Development Level

Tbio 871 | 10,625
Tchem 324 | 1,890
Tclin 152 | 602
Tdark 38 | 7,003

Collection

Eligible Ion Channel Proteins 11 | 117
Eligible Kinase Proteins 10 | 134
Eligible non-olfactory GPCR Proteins 2 | 143

IMPC Term

preweaning lethality, complete... 76 | 633
preweaning lethality, incomple... 42 | 260
abnormal behavior 32 | 226
decreased body weight 30 | 174
embryonic lethality prior to t... 29 | 187
decreased lean body mass 26 | 195
decreased total body fat amoun... 21 | 186
decreased grip strength 20 | 123
abnormal bone structure 19 | 131
decreased bone mineral content 18 | 157
enlarged heart 18 | 111
abnormal embryo size 16 | 112
abnormal retina morphology 16 | 100
increased circulating alkaline... 16 | 119
abnormal bone mineralization 14 | 55
decreased bone mineral density 14 | 126
hypoactivity 14 | 89
increased or absent threshold ... 13 | 128
decreased circulating choleste... 12 | 85
decreased prepulse inhibition 12 | 52
hyperactivity 12 | 108
increased lean body mass 12 | 107
abnormal lens morphology 11 | 73
decreased body length 11 | 108
decreased circulating triglyce... 11 | 83
increased blood urea nitrogen ... 11 | 44
increased circulating sodium l... 11 | 71
increased mean corpuscular vol... 11 | 91
short tibia 11 | 82
decreased circulating HDL chol... 10 | 77
decreased circulating alanine ... 10 | 53
decreased circulating glucose ... 10 | 121
embryonic lethality prior to o... 10 | 148
increased bone mineral content 10 | 92
increased startle reflex 10 | 38
improved glucose tolerance 9 | 56
increased circulating choleste... 9 | 53
increased heart weight 9 | 37
increased mean corpuscular hem... 9 | 93
increased total body fat amoun... 9 | 57
abnormal gait 8 | 51
decreased circulating alkaline... 8 | 41
decreased circulating serum al... 8 | 79
decreased circulating total pr... 8 | 41
decreased hemoglobin content 8 | 53
decreased startle reflex 8 | 48
impaired glucose tolerance 8 | 52
increased body weight 8 | 42
increased fasted circulating g... 8 | 68
increased hemoglobin content 8 | 45
abnormal tooth morphology 7 | 24
cardiovascular system phenotyp... 7 | 35
cataract 7 | 26
decreased circulating insulin ... 7 | 75
decreased circulating iron lev... 7 | 25
hydrops fetalis 7 | 22
increased circulating HDL chol... 7 | 63
increased circulating chloride... 7 | 43
increased circulating triglyce... 7 | 24
limb grasping 7 | 35
abnormal coat/hair pigmentatio... 6 | 54
abnormal locomotor activation 6 | 26
abnormal neural tube closure 6 | 37
abnormal vocalization 6 | 21
decreased circulating LDL chol... 6 | 37
decreased circulating creatini... 6 | 31
decreased hematocrit 6 | 25
decreased leukocyte cell numbe... 6 | 54
decreased mean corpuscular vol... 6 | 50
decreased vertical activity 6 | 22
increased circulating calcium ... 6 | 32
increased grip strength 6 | 83
increased hematocrit 6 | 36
male infertility 6 | 62
abnormal behavioral response t... 5 | 52
abnormal coping response 5 | 12
abnormal eye morphology 5 | 38
abnormal forebrain development 5 | 18
abnormal heart morphology 5 | 51
abnormal hindbrain development 5 | 24
decreased circulating aspartat... 5 | 27
decreased circulating calcium ... 5 | 33
decreased erythrocyte cell num... 5 | 43
increased circulating phosphat... 5 | 24
prenatal lethality prior to he... 5 | 64
small testis 5 | 37
thrombocytopenia 5 | 46
tremors 5 | 34
abnormal cornea morphology 4 | 24
abnormal sleep behavior 4 | 63
abnormal spleen morphology 4 | 36
abnormal vibrissa morphology 4 | 17
absent startle reflex 4 | 15
decreased circulating glycerol... 4 | 19
decreased fasted circulating g... 4 | 49
enlarged spleen 4 | 26
increased cardiac muscle contr... 4 | 5
increased circulating iron lev... 4 | 25
increased sacral vertebrae num... 4 | 62
vertebral fusion 4 | 23

Disease

ovarian cancer 786 | 8,484
psoriasis 667 | 6,685
osteosarcoma 650 | 7,933
medulloblastoma, large-cell 603 | 6,234
glioblastoma 585 | 5,572
lung cancer 541 | 4,466
Cancer 472 | 2,346
atypical teratoid / rhabdoid tumor 445 | 4,369
malignant mesothelioma 392 | 3,162
invasive ductal carcinoma 391 | 2,950
pilocytic astrocytoma 367 | 3,086
Breast cancer 365 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 361 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 350 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 350 | 2,988
lung adenocarcinoma 341 | 2,713
Carcinoma 338 | 2,147
lung carcinoma 330 | 2,844
oligodendroglioma 327 | 2,849
primitive neuroectodermal tumor 317 | 3,031
non-small cell lung cancer 305 | 2,798
pancreatic cancer 304 | 2,300
pediatric high grade glioma 296 | 2,712
ependymoma 276 | 2,514
interstitial cystitis 264 | 2,299
subependymal giant cell astrocytoma 260 | 2,287
ulcerative colitis 256 | 2,087
ductal carcinoma in situ 250 | 1,745
cystic fibrosis 245 | 1,665
pituitary cancer 242 | 1,972
breast carcinoma 236 | 1,614
diabetes mellitus 230 | 1,663
astrocytic glioma 223 | 2,241
colon cancer 223 | 1,475
astrocytoma 213 | 1,493
adult high grade glioma 207 | 2,148
group 4 medulloblastoma 200 | 1,875
primary pancreatic ductal adenocarcinoma 200 | 1,271
Pick disease 198 | 1,893
adrenocortical carcinoma 193 | 1,427
group 3 medulloblastoma 182 | 2,254
tuberculosis 179 | 1,557
posterior fossa group A ependymoma 173 | 1,511
acute quadriplegic myopathy 164 | 1,157
juvenile dermatomyositis 157 | 1,189
medulloblastoma 157 | 1,524
sonic hedgehog group medulloblastoma 154 | 1,482
pancreatic ductal adenocarcinoma liver metastasis 149 | 1,795
dermatomyositis 148 | 933
Obesity 147 | 616
gastric carcinoma 138 | 832
Rheumatoid Arthritis 130 | 1,160
posterior fossa group B ependymoma 125 | 1,530
Mammary Neoplasms 120 | 410
Duchenne muscular dystrophy 117 | 602
spina bifida 116 | 1,064
Alzheimer's disease 115 | 644
Atopic dermatitis 114 | 944
autosomal dominant Emery-Dreifuss muscular dystrophy 114 | 499
atypical teratoid/rhabdoid tumor 113 | 1,095
nasopharyngeal carcinoma 113 | 1,056
Heart disease 111 | 279
Multiple myeloma 110 | 1,327
Hypertension 108 | 287
cutaneous lupus erythematosus 108 | 1,056
Prostatic Neoplasms 107 | 471
Kidney disease 101 | 396
Amyotrophic Lateral Sclerosis 92 | 431
Neurodegenerative disease 90 | 383
active Crohn's disease 90 | 918
Hypertensive disease 88 | 193
Intellectual disability 87 | 573
esophageal adenocarcinoma 87 | 737
Atherosclerosis 85 | 275
Down syndrome 84 | 548
fibroadenoma 84 | 557
Myopathy 83 | 128
aldosterone-producing adenoma 81 | 664
Schizophrenia 80 | 501
Endometriosis 79 | 535
Vascular disease 78 | 281
Waldenstrons macroglobulinemia 78 | 765
Cerebrovascular disease 76 | 231
primary Sjogren syndrome 76 | 789
Coronary artery disease 75 | 240
Parkinson's disease 75 | 364
Autistic Disorder 74 | 320
non-small cell lung carcinoma 73 | 413
Multiple Sclerosis 72 | 498
Asthma 70 | 349
Neuropathy 70 | 210
Polycystic Ovary Syndrome 70 | 332
non primary Sjogren syndrome sicca 70 | 840
pancreatic carcinoma 70 | 567
Stomach Neoplasms 69 | 282
Cardiomyopathy 68 | 110
interstitial lung disease 66 | 291
acute myeloid leukemia 65 | 780
Lung Neoplasms 60 | 171
Osteoporosis 60 | 257

Tissue

Digestive Tract 1,376 | 18,473
Nervous System 1,376 | 18,561
Female tissues 1,375 | 18,647
Endocrine System 1,374 | 18,512
Urinary Tract 1,370 | 18,444
Liver and Pancreas 1,368 | 18,136
Male tissues 1,366 | 17,969
Cardiovascular System 1,365 | 17,958
Skin and soft tissues 1,363 | 18,115
Blood and immune system 1,361 | 17,995
Respiratory system 1,350 | 17,484

Target Family

Non-IDG 635 | 11,971
Enzyme 267 | 4,146
Transcription Factor 164 | 1,400
Kinase 127 | 634
Ion Channel 57 | 341
GPCR 46 | 406
Transporter 37 | 473
Epigenetic 27 | 242
Nuclear Receptor 21 | 48
TF/Epigenetic 4 | 38

MGI Term

muscle phenotype 1,385 | 1,385
mortality/aging 4,850 | 4,850
homeostasis/metabolism phenoty... 4,454 | 4,454
growth/size/body region phenot... 3,915 | 3,915
cellular phenotype 3,348 | 3,348
nervous system phenotype 3,201 | 3,201
behavior/neurological phenotyp... 3,192 | 3,192
immune system phenotype 3,148 | 3,148
hematopoietic system phenotype 3,145 | 3,145
cardiovascular system phenotyp... 2,448 | 2,448
endocrine/exocrine gland pheno... 2,084 | 2,084
skeleton phenotype 2,058 | 2,058
normal phenotype 1,916 | 1,916
reproductive system phenotype 1,873 | 1,873
integument phenotype 1,748 | 1,748
embryo phenotype 1,674 | 1,674
vision/eye phenotype 1,478 | 1,478
digestive/alimentary phenotype 1,292 | 1,292
respiratory system phenotype 1,291 | 1,291
liver/biliary system phenotype 1,160 | 1,160
renal/urinary system phenotype 1,157 | 1,157
craniofacial phenotype 1,077 | 1,077
limbs/digits/tail phenotype 1,011 | 1,011
neoplasm 918 | 918
adipose tissue phenotype 901 | 901
hearing/vestibular/ear phenoty... 692 | 692
pigmentation phenotype 459 | 459
taste/olfaction phenotype 142 | 142
obsolete other phenotype 69 | 69

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
Erythropoietin EPO Tbio Non-IDG -3.90053 8755.8 628
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.11372 127.6 466
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
Glial cell line-derived neurotrophic factor GDNF Tbio Non-IDG -3.30206 2301.5 303
Cardiac phospholamban PLN Tbio Non-IDG -1.89899 84.7 326