Development Level

Tbio 2,078 | 10,625
Tchem 688 | 1,890
Tclin 228 | 602
Tdark 154 | 7,003

Collection

Eligible Kinase Proteins 20 | 134
Eligible non-olfactory GPCR Proteins 13 | 143
Eligible Ion Channel Proteins 8 | 117

IMPC Term

preweaning lethality, complete... 172 | 633
preweaning lethality, incomple... 81 | 260
decreased lean body mass 74 | 195
abnormal behavior 69 | 226
decreased body weight 69 | 174
decreased total body fat amoun... 56 | 186
decreased bone mineral content 55 | 157
decreased bone mineral density 51 | 126
abnormal bone structure 49 | 131
decreased leukocyte cell numbe... 48 | 54
embryonic lethality prior to t... 48 | 187
decreased body length 44 | 108
increased circulating alkaline... 44 | 119
decreased grip strength 39 | 123
decreased circulating triglyce... 37 | 83
increased mean corpuscular hem... 37 | 93
decreased circulating glucose ... 36 | 121
enlarged heart 35 | 111
increased grip strength 33 | 83
increased leukocyte cell numbe... 33 | 37
increased mean corpuscular vol... 32 | 91
abnormal embryo size 31 | 112
increased bone mineral content 31 | 92
decreased circulating choleste... 30 | 85
abnormal retina morphology 29 | 100
decreased hemoglobin content 29 | 53
embryonic lethality prior to o... 28 | 148
abnormal bone mineralization 27 | 55
decreased circulating HDL chol... 27 | 77
decreased eosinophil cell numb... 27 | 41
hypoactivity 27 | 89
abnormal spleen morphology 26 | 36
decreased neutrophil cell numb... 26 | 37
increased lean body mass 26 | 107
short tibia 26 | 82
increased circulating HDL chol... 24 | 63
thrombocytopenia 24 | 46
increased or absent threshold ... 23 | 128
decreased B cell number 22 | 30
decreased T cell number 22 | 31
decreased circulating alanine ... 22 | 53
increased bone mineral density 22 | 52
decreased circulating serum al... 21 | 79
decreased mature B cell number 21 | 25
hyperactivity 20 | 108
increased blood urea nitrogen ... 20 | 44
increased hemoglobin content 20 | 45
abnormal lens morphology 19 | 73
decreased circulating insulin ... 19 | 75
decreased erythrocyte cell num... 19 | 43
decreased heart weight 19 | 44
decreased hematocrit 19 | 25
impaired glucose tolerance 19 | 52
increased circulating choleste... 19 | 53
male infertility 19 | 62
abnormal retinal pigmentation 18 | 61
decreased prepulse inhibition 18 | 52
increased body weight 18 | 42
increased circulating calcium ... 18 | 32
increased sacral vertebrae num... 18 | 62
increased total body fat amoun... 18 | 57
decreased CD4-positive, CD25-p... 17 | 24
decreased CD8-positive, alpha-... 17 | 26
decreased NK T cell number 17 | 28
decreased circulating alkaline... 17 | 41
decreased lumbar vertebrae num... 17 | 62
increased B cell number 17 | 23
increased monocyte cell number 17 | 27
abnormal sleep behavior 16 | 63
decreased fasted circulating g... 16 | 49
decreased monocyte cell number 16 | 28
decreased rib number 16 | 59
enlarged lymph nodes 16 | 27
increased circulating sodium l... 16 | 71
prenatal lethality prior to he... 16 | 64
decreased blood urea nitrogen ... 15 | 31
decreased circulating fructosa... 15 | 31
decreased circulating total pr... 15 | 41
decreased mean corpuscular hem... 15 | 34
improved glucose tolerance 15 | 56
increased NK cell number 15 | 19
increased heart weight 15 | 37
small testis 15 | 37
decreased gamma-delta T cell n... 14 | 18
decreased mean corpuscular vol... 14 | 50
enlarged spleen 14 | 26
increased hematocrit 14 | 36
tremors 14 | 34
abnormal behavioral response t... 13 | 52
abnormal eye morphology 13 | 38
abnormal gait 13 | 51
decreased Ly6C low monocyte nu... 13 | 23
decreased circulating LDL chol... 13 | 37
decreased circulating iron lev... 13 | 25
decreased startle reflex 13 | 48
increased circulating serum al... 13 | 25
abnormal cranium morphology 12 | 32
decreased caudal vertebrae num... 12 | 49
increased circulating chloride... 12 | 43
increased exploration in new e... 12 | 56

Disease

ovarian cancer 1,691 | 8,484
osteosarcoma 1,627 | 7,933
psoriasis 1,445 | 6,685
medulloblastoma, large-cell 1,180 | 6,234
lung cancer 1,168 | 4,466
glioblastoma 1,163 | 5,572
Cancer 1,112 | 2,346
malignant mesothelioma 802 | 3,162
lung carcinoma 792 | 2,844
invasive ductal carcinoma 768 | 2,950
non-small cell lung cancer 766 | 2,798
atypical teratoid / rhabdoid tumor 760 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 754 | 3,289
intraductal papillary-mucinous carcinoma (IPMC) 713 | 2,988
lung adenocarcinoma 707 | 2,713
Breast cancer 705 | 3,094
intraductal papillary-mucinous adenoma (IPMA) 703 | 2,956
interstitial cystitis 701 | 2,299
ulcerative colitis 700 | 2,087
pilocytic astrocytoma 695 | 3,086
pancreatic cancer 645 | 2,300
pediatric high grade glioma 562 | 2,712
subependymal giant cell astrocytoma 520 | 2,287
oligodendroglioma 514 | 2,849
primitive neuroectodermal tumor 506 | 3,031
tuberculosis 499 | 1,557
Carcinoma 484 | 2,147
cystic fibrosis 461 | 1,665
pituitary cancer 461 | 1,972
ductal carcinoma in situ 448 | 1,745
diabetes mellitus 435 | 1,663
ependymoma 429 | 2,514
group 4 medulloblastoma 413 | 1,875
breast carcinoma 405 | 1,614
colon cancer 405 | 1,475
adult high grade glioma 403 | 2,148
cutaneous lupus erythematosus 400 | 1,056
astrocytoma 388 | 1,493
group 3 medulloblastoma 385 | 2,254
Rheumatoid Arthritis 375 | 1,160
pancreatic ductal adenocarcinoma liver metastasis 361 | 1,795
primary pancreatic ductal adenocarcinoma 359 | 1,271
posterior fossa group A ependymoma 353 | 1,511
astrocytic glioma 350 | 2,241
juvenile dermatomyositis 338 | 1,189
adrenocortical carcinoma 336 | 1,427
primary Sjogren syndrome 320 | 789
Pick disease 312 | 1,893
medulloblastoma 277 | 1,524
acute quadriplegic myopathy 276 | 1,157
sonic hedgehog group medulloblastoma 267 | 1,482
Multiple myeloma 262 | 1,327
gastric carcinoma 254 | 832
dermatomyositis 252 | 933
Atopic dermatitis 249 | 944
nasopharyngeal carcinoma 238 | 1,056
posterior fossa group B ependymoma 238 | 1,530
active Crohn's disease 235 | 918
spina bifida 228 | 1,064
Multiple Sclerosis 227 | 498
esophageal adenocarcinoma 221 | 737
atypical teratoid/rhabdoid tumor 214 | 1,095
Obesity 213 | 616
Kidney disease 212 | 396
Asthma 210 | 349
Waldenstrons macroglobulinemia 209 | 765
Prostatic Neoplasms 205 | 471
Mammary Neoplasms 199 | 410
acute myeloid leukemia 190 | 780
Duchenne muscular dystrophy 189 | 602
Alzheimer's disease 184 | 644
Down syndrome 179 | 548
mucosa-associated lymphoid tissue lymphoma 174 | 480
Endometriosis 170 | 535
IGA Glomerulonephritis 169 | 454
aldosterone-producing adenoma 165 | 664
hepatocellular carcinoma 164 | 532
Arthritis 163 | 248
Vascular disease 155 | 281
pancreatic carcinoma 155 | 567
Hypersensitivity reaction type II disease 153 | 235
Atherosclerosis 151 | 275
autosomal dominant Emery-Dreifuss muscular dystrophy 150 | 499
fibroadenoma 150 | 557
non primary Sjogren syndrome sicca 147 | 840
Anemia 144 | 252
tuberculosis and treatment for 6 months 144 | 686
progressive supranuclear palsy 133 | 674
Hypertension 129 | 287
periodontitis 126 | 269
sarcoidosis 126 | 358
Liver disease 125 | 219
Neurodegenerative disease 123 | 383
Schizophrenia 123 | 501
non-small cell lung carcinoma 123 | 413
Amyotrophic Lateral Sclerosis 121 | 431
Crohn's disease 120 | 304
gastric cancer 120 | 430
Intellectual disability 118 | 573
Stomach Neoplasms 116 | 282

Tissue

Digestive Tract 3,097 | 18,473
Nervous System 3,097 | 18,561
Female tissues 3,095 | 18,647
Endocrine System 3,087 | 18,512
Urinary Tract 3,079 | 18,444
Liver and Pancreas 3,077 | 18,136
Blood and immune system 3,072 | 17,995
Male tissues 3,067 | 17,969
Cardiovascular System 3,053 | 17,958
Skin and soft tissues 3,051 | 18,115
Respiratory system 3,040 | 17,484

Target Family

Non-IDG 1,610 | 11,971
Enzyme 692 | 4,146
Transcription Factor 283 | 1,400
Kinase 224 | 634
GPCR 121 | 406
Epigenetic 64 | 242
Transporter 62 | 473
Ion Channel 54 | 341
Nuclear Receptor 27 | 48
TF/Epigenetic 11 | 38

MGI Term

immune system phenotype 3,148 | 3,148
mortality/aging 4,850 | 4,850
homeostasis/metabolism phenoty... 4,454 | 4,454
growth/size/body region phenot... 3,915 | 3,915
cellular phenotype 3,348 | 3,348
nervous system phenotype 3,201 | 3,201
behavior/neurological phenotyp... 3,192 | 3,192
hematopoietic system phenotype 3,145 | 3,145
cardiovascular system phenotyp... 2,448 | 2,448
endocrine/exocrine gland pheno... 2,084 | 2,084
skeleton phenotype 2,058 | 2,058
normal phenotype 1,916 | 1,916
reproductive system phenotype 1,873 | 1,873
integument phenotype 1,748 | 1,748
embryo phenotype 1,674 | 1,674
vision/eye phenotype 1,478 | 1,478
muscle phenotype 1,385 | 1,385
digestive/alimentary phenotype 1,292 | 1,292
respiratory system phenotype 1,291 | 1,291
liver/biliary system phenotype 1,160 | 1,160
renal/urinary system phenotype 1,157 | 1,157
craniofacial phenotype 1,077 | 1,077
limbs/digits/tail phenotype 1,011 | 1,011
neoplasm 918 | 918
adipose tissue phenotype 901 | 901
hearing/vestibular/ear phenoty... 692 | 692
pigmentation phenotype 459 | 459
taste/olfaction phenotype 142 | 142
obsolete other phenotype 69 | 69

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
Erythropoietin EPO Tbio Non-IDG -3.90053 8755.8 628