Development Level

Tbio 1,254 | 10,625
Tchem 390 | 1,890
Tclin 155 | 602
Tdark 117 | 7,003

Collection

Eligible Ion Channel Proteins 16 | 117
Eligible Kinase Proteins 11 | 134
Eligible non-olfactory GPCR Proteins 9 | 145

IMPC Term

preweaning lethality, complete... 74 | 633
preweaning lethality, incomple... 38 | 260
abnormal behavior 36 | 226
embryonic lethality prior to t... 33 | 187
decreased lean body mass 31 | 195
decreased bone mineral content 26 | 157
decreased total body fat amoun... 26 | 186
abnormal bone structure 24 | 131
decreased body weight 23 | 174
decreased bone mineral density 18 | 126
decreased grip strength 18 | 123
increased lean body mass 18 | 107
increased or absent threshold ... 18 | 128
decreased circulating glucose ... 17 | 121
abnormal embryo size 16 | 112
embryonic lethality prior to o... 16 | 148
abnormal bone mineralization 15 | 55
abnormal retina morphology 15 | 100
decreased body length 15 | 108
enlarged heart 14 | 111
hyperactivity 14 | 108
increased total body fat amoun... 14 | 57
hypoactivity 13 | 89
increased circulating alkaline... 13 | 119
increased mean corpuscular hem... 13 | 93
abnormal eye morphology 12 | 38
abnormal gait 12 | 51
decreased circulating insulin ... 12 | 75
increased blood urea nitrogen ... 12 | 44
increased circulating choleste... 12 | 53
decreased prepulse inhibition 11 | 52
increased circulating HDL chol... 11 | 63
abnormal lens morphology 10 | 73
decreased circulating choleste... 10 | 85
decreased circulating triglyce... 10 | 83
increased heart weight 10 | 37
short tibia 10 | 82
decreased circulating HDL chol... 9 | 77
decreased circulating alkaline... 9 | 41
decreased circulating iron lev... 9 | 25
impaired glucose tolerance 9 | 52
increased grip strength 9 | 83
increased mean corpuscular vol... 9 | 91
prenatal lethality prior to he... 9 | 64
abnormal retinal pigmentation 8 | 61
abnormal seminal vesicle morph... 8 | 47
abnormal sleep behavior 8 | 63
decreased fasted circulating g... 8 | 49
decreased hemoglobin content 8 | 53
decreased rib number 8 | 59
improved glucose tolerance 8 | 56
increased body weight 8 | 42
increased circulating calcium ... 8 | 32
increased circulating sodium l... 8 | 71
increased fasted circulating g... 8 | 68
limb grasping 8 | 35
thrombocytopenia 8 | 46
tremors 8 | 34
abnormal heart morphology 7 | 51
abnormal locomotor activation 7 | 26
decreased erythrocyte cell num... 7 | 43
decreased heart weight 7 | 44
decreased mean corpuscular vol... 7 | 50
decreased startle reflex 7 | 48
increased bone mineral content 7 | 92
increased hemoglobin content 7 | 45
abnormal coat/hair pigmentatio... 6 | 54
corneal opacity 6 | 25
decreased mature B cell number 6 | 25
hydrops fetalis 6 | 22
increased circulating triglyce... 6 | 24
increased hematocrit 6 | 36
increased leukocyte cell numbe... 6 | 37
male infertility 6 | 62
abnormal QRS complex 5 | 25
abnormal behavioral response t... 5 | 52
abnormal cornea morphology 5 | 24
abnormal hindbrain development 5 | 24
abnormal kidney morphology 5 | 30
abnormal limb bud morphology 5 | 15
abnormal neural tube closure 5 | 37
abnormal testis morphology 5 | 30
abnormal tooth morphology 5 | 24
cataract 5 | 26
decreased CD4-positive, CD25-p... 5 | 24
decreased blood urea nitrogen ... 5 | 31
decreased circulating total pr... 5 | 41
decreased lumbar vertebrae num... 5 | 62
decreased spleen weight 5 | 13
decreased vertical activity 5 | 22
enlarged lymph nodes 5 | 27
female infertility 5 | 34
increased body length 5 | 20
increased bone mineral density 5 | 52
increased circulating phosphat... 5 | 24
increased circulating serum al... 5 | 25
increased sacral vertebrae num... 5 | 62
microphthalmia 5 | 15
small testis 5 | 37
cardiovascular system phenotyp... 4 | 35

Disease

ovarian cancer 999 | 8,492
osteosarcoma 896 | 7,933
psoriasis 823 | 6,685
medulloblastoma, large-cell 789 | 6,234
glioblastoma 742 | 5,572
lung cancer 619 | 4,473
Cancer 610 | 2,346
atypical teratoid / rhabdoid tumor 571 | 4,369
malignant mesothelioma 484 | 3,163
pilocytic astrocytoma 460 | 3,086
Breast cancer 447 | 3,099
invasive ductal carcinoma 441 | 2,950
oligodendroglioma 429 | 2,849
non-small cell lung cancer 427 | 2,798
lung adenocarcinoma 412 | 2,714
lung carcinoma 409 | 2,844
primitive neuroectodermal tumor 405 | 3,031
pediatric high grade glioma 400 | 2,712
intraductal papillary-mucinous neoplasm (IPMN) 399 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 392 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 388 | 2,988
Carcinoma 354 | 2,147
interstitial cystitis 349 | 2,299
pancreatic cancer 347 | 2,300
ependymoma 340 | 2,514
subependymal giant cell astrocytoma 314 | 2,287
ulcerative colitis 313 | 2,087
pituitary cancer 309 | 1,972
cystic fibrosis 280 | 1,670
ductal carcinoma in situ 275 | 1,745
astrocytic glioma 271 | 2,241
breast carcinoma 269 | 1,614
group 4 medulloblastoma 265 | 1,875
astrocytoma 261 | 1,493
adult high grade glioma 247 | 2,148
group 3 medulloblastoma 245 | 2,254
diabetes mellitus 236 | 1,663
Pick disease 235 | 1,893
adrenocortical carcinoma 228 | 1,427
colon cancer 224 | 1,475
posterior fossa group A ependymoma 215 | 1,511
medulloblastoma 214 | 1,524
primary pancreatic ductal adenocarcinoma 214 | 1,271
tuberculosis 212 | 1,563
sonic hedgehog group medulloblastoma 200 | 1,482
Rheumatoid Arthritis 199 | 1,171
pancreatic ductal adenocarcinoma liver metastasis 172 | 1,795
cutaneous lupus erythematosus 164 | 1,056
juvenile dermatomyositis 163 | 1,189
atypical teratoid/rhabdoid tumor 161 | 1,095
acute quadriplegic myopathy 159 | 1,157
posterior fossa group B ependymoma 144 | 1,530
dermatomyositis 143 | 967
Alzheimer's disease 142 | 644
spina bifida 141 | 1,064
Multiple myeloma 139 | 1,328
gastric carcinoma 137 | 832
nasopharyngeal carcinoma 134 | 1,056
Mammary Neoplasms 132 | 410
Atopic dermatitis 131 | 944
Obesity 127 | 616
Endometriosis 121 | 535
Down syndrome 117 | 548
Prostatic Neoplasms 115 | 471
active Crohn's disease 115 | 918
primary Sjogren syndrome 113 | 789
Kidney disease 110 | 397
Duchenne muscular dystrophy 109 | 602
Schizophrenia 109 | 503
Waldenstrons macroglobulinemia 106 | 765
esophageal adenocarcinoma 106 | 737
autosomal dominant Emery-Dreifuss muscular dystrophy 103 | 499
acute myeloid leukemia 100 | 785
aldosterone-producing adenoma 100 | 664
Intellectual disability 95 | 573
Parkinson's disease 91 | 364
fibroadenoma 87 | 557
non primary Sjogren syndrome sicca 87 | 840
Autistic Disorder 83 | 320
Amyotrophic Lateral Sclerosis 82 | 432
pancreatic carcinoma 80 | 567
Asthma 78 | 349
Multiple Sclerosis 78 | 498
non-small cell lung carcinoma 77 | 413
Heart disease 74 | 279
Hypertension 73 | 293
Vascular disease 73 | 281
Epilepsy 72 | 346
Neurodegenerative disease 72 | 383
mucosa-associated lymphoid tissue lymphoma 71 | 480
Stomach Neoplasms 69 | 282
IGA Glomerulonephritis 67 | 454
Lung Neoplasms 67 | 171
gastric cancer 65 | 436
Cerebrovascular disease 64 | 231
Liver carcinoma 64 | 217
Atherosclerosis 63 | 275
Polycystic Ovary Syndrome 63 | 335
hepatocellular carcinoma 63 | 550
active ulcerative colitis 62 | 477

Tissue

Endocrine System 1,898 | 18,512
Nervous System 1,898 | 18,561
Female tissues 1,895 | 18,647
Digestive Tract 1,889 | 18,473
Urinary Tract 1,882 | 18,444
Skin and soft tissues 1,871 | 18,115
Liver and Pancreas 1,869 | 18,136
Male tissues 1,862 | 17,969
Cardiovascular System 1,856 | 17,958
Blood and immune system 1,855 | 17,995
Respiratory system 1,831 | 17,484

Target Family

Non-IDG 899 | 11,969
Enzyme 356 | 4,146
Transcription Factor 273 | 1,400
Kinase 147 | 634
GPCR 71 | 408
Ion Channel 59 | 341
Epigenetic 49 | 242
Transporter 27 | 473
Nuclear Receptor 23 | 48
TF/Epigenetic 11 | 38
oGPCR 1 | 421

MGI Term

normal phenotype 1,916 | 1,916
mortality/aging 4,850 | 4,850
homeostasis/metabolism phenoty... 4,454 | 4,454
growth/size/body region phenot... 3,915 | 3,915
cellular phenotype 3,348 | 3,348
nervous system phenotype 3,201 | 3,201
behavior/neurological phenotyp... 3,192 | 3,192
immune system phenotype 3,148 | 3,148
hematopoietic system phenotype 3,145 | 3,145
cardiovascular system phenotyp... 2,448 | 2,448
endocrine/exocrine gland pheno... 2,084 | 2,084
skeleton phenotype 2,058 | 2,058
reproductive system phenotype 1,873 | 1,873
integument phenotype 1,748 | 1,748
embryo phenotype 1,674 | 1,674
vision/eye phenotype 1,478 | 1,478
muscle phenotype 1,385 | 1,385
digestive/alimentary phenotype 1,292 | 1,292
respiratory system phenotype 1,291 | 1,291
liver/biliary system phenotype 1,160 | 1,160
renal/urinary system phenotype 1,157 | 1,157
craniofacial phenotype 1,077 | 1,077
limbs/digits/tail phenotype 1,011 | 1,011
neoplasm 918 | 918
adipose tissue phenotype 901 | 901
hearing/vestibular/ear phenoty... 692 | 692
pigmentation phenotype 459 | 459
taste/olfaction phenotype 142 | 142
obsolete other phenotype 69 | 69

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
NACHT, LRR and PYD domains-containing protein 3 NLRP3 Tchem Non-IDG -3.22772 1655.7 459
Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B Tbio Non-IDG -2.59865 595.2 386
Protein C-ets-2 ETS2 Tbio Transcription Factor -2.39443 244.9 192
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha PIP5K1A Tbio Kinase -0.55632 4.98 106
Plakophilin-3 PKP3 Tbio Non-IDG -1.31567 24.3 165
Zinc finger protein ZFPM2 ZFPM2 Tbio Transcription Factor -1.75745 57.5 78
Paired mesoderm homeobox protein 2 PRRX2 Tbio Transcription Factor -0.73611 6.19 114
Rho GDP-dissociation inhibitor 3 ARHGDIG Tbio Non-IDG -0.79022 8.54 95
Tumor susceptibility gene 101 protein TSG101 Tbio Non-IDG -2.44656 282.1 289
Limb region 1 protein homolog LMBR1 Tbio Non-IDG -2.37910 241.6 103