Development Level

Tbio 576 | 11,445
Tchem 84 | 1,598
Tclin 56 | 613
Tdark 51 | 6,588

Collection

RFA-RM-18-021 9 | 328
Ion Channel: IDG Consortium (T... 6 | 99
Kinase: IDG Consortium (Target... 3 | 125
GPCR: IDG Consortium (Complete... 1 | 25
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 75 | 979
increased or absent threshold ... 59 | 101
preweaning lethality, incomple... 58 | 499
abnormal behavior 36 | 298
abnormal bone structure 31 | 187
decreased prepulse inhibition 28 | 82
embryonic lethality prior to t... 28 | 278
decreased body weight 26 | 161
decreased startle reflex 26 | 75
increased lean body mass 25 | 172
hyperactivity 24 | 148
enlarged heart 23 | 210
abnormal embryo size 22 | 220
decreased total body fat amoun... 21 | 207
decreased vertical activity 21 | 208
increased total body fat amoun... 20 | 134
decreased lean body mass 17 | 135
increased circulating alkaline... 17 | 122
decreased body length 16 | 101
decreased grip strength 16 | 116
decreased bone mineral content 15 | 151
decreased bone mineral density 15 | 126
increased bone mineral content 15 | 108
increased startle reflex 15 | 112
embryonic lethality prior to o... 14 | 239
increased heart weight 14 | 62
abnormal heart morphology 13 | 162
hypoactivity 13 | 132
abnormal gait 12 | 69
abnormal retina morphology 12 | 71
absent startle reflex 12 | 24
decreased circulating insulin ... 12 | 76
limb grasping 12 | 41
short tibia 12 | 97
absent pinna reflex 11 | 23
cataract 11 | 92
decreased circulating amylase ... 11 | 28
decreased circulating serum al... 11 | 82
decreased circulating triglyce... 11 | 79
decreased hemoglobin content 11 | 68
increased circulating choleste... 11 | 66
decreased circulating glucose ... 10 | 126
decreased circulating total pr... 10 | 49
embryonic growth retardation 10 | 106
impaired glucose tolerance 10 | 75
increased mean corpuscular vol... 10 | 92
abnormal lens morphology 9 | 81
abnormal seminal vesicle morph... 9 | 114
decreased circulating HDL chol... 9 | 68
decreased fasted circulating g... 9 | 65
increased circulating HDL chol... 9 | 80
increased mean corpuscular hem... 9 | 96
male infertility 9 | 123
abnormal behavioral response t... 8 | 66
abnormal kidney morphology 8 | 65
decreased circulating choleste... 8 | 93
decreased leukocyte cell numbe... 8 | 73
enlarged lymph nodes 8 | 37
female infertility 8 | 60
improved glucose tolerance 8 | 79
increased bone mineral density 8 | 72
increased circulating sodium l... 8 | 71
increased fasted circulating g... 8 | 76
prenatal lethality prior to he... 8 | 87
small testis 8 | 58
abnormal craniofacial morpholo... 7 | 33
abnormal eye morphology 7 | 68
abnormal spleen morphology 7 | 55
abnormal startle reflex 7 | 15
abnormal testis morphology 7 | 43
decreased blood urea nitrogen ... 7 | 51
decreased erythrocyte cell num... 7 | 62
decreased hematocrit 7 | 46
increased blood urea nitrogen ... 7 | 48
increased body length 7 | 32
increased vertical activity 7 | 24
mammalian phenotype 7 | 17
small superior vagus ganglion 7 | 74
tremors 7 | 39
trunk curl 7 | 16
abnormal coat-hair pigmentatio... 6 | 64
abnormal epididymis morphology 6 | 42
abnormal locomotor activation 6 | 16
abnormal retinal blood vessel ... 6 | 26
abnormal sleep behavior 6 | 70
decreased circulating alanine ... 6 | 47
decreased mean corpuscular vol... 6 | 79
decreased threshold for audito... 6 | 26
increased circulating chloride... 6 | 41
increased hemoglobin content 6 | 45
increased leukocyte cell numbe... 6 | 47
persistence of hyaloid vascula... 6 | 33
thrombocytopenia 6 | 56
abnormal cornea morphology 5 | 31
abnormal ear morphology 5 | 9
abnormal heart left ventricle ... 5 | 16
abnormal retinal vasculature m... 5 | 27
corneal opacity 5 | 32
decreased neutrophil cell numb... 5 | 42
enlarged spleen 5 | 41

Disease

Carcinoma 567 | 11,493
ovarian cancer 394 | 8,520
osteosarcoma 358 | 7,950
psoriasis 327 | 6,694
medulloblastoma, large-cell 326 | 6,241
glioblastoma 319 | 5,792
atypical teratoid / rhabdoid tumor 294 | 5,112
ependymoma 271 | 4,679
lung cancer 249 | 4,740
Breast cancer 220 | 3,578
Cancer 207 | 2,499
group 3 medulloblastoma 204 | 4,104
adult high grade glioma 203 | 3,801
Kidney cancer 189 | 2,613
Astrocytoma, Pilocytic 181 | 3,081
malignant mesothelioma 178 | 3,232
primitive neuroectodermal tumor 173 | 3,035
Autosomal recessive predisposition 167 | 1,442
invasive ductal carcinoma 167 | 2,951
oligodendroglioma 164 | 2,850
lung carcinoma 160 | 2,843
intraductal papillary-mucinous adenoma (IPMA) 156 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 155 | 3,291
lung adenocarcinoma 153 | 2,716
non-small cell lung cancer 145 | 2,890
astrocytic glioma 144 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 144 | 2,989
pituitary cancer 141 | 1,972
interstitial cystitis 139 | 2,312
pancreatic cancer 138 | 2,398
Intellectual disability 134 | 1,016
subependymal giant cell astrocytoma 120 | 2,287
cystic fibrosis 113 | 1,696
Dull intelligence 108 | 645
Low intelligence 108 | 645
Mental Retardation 108 | 645
Mental deficiency 108 | 645
Poor school performance 108 | 645
breast carcinoma 107 | 1,638
Schizophrenia 105 | 1,160
ductal carcinoma in situ 104 | 1,745
group 4 medulloblastoma 103 | 1,855
adrenocortical carcinoma 94 | 1,428
pancreatic ductal adenocarcinoma liver metastasis 94 | 1,962
tuberculosis 94 | 2,010
Short stature 90 | 531
Epilepsy 89 | 792
Pick disease 87 | 1,894
Cognitive delay 86 | 608
Global developmental delay 86 | 608
Mental and motor retardation 86 | 608
diabetes mellitus 82 | 1,728
ulcerative colitis 81 | 1,819
astrocytoma 80 | 1,146
spina bifida 80 | 1,074
colon cancer 78 | 1,478
Muscle hypotonia 74 | 571
Nonsyndromic deafness 73 | 142
Rheumatoid arthritis 73 | 1,191
Sensorineural Hearing Loss (disorder) 73 | 284
Seizures 71 | 596
Cleft Palate 68 | 271
Liver cancer 67 | 604
Obesity 66 | 678
pediatric high grade glioma 66 | 1,064
Craniofacial Abnormalities 65 | 151
primary pancreatic ductal adenocarcinoma 63 | 1,109
Melanoma 61 | 711
Bipolar Disorder 60 | 666
Breast Neoplasms 60 | 445
Sensorineural hearing loss 60 | 106
Mammary Neoplasms 58 | 425
Nystagmus 58 | 317
Cryptorchidism 54 | 296
Small head 54 | 374
Alzheimer's disease 53 | 658
Orbital separation excessive 53 | 244
gastric carcinoma 53 | 807
Deafness 52 | 198
Prostatic Neoplasms 52 | 495
Cataract 51 | 297
Strabismus 51 | 270
hearing impairment 51 | 199
Hypoplastic mandible condyle 50 | 275
Mandibular hypoplasia 50 | 275
Micrognathism 50 | 275
cutaneous lupus erythematosus 50 | 1,057
Hypertensive disease 48 | 292
Skin cancer 48 | 469
Osteoporosis 47 | 363
nasopharyngeal carcinoma 47 | 1,058
Atopic dermatitis 45 | 952
Lens Opacities 45 | 231
Multiple myeloma 45 | 1,332
acute quadriplegic myopathy 45 | 1,158
medulloblastoma 45 | 720
Congenital deafness 44 | 185
Hearing Loss, Partial 44 | 185
active ulcerative colitis 43 | 764
juvenile dermatomyositis 43 | 1,187

Tissue

Endocrine System 742 | 18,159
Digestive Tract 721 | 17,369
Female tissues 719 | 17,400
Skin and soft tissues 719 | 17,230
Male tissues 713 | 17,142
Nervous System 705 | 16,725
Urinary Tract 704 | 16,678
Blood and immune system 698 | 16,909
Liver and Pancreas 696 | 16,750
Respiratory system 684 | 16,393
Cardiovascular System 630 | 15,192

Target Family

Non-IDG 390 | 12,091
Enzyme 126 | 4,145
Transcription Factor 116 | 1,400
Kinase 37 | 634
Ion Channel 33 | 344
Transporter 23 | 473
GPCR 18 | 408
Nuclear Receptor 14 | 48
Epigenetic 8 | 242
TF/Epigenetic 2 | 38

MGI Phenotype

hearing-vestibular-ear phenoty... 767 | 767
mortality-aging 5,018 | 5,018
homeostasis-metabolism phenoty... 4,747 | 4,747
growth-size-body region phenot... 4,157 | 4,157
cellular phenotype 3,637 | 3,637
immune system phenotype 3,461 | 3,461
nervous system phenotype 3,447 | 3,447
behavior-neurological phenotyp... 3,401 | 3,401
hematopoietic system phenotype 3,383 | 3,383
cardiovascular system phenotyp... 2,660 | 2,660
endocrine-exocrine gland pheno... 2,293 | 2,293
skeleton phenotype 2,222 | 2,222
normal phenotype 1,999 | 1,999
reproductive system phenotype 1,999 | 1,999
integument phenotype 1,874 | 1,874
embryo phenotype 1,827 | 1,827
vision-eye phenotype 1,622 | 1,622
muscle phenotype 1,479 | 1,479
digestive-alimentary phenotype 1,398 | 1,398
respiratory system phenotype 1,390 | 1,390
liver-biliary system phenotype 1,300 | 1,300
renal-urinary system phenotype 1,269 | 1,269
craniofacial phenotype 1,182 | 1,182
limbs-digits-tail phenotype 1,071 | 1,071
adipose tissue phenotype 992 | 992
neoplasm 975 | 975
pigmentation phenotype 506 | 506
taste-olfaction phenotype 147 | 147
no phenotypic analysis 5 | 5

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Inactive cytidine monophosphate-N-acetylneuraminic acid hydroxylase CMAHP Tbio Enzyme -1.76743 57.3 0
Glutaredoxin domain-containing cysteine-rich protein 2 GRXCR2 Tbio Non-IDG 0.00000 1.00 14
Homeobox protein MSX-1 MSX1 Tbio Transcription Factor -2.59245 390.1 298
Meiotic recombination protein SPO11 SPO11 Tbio Non-IDG -2.33263 208.9 148
Nucleoredoxin NXN Tbio Non-IDG -2.54390 345.4 96
Transcription factor Sp5 SP5 Tdark Transcription Factor 0.30 0.34 21
Retinal dehydrogenase 2 ALDH1A2 Tbio Enzyme -2.25078 175.3 229
Activin receptor type-2A ACVR2A Tchem Kinase -2.08745 108.0 315
Calbindin CALB1 Tbio Non-IDG -3.31956 2149.9 287
Forkhead box protein C2 FOXC2 Tbio Transcription Factor -2.23435 187.0 419