 1,493
pancreatic ductal adenocarcinoma liver metastasis 158 | 1,795
primary pancreatic ductal adenocarcinoma 158 | 1,271
astrocytic glioma 157 | 2,241
group 3 medulloblastoma 149 | 2,254
adrenocortical carcinoma 146 | 1,427
Pick disease 142 | 1,893
posterior fossa group A ependymoma 132 | 1,511
cutaneous lupus erythematosus 131 | 1,056
Rheumatoid Arthritis 127 | 1,160
acute quadriplegic myopathy 122 | 1,157
Obesity 118 | 616
medulloblastoma 115 | 1,524
posterior fossa group B ependymoma 114 | 1,530
sonic hedgehog group medulloblastoma 114 | 1,482
juvenile dermatomyositis 111 | 1,189
gastric carcinoma 101 | 832
Multiple myeloma 100 | 1,327
Atopic dermatitis 94 | 944
Hypertension 94 | 287
Endometriosis 93 | 535
spina bifida 93 | 1,064
Prostatic Neoplasms 89 | 471
dermatomyositis 89 | 933
atypical teratoid/rhabdoid tumor 87 | 1,095
nasopharyngeal carcinoma 87 | 1,056
Mammary Neoplasms 85 | 410
active Crohn's disease 84 | 918
Alzheimer's disease 83 | 644
Down syndrome 80 | 548
primary Sjogren syndrome 79 | 789
esophageal adenocarcinoma 78 | 737
autosomal dominant Emery-Dreifuss muscular dystrophy 76 | 499
Duchenne muscular dystrophy 74 | 602
Intellectual disability 74 | 573
Heart disease 72 | 279
Asthma 71 | 349
Atherosclerosis 71 | 275
Hypertensive disease 71 | 193
aldosterone-producing adenoma 71 | 664
Vascular disease 68 | 281
nephrosclerosis 68 | 329
Cerebrovascular disease 66 | 231
Multiple Sclerosis 63 | 498
pancreatic carcinoma 63 | 567
Osteoporosis 60 | 257
Schizophrenia 60 | 501
Coronary artery disease 59 | 240
Arthritis 58 | 248
acute myeloid leukemia 58 | 780
non primary Sjogren syndrome sicca 58 | 840
Stomach Neoplasms 57 | 282
non-small cell lung carcinoma 56 | 413
Adenoma 55 | 165
Liver disease 55 | 219
Neurodegenerative disease 55 | 383
Autistic Disorder 54 | 320
Waldenstrons macroglobulinemia 54 | 765
active ulcerative colitis 54 | 477
fibroadenoma 54 | 557
mucosa-associated lymphoid tissue lymphoma 54 | 480
Anemia 53 | 252
chronic rhinosinusitis 53 | 512

Tissue

Digestive Tract 1,151 | 18,473
Nervous System 1,150 | 18,561
Female tissues 1,148 | 18,647
Urinary Tract 1,148 | 18,444
Endocrine System 1,147 | 18,512
Liver and Pancreas 1,141 | 18,136
Skin and soft tissues 1,138 | 18,115
Cardiovascular System 1,137 | 17,958
Blood and immune system 1,131 | 17,995
Male tissues 1,131 | 17,969
Respiratory system 1,121 | 17,484

Target Family

Non-IDG 538 | 11,971
Enzyme 256 | 4,146
Transcription Factor 114 | 1,400
Kinase 79 | 634
Transporter 63 | 473
GPCR 45 | 406
Ion Channel 34 | 341
Epigenetic 13 | 242
Nuclear Receptor 12 | 48
TF/Epigenetic 3 | 38

MGI Term

renal/urinary system phenotype 1,157 | 1,157
mortality/aging 4,850 | 4,850
homeostasis/metabolism phenoty... 4,454 | 4,454
growth/size/body region phenot... 3,915 | 3,915
cellular phenotype 3,348 | 3,348
nervous system phenotype 3,201 | 3,201
behavior/neurological phenotyp... 3,192 | 3,192
immune system phenotype 3,148 | 3,148
hematopoietic system phenotype 3,145 | 3,145
cardiovascular system phenotyp... 2,448 | 2,448
endocrine/exocrine gland pheno... 2,084 | 2,084
skeleton phenotype 2,058 | 2,058
normal phenotype 1,916 | 1,916
reproductive system phenotype 1,873 | 1,873
integument phenotype 1,748 | 1,748
embryo phenotype 1,674 | 1,674
vision/eye phenotype 1,478 | 1,478
muscle phenotype 1,385 | 1,385
digestive/alimentary phenotype 1,292 | 1,292
respiratory system phenotype 1,291 | 1,291
liver/biliary system phenotype 1,160 | 1,160
craniofacial phenotype 1,077 | 1,077
limbs/digits/tail phenotype 1,011 | 1,011
neoplasm 918 | 918
adipose tissue phenotype 901 | 901
hearing/vestibular/ear phenoty... 692 | 692
pigmentation phenotype 459 | 459
taste/olfaction phenotype 142 | 142
obsolete other phenotype 69 | 69

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
G2/mitotic-specific cyclin-B1 CCNB1 Tchem Non-IDG -3.09727 1121.4 955
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.11372 127.6 466
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Glial cell line-derived neurotrophic factor GDNF Tbio Non-IDG -3.30206 2301.5 303
Insulin receptor-related protein INSRR Tchem Kinase -1.96888 93.2 241
Zinc finger protein 148 ZNF148 Tbio Transcription Factor -1.71996 60.7 178
Programmed cell death protein 4 PDCD4 Tchem Non-IDG -2.40380 284.9 546
Solute carrier family 13 member 1 SLC13A1 Tbio Transporter -1.70334 62.7 18