Development Level

Tbio 478 | 10,625
Tchem 107 | 1,890
Tclin 55 | 602
Tdark 52 | 7,003

Collection

Eligible Ion Channel Proteins 8 | 117
Eligible Kinase Proteins 4 | 134

IMPC Term

increased or absent threshold ... 94 | 128
preweaning lethality, complete... 46 | 633
preweaning lethality, incomple... 38 | 260
decreased lean body mass 28 | 195
abnormal behavior 25 | 226
decreased body weight 22 | 174
decreased threshold for audito... 22 | 32
decreased grip strength 21 | 123
decreased total body fat amoun... 20 | 186
abnormal bone structure 19 | 131
decreased prepulse inhibition 19 | 52
embryonic lethality prior to t... 19 | 187
enlarged heart 18 | 111
decreased startle reflex 17 | 48
hyperactivity 17 | 108
decreased bone mineral density 15 | 126
abnormal bone mineralization 14 | 55
decreased body length 14 | 108
decreased bone mineral content 14 | 157
decreased circulating glucose ... 14 | 121
decreased circulating triglyce... 14 | 83
increased lean body mass 13 | 107
decreased circulating choleste... 12 | 85
abnormal embryo size 11 | 112
decreased circulating HDL chol... 11 | 77
increased circulating alkaline... 11 | 119
limb grasping 11 | 35
abnormal retina morphology 10 | 100
decreased circulating amylase ... 10 | 24
decreased circulating serum al... 10 | 79
increased bone mineral content 10 | 92
increased grip strength 10 | 83
absent pinna reflex 9 | 21
absent startle reflex 9 | 15
decreased circulating insulin ... 9 | 75
decreased hemoglobin content 9 | 53
embryonic lethality prior to o... 9 | 148
hypoactivity 9 | 89
increased mean corpuscular hem... 9 | 93
abnormal gait 8 | 51
increased blood urea nitrogen ... 8 | 44
increased circulating sodium l... 8 | 71
increased mean corpuscular vol... 8 | 91
abnormal lens morphology 7 | 73
abnormal retinal pigmentation 7 | 61
abnormal startle reflex 7 | 14
decreased caudal vertebrae num... 7 | 49
decreased circulating alanine ... 7 | 53
decreased heart weight 7 | 44
decreased lumbar vertebrae num... 7 | 62
enlarged lymph nodes 7 | 27
impaired glucose tolerance 7 | 52
increased bone mineral density 7 | 52
increased circulating HDL chol... 7 | 63
increased heart weight 7 | 37
short tibia 7 | 82
straub tail 7 | 26
trunk curl 7 | 15
abnormal coat/hair pigmentatio... 6 | 54
abnormal locomotor activation 6 | 26
decreased circulating alkaline... 6 | 41
decreased fasted circulating g... 6 | 49
decreased rib number 6 | 59
increased circulating chloride... 6 | 43
increased hemoglobin content 6 | 45
increased total body fat amoun... 6 | 57
small testis 6 | 37
abnormal cornea morphology 5 | 24
abnormal ear morphology 5 | 5
abnormal epididymis morphology 5 | 31
abnormal heart morphology 5 | 51
abnormal sleep behavior 5 | 63
abnormal testis morphology 5 | 30
corneal opacity 5 | 25
decreased circulating total pr... 5 | 41
decreased erythrocyte cell num... 5 | 43
decreased leukocyte cell numbe... 5 | 54
decreased spleen weight 5 | 13
impaired righting response 5 | 19
increased body weight 5 | 42
increased circulating choleste... 5 | 53
increased fasted circulating g... 5 | 68
increased sacral vertebrae num... 5 | 62
narrow eye opening 5 | 15
small superior vagus ganglion 5 | 20
tremors 5 | 34
abnormal behavioral response t... 4 | 52
abnormal heart left ventricle ... 4 | 20
abnormal kidney morphology 4 | 30
abnormal spleen morphology 4 | 36
abnormal tooth morphology 4 | 24
decreased circulating free fat... 4 | 39
decreased eosinophil cell numb... 4 | 41
decreased total retina thickne... 4 | 20
enlarged epididymis 4 | 27
female infertility 4 | 34
improved glucose tolerance 4 | 56
increased mean corpuscular hem... 4 | 25
persistence of hyaloid vascula... 4 | 22
prenatal lethality prior to he... 4 | 64

Disease

ovarian cancer 348 | 8,484
osteosarcoma 319 | 7,933
psoriasis 293 | 6,685
medulloblastoma, large-cell 290 | 6,234
glioblastoma 274 | 5,572
atypical teratoid / rhabdoid tumor 222 | 4,369
lung cancer 211 | 4,466
Cancer 189 | 2,346
pilocytic astrocytoma 168 | 3,086
Breast cancer 165 | 3,094
primitive neuroectodermal tumor 164 | 3,031
malignant mesothelioma 160 | 3,162
Carcinoma 157 | 2,147
invasive ductal carcinoma 150 | 2,950
oligodendroglioma 150 | 2,849
lung carcinoma 149 | 2,844
pediatric high grade glioma 146 | 2,712
ependymoma 143 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 143 | 2,956
intraductal papillary-mucinous neoplasm (IPMN) 142 | 3,289
lung adenocarcinoma 139 | 2,713
pituitary cancer 132 | 1,972
interstitial cystitis 129 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 129 | 2,988
non-small cell lung cancer 128 | 2,798
pancreatic cancer 112 | 2,300
group 4 medulloblastoma 109 | 1,875
subependymal giant cell astrocytoma 108 | 2,287
astrocytic glioma 104 | 2,241
cystic fibrosis 103 | 1,665
breast carcinoma 99 | 1,614
adult high grade glioma 98 | 2,148
ductal carcinoma in situ 96 | 1,745
astrocytoma 94 | 1,493
group 3 medulloblastoma 89 | 2,254
sonic hedgehog group medulloblastoma 88 | 1,482
adrenocortical carcinoma 85 | 1,427
posterior fossa group A ependymoma 85 | 1,511
ulcerative colitis 85 | 2,087
Pick disease 79 | 1,893
pancreatic ductal adenocarcinoma liver metastasis 74 | 1,795
colon cancer 71 | 1,475
posterior fossa group B ependymoma 68 | 1,530
spina bifida 68 | 1,064
tuberculosis 68 | 1,557
diabetes mellitus 67 | 1,663
medulloblastoma 67 | 1,524
atypical teratoid/rhabdoid tumor 64 | 1,095
primary pancreatic ductal adenocarcinoma 64 | 1,271
Craniofacial Abnormalities 63 | 147
Nonsyndromic deafness 63 | 121
Intellectual disability 62 | 573
Rheumatoid Arthritis 62 | 1,160
Sensorineural hearing loss 61 | 107
Obesity 58 | 616
Mammary Neoplasms 51 | 410
gastric carcinoma 51 | 832
Alzheimer's disease 48 | 644
Prostatic Neoplasms 46 | 471
nasopharyngeal carcinoma 45 | 1,056
cutaneous lupus erythematosus 44 | 1,056
Cleft palate 42 | 125
Multiple myeloma 42 | 1,327
acute quadriplegic myopathy 42 | 1,157
Atopic dermatitis 41 | 944
esophageal adenocarcinoma 38 | 737
Epilepsy 37 | 346
juvenile dermatomyositis 37 | 1,189
Autistic Disorder 36 | 320
Kidney disease 36 | 396
Neuropathy 36 | 210
dermatomyositis 36 | 933
Neurodegenerative disease 35 | 383
Lung Neoplasms 34 | 171
Osteoporosis 34 | 257
Endometriosis 33 | 535
Down syndrome 32 | 548
Multiple Sclerosis 32 | 498
active Crohn's disease 32 | 918
fibroadenoma 32 | 557
Duchenne muscular dystrophy 31 | 602
chronic rhinosinusitis 31 | 512
Schizophrenia 30 | 501
Parkinson's disease 29 | 364
Stomach Neoplasms 29 | 282
acute myeloid leukemia 29 | 780
autosomal dominant Emery-Dreifuss muscular dystrophy 29 | 499
non primary Sjogren syndrome sicca 29 | 840
progressive supranuclear palsy 28 | 674
Cleft Lip 27 | 91
Hypertension 27 | 287
glioblastoma multiforme 27 | 347
Heart disease 26 | 279
aldosterone-producing adenoma 26 | 664
Adenoma 25 | 165
Hypertensive disease 25 | 193
active ulcerative colitis 25 | 477
Melanoma 24 | 261
Vascular disease 24 | 281
non-small cell lung carcinoma 24 | 413

Tissue

Nervous System 684 | 18,561
Endocrine System 683 | 18,512
Female tissues 682 | 18,647
Digestive Tract 681 | 18,473
Urinary Tract 681 | 18,444
Liver and Pancreas 675 | 18,136
Skin and soft tissues 674 | 18,115
Cardiovascular System 671 | 17,958
Male tissues 670 | 17,969
Blood and immune system 669 | 17,995
Respiratory system 656 | 17,484

Target Family

Non-IDG 352 | 11,971
Enzyme 105 | 4,146
Transcription Factor 105 | 1,400
Kinase 35 | 634
Ion Channel 33 | 341
Transporter 22 | 473
GPCR 18 | 406
Nuclear Receptor 14 | 48
Epigenetic 7 | 242
TF/Epigenetic 1 | 38

MGI Term

hearing/vestibular/ear phenoty... 692 | 692
mortality/aging 4,850 | 4,850
homeostasis/metabolism phenoty... 4,454 | 4,454
growth/size/body region phenot... 3,915 | 3,915
cellular phenotype 3,348 | 3,348
nervous system phenotype 3,201 | 3,201
behavior/neurological phenotyp... 3,192 | 3,192
immune system phenotype 3,148 | 3,148
hematopoietic system phenotype 3,145 | 3,145
cardiovascular system phenotyp... 2,448 | 2,448
endocrine/exocrine gland pheno... 2,084 | 2,084
skeleton phenotype 2,058 | 2,058
normal phenotype 1,916 | 1,916
reproductive system phenotype 1,873 | 1,873
integument phenotype 1,748 | 1,748
embryo phenotype 1,674 | 1,674
vision/eye phenotype 1,478 | 1,478
muscle phenotype 1,385 | 1,385
digestive/alimentary phenotype 1,292 | 1,292
respiratory system phenotype 1,291 | 1,291
liver/biliary system phenotype 1,160 | 1,160
renal/urinary system phenotype 1,157 | 1,157
craniofacial phenotype 1,077 | 1,077
limbs/digits/tail phenotype 1,011 | 1,011
neoplasm 918 | 918
adipose tissue phenotype 901 | 901
pigmentation phenotype 459 | 459
taste/olfaction phenotype 142 | 142
obsolete other phenotype 69 | 69

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Stereocilin STRC Tbio Non-IDG 35.9 7
V(D)J recombination-activating protein 1 RAG1 Tbio Non-IDG -3.00063 1061.1 65
POU domain, class 3, transcription factor 4 POU3F4 Tbio Transcription Factor -2.24459 179.3 55
High mobility group protein HMGI-C HMGA2 Tbio Transcription Factor -3.21092 1667.7 216
Methyl-CpG-binding protein 2 MECP2 Tchem Transcription Factor -3.22710 1827.6 567
Epidermal growth factor receptor kinase substrate 8 EPS8 Tbio Enzyme -1.80380 77.2 248
Hermansky-Pudlak syndrome 5 protein HPS5 Tbio Non-IDG -1.13658 13.9 71