Development Level

Tbio 2,067 | 10,625
Tchem 670 | 1,890
Tclin 207 | 602
Tdark 201 | 7,003

Collection

Eligible Kinase Proteins 20 | 134
Eligible non-olfactory GPCR Proteins 12 | 143
Eligible Ion Channel Proteins 6 | 117

IMPC Term

preweaning lethality, complete... 199 | 633
decreased lean body mass 97 | 195
decreased total body fat amoun... 89 | 186
decreased body weight 87 | 174
abnormal behavior 85 | 226
increased mean corpuscular hem... 83 | 93
preweaning lethality, incomple... 80 | 260
increased mean corpuscular vol... 77 | 91
decreased bone mineral content 75 | 157
increased circulating alkaline... 66 | 119
abnormal bone structure 64 | 131
decreased bone mineral density 62 | 126
embryonic lethality prior to t... 62 | 187
decreased body length 57 | 108
decreased circulating glucose ... 50 | 121
decreased circulating triglyce... 49 | 83
decreased leukocyte cell numbe... 48 | 54
decreased hemoglobin content 45 | 53
decreased mean corpuscular vol... 45 | 50
abnormal retina morphology 44 | 100
decreased circulating choleste... 44 | 85
increased lean body mass 43 | 107
decreased grip strength 42 | 123
hypoactivity 42 | 89
decreased circulating HDL chol... 41 | 77
enlarged heart 40 | 111
increased bone mineral content 40 | 92
increased hemoglobin content 40 | 45
decreased circulating serum al... 39 | 79
thrombocytopenia 39 | 46
decreased erythrocyte cell num... 37 | 43
increased grip strength 37 | 83
short tibia 35 | 82
abnormal embryo size 33 | 112
increased leukocyte cell numbe... 33 | 37
abnormal bone mineralization 32 | 55
decreased mean corpuscular hem... 32 | 34
embryonic lethality prior to o... 31 | 148
increased hematocrit 31 | 36
increased or absent threshold ... 31 | 128
decreased eosinophil cell numb... 30 | 41
hyperactivity 30 | 108
increased circulating HDL chol... 28 | 63
abnormal spleen morphology 27 | 36
decreased circulating insulin ... 27 | 75
decreased neutrophil cell numb... 27 | 37
abnormal lens morphology 26 | 73
abnormal retinal pigmentation 25 | 61
decreased prepulse inhibition 25 | 52
increased circulating sodium l... 25 | 71
decreased T cell number 24 | 31
decreased circulating alanine ... 24 | 53
decreased hematocrit 24 | 25
abnormal sleep behavior 23 | 63
decreased B cell number 23 | 30
decreased lumbar vertebrae num... 23 | 62
increased blood urea nitrogen ... 23 | 44
increased circulating choleste... 23 | 53
increased mean corpuscular hem... 23 | 25
increased sacral vertebrae num... 23 | 62
prenatal lethality prior to he... 23 | 64
decreased NK T cell number 22 | 28
decreased circulating total pr... 22 | 41
decreased heart weight 22 | 44
increased body weight 22 | 42
increased heart weight 22 | 37
decreased circulating LDL chol... 21 | 37
decreased mature B cell number 21 | 25
decreased rib number 21 | 59
impaired glucose tolerance 21 | 52
increased bone mineral density 21 | 52
increased circulating calcium ... 21 | 32
increased erythrocyte cell num... 21 | 26
abnormal coat/hair pigmentatio... 20 | 54
abnormal cranium morphology 20 | 32
abnormal gait 20 | 51
decreased circulating alkaline... 20 | 41
decreased circulating fructosa... 20 | 31
increased monocyte cell number 20 | 27
increased total body fat amoun... 20 | 57
male infertility 20 | 62
decreased CD8-positive, alpha-... 19 | 26
decreased fasted circulating g... 19 | 49
decreased monocyte cell number 19 | 28
increased red blood cell distr... 19 | 21
decreased caudal vertebrae num... 18 | 49
improved glucose tolerance 18 | 56
increased B cell number 18 | 23
tremors 18 | 34
abnormal behavioral response t... 17 | 52
decreased CD4-positive, CD25-p... 17 | 24
decreased circulating free fat... 17 | 39
decreased mean corpuscular hem... 17 | 19
decreased startle reflex 17 | 48
increased NK cell number 17 | 19
increased fasted circulating g... 17 | 68
increased mean platelet volume 17 | 19
cardiovascular system phenotyp... 16 | 35
decreased circulating calcium ... 16 | 33
thrombocytosis 16 | 23

Disease

ovarian cancer 1,715 | 8,484
osteosarcoma 1,671 | 7,933
psoriasis 1,411 | 6,685
glioblastoma 1,197 | 5,572
medulloblastoma, large-cell 1,189 | 6,234
lung cancer 1,155 | 4,466
Cancer 1,061 | 2,346
atypical teratoid / rhabdoid tumor 799 | 4,369
malignant mesothelioma 798 | 3,162
non-small cell lung cancer 765 | 2,798
lung carcinoma 761 | 2,844
invasive ductal carcinoma 759 | 2,950
intraductal papillary-mucinous neoplasm (IPMN) 731 | 3,289
Breast cancer 704 | 3,094
intraductal papillary-mucinous carcinoma (IPMC) 697 | 2,988
pilocytic astrocytoma 693 | 3,086
lung adenocarcinoma 687 | 2,713
interstitial cystitis 667 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 667 | 2,956
ulcerative colitis 661 | 2,087
pancreatic cancer 610 | 2,300
pediatric high grade glioma 584 | 2,712
primitive neuroectodermal tumor 555 | 3,031
subependymal giant cell astrocytoma 523 | 2,287
oligodendroglioma 522 | 2,849
tuberculosis 483 | 1,557
Carcinoma 467 | 2,147
ependymoma 446 | 2,514
pituitary cancer 433 | 1,972
ductal carcinoma in situ 429 | 1,745
cystic fibrosis 424 | 1,665
diabetes mellitus 419 | 1,663
adult high grade glioma 404 | 2,148
group 4 medulloblastoma 404 | 1,875
group 3 medulloblastoma 403 | 2,254
breast carcinoma 401 | 1,614
cutaneous lupus erythematosus 395 | 1,056
Rheumatoid Arthritis 385 | 1,160
astrocytoma 378 | 1,493
colon cancer 377 | 1,475
astrocytic glioma 369 | 2,241
adrenocortical carcinoma 358 | 1,427
posterior fossa group A ependymoma 355 | 1,511
pancreatic ductal adenocarcinoma liver metastasis 354 | 1,795
primary pancreatic ductal adenocarcinoma 352 | 1,271
juvenile dermatomyositis 337 | 1,189
Pick disease 331 | 1,893
primary Sjogren syndrome 316 | 789
medulloblastoma 285 | 1,524
sonic hedgehog group medulloblastoma 283 | 1,482
acute quadriplegic myopathy 277 | 1,157
Multiple myeloma 275 | 1,327
dermatomyositis 253 | 933
gastric carcinoma 242 | 832
posterior fossa group B ependymoma 236 | 1,530
Atopic dermatitis 234 | 944
spina bifida 232 | 1,064
nasopharyngeal carcinoma 229 | 1,056
active Crohn's disease 223 | 918
Waldenstrons macroglobulinemia 222 | 765
atypical teratoid/rhabdoid tumor 216 | 1,095
Multiple Sclerosis 215 | 498
esophageal adenocarcinoma 213 | 737
Kidney disease 207 | 396
Prostatic Neoplasms 199 | 471
Asthma 195 | 349
acute myeloid leukemia 193 | 780
Mammary Neoplasms 192 | 410
Obesity 188 | 616
mucosa-associated lymphoid tissue lymphoma 177 | 480
Alzheimer's disease 174 | 644
aldosterone-producing adenoma 172 | 664
Endometriosis 170 | 535
IGA Glomerulonephritis 170 | 454
Down syndrome 169 | 548
Duchenne muscular dystrophy 169 | 602
hepatocellular carcinoma 165 | 532
pancreatic carcinoma 165 | 567
Arthritis 159 | 248
Anemia 157 | 252
Hypersensitivity reaction type II disease 151 | 235
Vascular disease 149 | 281
tuberculosis and treatment for 6 months 149 | 686
non primary Sjogren syndrome sicca 148 | 840
fibroadenoma 142 | 557
progressive supranuclear palsy 141 | 674
Atherosclerosis 139 | 275
autosomal dominant Emery-Dreifuss muscular dystrophy 137 | 499
Schizophrenia 128 | 501
Neurodegenerative disease 127 | 383
sarcoidosis 126 | 358
Intellectual disability 125 | 573
gastric cancer 122 | 430
Hypertension 121 | 287
Liver disease 121 | 219
Crohn's disease 118 | 304
Amyotrophic Lateral Sclerosis 117 | 431
periodontitis 117 | 269
Heart disease 115 | 279
inflammatory breast cancer 114 | 404

Tissue

Nervous System 3,098 | 18,561
Digestive Tract 3,096 | 18,473
Female tissues 3,096 | 18,647
Endocrine System 3,089 | 18,512
Urinary Tract 3,084 | 18,444
Liver and Pancreas 3,081 | 18,136
Blood and immune system 3,079 | 17,995
Male tissues 3,069 | 17,969
Cardiovascular System 3,059 | 17,958
Skin and soft tissues 3,053 | 18,115
Respiratory system 3,050 | 17,484

Target Family

Non-IDG 1,640 | 11,971
Enzyme 687 | 4,146
Transcription Factor 278 | 1,400
Kinase 213 | 634
GPCR 109 | 406
Epigenetic 67 | 242
Transporter 66 | 473
Ion Channel 46 | 341
Nuclear Receptor 27 | 48
TF/Epigenetic 12 | 38

MGI Term

hematopoietic system phenotype 3,145 | 3,145
mortality/aging 4,850 | 4,850
homeostasis/metabolism phenoty... 4,454 | 4,454
growth/size/body region phenot... 3,915 | 3,915
cellular phenotype 3,348 | 3,348
nervous system phenotype 3,201 | 3,201
behavior/neurological phenotyp... 3,192 | 3,192
immune system phenotype 3,148 | 3,148
cardiovascular system phenotyp... 2,448 | 2,448
endocrine/exocrine gland pheno... 2,084 | 2,084
skeleton phenotype 2,058 | 2,058
normal phenotype 1,916 | 1,916
reproductive system phenotype 1,873 | 1,873
integument phenotype 1,748 | 1,748
embryo phenotype 1,674 | 1,674
vision/eye phenotype 1,478 | 1,478
muscle phenotype 1,385 | 1,385
digestive/alimentary phenotype 1,292 | 1,292
respiratory system phenotype 1,291 | 1,291
liver/biliary system phenotype 1,160 | 1,160
renal/urinary system phenotype 1,157 | 1,157
craniofacial phenotype 1,077 | 1,077
limbs/digits/tail phenotype 1,011 | 1,011
neoplasm 918 | 918
adipose tissue phenotype 901 | 901
hearing/vestibular/ear phenoty... 692 | 692
pigmentation phenotype 459 | 459
taste/olfaction phenotype 142 | 142
obsolete other phenotype 69 | 69

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
Chitinase-3-like protein 1 CHI3L1 Tbio Enzyme -2.73776 668.3 248
Retinaldehyde-binding protein 1 RLBP1 Tbio Non-IDG -2.12314 137.8 95
Lumican LUM Tbio Non-IDG -2.67820 509.4 209