Development Level

Tbio 1,362 | 11,445
Tchem 362 | 1,598
Tclin 157 | 613
Tdark 118 | 6,588

Collection

RFA-RM-18-021 34 | 328
Ion Channel: IDG Consortium (T... 15 | 99
Kinase: IDG Consortium (Target... 11 | 125
GPCR: IDG Consortium (Targets) 9 | 126
GPCR: IDG Consortium (Complete... 8 | 25
Kinase: IDG Consortium (Comple... 5 | 37

IMPC Phenotype

preweaning lethality, complete... 137 | 979
preweaning lethality, incomple... 72 | 499
embryonic lethality prior to t... 47 | 278
abnormal behavior 46 | 298
decreased vertical activity 39 | 208
abnormal bone structure 33 | 187
increased total body fat amoun... 32 | 134
abnormal embryo size 31 | 220
decreased total body fat amoun... 30 | 207
increased lean body mass 30 | 172
embryonic lethality prior to o... 29 | 239
decreased body weight 26 | 161
decreased bone mineral content 26 | 151
enlarged heart 26 | 210
abnormal heart morphology 22 | 162
decreased lean body mass 22 | 135
hypoactivity 21 | 132
abnormal seminal vesicle morph... 20 | 114
decreased circulating glucose ... 20 | 126
increased startle reflex 20 | 112
hyperactivity 19 | 148
decreased bone mineral density 18 | 126
decreased circulating choleste... 17 | 93
increased circulating alkaline... 17 | 122
prenatal lethality prior to he... 17 | 87
abnormal gait 16 | 69
impaired glucose tolerance 16 | 75
decreased lymphocyte cell numb... 15 | 83
decreased grip strength 14 | 116
increased bone mineral content 14 | 108
increased mean corpuscular hem... 14 | 96
abnormal eye morphology 13 | 68
abnormal retina morphology 13 | 71
decreased body length 13 | 101
decreased circulating insulin ... 13 | 76
decreased prepulse inhibition 13 | 82
increased circulating HDL chol... 13 | 80
increased circulating choleste... 13 | 66
decreased circulating HDL chol... 12 | 68
improved glucose tolerance 12 | 79
increased mean corpuscular vol... 12 | 92
increased monocyte cell number 12 | 63
increased neutrophil cell numb... 12 | 46
abnormal lens morphology 11 | 81
decreased circulating iron lev... 11 | 32
decreased mean corpuscular vol... 11 | 79
edema 11 | 59
embryonic growth retardation 11 | 106
increased heart weight 11 | 62
male infertility 11 | 123
abnormal kidney morphology 10 | 65
abnormal sleep behavior 10 | 70
cataract 10 | 92
decreased erythrocyte cell num... 10 | 62
decreased hemoglobin content 10 | 68
increased circulating sodium l... 10 | 71
increased circulating triglyce... 10 | 42
increased or absent threshold ... 10 | 101
short tibia 10 | 97
abnormal skin morphology 9 | 50
decreased circulating alkaline... 9 | 46
decreased circulating triglyce... 9 | 79
increased circulating chloride... 9 | 41
increased circulating iron lev... 9 | 30
increased fasted circulating g... 9 | 76
increased hemoglobin content 9 | 45
limb grasping 9 | 41
thrombocytopenia 9 | 56
tremors 9 | 39
abnormal epididymis morphology 8 | 42
decreased fasted circulating g... 8 | 65
decreased neutrophil cell numb... 8 | 42
decreased startle reflex 8 | 75
female infertility 8 | 60
increased blood urea nitrogen ... 8 | 48
increased bone mineral density 8 | 72
increased circulating serum al... 8 | 22
microphthalmia 8 | 26
abnormal bone mineralization 7 | 38
abnormal retinal blood vessel ... 7 | 26
abnormal retinal vasculature m... 7 | 27
abnormal testis morphology 7 | 43
anophthalmia 7 | 33
corneal opacity 7 | 32
decreased circulating amylase ... 7 | 28
decreased circulating serum al... 7 | 82
decreased heart weight 7 | 27
decreased hematocrit 7 | 46
decreased leukocyte cell numbe... 7 | 73
enlarged lymph nodes 7 | 37
increased body weight 7 | 25
increased circulating amylase ... 7 | 25
increased circulating creatini... 7 | 38
increased circulating glucose ... 7 | 24
increased circulating total pr... 7 | 28
small superior vagus ganglion 7 | 74
abnormal coat-hair pigmentatio... 6 | 64
decreased circulating total pr... 6 | 49
decreased spleen weight 6 | 10
pallor 6 | 34

Disease

Carcinoma 1,373 | 11,493
ovarian cancer 1,040 | 8,520
osteosarcoma 933 | 7,950
psoriasis 853 | 6,694
medulloblastoma, large-cell 826 | 6,241
glioblastoma 813 | 5,792
atypical teratoid / rhabdoid tumor 712 | 5,112
lung cancer 671 | 4,740
Cancer 653 | 2,499
ependymoma 630 | 4,679
Breast cancer 548 | 3,578
group 3 medulloblastoma 532 | 4,104
adult high grade glioma 515 | 3,801
malignant mesothelioma 514 | 3,232
Astrocytoma, Pilocytic 462 | 3,081
non-small cell lung cancer 450 | 2,890
invasive ductal carcinoma 447 | 2,951
oligodendroglioma 444 | 2,850
lung carcinoma 423 | 2,843
lung adenocarcinoma 421 | 2,716
primitive neuroectodermal tumor 420 | 3,035
Kidney cancer 419 | 2,613
intraductal papillary-mucinous neoplasm (IPMN) 412 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 406 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 400 | 2,989
pancreatic cancer 380 | 2,398
astrocytic glioma 366 | 2,597
interstitial cystitis 358 | 2,312
subependymal giant cell astrocytoma 327 | 2,287
pituitary cancer 318 | 1,972
cystic fibrosis 289 | 1,696
breast carcinoma 287 | 1,638
ductal carcinoma in situ 279 | 1,745
ulcerative colitis 275 | 1,819
Schizophrenia 267 | 1,160
tuberculosis 267 | 2,010
diabetes mellitus 256 | 1,728
group 4 medulloblastoma 246 | 1,855
Pick disease 244 | 1,894
adrenocortical carcinoma 235 | 1,428
colon cancer 228 | 1,478
Autosomal recessive predisposition 220 | 1,442
pancreatic ductal adenocarcinoma liver metastasis 206 | 1,962
Rheumatoid arthritis 204 | 1,191
primary pancreatic ductal adenocarcinoma 192 | 1,109
astrocytoma 187 | 1,146
Intellectual disability 184 | 1,016
juvenile dermatomyositis 170 | 1,187
Epilepsy 166 | 792
cutaneous lupus erythematosus 166 | 1,057
acute quadriplegic myopathy 164 | 1,158
pediatric high grade glioma 157 | 1,064
Bipolar Disorder 155 | 666
spina bifida 151 | 1,074
Alzheimer's disease 149 | 658
Obesity 149 | 678
Liver Cirrhosis, Experimental 147 | 769
dermatomyositis 146 | 966
Multiple myeloma 145 | 1,332
Melanoma 140 | 711
nasopharyngeal carcinoma 140 | 1,058
Breast Neoplasms 138 | 445
Seizures 138 | 596
gastric carcinoma 137 | 807
Dull intelligence 136 | 645
Low intelligence 136 | 645
Mammary Neoplasms 136 | 425
Mental Retardation 136 | 645
Mental deficiency 136 | 645
Poor school performance 136 | 645
Atopic dermatitis 134 | 952
Short stature 131 | 531
Endometriosis 124 | 540
Liver cancer 123 | 604
Cognitive delay 122 | 608
Global developmental delay 122 | 608
Mental and motor retardation 122 | 608
Prostatic Neoplasms 122 | 495
active Crohn's disease 120 | 922
medulloblastoma 118 | 720
Kidney disease 113 | 430
Depressive disorder 111 | 409
Duchenne muscular dystrophy 111 | 601
Muscle hypotonia 111 | 571
esophageal adenocarcinoma 111 | 737
Down syndrome 109 | 499
Waldenstrons macroglobulinemia 108 | 765
autosomal dominant Emery-Dreifuss muscular dystrophy 107 | 510
active ulcerative colitis 106 | 764
non primary Sjogren syndrome sicca 106 | 891
Hypertension 105 | 396
acute myeloid leukemia 102 | 783
primary Sjogren syndrome 102 | 735
aldosterone-producing adenoma 101 | 665
Parkinson's disease 98 | 392
Skin cancer 96 | 469
Autistic Disorder 94 | 364
Major Depressive Disorder 92 | 301
Multiple Sclerosis 88 | 540
fibroadenoma 87 | 559

Tissue

Endocrine System 1,943 | 18,159
Digestive Tract 1,904 | 17,369
Skin and soft tissues 1,883 | 17,230
Female tissues 1,878 | 17,400
Male tissues 1,860 | 17,142
Blood and immune system 1,837 | 16,909
Nervous System 1,831 | 16,725
Urinary Tract 1,831 | 16,678
Liver and Pancreas 1,827 | 16,750
Respiratory system 1,784 | 16,393
Cardiovascular System 1,680 | 15,192

Target Family

Non-IDG 943 | 12,091
Enzyme 380 | 4,145
Transcription Factor 277 | 1,400
Kinase 150 | 634
GPCR 73 | 408
Ion Channel 61 | 344
Epigenetic 51 | 242
Transporter 29 | 473
Nuclear Receptor 23 | 48
TF/Epigenetic 11 | 38
oGPCR 1 | 421

MGI Phenotype

normal phenotype 1,999 | 1,999
mortality-aging 5,018 | 5,018
homeostasis-metabolism phenoty... 4,747 | 4,747
growth-size-body region phenot... 4,157 | 4,157
cellular phenotype 3,637 | 3,637
immune system phenotype 3,461 | 3,461
nervous system phenotype 3,447 | 3,447
behavior-neurological phenotyp... 3,401 | 3,401
hematopoietic system phenotype 3,383 | 3,383
cardiovascular system phenotyp... 2,660 | 2,660
endocrine-exocrine gland pheno... 2,293 | 2,293
skeleton phenotype 2,222 | 2,222
reproductive system phenotype 1,999 | 1,999
integument phenotype 1,874 | 1,874
embryo phenotype 1,827 | 1,827
vision-eye phenotype 1,622 | 1,622
muscle phenotype 1,479 | 1,479
digestive-alimentary phenotype 1,398 | 1,398
respiratory system phenotype 1,390 | 1,390
liver-biliary system phenotype 1,300 | 1,300
renal-urinary system phenotype 1,269 | 1,269
craniofacial phenotype 1,182 | 1,182
limbs-digits-tail phenotype 1,071 | 1,071
adipose tissue phenotype 992 | 992
neoplasm 975 | 975
hearing-vestibular-ear phenoty... 767 | 767
pigmentation phenotype 506 | 506
taste-olfaction phenotype 147 | 147
no phenotypic analysis 5 | 5

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Probable global transcription activator SNF2L1 SMARCA1 Tbio Non-IDG -2.20560 145.6 116
Pyruvate kinase PKLR PKLR Tbio Kinase -2.37549 231.1 391
Anaphase-promoting complex subunit 2 ANAPC2 Tbio Enzyme -0.45557 2.44 166
Rab-3A-interacting protein RAB3IP Tbio Non-IDG -1.03500 11.6 89
CCAAT/enhancer-binding protein beta CEBPB Tbio Transcription Factor -2.96589 857.9 436
Protein pelota homolog PELO Tbio Non-IDG -1.33842 18.2 100
Choline O-acetyltransferase CHAT Tchem Enzyme -3.40175 2597.2 436
Putative methyl-CpG-binding domain protein 3-like 4 MBD3L4 Tdark Non-IDG 0.00000 0
Transient receptor potential cation channel subfamily M member 2 TRPM2 Tchem Ion Channel -1.34318 25.1 209
Pro-neuregulin-4, membrane-bound isoform NRG4 Tbio Non-IDG -1.33564 24.6 137