Development Level

Tbio 2,182 | 10,625
Tchem 601 | 1,890
Tclin 271 | 602
Tdark 147 | 7,003

Collection

Eligible Ion Channel Proteins 36 | 117
Eligible Kinase Proteins 23 | 134
Eligible non-olfactory GPCR Proteins 11 | 143

IMPC Term

preweaning lethality, complete... 166 | 633
preweaning lethality, incomple... 82 | 260
abnormal behavior 75 | 226
embryonic lethality prior to t... 66 | 187
decreased lean body mass 65 | 195
decreased total body fat amoun... 57 | 186
decreased bone mineral content 55 | 157
decreased body weight 53 | 174
abnormal bone structure 49 | 131
abnormal embryo size 44 | 112
decreased prepulse inhibition 44 | 52
increased or absent threshold ... 44 | 128
decreased bone mineral density 42 | 126
decreased grip strength 38 | 123
hypoactivity 37 | 89
enlarged heart 36 | 111
abnormal retina morphology 35 | 100
hyperactivity 34 | 108
decreased body length 33 | 108
increased circulating alkaline... 31 | 119
increased lean body mass 30 | 107
embryonic lethality prior to o... 29 | 148
short tibia 28 | 82
decreased circulating glucose ... 27 | 121
increased mean corpuscular hem... 27 | 93
decreased circulating choleste... 26 | 85
increased bone mineral content 26 | 92
decreased circulating HDL chol... 25 | 77
decreased circulating triglyce... 25 | 83
decreased fasted circulating g... 24 | 49
increased mean corpuscular vol... 24 | 91
abnormal neural tube closure 23 | 37
abnormal sleep behavior 23 | 63
decreased startle reflex 23 | 48
abnormal bone mineralization 22 | 55
abnormal gait 22 | 51
decreased circulating serum al... 22 | 79
decreased hemoglobin content 22 | 53
increased grip strength 22 | 83
limb grasping 21 | 35
abnormal heart morphology 20 | 51
abnormal lens morphology 20 | 73
decreased circulating insulin ... 20 | 75
impaired glucose tolerance 20 | 52
abnormal retinal pigmentation 19 | 61
increased circulating sodium l... 19 | 71
abnormal hindbrain development 18 | 24
abnormal midbrain development 18 | 22
increased circulating HDL chol... 18 | 63
increased fasted circulating g... 18 | 68
increased total body fat amoun... 18 | 57
tremors 18 | 34
decreased mean corpuscular vol... 17 | 50
decreased rib number 17 | 59
increased circulating choleste... 17 | 53
increased prepulse inhibition 17 | 21
increased startle reflex 17 | 38
prenatal lethality prior to he... 17 | 64
improved glucose tolerance 16 | 56
increased blood urea nitrogen ... 16 | 44
increased circulating chloride... 16 | 43
abnormal forebrain development 15 | 18
decreased circulating alanine ... 15 | 53
increased body weight 15 | 42
male infertility 15 | 62
abnormal spleen morphology 14 | 36
decreased blood urea nitrogen ... 14 | 31
decreased circulating amylase ... 14 | 24
decreased heart weight 14 | 44
enlarged lymph nodes 14 | 27
increased heart weight 14 | 37
abnormal locomotor activation 13 | 26
decreased circulating total pr... 13 | 41
decreased erythrocyte cell num... 13 | 43
increased bone mineral density 13 | 52
increased leukocyte cell numbe... 13 | 37
thrombocytopenia 13 | 46
abnormal behavioral response t... 12 | 52
abnormal coat/hair pigmentatio... 12 | 54
abnormal eye morphology 12 | 38
abnormal seminal vesicle morph... 12 | 47
decreased caudal vertebrae num... 12 | 49
increased hemoglobin content 12 | 45
absent startle reflex 11 | 15
cardiovascular system phenotyp... 11 | 35
cataract 11 | 26
decreased circulating LDL chol... 11 | 37
small testis 11 | 37
straub tail 11 | 26
abnormal epididymis morphology 10 | 31
abnormal optic disc morphology 10 | 10
decreased circulating alkaline... 10 | 41
decreased circulating iron lev... 10 | 25
decreased leukocyte cell numbe... 10 | 54
decreased vertical activity 10 | 22
increased circulating triglyce... 10 | 24
increased exploration in new e... 10 | 56
persistence of hyaloid vascula... 10 | 22
abnormal cranium morphology 9 | 32
decreased circulating free fat... 9 | 39

Disease

ovarian cancer 1,652 | 8,484
medulloblastoma, large-cell 1,490 | 6,234
osteosarcoma 1,485 | 7,933
psoriasis 1,408 | 6,685
glioblastoma 1,393 | 5,572
atypical teratoid / rhabdoid tumor 1,101 | 4,369
lung cancer 1,041 | 4,466
pilocytic astrocytoma 885 | 3,086
oligodendroglioma 844 | 2,849
Cancer 841 | 2,346
primitive neuroectodermal tumor 811 | 3,031
malignant mesothelioma 777 | 3,162
pediatric high grade glioma 736 | 2,712
Breast cancer 731 | 3,094
Carcinoma 708 | 2,147
lung carcinoma 689 | 2,844
ependymoma 669 | 2,514
invasive ductal carcinoma 667 | 2,950
intraductal papillary-mucinous neoplasm (IPMN) 658 | 3,289
subependymal giant cell astrocytoma 637 | 2,287
intraductal papillary-mucinous adenoma (IPMA) 635 | 2,956
lung adenocarcinoma 617 | 2,713
intraductal papillary-mucinous carcinoma (IPMC) 610 | 2,988
non-small cell lung cancer 601 | 2,798
astrocytic glioma 590 | 2,241
pituitary cancer 543 | 1,972
adult high grade glioma 525 | 2,148
Pick disease 510 | 1,893
group 4 medulloblastoma 499 | 1,875
pancreatic cancer 499 | 2,300
interstitial cystitis 496 | 2,299
group 3 medulloblastoma 471 | 2,254
astrocytoma 455 | 1,493
ulcerative colitis 440 | 2,087
cystic fibrosis 417 | 1,665
ductal carcinoma in situ 415 | 1,745
medulloblastoma 407 | 1,524
posterior fossa group A ependymoma 406 | 1,511
breast carcinoma 404 | 1,614
colon cancer 396 | 1,475
sonic hedgehog group medulloblastoma 373 | 1,482
diabetes mellitus 350 | 1,663
tuberculosis 334 | 1,557
posterior fossa group B ependymoma 329 | 1,530
adrenocortical carcinoma 315 | 1,427
atypical teratoid/rhabdoid tumor 314 | 1,095
pancreatic ductal adenocarcinoma liver metastasis 303 | 1,795
primary pancreatic ductal adenocarcinoma 297 | 1,271
Intellectual disability 281 | 573
Rheumatoid Arthritis 258 | 1,160
juvenile dermatomyositis 258 | 1,189
acute quadriplegic myopathy 254 | 1,157
Alzheimer's disease 252 | 644
Schizophrenia 243 | 501
cutaneous lupus erythematosus 235 | 1,056
Obesity 230 | 616
Neurodegenerative disease 219 | 383
Epilepsy 217 | 346
spina bifida 215 | 1,064
dermatomyositis 210 | 933
gastric carcinoma 208 | 832
Multiple myeloma 202 | 1,327
nasopharyngeal carcinoma 200 | 1,056
Atopic dermatitis 196 | 944
Down syndrome 194 | 548
Mammary Neoplasms 190 | 410
Autistic Disorder 181 | 320
Parkinson's disease 176 | 364
Duchenne muscular dystrophy 175 | 602
Kidney disease 169 | 396
Prostatic Neoplasms 168 | 471
progressive supranuclear palsy 167 | 674
active Crohn's disease 166 | 918
esophageal adenocarcinoma 166 | 737
Multiple Sclerosis 160 | 498
non primary Sjogren syndrome sicca 154 | 840
Endometriosis 152 | 535
autosomal dominant Emery-Dreifuss muscular dystrophy 152 | 499
Amyotrophic Lateral Sclerosis 150 | 431
Waldenstrons macroglobulinemia 149 | 765
aldosterone-producing adenoma 146 | 664
primary Sjogren syndrome 137 | 789
fibroadenoma 133 | 557
Vascular disease 129 | 281
Neuropathy 128 | 210
acute myeloid leukemia 127 | 780
Bipolar Disorder 124 | 266
Heart disease 122 | 279
Hypertension 121 | 287
chronic rhinosinusitis 116 | 512
non-small cell lung carcinoma 113 | 413
Asthma 111 | 349
Cerebrovascular disease 109 | 231
IGA Glomerulonephritis 109 | 454
pancreatic carcinoma 109 | 567
Peripheral Neuropathy 106 | 303
active ulcerative colitis 106 | 477
Arthritis 103 | 248
Stomach Neoplasms 102 | 282
Atherosclerosis 101 | 275

Tissue

Nervous System 3,165 | 18,561
Female tissues 3,158 | 18,647
Endocrine System 3,154 | 18,512
Digestive Tract 3,152 | 18,473
Urinary Tract 3,140 | 18,444
Liver and Pancreas 3,123 | 18,136
Skin and soft tissues 3,113 | 18,115
Cardiovascular System 3,108 | 17,958
Blood and immune system 3,101 | 17,995
Male tissues 3,096 | 17,969
Respiratory system 3,046 | 17,484

Target Family

Non-IDG 1,550 | 11,971
Enzyme 594 | 4,146
Transcription Factor 374 | 1,400
Kinase 198 | 634
Ion Channel 164 | 341
GPCR 134 | 406
Transporter 85 | 473
Epigenetic 53 | 242
Nuclear Receptor 32 | 48
TF/Epigenetic 10 | 38
oGPCR 7 | 421

MGI Term

nervous system phenotype 3,201 | 3,201
mortality/aging 4,850 | 4,850
homeostasis/metabolism phenoty... 4,454 | 4,454
growth/size/body region phenot... 3,915 | 3,915
cellular phenotype 3,348 | 3,348
behavior/neurological phenotyp... 3,192 | 3,192
immune system phenotype 3,148 | 3,148
hematopoietic system phenotype 3,145 | 3,145
cardiovascular system phenotyp... 2,448 | 2,448
endocrine/exocrine gland pheno... 2,084 | 2,084
skeleton phenotype 2,058 | 2,058
normal phenotype 1,916 | 1,916
reproductive system phenotype 1,873 | 1,873
integument phenotype 1,748 | 1,748
embryo phenotype 1,674 | 1,674
vision/eye phenotype 1,478 | 1,478
muscle phenotype 1,385 | 1,385
digestive/alimentary phenotype 1,292 | 1,292
respiratory system phenotype 1,291 | 1,291
liver/biliary system phenotype 1,160 | 1,160
renal/urinary system phenotype 1,157 | 1,157
craniofacial phenotype 1,077 | 1,077
limbs/digits/tail phenotype 1,011 | 1,011
neoplasm 918 | 918
adipose tissue phenotype 901 | 901
hearing/vestibular/ear phenoty... 692 | 692
pigmentation phenotype 459 | 459
taste/olfaction phenotype 142 | 142
obsolete other phenotype 69 | 69

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
Retinaldehyde-binding protein 1 RLBP1 Tbio Non-IDG -2.12314 137.8 95
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.39907 258.0 359
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Glial cell line-derived neurotrophic factor GDNF Tbio Non-IDG -3.30206 2301.5 303