Development Level

Tbio 2,984 | 11,445
Tchem 672 | 1,598
Tclin 286 | 613
Tdark 215 | 6,588

Collection

RFA-RM-18-021 45 | 328
Kinase: IDG Consortium (Target... 18 | 125
GPCR: IDG Consortium (Targets) 14 | 126
Ion Channel: IDG Consortium (T... 13 | 99
Kinase: IDG Consortium (Comple... 10 | 37
GPCR: IDG Consortium (Complete... 5 | 25

IMPC Phenotype

preweaning lethality, complete... 431 | 979
preweaning lethality, incomple... 219 | 499
abnormal embryo size 156 | 220
embryonic lethality prior to t... 139 | 278
abnormal behavior 138 | 298
decreased body weight 137 | 161
decreased total body fat amoun... 126 | 207
abnormal bone structure 118 | 187
increased lean body mass 114 | 172
decreased lean body mass 95 | 135
embryonic lethality prior to o... 92 | 239
decreased bone mineral content 91 | 151
increased total body fat amoun... 82 | 134
decreased vertical activity 71 | 208
embryonic growth retardation 71 | 106
decreased body length 70 | 101
decreased bone mineral density 70 | 126
enlarged heart 70 | 210
increased circulating alkaline... 69 | 122
hyperactivity 66 | 148
hypoactivity 63 | 132
abnormal heart morphology 61 | 162
increased startle reflex 60 | 112
decreased circulating glucose ... 58 | 126
increased bone mineral content 53 | 108
decreased grip strength 52 | 116
decreased circulating choleste... 51 | 93
short tibia 48 | 97
decreased circulating serum al... 45 | 82
decreased prepulse inhibition 45 | 82
abnormal seminal vesicle morph... 43 | 114
increased bone mineral density 42 | 72
male infertility 42 | 123
edema 41 | 59
prenatal lethality prior to he... 41 | 87
decreased circulating triglyce... 40 | 79
impaired glucose tolerance 40 | 75
increased mean corpuscular hem... 40 | 96
decreased circulating HDL chol... 39 | 68
increased mean corpuscular vol... 38 | 92
abnormal eye morphology 37 | 68
abnormal gait 35 | 69
abnormal retina morphology 34 | 71
increased heart weight 34 | 62
decreased mean corpuscular vol... 33 | 79
improved glucose tolerance 33 | 79
abnormal neural tube closure 32 | 46
cataract 32 | 92
decreased circulating total pr... 32 | 49
decreased hemoglobin content 32 | 68
decreased circulating alkaline... 31 | 46
increased blood urea nitrogen ... 31 | 48
increased circulating HDL chol... 31 | 80
increased circulating choleste... 31 | 66
abnormal cranium morphology 30 | 36
increased leukocyte cell numbe... 30 | 47
increased or absent threshold ... 30 | 101
decreased fasted circulating g... 29 | 65
abnormal craniofacial morpholo... 28 | 33
decreased erythrocyte cell num... 28 | 62
decreased leukocyte cell numbe... 28 | 73
decreased lymphocyte cell numb... 28 | 83
decreased startle reflex 28 | 75
increased circulating sodium l... 28 | 71
pallor 28 | 34
small superior vagus ganglion 28 | 74
abnormal kidney morphology 27 | 65
abnormal sleep behavior 27 | 70
anophthalmia 27 | 33
decreased circulating LDL chol... 27 | 38
decreased circulating alanine ... 27 | 47
decreased circulating insulin ... 27 | 76
increased hemoglobin content 26 | 45
abnormal lens morphology 25 | 81
increased fasted circulating g... 25 | 76
increased circulating chloride... 24 | 41
thrombocytopenia 24 | 56
abnormal behavioral response t... 23 | 66
abnormal bone mineralization 23 | 38
abnormal coat-hair pigmentatio... 23 | 64
abnormal tooth morphology 23 | 24
decreased blood urea nitrogen ... 23 | 51
increased body weight 23 | 25
increased circulating triglyce... 23 | 42
tremors 23 | 39
limb grasping 22 | 41
abnormal snout morphology 21 | 23
decreased hematocrit 21 | 46
decreased mean corpuscular hem... 21 | 50
abnormal embryo turning 20 | 31
abnormal skin morphology 20 | 50
decreased circulating amylase ... 20 | 28
decreased circulating aspartat... 20 | 34
increased body length 20 | 32
increased mean corpuscular hem... 20 | 36
pale yolk sac 20 | 25
prenatal lethality 20 | 28
corneal opacity 19 | 32
increased mean platelet volume 19 | 45
small testis 19 | 58

Disease

Carcinoma 2,927 | 11,493
ovarian cancer 2,319 | 8,520
osteosarcoma 2,019 | 7,950
psoriasis 1,834 | 6,694
medulloblastoma, large-cell 1,688 | 6,241
glioblastoma 1,638 | 5,792
lung cancer 1,455 | 4,740
atypical teratoid / rhabdoid tumor 1,445 | 5,112
ependymoma 1,299 | 4,679
Cancer 1,195 | 2,499
Breast cancer 1,166 | 3,578
group 3 medulloblastoma 1,105 | 4,104
malignant mesothelioma 1,051 | 3,232
adult high grade glioma 1,026 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 932 | 3,291
Astrocytoma, Pilocytic 897 | 3,081
invasive ductal carcinoma 885 | 2,951
Kidney cancer 880 | 2,613
intraductal papillary-mucinous carcinoma (IPMC) 876 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 867 | 2,955
primitive neuroectodermal tumor 862 | 3,035
non-small cell lung cancer 860 | 2,890
oligodendroglioma 840 | 2,850
lung adenocarcinoma 820 | 2,716
lung carcinoma 797 | 2,843
pancreatic cancer 797 | 2,398
astrocytic glioma 741 | 2,597
Autosomal recessive predisposition 699 | 1,442
interstitial cystitis 668 | 2,312
subependymal giant cell astrocytoma 651 | 2,287
pituitary cancer 626 | 1,972
Pick disease 577 | 1,894
diabetes mellitus 566 | 1,728
tuberculosis 564 | 2,010
ulcerative colitis 564 | 1,819
ductal carcinoma in situ 557 | 1,745
pancreatic ductal adenocarcinoma liver metastasis 555 | 1,962
breast carcinoma 542 | 1,638
Schizophrenia 526 | 1,160
Intellectual disability 524 | 1,016
group 4 medulloblastoma 524 | 1,855
cystic fibrosis 516 | 1,696
colon cancer 509 | 1,478
adrenocortical carcinoma 448 | 1,428
Epilepsy 403 | 792
acute quadriplegic myopathy 398 | 1,158
Obesity 390 | 678
Rheumatoid arthritis 390 | 1,191
astrocytoma 389 | 1,146
primary pancreatic ductal adenocarcinoma 386 | 1,109
juvenile dermatomyositis 372 | 1,187
Multiple myeloma 366 | 1,332
Dull intelligence 365 | 645
Low intelligence 365 | 645
Mental Retardation 365 | 645
Mental deficiency 365 | 645
Poor school performance 365 | 645
Cognitive delay 345 | 608
Global developmental delay 345 | 608
Mental and motor retardation 345 | 608
Short stature 345 | 531
spina bifida 338 | 1,074
Seizures 336 | 596
pediatric high grade glioma 330 | 1,064
Muscle hypotonia 316 | 571
Bipolar Disorder 315 | 666
dermatomyositis 315 | 966
cutaneous lupus erythematosus 287 | 1,057
nasopharyngeal carcinoma 287 | 1,058
Alzheimer's disease 285 | 658
Atopic dermatitis 284 | 952
gastric carcinoma 271 | 807
Breast Neoplasms 255 | 445
Liver Cirrhosis, Experimental 252 | 769
Liver cancer 248 | 604
Melanoma 248 | 711
active Crohn's disease 245 | 922
Mammary Neoplasms 244 | 425
esophageal adenocarcinoma 233 | 737
non primary Sjogren syndrome sicca 233 | 891
Waldenstrons macroglobulinemia 231 | 765
Small head 229 | 374
Depressive disorder 228 | 409
Prostatic Neoplasms 227 | 495
Down syndrome 225 | 499
autosomal dominant Emery-Dreifuss muscular dystrophy 220 | 510
active ulcerative colitis 218 | 764
Duchenne muscular dystrophy 217 | 601
Kidney disease 217 | 430
Hypertension 215 | 396
acute myeloid leukemia 215 | 783
medulloblastoma 214 | 720
Failure to gain weight 208 | 365
Pediatric failure to thrive 208 | 365
aldosterone-producing adenoma 206 | 665
progressive supranuclear palsy 195 | 676
Neurodegenerative disease 191 | 414
Autistic Disorder 186 | 364
Endometriosis 186 | 540
Curvature of spine 185 | 282

Tissue

Endocrine System 4,075 | 18,159
Digestive Tract 4,007 | 17,369
Skin and soft tissues 3,977 | 17,230
Female tissues 3,972 | 17,400
Male tissues 3,927 | 17,142
Nervous System 3,906 | 16,725
Blood and immune system 3,898 | 16,909
Liver and Pancreas 3,887 | 16,750
Urinary Tract 3,887 | 16,678
Respiratory system 3,796 | 16,393
Cardiovascular System 3,612 | 15,192

Target Family

Non-IDG 1,984 | 12,091
Enzyme 940 | 4,145
Transcription Factor 476 | 1,400
Kinase 240 | 634
Transporter 123 | 473
GPCR 116 | 408
Epigenetic 111 | 242
Ion Channel 109 | 344
Nuclear Receptor 37 | 48
TF/Epigenetic 17 | 38
oGPCR 4 | 421

MGI Phenotype

growth-size-body region phenot... 4,157 | 4,157
mortality-aging 5,018 | 5,018
homeostasis-metabolism phenoty... 4,747 | 4,747
cellular phenotype 3,637 | 3,637
immune system phenotype 3,461 | 3,461
nervous system phenotype 3,447 | 3,447
behavior-neurological phenotyp... 3,401 | 3,401
hematopoietic system phenotype 3,383 | 3,383
cardiovascular system phenotyp... 2,660 | 2,660
endocrine-exocrine gland pheno... 2,293 | 2,293
skeleton phenotype 2,222 | 2,222
normal phenotype 1,999 | 1,999
reproductive system phenotype 1,999 | 1,999
integument phenotype 1,874 | 1,874
embryo phenotype 1,827 | 1,827
vision-eye phenotype 1,622 | 1,622
muscle phenotype 1,479 | 1,479
digestive-alimentary phenotype 1,398 | 1,398
respiratory system phenotype 1,390 | 1,390
liver-biliary system phenotype 1,300 | 1,300
renal-urinary system phenotype 1,269 | 1,269
craniofacial phenotype 1,182 | 1,182
limbs-digits-tail phenotype 1,071 | 1,071
adipose tissue phenotype 992 | 992
neoplasm 975 | 975
hearing-vestibular-ear phenoty... 767 | 767
pigmentation phenotype 506 | 506
taste-olfaction phenotype 147 | 147
no phenotypic analysis 5 | 5

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Potassium voltage-gated channel subfamily A member 2 KCNA2 Tclin Ion Channel -2.55550 343.3 205
Probable global transcription activator SNF2L1 SMARCA1 Tbio Non-IDG -2.20560 145.6 116
Shadow of prion protein SPRN Tbio Non-IDG -2.49698 315.1 88
Homeobox protein MSX-1 MSX1 Tbio Transcription Factor -2.59245 390.1 298
MAGE-like protein 2 MAGEL2 Tbio Non-IDG -1.95242 83.8 86
Metabotropic glutamate receptor 5 GRM5 Tchem GPCR -3.12353 1370.3 396
Anaphase-promoting complex subunit 4 ANAPC4 Tbio Enzyme 0.43 0.13 156
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 ST6GALNAC2 Tbio Enzyme -1.74190 55.6 59
Leukemia inhibitory factor LIF Tbio Non-IDG -2.86943 538.7 413
Neuromodulin GAP43 Tbio Non-IDG -2.93905 762.9 597