Development Level

Tbio 717 | 10,625
Tchem 322 | 1,890
Tclin 87 | 602
Tdark 34 | 7,003

Collection

Eligible Kinase Proteins 6 | 134
Eligible non-olfactory GPCR Proteins 4 | 143
Eligible Ion Channel Proteins 2 | 117

IMPC Term

preweaning lethality, complete... 54 | 633
preweaning lethality, incomple... 30 | 260
decreased total body fat amoun... 24 | 186
decreased lean body mass 21 | 195
abnormal bone structure 20 | 131
decreased body weight 20 | 174
embryonic lethality prior to t... 20 | 187
abnormal behavior 18 | 226
decreased bone mineral content 16 | 157
enlarged heart 16 | 111
abnormal bone mineralization 14 | 55
decreased bone mineral density 14 | 126
hypoactivity 14 | 89
increased circulating alkaline... 14 | 119
abnormal embryo size 13 | 112
decreased body length 13 | 108
decreased grip strength 12 | 123
decreased hemoglobin content 12 | 53
increased lean body mass 12 | 107
increased circulating choleste... 11 | 53
abnormal retina morphology 10 | 100
decreased circulating alkaline... 10 | 41
decreased circulating choleste... 9 | 85
increased circulating HDL chol... 9 | 63
increased grip strength 9 | 83
increased mean corpuscular vol... 9 | 91
decreased circulating HDL chol... 8 | 77
decreased circulating alanine ... 8 | 53
decreased circulating glucose ... 8 | 121
decreased circulating serum al... 8 | 79
decreased circulating triglyce... 8 | 83
decreased erythrocyte cell num... 8 | 43
increased total body fat amoun... 8 | 57
short tibia 8 | 82
abnormal lens morphology 7 | 73
decreased circulating LDL chol... 7 | 37
decreased circulating total pr... 7 | 41
decreased heart weight 7 | 44
decreased hematocrit 7 | 25
decreased mean corpuscular hem... 7 | 34
decreased mean corpuscular vol... 7 | 50
decreased prepulse inhibition 7 | 52
increased blood urea nitrogen ... 7 | 44
increased circulating triglyce... 7 | 24
increased hemoglobin content 7 | 45
increased mean corpuscular hem... 7 | 93
increased or absent threshold ... 7 | 128
prenatal lethality prior to he... 7 | 64
abnormal heart morphology 6 | 51
abnormal neural tube closure 6 | 37
abnormal startle reflex 6 | 14
abnormal tooth morphology 6 | 24
decreased T cell number 6 | 31
decreased circulating amylase ... 6 | 24
decreased circulating aspartat... 6 | 27
decreased circulating insulin ... 6 | 75
decreased circulating iron lev... 6 | 25
embryonic lethality prior to o... 6 | 148
enlarged spleen 6 | 26
increased body weight 6 | 42
increased bone mineral content 6 | 92
increased circulating calcium ... 6 | 32
increased circulating creatini... 6 | 29
increased circulating potassiu... 6 | 31
increased heart weight 6 | 37
increased mean corpuscular hem... 6 | 25
thrombocytopenia 6 | 46
abnormal behavioral response t... 5 | 52
abnormal forebrain development 5 | 18
abnormal hindbrain development 5 | 24
cardiovascular system phenotyp... 5 | 35
cataract 5 | 26
decreased B cell number 5 | 30
decreased CD8-positive, alpha-... 5 | 26
decreased lactate dehydrogenas... 5 | 14
decreased leukocyte cell numbe... 5 | 54
decreased rib number 5 | 59
female infertility 5 | 34
impaired glucose tolerance 5 | 52
increased bone mineral density 5 | 52
increased circulating sodium l... 5 | 71
increased hematocrit 5 | 36
limb grasping 5 | 35
tremors 5 | 34
abnormal cranium morphology 4 | 32
abnormal epididymis morphology 4 | 31
abnormal gait 4 | 51
abnormal lung morphology 4 | 15
abnormal sleep behavior 4 | 63
abnormal spleen morphology 4 | 36
decreased circulating free fat... 4 | 39
decreased startle reflex 4 | 48
improved glucose tolerance 4 | 56
increased circulating aspartat... 4 | 17
increased circulating bilirubi... 4 | 16
increased circulating iron lev... 4 | 25
increased fasted circulating g... 4 | 68
male infertility 4 | 62
thrombocytosis 4 | 23
vertebral fusion 4 | 23

Disease

ovarian cancer 661 | 8,484
osteosarcoma 579 | 7,933
psoriasis 561 | 6,685
Cancer 473 | 2,346
medulloblastoma, large-cell 459 | 6,234
lung cancer 432 | 4,466
glioblastoma 430 | 5,572
intraductal papillary-mucinous neoplasm (IPMN) 315 | 3,289
atypical teratoid / rhabdoid tumor 302 | 4,369
intraductal papillary-mucinous adenoma (IPMA) 298 | 2,956
malignant mesothelioma 293 | 3,162
intraductal papillary-mucinous carcinoma (IPMC) 291 | 2,988
invasive ductal carcinoma 275 | 2,950
pancreatic cancer 255 | 2,300
lung adenocarcinoma 254 | 2,713
non-small cell lung cancer 253 | 2,798
Breast cancer 252 | 3,094
lung carcinoma 251 | 2,844
diabetes mellitus 240 | 1,663
ulcerative colitis 233 | 2,087
pilocytic astrocytoma 221 | 3,086
Carcinoma 215 | 2,147
pediatric high grade glioma 215 | 2,712
pancreatic ductal adenocarcinoma liver metastasis 211 | 1,795
primitive neuroectodermal tumor 208 | 3,031
interstitial cystitis 207 | 2,299
subependymal giant cell astrocytoma 199 | 2,287
pituitary cancer 198 | 1,972
oligodendroglioma 193 | 2,849
tuberculosis 186 | 1,557
ductal carcinoma in situ 181 | 1,745
Obesity 180 | 616
astrocytoma 167 | 1,493
group 4 medulloblastoma 167 | 1,875
breast carcinoma 166 | 1,614
ependymoma 160 | 2,514
colon cancer 155 | 1,475
cystic fibrosis 155 | 1,665
adrenocortical carcinoma 149 | 1,427
Rheumatoid Arthritis 145 | 1,160
group 3 medulloblastoma 145 | 2,254
primary pancreatic ductal adenocarcinoma 138 | 1,271
astrocytic glioma 136 | 2,241
Pick disease 133 | 1,893
acute quadriplegic myopathy 129 | 1,157
adult high grade glioma 129 | 2,148
posterior fossa group A ependymoma 128 | 1,511
juvenile dermatomyositis 124 | 1,189
Multiple myeloma 120 | 1,327
medulloblastoma 108 | 1,524
Mammary Neoplasms 106 | 410
dermatomyositis 105 | 933
Kidney disease 103 | 396
Atopic dermatitis 97 | 944
Prostatic Neoplasms 95 | 471
gastric carcinoma 95 | 832
cutaneous lupus erythematosus 93 | 1,056
spina bifida 89 | 1,064
active Crohn's disease 88 | 918
posterior fossa group B ependymoma 88 | 1,530
sonic hedgehog group medulloblastoma 88 | 1,482
Atherosclerosis 87 | 275
nasopharyngeal carcinoma 85 | 1,056
Liver carcinoma 84 | 217
Vascular disease 84 | 281
Liver disease 82 | 219
atypical teratoid/rhabdoid tumor 82 | 1,095
esophageal adenocarcinoma 82 | 737
Alzheimer's disease 78 | 644
autosomal dominant Emery-Dreifuss muscular dystrophy 77 | 499
Down syndrome 75 | 548
Waldenstrons macroglobulinemia 75 | 765
Endometriosis 74 | 535
primary Sjogren syndrome 74 | 789
Duchenne muscular dystrophy 73 | 602
acute myeloid leukemia 73 | 780
Anemia 72 | 252
Arthritis 72 | 248
Asthma 72 | 349
aldosterone-producing adenoma 72 | 664
pancreatic carcinoma 72 | 567
Stomach Neoplasms 70 | 282
Metabolic syndrome X 69 | 155
Coronary artery disease 67 | 240
Lung Neoplasms 66 | 171
Multiple Sclerosis 66 | 498
fibroadenoma 65 | 557
hepatocellular carcinoma 64 | 532
Heart disease 63 | 279
Hypertension 63 | 287
mucosa-associated lymphoid tissue lymphoma 62 | 480
non primary Sjogren syndrome sicca 61 | 840
Colorectal Neoplasms 59 | 217
Diabetes Mellitus, Non-Insulin-Dependent 59 | 157
Schizophrenia 59 | 501
non-small cell lung carcinoma 58 | 413
Adenoma 57 | 165
IGA Glomerulonephritis 57 | 454
Intellectual disability 57 | 573
Peripheral Neuropathy 57 | 303

Tissue

Nervous System 1,155 | 18,561
Endocrine System 1,154 | 18,512
Digestive Tract 1,153 | 18,473
Female tissues 1,153 | 18,647
Liver and Pancreas 1,151 | 18,136
Urinary Tract 1,145 | 18,444
Male tissues 1,142 | 17,969
Cardiovascular System 1,140 | 17,958
Blood and immune system 1,139 | 17,995
Skin and soft tissues 1,134 | 18,115
Respiratory system 1,130 | 17,484

Target Family

Non-IDG 527 | 11,971
Enzyme 287 | 4,146
Transcription Factor 115 | 1,400
Kinase 92 | 634
Transporter 44 | 473
GPCR 32 | 406
Epigenetic 25 | 242
Nuclear Receptor 22 | 48
TF/Epigenetic 9 | 38
Ion Channel 7 | 341

MGI Term

liver/biliary system phenotype 1,160 | 1,160
mortality/aging 4,850 | 4,850
homeostasis/metabolism phenoty... 4,454 | 4,454
growth/size/body region phenot... 3,915 | 3,915
cellular phenotype 3,348 | 3,348
nervous system phenotype 3,201 | 3,201
behavior/neurological phenotyp... 3,192 | 3,192
immune system phenotype 3,148 | 3,148
hematopoietic system phenotype 3,145 | 3,145
cardiovascular system phenotyp... 2,448 | 2,448
endocrine/exocrine gland pheno... 2,084 | 2,084
skeleton phenotype 2,058 | 2,058
normal phenotype 1,916 | 1,916
reproductive system phenotype 1,873 | 1,873
integument phenotype 1,748 | 1,748
embryo phenotype 1,674 | 1,674
vision/eye phenotype 1,478 | 1,478
muscle phenotype 1,385 | 1,385
digestive/alimentary phenotype 1,292 | 1,292
respiratory system phenotype 1,291 | 1,291
renal/urinary system phenotype 1,157 | 1,157
craniofacial phenotype 1,077 | 1,077
limbs/digits/tail phenotype 1,011 | 1,011
neoplasm 918 | 918
adipose tissue phenotype 901 | 901
hearing/vestibular/ear phenoty... 692 | 692
pigmentation phenotype 459 | 459
taste/olfaction phenotype 142 | 142
obsolete other phenotype 69 | 69

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Erythropoietin EPO Tbio Non-IDG -3.90053 8755.8 628
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851
Transmembrane protease serine 6 TMPRSS6 Tchem Enzyme -1.99222 118.1 102
Protein Smaug homolog 1 SAMD4A Tbio Non-IDG 16.8 58
Class A basic helix-loop-helix protein 15 BHLHA15 Tbio Transcription Factor -1.24086 19.1 70
Solute carrier family 13 member 1 SLC13A1 Tbio Transporter -1.70334 62.7 18