Development Level

Tbio 2,361 | 11,445
Tchem 604 | 1,598
Tclin 221 | 613
Tdark 197 | 6,588

Collection

RFA-RM-18-021 36 | 328
Kinase: IDG Consortium (Target... 20 | 125
GPCR: IDG Consortium (Complete... 11 | 25
GPCR: IDG Consortium (Targets) 11 | 126
Ion Channel: IDG Consortium (T... 5 | 99
Kinase: IDG Consortium (Comple... 5 | 37

IMPC Phenotype

preweaning lethality, complete... 307 | 979
preweaning lethality, incomple... 169 | 499
decreased total body fat amoun... 103 | 207
abnormal behavior 102 | 298
abnormal bone structure 89 | 187
embryonic lethality prior to t... 87 | 278
decreased body weight 83 | 161
increased mean corpuscular hem... 78 | 96
increased lean body mass 73 | 172
increased circulating alkaline... 72 | 122
decreased vertical activity 71 | 208
abnormal embryo size 70 | 220
enlarged heart 69 | 210
increased mean corpuscular vol... 69 | 92
decreased bone mineral content 67 | 151
decreased lean body mass 67 | 135
decreased bone mineral density 62 | 126
embryonic lethality prior to o... 60 | 239
increased total body fat amoun... 59 | 134
decreased leukocyte cell numbe... 57 | 73
decreased circulating glucose ... 55 | 126
decreased mean corpuscular vol... 55 | 79
hypoactivity 55 | 132
decreased body length 47 | 101
increased bone mineral content 47 | 108
thrombocytopenia 47 | 56
decreased circulating choleste... 46 | 93
decreased circulating triglyce... 46 | 79
decreased erythrocyte cell num... 44 | 62
decreased circulating serum al... 43 | 82
hyperactivity 43 | 148
increased startle reflex 43 | 112
abnormal retina morphology 41 | 71
abnormal seminal vesicle morph... 41 | 114
decreased grip strength 41 | 116
decreased hemoglobin content 41 | 68
male infertility 40 | 123
decreased lymphocyte cell numb... 39 | 83
short tibia 39 | 97
abnormal heart morphology 38 | 162
abnormal spleen morphology 38 | 55
increased or absent threshold ... 38 | 101
decreased mean corpuscular hem... 37 | 50
increased circulating HDL chol... 37 | 80
increased hemoglobin content 37 | 45
increased bone mineral density 36 | 72
cataract 35 | 92
decreased circulating HDL chol... 35 | 68
prenatal lethality prior to he... 35 | 87
increased circulating choleste... 34 | 66
increased leukocyte cell numbe... 34 | 47
abnormal lens morphology 33 | 81
increased heart weight 33 | 62
decreased prepulse inhibition 32 | 82
increased hematocrit 32 | 46
embryonic growth retardation 31 | 106
impaired glucose tolerance 31 | 75
improved glucose tolerance 31 | 79
abnormal cranium morphology 29 | 36
abnormal sleep behavior 29 | 70
decreased circulating insulin ... 29 | 76
decreased startle reflex 29 | 75
decreased circulating total pr... 28 | 49
increased neutrophil cell numb... 28 | 46
abnormal gait 27 | 69
decreased blood urea nitrogen ... 27 | 51
decreased hematocrit 27 | 46
enlarged spleen 27 | 41
increased circulating sodium l... 27 | 71
increased red blood cell distr... 27 | 34
small superior vagus ganglion 27 | 74
abnormal eye morphology 26 | 68
decreased caudal vertebrae num... 26 | 53
increased erythrocyte cell num... 26 | 39
increased mean corpuscular hem... 26 | 36
increased monocyte cell number 26 | 63
abnormal coat-hair pigmentatio... 25 | 64
decreased neutrophil cell numb... 24 | 42
edema 24 | 59
increased fasted circulating g... 24 | 76
increased mean platelet volume 24 | 45
decreased circulating alanine ... 23 | 47
decreased red blood cell distr... 23 | 41
increased circulating calcium ... 23 | 34
abnormal behavioral response t... 22 | 66
increased blood urea nitrogen ... 22 | 48
increased grip strength 22 | 41
decreased circulating alkaline... 21 | 46
decreased circulating amylase ... 21 | 28
enlarged lymph nodes 21 | 37
corneal opacity 20 | 32
decreased circulating LDL chol... 20 | 38
decreased circulating creatini... 20 | 39
decreased fasted circulating g... 20 | 65
increased circulating iron lev... 20 | 30
increased circulating triglyce... 20 | 42
thrombocytosis 20 | 27
tremors 20 | 39
abnormal bone mineralization 19 | 38
decreased circulating fructosa... 19 | 30

Disease

Carcinoma 2,257 | 11,493
ovarian cancer 1,858 | 8,520
osteosarcoma 1,791 | 7,950
psoriasis 1,487 | 6,694
glioblastoma 1,333 | 5,792
medulloblastoma, large-cell 1,287 | 6,241
lung cancer 1,273 | 4,740
Cancer 1,140 | 2,499
atypical teratoid / rhabdoid tumor 1,022 | 5,112
ependymoma 931 | 4,679
Breast cancer 886 | 3,578
malignant mesothelioma 883 | 3,232
non-small cell lung cancer 825 | 2,890
invasive ductal carcinoma 806 | 2,951
group 3 medulloblastoma 801 | 4,104
lung carcinoma 799 | 2,843
adult high grade glioma 785 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 778 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 738 | 2,989
Astrocytoma, Pilocytic 723 | 3,081
lung adenocarcinoma 723 | 2,716
intraductal papillary-mucinous adenoma (IPMA) 718 | 2,955
interstitial cystitis 702 | 2,312
pancreatic cancer 666 | 2,398
tuberculosis 650 | 2,010
ulcerative colitis 607 | 1,819
primitive neuroectodermal tumor 593 | 3,035
Kidney cancer 573 | 2,613
oligodendroglioma 565 | 2,850
subependymal giant cell astrocytoma 549 | 2,287
Autosomal recessive predisposition 492 | 1,442
astrocytic glioma 486 | 2,597
pituitary cancer 470 | 1,972
diabetes mellitus 466 | 1,728
ductal carcinoma in situ 449 | 1,745
cystic fibrosis 448 | 1,696
pancreatic ductal adenocarcinoma liver metastasis 435 | 1,962
breast carcinoma 433 | 1,638
Rheumatoid arthritis 421 | 1,191
group 4 medulloblastoma 415 | 1,855
cutaneous lupus erythematosus 410 | 1,057
colon cancer 399 | 1,478
adrenocortical carcinoma 381 | 1,428
Schizophrenia 372 | 1,160
Pick disease 357 | 1,894
juvenile dermatomyositis 356 | 1,187
astrocytoma 330 | 1,146
primary pancreatic ductal adenocarcinoma 328 | 1,109
Liver Cirrhosis, Experimental 304 | 769
Multiple myeloma 302 | 1,332
primary Sjogren syndrome 299 | 735
acute quadriplegic myopathy 296 | 1,158
Intellectual disability 284 | 1,016
dermatomyositis 265 | 966
pediatric high grade glioma 265 | 1,064
spina bifida 259 | 1,074
Atopic dermatitis 254 | 952
Multiple Sclerosis 245 | 540
nasopharyngeal carcinoma 241 | 1,058
gastric carcinoma 239 | 807
Waldenstrons macroglobulinemia 235 | 765
active Crohn's disease 234 | 922
esophageal adenocarcinoma 226 | 737
Obesity 221 | 678
Prostatic Neoplasms 221 | 495
Anemia 220 | 365
acute myeloid leukemia 219 | 783
Bipolar Disorder 215 | 666
Epilepsy 215 | 792
Breast Neoplasms 214 | 445
Kidney disease 211 | 430
Dull intelligence 209 | 645
Low intelligence 209 | 645
Mental Retardation 209 | 645
Mental deficiency 209 | 645
Poor school performance 209 | 645
Asthma 207 | 385
Mammary Neoplasms 207 | 425
Short stature 205 | 531
active ulcerative colitis 198 | 764
Melanoma 191 | 711
non primary Sjogren syndrome sicca 191 | 891
Seizures 188 | 596
Cognitive delay 187 | 608
Global developmental delay 187 | 608
Mental and motor retardation 187 | 608
mucosa-associated lymphoid tissue lymphoma 185 | 484
Alzheimer's disease 184 | 658
Arthritis 184 | 290
Hypertension 181 | 396
Endometriosis 177 | 540
aldosterone-producing adenoma 176 | 665
hepatocellular carcinoma 176 | 547
Duchenne muscular dystrophy 175 | 601
Muscle hypotonia 173 | 571
medulloblastoma 172 | 720
Hypersensitivity reaction type II disease 169 | 253
Down syndrome 168 | 499
pancreatic carcinoma 168 | 562
Depressive disorder 164 | 409

Tissue

Endocrine System 3,301 | 18,159
Digestive Tract 3,276 | 17,369
Female tissues 3,259 | 17,400
Skin and soft tissues 3,255 | 17,230
Blood and immune system 3,239 | 16,909
Male tissues 3,233 | 17,142
Liver and Pancreas 3,231 | 16,750
Urinary Tract 3,217 | 16,678
Respiratory system 3,201 | 16,393
Nervous System 3,168 | 16,725
Cardiovascular System 3,034 | 15,192

Target Family

Non-IDG 1,782 | 12,091
Enzyme 756 | 4,145
Transcription Factor 289 | 1,400
Kinase 216 | 634
GPCR 109 | 408
Transporter 71 | 473
Epigenetic 70 | 242
Ion Channel 51 | 344
Nuclear Receptor 27 | 48
TF/Epigenetic 12 | 38

MGI Phenotype

hematopoietic system phenotype 3,383 | 3,383
mortality-aging 5,018 | 5,018
homeostasis-metabolism phenoty... 4,747 | 4,747
growth-size-body region phenot... 4,157 | 4,157
cellular phenotype 3,637 | 3,637
immune system phenotype 3,461 | 3,461
nervous system phenotype 3,447 | 3,447
behavior-neurological phenotyp... 3,401 | 3,401
cardiovascular system phenotyp... 2,660 | 2,660
endocrine-exocrine gland pheno... 2,293 | 2,293
skeleton phenotype 2,222 | 2,222
normal phenotype 1,999 | 1,999
reproductive system phenotype 1,999 | 1,999
integument phenotype 1,874 | 1,874
embryo phenotype 1,827 | 1,827
vision-eye phenotype 1,622 | 1,622
muscle phenotype 1,479 | 1,479
digestive-alimentary phenotype 1,398 | 1,398
respiratory system phenotype 1,390 | 1,390
liver-biliary system phenotype 1,300 | 1,300
renal-urinary system phenotype 1,269 | 1,269
craniofacial phenotype 1,182 | 1,182
limbs-digits-tail phenotype 1,071 | 1,071
adipose tissue phenotype 992 | 992
neoplasm 975 | 975
hearing-vestibular-ear phenoty... 767 | 767
pigmentation phenotype 506 | 506
taste-olfaction phenotype 147 | 147
no phenotypic analysis 5 | 5

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Inactive cytidine monophosphate-N-acetylneuraminic acid hydroxylase CMAHP Tbio Enzyme -1.76743 57.3 0
Protein unc-13 homolog D UNC13D Tbio Non-IDG -1.93790 85.1 158
Pyruvate kinase PKLR PKLR Tbio Kinase -2.37549 231.1 391
Anaphase-promoting complex subunit 2 ANAPC2 Tbio Enzyme -0.45557 2.44 166
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 ST6GALNAC2 Tbio Enzyme -1.74190 55.6 59
Leukemia inhibitory factor LIF Tbio Non-IDG -2.86943 538.7 413
CCAAT/enhancer-binding protein beta CEBPB Tbio Transcription Factor -2.96589 857.9 436
Zinc transporter ZIP3 SLC39A3 Tbio Transporter -0.52290 3.15 87
Chondroitin sulfate synthase 1 CHSY1 Tbio Enzyme -1.69082 48.5 101
Transient receptor potential cation channel subfamily M member 2 TRPM2 Tchem Ion Channel -1.34318 25.1 209