Development Level

Tbio 708 | 10,625
Tchem 178 | 1,890
Tdark 67 | 7,003
Tclin 58 | 602

Collection

Eligible Kinase Proteins 4 | 134
Eligible Ion Channel Proteins 2 | 117
Eligible non-olfactory GPCR Proteins 2 | 143

IMPC Term

preweaning lethality, complete... 102 | 633
short tibia 63 | 82
decreased lean body mass 55 | 195
abnormal behavior 47 | 226
decreased bone mineral content 45 | 157
decreased total body fat amoun... 42 | 186
decreased body weight 40 | 174
preweaning lethality, incomple... 40 | 260
decreased body length 39 | 108
decreased caudal vertebrae num... 37 | 49
abnormal bone structure 35 | 131
embryonic lethality prior to t... 34 | 187
decreased bone mineral density 33 | 126
increased circulating alkaline... 24 | 119
increased or absent threshold ... 24 | 128
abnormal embryo size 23 | 112
decreased grip strength 23 | 123
hypoactivity 20 | 89
polydactyly 20 | 22
abnormal retina morphology 19 | 100
decreased circulating choleste... 19 | 85
enlarged heart 19 | 111
decreased hemoglobin content 18 | 53
decreased lumbar vertebrae num... 18 | 62
embryonic lethality prior to o... 18 | 148
hyperactivity 18 | 108
increased bone mineral content 18 | 92
decreased circulating serum al... 17 | 79
decreased rib number 17 | 59
abnormal bone mineralization 16 | 55
decreased circulating glucose ... 16 | 121
increased grip strength 16 | 83
increased sacral vertebrae num... 16 | 62
abnormal gait 15 | 51
decreased circulating triglyce... 15 | 83
decreased circulating HDL chol... 14 | 77
decreased erythrocyte cell num... 14 | 43
decreased prepulse inhibition 14 | 52
increased lean body mass 14 | 107
abnormal cranium morphology 13 | 32
abnormal femur morphology 13 | 14
abnormal tail morphology 13 | 17
decreased heart weight 13 | 44
impaired glucose tolerance 13 | 52
increased mean corpuscular vol... 13 | 91
abnormal coat/hair pigmentatio... 12 | 54
abnormal digit morphology 12 | 13
abnormal joint morphology 12 | 14
abnormal tibia morphology 12 | 14
increased mean corpuscular hem... 12 | 93
increased total body fat amoun... 12 | 57
prenatal lethality prior to he... 12 | 64
thrombocytopenia 12 | 46
abnormal eye morphology 11 | 38
increased blood urea nitrogen ... 11 | 44
increased circulating HDL chol... 11 | 63
increased hemoglobin content 11 | 45
abnormal heart morphology 10 | 51
abnormal neural tube closure 10 | 37
decreased circulating insulin ... 10 | 75
decreased circulating total pr... 10 | 41
decreased mean corpuscular vol... 10 | 50
increased body weight 10 | 42
abnormal humerus morphology 9 | 11
abnormal locomotor activation 9 | 26
abnormal rib morphology 9 | 28
abnormal seminal vesicle morph... 9 | 47
abnormal tooth morphology 9 | 24
decreased circulating iron lev... 9 | 25
increased bone mineral density 9 | 52
long tibia 9 | 13
oligodactyly 9 | 14
abnormal retinal pigmentation 8 | 61
abnormal vertebrae morphology 8 | 14
corneal opacity 8 | 25
decreased circulating LDL chol... 8 | 37
decreased circulating alkaline... 8 | 41
decreased hematocrit 8 | 25
decreased spleen weight 8 | 13
increased circulating choleste... 8 | 53
increased fasted circulating g... 8 | 68
increased heart weight 8 | 37
limb grasping 8 | 35
narrow eye opening 8 | 15
prenatal lethality 8 | 16
abnormal facial morphology 7 | 9
abnormal lens morphology 7 | 73
abnormal limb bud morphology 7 | 15
abnormal pelvic girdle bone mo... 7 | 11
abnormal snout morphology 7 | 18
abnormal startle reflex 7 | 14
cardiovascular system phenotyp... 7 | 35
decreased monocyte cell number 7 | 28
decreased startle reflex 7 | 48
decreased total retina thickne... 7 | 20
enlarged lymph nodes 7 | 27
increased caudal vertebrae num... 7 | 8
increased circulating chloride... 7 | 43
tremors 7 | 34
vertebral fusion 7 | 23

Disease

ovarian cancer 591 | 8,484
osteosarcoma 514 | 7,933
psoriasis 456 | 6,685
medulloblastoma, large-cell 410 | 6,234
glioblastoma 394 | 5,572
lung cancer 355 | 4,466
atypical teratoid / rhabdoid tumor 323 | 4,369
Cancer 305 | 2,346
Breast cancer 296 | 3,094
malignant mesothelioma 274 | 3,162
invasive ductal carcinoma 263 | 2,950
pilocytic astrocytoma 241 | 3,086
intraductal papillary-mucinous neoplasm (IPMN) 240 | 3,289
intraductal papillary-mucinous adenoma (IPMA) 237 | 2,956
non-small cell lung cancer 234 | 2,798
Carcinoma 225 | 2,147
intraductal papillary-mucinous carcinoma (IPMC) 223 | 2,988
primitive neuroectodermal tumor 217 | 3,031
pancreatic cancer 216 | 2,300
lung adenocarcinoma 204 | 2,713
oligodendroglioma 198 | 2,849
pediatric high grade glioma 196 | 2,712
lung carcinoma 195 | 2,844
interstitial cystitis 194 | 2,299
pituitary cancer 182 | 1,972
ductal carcinoma in situ 177 | 1,745
ependymoma 169 | 2,514
ulcerative colitis 167 | 2,087
breast carcinoma 158 | 1,614
group 4 medulloblastoma 154 | 1,875
cystic fibrosis 153 | 1,665
subependymal giant cell astrocytoma 153 | 2,287
group 3 medulloblastoma 147 | 2,254
astrocytic glioma 140 | 2,241
posterior fossa group A ependymoma 137 | 1,511
sonic hedgehog group medulloblastoma 137 | 1,482
adult high grade glioma 135 | 2,148
primary pancreatic ductal adenocarcinoma 131 | 1,271
Pick disease 130 | 1,893
astrocytoma 130 | 1,493
adrenocortical carcinoma 129 | 1,427
diabetes mellitus 129 | 1,663
colon cancer 123 | 1,475
pancreatic ductal adenocarcinoma liver metastasis 121 | 1,795
Rheumatoid Arthritis 103 | 1,160
acute quadriplegic myopathy 101 | 1,157
posterior fossa group B ependymoma 101 | 1,530
medulloblastoma 97 | 1,524
juvenile dermatomyositis 95 | 1,189
tuberculosis 95 | 1,557
gastric carcinoma 94 | 832
atypical teratoid/rhabdoid tumor 88 | 1,095
Atopic dermatitis 84 | 944
nasopharyngeal carcinoma 81 | 1,056
Multiple myeloma 79 | 1,327
dermatomyositis 79 | 933
Mammary Neoplasms 78 | 410
Obesity 78 | 616
spina bifida 77 | 1,064
Alzheimer's disease 75 | 644
Prostatic Neoplasms 73 | 471
cutaneous lupus erythematosus 70 | 1,056
Duchenne muscular dystrophy 69 | 602
Intellectual disability 68 | 573
autosomal dominant Emery-Dreifuss muscular dystrophy 68 | 499
Craniofacial Abnormalities 67 | 147
Osteoporosis 65 | 257
esophageal adenocarcinoma 65 | 737
active Crohn's disease 61 | 918
Endometriosis 59 | 535
primary Sjogren syndrome 58 | 789
progressive supranuclear palsy 55 | 674
Down syndrome 54 | 548
fibroadenoma 54 | 557
Cleft palate 53 | 125
non primary Sjogren syndrome sicca 53 | 840
Kidney disease 51 | 396
acute myeloid leukemia 51 | 780
aldosterone-producing adenoma 51 | 664
Polydactyly 50 | 93
Waldenstrons macroglobulinemia 46 | 765
active ulcerative colitis 45 | 477
glioblastoma multiforme 45 | 347
Polycystic Ovary Syndrome 43 | 332
pancreatic carcinoma 42 | 567
Arthritis 41 | 248
IGA Glomerulonephritis 40 | 454
Adenoma 38 | 165
Lung Neoplasms 38 | 171
Multiple Sclerosis 38 | 498
non-small cell lung carcinoma 38 | 413
tuberculosis and treatment for 6 months 38 | 686
Amyotrophic Lateral Sclerosis 37 | 431
Melanoma 37 | 261
Neurodegenerative disease 37 | 383
Parkinson's disease 37 | 364
Cleft Lip 36 | 91
Colorectal Neoplasms 36 | 217
Acquired metabolic disease 35 | 267
Osteoarthritis 35 | 96

Tissue

Nervous System 1,006 | 18,561
Digestive Tract 1,004 | 18,473
Female tissues 1,004 | 18,647
Endocrine System 1,003 | 18,512
Urinary Tract 998 | 18,444
Male tissues 992 | 17,969
Cardiovascular System 990 | 17,958
Skin and soft tissues 989 | 18,115
Liver and Pancreas 988 | 18,136
Blood and immune system 985 | 17,995
Respiratory system 977 | 17,484

Target Family

Non-IDG 489 | 11,971
Enzyme 204 | 4,146
Transcription Factor 160 | 1,400
Kinase 60 | 634
GPCR 29 | 406
Epigenetic 28 | 242
Transporter 16 | 473
Ion Channel 11 | 341
Nuclear Receptor 11 | 48
TF/Epigenetic 3 | 38

MGI Term

limbs/digits/tail phenotype 1,011 | 1,011
mortality/aging 4,850 | 4,850
homeostasis/metabolism phenoty... 4,454 | 4,454
growth/size/body region phenot... 3,915 | 3,915
cellular phenotype 3,348 | 3,348
nervous system phenotype 3,201 | 3,201
behavior/neurological phenotyp... 3,192 | 3,192
immune system phenotype 3,148 | 3,148
hematopoietic system phenotype 3,145 | 3,145
cardiovascular system phenotyp... 2,448 | 2,448
endocrine/exocrine gland pheno... 2,084 | 2,084
skeleton phenotype 2,058 | 2,058
normal phenotype 1,916 | 1,916
reproductive system phenotype 1,873 | 1,873
integument phenotype 1,748 | 1,748
embryo phenotype 1,674 | 1,674
vision/eye phenotype 1,478 | 1,478
muscle phenotype 1,385 | 1,385
digestive/alimentary phenotype 1,292 | 1,292
respiratory system phenotype 1,291 | 1,291
liver/biliary system phenotype 1,160 | 1,160
renal/urinary system phenotype 1,157 | 1,157
craniofacial phenotype 1,077 | 1,077
neoplasm 918 | 918
adipose tissue phenotype 901 | 901
hearing/vestibular/ear phenoty... 692 | 692
pigmentation phenotype 459 | 459
taste/olfaction phenotype 142 | 142
obsolete other phenotype 69 | 69

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
Erythropoietin EPO Tbio Non-IDG -3.90053 8755.8 628
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Basic helix-loop-helix transcription factor scleraxis SCX Tbio Transcription Factor -2.80657 344.1 42
Solute carrier family 13 member 1 SLC13A1 Tbio Transporter -1.70334 62.7 18
Glypican-3 GPC3 Tbio Non-IDG -2.85848 794.8 523
High mobility group protein HMGI-C HMGA2 Tbio Transcription Factor -3.21092 1667.7 216