Development Level

Tbio 2,856 | 10,625
Tchem 952 | 1,890
Tclin 350 | 602
Tdark 296 | 7,003

Collection

Eligible non-olfactory GPCR Proteins 24 | 143
Eligible Ion Channel Proteins 21 | 117
Eligible Kinase Proteins 19 | 134

IMPC Term

preweaning lethality, complete... 279 | 633
preweaning lethality, incomple... 133 | 260
abnormal behavior 127 | 226
decreased body weight 119 | 174
decreased total body fat amoun... 117 | 186
decreased lean body mass 116 | 195
increased circulating alkaline... 112 | 119
decreased circulating glucose ... 99 | 121
decreased bone mineral content 95 | 157
embryonic lethality prior to t... 88 | 187
abnormal bone structure 82 | 131
decreased bone mineral density 82 | 126
decreased circulating choleste... 77 | 85
decreased circulating triglyce... 74 | 83
decreased circulating serum al... 71 | 79
decreased circulating HDL chol... 70 | 77
decreased grip strength 69 | 123
increased fasted circulating g... 65 | 68
decreased body length 64 | 108
increased circulating sodium l... 63 | 71
increased circulating HDL chol... 61 | 63
increased lean body mass 61 | 107
abnormal retina morphology 60 | 100
increased or absent threshold ... 60 | 128
abnormal embryo size 57 | 112
decreased circulating insulin ... 57 | 75
increased mean corpuscular hem... 57 | 93
hypoactivity 56 | 89
hyperactivity 55 | 108
increased mean corpuscular vol... 55 | 91
embryonic lethality prior to o... 54 | 148
decreased circulating alanine ... 52 | 53
improved glucose tolerance 50 | 56
increased circulating choleste... 50 | 53
enlarged heart 49 | 111
short tibia 49 | 82
impaired glucose tolerance 48 | 52
increased grip strength 46 | 83
decreased fasted circulating g... 45 | 49
decreased hemoglobin content 42 | 53
increased bone mineral content 42 | 92
abnormal bone mineralization 40 | 55
abnormal lens morphology 40 | 73
increased blood urea nitrogen ... 40 | 44
abnormal sleep behavior 39 | 63
decreased circulating total pr... 39 | 41
decreased circulating alkaline... 38 | 41
abnormal retinal pigmentation 37 | 61
decreased circulating free fat... 37 | 39
decreased mean corpuscular vol... 37 | 50
decreased circulating LDL chol... 36 | 37
increased circulating chloride... 35 | 43
increased total body fat amoun... 35 | 57
thrombocytopenia 35 | 46
abnormal gait 34 | 51
abnormal behavioral response t... 32 | 52
decreased prepulse inhibition 32 | 52
increased circulating calcium ... 32 | 32
increased sacral vertebrae num... 32 | 62
decreased leukocyte cell numbe... 31 | 54
increased bone mineral density 31 | 52
increased hemoglobin content 31 | 45
male infertility 31 | 62
decreased circulating fructosa... 30 | 31
increased leukocyte cell numbe... 30 | 37
decreased circulating creatini... 29 | 31
decreased heart weight 29 | 44
decreased rib number 29 | 59
decreased lumbar vertebrae num... 28 | 62
decreased erythrocyte cell num... 27 | 43
decreased mean corpuscular hem... 27 | 34
decreased startle reflex 27 | 48
increased circulating potassiu... 27 | 31
decreased circulating calcium ... 26 | 33
increased circulating creatini... 26 | 29
abnormal coat/hair pigmentatio... 25 | 54
decreased blood urea nitrogen ... 25 | 31
decreased circulating aspartat... 25 | 27
decreased circulating chloride... 25 | 32
increased circulating iron lev... 25 | 25
abnormal eye morphology 24 | 38
increased circulating phosphat... 24 | 24
increased startle reflex 24 | 38
prenatal lethality prior to he... 24 | 64
decreased circulating iron lev... 23 | 25
increased circulating serum al... 23 | 25
increased circulating triglyce... 23 | 24
limb grasping 23 | 35
decreased caudal vertebrae num... 22 | 49
decreased hematocrit 22 | 25
increased heart weight 22 | 37
abnormal cranium morphology 21 | 32
abnormal seminal vesicle morph... 21 | 47
cataract 21 | 26
decreased circulating amylase ... 21 | 24
tremors 21 | 34
cardiovascular system phenotyp... 20 | 35
increased body weight 20 | 42
increased circulating total pr... 20 | 20
increased hematocrit 20 | 36

Disease

ovarian cancer 2,277 | 8,484
osteosarcoma 2,109 | 7,933
psoriasis 2,002 | 6,685
medulloblastoma, large-cell 1,735 | 6,234
glioblastoma 1,623 | 5,572
lung cancer 1,477 | 4,466
Cancer 1,211 | 2,346
atypical teratoid / rhabdoid tumor 1,202 | 4,369
malignant mesothelioma 1,062 | 3,162
intraductal papillary-mucinous neoplasm (IPMN) 1,015 | 3,289
pilocytic astrocytoma 976 | 3,086
lung carcinoma 975 | 2,844
invasive ductal carcinoma 970 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 967 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 958 | 2,988
non-small cell lung cancer 935 | 2,798
Breast cancer 928 | 3,094
lung adenocarcinoma 894 | 2,713
primitive neuroectodermal tumor 836 | 3,031
pediatric high grade glioma 835 | 2,712
pancreatic cancer 831 | 2,300
oligodendroglioma 823 | 2,849
ulcerative colitis 784 | 2,087
interstitial cystitis 766 | 2,299
Carcinoma 708 | 2,147
subependymal giant cell astrocytoma 707 | 2,287
ependymoma 680 | 2,514
pituitary cancer 652 | 1,972
diabetes mellitus 630 | 1,663
ductal carcinoma in situ 623 | 1,745
group 3 medulloblastoma 599 | 2,254
adult high grade glioma 589 | 2,148
astrocytic glioma 588 | 2,241
cystic fibrosis 578 | 1,665
group 4 medulloblastoma 573 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 573 | 1,795
breast carcinoma 564 | 1,614
tuberculosis 542 | 1,557
astrocytoma 539 | 1,493
Pick disease 535 | 1,893
colon cancer 532 | 1,475
adrenocortical carcinoma 494 | 1,427
posterior fossa group A ependymoma 481 | 1,511
primary pancreatic ductal adenocarcinoma 450 | 1,271
medulloblastoma 428 | 1,524
Rheumatoid Arthritis 410 | 1,160
juvenile dermatomyositis 395 | 1,189
cutaneous lupus erythematosus 389 | 1,056
acute quadriplegic myopathy 384 | 1,157
Obesity 383 | 616
sonic hedgehog group medulloblastoma 379 | 1,482
posterior fossa group B ependymoma 362 | 1,530
dermatomyositis 335 | 933
Atopic dermatitis 332 | 944
atypical teratoid/rhabdoid tumor 324 | 1,095
Multiple myeloma 322 | 1,327
spina bifida 308 | 1,064
gastric carcinoma 307 | 832
Alzheimer's disease 303 | 644
active Crohn's disease 297 | 918
nasopharyngeal carcinoma 295 | 1,056
esophageal adenocarcinoma 280 | 737
primary Sjogren syndrome 269 | 789
Kidney disease 263 | 396
Prostatic Neoplasms 260 | 471
Mammary Neoplasms 230 | 410
Down syndrome 229 | 548
Duchenne muscular dystrophy 229 | 602
acute myeloid leukemia 221 | 780
aldosterone-producing adenoma 218 | 664
Waldenstrons macroglobulinemia 217 | 765
Schizophrenia 214 | 501
Atherosclerosis 211 | 275
Endometriosis 209 | 535
Intellectual disability 209 | 573
non primary Sjogren syndrome sicca 209 | 840
Asthma 206 | 349
Hypertension 203 | 287
autosomal dominant Emery-Dreifuss muscular dystrophy 201 | 499
Vascular disease 199 | 281
pancreatic carcinoma 198 | 567
fibroadenoma 197 | 557
Multiple Sclerosis 193 | 498
mucosa-associated lymphoid tissue lymphoma 193 | 480
progressive supranuclear palsy 193 | 674
Neurodegenerative disease 186 | 383
Parkinson's disease 184 | 364
Heart disease 178 | 279
Coronary artery disease 169 | 240
active ulcerative colitis 169 | 477
Amyotrophic Lateral Sclerosis 168 | 431
hepatocellular carcinoma 167 | 532
IGA Glomerulonephritis 166 | 454
non-small cell lung carcinoma 162 | 413
tuberculosis and treatment for 6 months 161 | 686
Autistic Disorder 159 | 320
Cerebrovascular disease 156 | 231
Hypertensive disease 154 | 193
Epilepsy 150 | 346
Arthritis 149 | 248

Tissue

Digestive Tract 4,417 | 18,473
Nervous System 4,414 | 18,561
Female tissues 4,412 | 18,647
Endocrine System 4,406 | 18,512
Urinary Tract 4,395 | 18,444
Liver and Pancreas 4,389 | 18,136
Blood and immune system 4,355 | 17,995
Skin and soft tissues 4,354 | 18,115
Cardiovascular System 4,351 | 17,958
Male tissues 4,347 | 17,969
Respiratory system 4,292 | 17,484

Target Family

Non-IDG 2,117 | 11,971
Enzyme 1,076 | 4,146
Transcription Factor 361 | 1,400
Kinase 269 | 634
GPCR 193 | 406
Transporter 184 | 473
Ion Channel 121 | 341
Epigenetic 87 | 242
Nuclear Receptor 37 | 48
TF/Epigenetic 9 | 38

MGI Term

homeostasis/metabolism phenoty... 4,454 | 4,454
mortality/aging 4,850 | 4,850
growth/size/body region phenot... 3,915 | 3,915
cellular phenotype 3,348 | 3,348
nervous system phenotype 3,201 | 3,201
behavior/neurological phenotyp... 3,192 | 3,192
immune system phenotype 3,148 | 3,148
hematopoietic system phenotype 3,145 | 3,145
cardiovascular system phenotyp... 2,448 | 2,448
endocrine/exocrine gland pheno... 2,084 | 2,084
skeleton phenotype 2,058 | 2,058
normal phenotype 1,916 | 1,916
reproductive system phenotype 1,873 | 1,873
integument phenotype 1,748 | 1,748
embryo phenotype 1,674 | 1,674
vision/eye phenotype 1,478 | 1,478
muscle phenotype 1,385 | 1,385
digestive/alimentary phenotype 1,292 | 1,292
respiratory system phenotype 1,291 | 1,291
liver/biliary system phenotype 1,160 | 1,160
renal/urinary system phenotype 1,157 | 1,157
craniofacial phenotype 1,077 | 1,077
limbs/digits/tail phenotype 1,011 | 1,011
neoplasm 918 | 918
adipose tissue phenotype 901 | 901
hearing/vestibular/ear phenoty... 692 | 692
pigmentation phenotype 459 | 459
taste/olfaction phenotype 142 | 142
obsolete other phenotype 69 | 69

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
Erythropoietin EPO Tbio Non-IDG -3.90053 8755.8 628
Interstitial collagenase MMP1 Tchem Enzyme -3.40801 2529.5 682