Development Level

Tbio 2,461 | 11,445
Tchem 548 | 1,598
Tclin 281 | 613
Tdark 157 | 6,588

Collection

RFA-RM-18-021 56 | 328
Ion Channel: IDG Consortium (T... 30 | 99
Kinase: IDG Consortium (Target... 19 | 125
Kinase: IDG Consortium (Comple... 10 | 37
GPCR: IDG Consortium (Targets) 9 | 126
GPCR: IDG Consortium (Complete... 7 | 25

IMPC Phenotype

preweaning lethality, complete... 290 | 979
preweaning lethality, incomple... 160 | 499
embryonic lethality prior to t... 102 | 278
abnormal behavior 98 | 298
abnormal embryo size 89 | 220
abnormal bone structure 67 | 187
decreased vertical activity 64 | 208
enlarged heart 61 | 210
decreased prepulse inhibition 59 | 82
decreased total body fat amoun... 59 | 207
decreased body weight 57 | 161
abnormal heart morphology 52 | 162
embryonic lethality prior to o... 52 | 239
increased lean body mass 51 | 172
hypoactivity 49 | 132
hyperactivity 48 | 148
increased total body fat amoun... 48 | 134
increased startle reflex 47 | 112
decreased bone mineral content 46 | 151
embryonic growth retardation 46 | 106
decreased lean body mass 42 | 135
decreased circulating glucose ... 39 | 126
abnormal seminal vesicle morph... 37 | 114
increased bone mineral content 37 | 108
small superior vagus ganglion 36 | 74
decreased grip strength 35 | 116
abnormal neural tube closure 33 | 46
decreased startle reflex 33 | 75
abnormal gait 32 | 69
abnormal retina morphology 32 | 71
increased circulating alkaline... 32 | 122
increased or absent threshold ... 32 | 101
decreased body length 30 | 101
decreased bone mineral density 30 | 126
impaired glucose tolerance 30 | 75
decreased circulating serum al... 29 | 82
decreased fasted circulating g... 29 | 65
abnormal sleep behavior 28 | 70
decreased hemoglobin content 28 | 68
decreased mean corpuscular vol... 28 | 79
increased mean corpuscular vol... 28 | 92
prenatal lethality prior to he... 28 | 87
abnormal eye morphology 27 | 68
decreased circulating choleste... 27 | 93
male infertility 27 | 123
short tibia 27 | 97
decreased circulating insulin ... 26 | 76
edema 26 | 59
increased mean corpuscular hem... 26 | 96
decreased circulating triglyce... 25 | 79
improved glucose tolerance 25 | 79
increased circulating sodium l... 24 | 71
limb grasping 24 | 41
increased heart weight 23 | 62
increased bone mineral density 22 | 72
increased circulating chloride... 22 | 41
increased fasted circulating g... 22 | 76
cataract 21 | 92
decreased blood urea nitrogen ... 21 | 51
decreased circulating HDL chol... 21 | 68
decreased lymphocyte cell numb... 21 | 83
enlarged lymph nodes 21 | 37
increased circulating choleste... 21 | 66
tremors 21 | 39
decreased erythrocyte cell num... 20 | 62
increased circulating HDL chol... 20 | 80
increased circulating triglyce... 20 | 42
increased monocyte cell number 20 | 63
increased prepulse inhibition 20 | 32
small testis 20 | 58
abnormal behavioral response t... 19 | 66
abnormal craniofacial morpholo... 18 | 33
abnormal lens morphology 18 | 81
decreased circulating total pr... 18 | 49
hydrometra 18 | 53
decreased circulating amylase ... 17 | 28
increased leukocyte cell numbe... 17 | 47
thrombocytopenia 17 | 56
abnormal epididymis morphology 16 | 42
increased blood urea nitrogen ... 16 | 48
pale yolk sac 16 | 25
pallor 16 | 34
abnormal bone mineralization 15 | 38
abnormal coat-hair pigmentatio... 15 | 64
abnormal cranium morphology 15 | 36
abnormal pericardium morpholog... 15 | 26
abnormal skin morphology 15 | 50
decreased caudal vertebrae num... 15 | 53
decreased leukocyte cell numbe... 15 | 73
impaired pupillary reflex 15 | 26
abnormal embryo turning 14 | 31
abnormal kidney morphology 14 | 65
abnormal testis morphology 14 | 43
decreased circulating alkaline... 14 | 46
hemorrhage 14 | 23
increased hemoglobin content 14 | 45
increased mean platelet volume 14 | 45
increased neutrophil cell numb... 14 | 46
microphthalmia 14 | 26
persistence of hyaloid vascula... 14 | 33

Disease

Carcinoma 2,488 | 11,493
ovarian cancer 1,793 | 8,520
osteosarcoma 1,601 | 7,950
medulloblastoma, large-cell 1,595 | 6,241
glioblastoma 1,562 | 5,792
psoriasis 1,505 | 6,694
atypical teratoid / rhabdoid tumor 1,411 | 5,112
ependymoma 1,309 | 4,679
lung cancer 1,186 | 4,740
group 3 medulloblastoma 1,093 | 4,104
adult high grade glioma 1,068 | 3,801
Breast cancer 940 | 3,578
Astrocytoma, Pilocytic 926 | 3,081
Cancer 923 | 2,499
oligodendroglioma 899 | 2,850
primitive neuroectodermal tumor 865 | 3,035
malignant mesothelioma 863 | 3,232
Kidney cancer 841 | 2,613
astrocytic glioma 788 | 2,597
lung carcinoma 730 | 2,843
invasive ductal carcinoma 713 | 2,951
intraductal papillary-mucinous neoplasm (IPMN) 703 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 677 | 2,955
non-small cell lung cancer 676 | 2,890
subependymal giant cell astrocytoma 675 | 2,287
lung adenocarcinoma 661 | 2,716
intraductal papillary-mucinous carcinoma (IPMC) 646 | 2,989
Schizophrenia 594 | 1,160
Autosomal recessive predisposition 584 | 1,442
pancreatic cancer 580 | 2,398
pituitary cancer 578 | 1,972
Pick disease 547 | 1,894
interstitial cystitis 527 | 2,312
Intellectual disability 526 | 1,016
group 4 medulloblastoma 487 | 1,855
tuberculosis 452 | 2,010
cystic fibrosis 450 | 1,696
ductal carcinoma in situ 444 | 1,745
Epilepsy 442 | 792
breast carcinoma 441 | 1,638
colon cancer 422 | 1,478
ulcerative colitis 422 | 1,819
diabetes mellitus 397 | 1,728
pancreatic ductal adenocarcinoma liver metastasis 374 | 1,962
Dull intelligence 354 | 645
Low intelligence 354 | 645
Mental Retardation 354 | 645
Mental deficiency 354 | 645
Poor school performance 354 | 645
Bipolar Disorder 352 | 666
Seizures 350 | 596
astrocytoma 345 | 1,146
adrenocortical carcinoma 341 | 1,428
Obesity 298 | 678
Cognitive delay 295 | 608
Global developmental delay 295 | 608
Mental and motor retardation 295 | 608
Muscle hypotonia 290 | 571
Rheumatoid arthritis 283 | 1,191
pediatric high grade glioma 281 | 1,064
primary pancreatic ductal adenocarcinoma 281 | 1,109
acute quadriplegic myopathy 276 | 1,158
juvenile dermatomyositis 275 | 1,187
Alzheimer's disease 271 | 658
Short stature 268 | 531
Liver cancer 265 | 604
Depressive disorder 264 | 409
Melanoma 255 | 711
cutaneous lupus erythematosus 253 | 1,057
spina bifida 245 | 1,074
Neurodegenerative disease 233 | 414
dermatomyositis 225 | 966
Multiple myeloma 224 | 1,332
Autistic Disorder 213 | 364
nasopharyngeal carcinoma 213 | 1,058
Breast Neoplasms 208 | 445
Atopic dermatitis 205 | 952
gastric carcinoma 205 | 807
Mental Depression 202 | 333
Liver Cirrhosis, Experimental 200 | 769
Mammary Neoplasms 200 | 425
Small head 199 | 374
Down syndrome 196 | 499
Parkinson's disease 194 | 392
medulloblastoma 193 | 720
Duchenne muscular dystrophy 187 | 601
Hypertension 185 | 396
Prostatic Neoplasms 185 | 495
progressive supranuclear palsy 181 | 676
Kidney disease 180 | 430
Skin cancer 180 | 469
Multiple Sclerosis 178 | 540
active Crohn's disease 178 | 922
non primary Sjogren syndrome sicca 178 | 891
Nystagmus 174 | 317
esophageal adenocarcinoma 174 | 737
Amyotrophic lateral sclerosis 168 | 451
active ulcerative colitis 166 | 764
Major Depressive Disorder 165 | 301
autosomal dominant Emery-Dreifuss muscular dystrophy 164 | 510

Tissue

Endocrine System 3,346 | 18,159
Digestive Tract 3,250 | 17,369
Skin and soft tissues 3,230 | 17,230
Female tissues 3,226 | 17,400
Nervous System 3,225 | 16,725
Male tissues 3,186 | 17,142
Blood and immune system 3,143 | 16,909
Liver and Pancreas 3,129 | 16,750
Urinary Tract 3,124 | 16,678
Respiratory system 3,073 | 16,393
Cardiovascular System 2,854 | 15,192

Target Family

Non-IDG 1,692 | 12,091
Enzyme 648 | 4,145
Transcription Factor 393 | 1,400
Kinase 205 | 634
Ion Channel 166 | 344
GPCR 140 | 408
Transporter 93 | 473
Epigenetic 61 | 242
Nuclear Receptor 32 | 48
TF/Epigenetic 10 | 38
oGPCR 7 | 421

MGI Phenotype

nervous system phenotype 3,447 | 3,447
mortality-aging 5,018 | 5,018
homeostasis-metabolism phenoty... 4,747 | 4,747
growth-size-body region phenot... 4,157 | 4,157
cellular phenotype 3,637 | 3,637
immune system phenotype 3,461 | 3,461
behavior-neurological phenotyp... 3,401 | 3,401
hematopoietic system phenotype 3,383 | 3,383
cardiovascular system phenotyp... 2,660 | 2,660
endocrine-exocrine gland pheno... 2,293 | 2,293
skeleton phenotype 2,222 | 2,222
normal phenotype 1,999 | 1,999
reproductive system phenotype 1,999 | 1,999
integument phenotype 1,874 | 1,874
embryo phenotype 1,827 | 1,827
vision-eye phenotype 1,622 | 1,622
muscle phenotype 1,479 | 1,479
digestive-alimentary phenotype 1,398 | 1,398
respiratory system phenotype 1,390 | 1,390
liver-biliary system phenotype 1,300 | 1,300
renal-urinary system phenotype 1,269 | 1,269
craniofacial phenotype 1,182 | 1,182
limbs-digits-tail phenotype 1,071 | 1,071
adipose tissue phenotype 992 | 992
neoplasm 975 | 975
hearing-vestibular-ear phenoty... 767 | 767
pigmentation phenotype 506 | 506
taste-olfaction phenotype 147 | 147
no phenotypic analysis 5 | 5

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Inactive cytidine monophosphate-N-acetylneuraminic acid hydroxylase CMAHP Tbio Enzyme -1.76743 57.3 0
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
Probable global transcription activator SNF2L1 SMARCA1 Tbio Non-IDG -2.20560 145.6 116
Protein unc-13 homolog D UNC13D Tbio Non-IDG -1.93790 85.1 158
Homeobox protein MSX-1 MSX1 Tbio Transcription Factor -2.59245 390.1 298
Methyl-CpG-binding domain protein 1 MBD1 Tbio Transcription Factor -2.23809 171.1 297
MAGE-like protein 2 MAGEL2 Tbio Non-IDG -1.95242 83.8 86
Metabotropic glutamate receptor 5 GRM5 Tchem GPCR -3.12353 1370.3 396
Rab-3A-interacting protein RAB3IP Tbio Non-IDG -1.03500 11.6 89
Leukemia inhibitory factor LIF Tbio Non-IDG -2.86943 538.7 413