Development Level

Tbio 1,116 | 10,625
Tchem 402 | 1,890
Tclin 161 | 602
Tdark 69 | 7,003

Collection

Eligible Ion Channel Proteins 10 | 117
Eligible Kinase Proteins 6 | 134
Eligible non-olfactory GPCR Proteins 5 | 143

IMPC Term

preweaning lethality, complete... 97 | 633
preweaning lethality, incomple... 54 | 260
abnormal behavior 53 | 226
decreased body weight 47 | 174
abnormal coat/hair pigmentatio... 44 | 54
decreased lean body mass 42 | 195
decreased total body fat amoun... 39 | 186
abnormal bone structure 34 | 131
embryonic lethality prior to t... 33 | 187
decreased bone mineral content 32 | 157
decreased bone mineral density 32 | 126
decreased circulating glucose ... 29 | 121
decreased grip strength 29 | 123
hypoactivity 29 | 89
decreased circulating triglyce... 28 | 83
decreased circulating choleste... 27 | 85
enlarged heart 25 | 111
increased mean corpuscular vol... 25 | 91
abnormal embryo size 24 | 112
increased circulating alkaline... 22 | 119
abnormal bone mineralization 21 | 55
decreased circulating HDL chol... 21 | 77
abnormal retina morphology 20 | 100
increased mean corpuscular hem... 20 | 93
increased or absent threshold ... 20 | 128
decreased body length 19 | 108
hyperactivity 19 | 108
increased lean body mass 19 | 107
abnormal coat/ hair morphology 18 | 18
abnormal gait 18 | 51
short tibia 18 | 82
increased bone mineral content 17 | 92
abnormal eye morphology 16 | 38
decreased prepulse inhibition 16 | 52
abnormal vibrissa morphology 15 | 17
decreased circulating alkaline... 15 | 41
decreased circulating insulin ... 15 | 75
decreased circulating serum al... 15 | 79
embryonic lethality prior to o... 15 | 148
abnormal coat appearance 14 | 25
abnormal response to tactile s... 14 | 16
decreased erythrocyte cell num... 14 | 43
decreased fasted circulating g... 14 | 49
decreased hemoglobin content 14 | 53
decreased circulating LDL chol... 13 | 37
decreased circulating alanine ... 13 | 53
decreased circulating total pr... 13 | 41
decreased heart weight 13 | 44
increased circulating choleste... 13 | 53
increased grip strength 13 | 83
abnormal skin morphology 12 | 23
impaired glucose tolerance 12 | 52
increased circulating HDL chol... 12 | 63
limb grasping 12 | 35
tremors 12 | 34
abnormal cranium morphology 11 | 32
abnormal retinal pigmentation 11 | 61
abnormal sleep behavior 11 | 63
abnormal startle reflex 11 | 14
increased bone mineral density 11 | 52
increased circulating sodium l... 11 | 71
increased hematocrit 11 | 36
increased hemoglobin content 11 | 45
increased leukocyte cell numbe... 11 | 37
male infertility 11 | 62
abnormal behavioral response t... 10 | 52
abnormal epididymis morphology 10 | 31
abnormal lens morphology 10 | 73
abnormal seminal vesicle morph... 10 | 47
absent vibrissae 10 | 14
cataract 10 | 26
decreased T cell number 10 | 31
decreased caudal vertebrae num... 10 | 49
decreased leukocyte cell numbe... 10 | 54
decreased startle reflex 10 | 48
hydrops fetalis 10 | 22
increased blood urea nitrogen ... 10 | 44
increased body weight 10 | 42
increased circulating calcium ... 10 | 32
increased circulating chloride... 10 | 43
increased exploration in new e... 10 | 56
increased total body fat amoun... 10 | 57
thrombocytopenia 10 | 46
abnormal spleen morphology 9 | 36
abnormal tooth morphology 9 | 24
decreased circulating aspartat... 9 | 27
decreased mean corpuscular vol... 9 | 50
decreased rib number 9 | 59
increased B cell number 9 | 23
increased circulating triglyce... 9 | 24
increased fasted circulating g... 9 | 68
abnormal cornea morphology 8 | 24
abnormal heart morphology 8 | 51
abnormal neural tube closure 8 | 37
decreased blood urea nitrogen ... 8 | 31
decreased circulating calcium ... 8 | 33
decreased mean corpuscular hem... 8 | 34
female infertility 8 | 34
increased heart weight 8 | 37
small testis 8 | 37

Disease

ovarian cancer 957 | 8,484
osteosarcoma 877 | 7,933
psoriasis 845 | 6,685
medulloblastoma, large-cell 691 | 6,234
glioblastoma 670 | 5,572
Cancer 637 | 2,346
lung cancer 636 | 4,466
atypical teratoid / rhabdoid tumor 503 | 4,369
malignant mesothelioma 452 | 3,162
Breast cancer 443 | 3,094
pilocytic astrocytoma 436 | 3,086
invasive ductal carcinoma 418 | 2,950
non-small cell lung cancer 410 | 2,798
intraductal papillary-mucinous neoplasm (IPMN) 409 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 387 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 380 | 2,956
Carcinoma 371 | 2,147
lung carcinoma 371 | 2,844
pancreatic cancer 369 | 2,300
lung adenocarcinoma 362 | 2,713
primitive neuroectodermal tumor 358 | 3,031
pediatric high grade glioma 353 | 2,712
oligodendroglioma 352 | 2,849
interstitial cystitis 337 | 2,299
ulcerative colitis 313 | 2,087
subependymal giant cell astrocytoma 295 | 2,287
pituitary cancer 291 | 1,972
ependymoma 282 | 2,514
ductal carcinoma in situ 275 | 1,745
breast carcinoma 268 | 1,614
cystic fibrosis 255 | 1,665
diabetes mellitus 252 | 1,663
adult high grade glioma 247 | 2,148
astrocytic glioma 242 | 2,241
astrocytoma 241 | 1,493
group 3 medulloblastoma 228 | 2,254
group 4 medulloblastoma 227 | 1,875
colon cancer 223 | 1,475
primary pancreatic ductal adenocarcinoma 219 | 1,271
posterior fossa group A ependymoma 215 | 1,511
tuberculosis 211 | 1,557
Pick disease 206 | 1,893
pancreatic ductal adenocarcinoma liver metastasis 196 | 1,795
sonic hedgehog group medulloblastoma 189 | 1,482
adrenocortical carcinoma 185 | 1,427
medulloblastoma 180 | 1,524
cutaneous lupus erythematosus 179 | 1,056
Rheumatoid Arthritis 172 | 1,160
juvenile dermatomyositis 170 | 1,189
acute quadriplegic myopathy 163 | 1,157
Atopic dermatitis 161 | 944
Obesity 157 | 616
spina bifida 148 | 1,064
Mammary Neoplasms 146 | 410
nasopharyngeal carcinoma 146 | 1,056
gastric carcinoma 145 | 832
esophageal adenocarcinoma 142 | 737
Multiple myeloma 140 | 1,327
posterior fossa group B ependymoma 140 | 1,530
Alzheimer's disease 139 | 644
dermatomyositis 133 | 933
atypical teratoid/rhabdoid tumor 131 | 1,095
Prostatic Neoplasms 129 | 471
aldosterone-producing adenoma 118 | 664
Duchenne muscular dystrophy 117 | 602
autosomal dominant Emery-Dreifuss muscular dystrophy 116 | 499
primary Sjogren syndrome 115 | 789
Kidney disease 110 | 396
active Crohn's disease 109 | 918
Schizophrenia 106 | 501
Down syndrome 105 | 548
Endometriosis 104 | 535
Intellectual disability 101 | 573
Hypertension 97 | 287
Vascular disease 95 | 281
Autistic Disorder 94 | 320
pancreatic carcinoma 94 | 567
Amyotrophic Lateral Sclerosis 90 | 431
Asthma 90 | 349
Neurodegenerative disease 90 | 383
fibroadenoma 89 | 557
non primary Sjogren syndrome sicca 89 | 840
Atherosclerosis 86 | 275
Arthritis 85 | 248
Stomach Neoplasms 85 | 282
Waldenstrons macroglobulinemia 85 | 765
Heart disease 83 | 279
Multiple Sclerosis 83 | 498
non-small cell lung carcinoma 83 | 413
Epilepsy 82 | 346
acute myeloid leukemia 82 | 780
Parkinson's disease 78 | 364
progressive supranuclear palsy 77 | 674
Lung Neoplasms 76 | 171
Polycystic Ovary Syndrome 75 | 332
Liver carcinoma 74 | 217
Peripheral Neuropathy 74 | 303
Anemia 73 | 252
Hypertensive disease 72 | 193
IGA Glomerulonephritis 72 | 454

Tissue

Endocrine System 1,737 | 18,512
Female tissues 1,736 | 18,647
Nervous System 1,736 | 18,561
Digestive Tract 1,735 | 18,473
Urinary Tract 1,730 | 18,444
Liver and Pancreas 1,724 | 18,136
Cardiovascular System 1,721 | 17,958
Skin and soft tissues 1,719 | 18,115
Male tissues 1,714 | 17,969
Blood and immune system 1,710 | 17,995
Respiratory system 1,698 | 17,484

Target Family

Non-IDG 778 | 11,971
Enzyme 375 | 4,146
Transcription Factor 218 | 1,400
Kinase 122 | 634
GPCR 80 | 406
Ion Channel 60 | 341
Transporter 51 | 473
Epigenetic 37 | 242
Nuclear Receptor 19 | 48
TF/Epigenetic 8 | 38

MGI Term

integument phenotype 1,748 | 1,748
mortality/aging 4,850 | 4,850
homeostasis/metabolism phenoty... 4,454 | 4,454
growth/size/body region phenot... 3,915 | 3,915
cellular phenotype 3,348 | 3,348
nervous system phenotype 3,201 | 3,201
behavior/neurological phenotyp... 3,192 | 3,192
immune system phenotype 3,148 | 3,148
hematopoietic system phenotype 3,145 | 3,145
cardiovascular system phenotyp... 2,448 | 2,448
endocrine/exocrine gland pheno... 2,084 | 2,084
skeleton phenotype 2,058 | 2,058
normal phenotype 1,916 | 1,916
reproductive system phenotype 1,873 | 1,873
embryo phenotype 1,674 | 1,674
vision/eye phenotype 1,478 | 1,478
muscle phenotype 1,385 | 1,385
digestive/alimentary phenotype 1,292 | 1,292
respiratory system phenotype 1,291 | 1,291
liver/biliary system phenotype 1,160 | 1,160
renal/urinary system phenotype 1,157 | 1,157
craniofacial phenotype 1,077 | 1,077
limbs/digits/tail phenotype 1,011 | 1,011
neoplasm 918 | 918
adipose tissue phenotype 901 | 901
hearing/vestibular/ear phenoty... 692 | 692
pigmentation phenotype 459 | 459
taste/olfaction phenotype 142 | 142
obsolete other phenotype 69 | 69

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
Retinaldehyde-binding protein 1 RLBP1 Tbio Non-IDG -2.12314 137.8 95
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.39907 258.0 359
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
Erythropoietin EPO Tbio Non-IDG -3.90053 8755.8 628
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851