Development Level

Tbio 2,677 | 10,625
Tchem 756 | 1,890
Tclin 271 | 602
Tdark 211 | 7,003

Collection

Eligible Kinase Proteins 21 | 134
Eligible Ion Channel Proteins 18 | 117
Eligible non-olfactory GPCR Proteins 12 | 143

IMPC Term

preweaning lethality, complete... 256 | 633
decreased lean body mass 170 | 195
decreased body weight 150 | 174
decreased total body fat amoun... 132 | 186
decreased bone mineral content 111 | 157
abnormal behavior 110 | 226
preweaning lethality, incomple... 110 | 260
decreased body length 98 | 108
embryonic lethality prior to t... 91 | 187
abnormal bone structure 90 | 131
increased lean body mass 88 | 107
decreased bone mineral density 87 | 126
decreased grip strength 74 | 123
abnormal embryo size 70 | 112
increased circulating alkaline... 70 | 119
increased bone mineral content 55 | 92
increased or absent threshold ... 54 | 128
decreased circulating choleste... 53 | 85
embryonic lethality prior to o... 50 | 148
hyperactivity 50 | 108
decreased circulating HDL chol... 49 | 77
decreased circulating glucose ... 49 | 121
abnormal retina morphology 47 | 100
short tibia 45 | 82
decreased circulating triglyce... 44 | 83
increased mean corpuscular vol... 43 | 91
hypoactivity 42 | 89
increased mean corpuscular hem... 42 | 93
increased grip strength 39 | 83
decreased circulating serum al... 38 | 79
increased body weight 38 | 42
abnormal bone mineralization 37 | 55
enlarged heart 36 | 111
increased total body fat amoun... 35 | 57
decreased circulating insulin ... 31 | 75
increased blood urea nitrogen ... 31 | 44
decreased heart weight 30 | 44
increased bone mineral density 30 | 52
abnormal gait 29 | 51
decreased circulating LDL chol... 29 | 37
decreased circulating alanine ... 29 | 53
decreased circulating alkaline... 29 | 41
decreased hemoglobin content 28 | 53
decreased rib number 28 | 59
increased circulating sodium l... 27 | 71
abnormal neural tube closure 26 | 37
decreased circulating total pr... 26 | 41
impaired glucose tolerance 26 | 52
abnormal cranium morphology 25 | 32
decreased prepulse inhibition 25 | 52
improved glucose tolerance 25 | 56
decreased erythrocyte cell num... 24 | 43
prenatal lethality prior to he... 24 | 64
abnormal lens morphology 23 | 73
abnormal retinal pigmentation 23 | 61
abnormal tooth morphology 23 | 24
increased hemoglobin content 23 | 45
thrombocytopenia 23 | 46
abnormal eye morphology 22 | 38
decreased fasted circulating g... 22 | 49
decreased mean corpuscular vol... 22 | 50
increased sacral vertebrae num... 22 | 62
male infertility 22 | 62
abnormal coat/hair pigmentatio... 21 | 54
abnormal sleep behavior 21 | 63
decreased leukocyte cell numbe... 21 | 54
decreased lumbar vertebrae num... 21 | 62
increased circulating HDL chol... 21 | 63
increased circulating chloride... 21 | 43
increased heart weight 21 | 37
tremors 21 | 34
increased leukocyte cell numbe... 20 | 37
limb grasping 20 | 35
abnormal behavioral response t... 19 | 52
abnormal hindbrain development 19 | 24
decreased circulating amylase ... 19 | 24
increased fasted circulating g... 19 | 68
increased startle reflex 18 | 38
abnormal cornea morphology 17 | 24
abnormal locomotor activation 17 | 26
abnormal midbrain development 17 | 22
abnormal snout morphology 17 | 18
decreased T cell number 17 | 31
decreased caudal vertebrae num... 17 | 49
decreased startle reflex 17 | 48
increased circulating choleste... 17 | 53
abnormal heart morphology 16 | 51
corneal opacity 16 | 25
decreased circulating aspartat... 16 | 27
decreased circulating calcium ... 16 | 33
decreased hematocrit 16 | 25
embryonic growth retardation 16 | 28
increased body length 16 | 20
increased circulating calcium ... 16 | 32
increased hematocrit 16 | 36
vertebral fusion 16 | 23
abnormal rib morphology 15 | 28
female infertility 15 | 34
increased circulating creatini... 15 | 29
increased circulating potassiu... 15 | 31

Disease

ovarian cancer 2,173 | 8,484
osteosarcoma 1,892 | 7,933
psoriasis 1,745 | 6,685
medulloblastoma, large-cell 1,592 | 6,234
glioblastoma 1,493 | 5,572
lung cancer 1,335 | 4,466
atypical teratoid / rhabdoid tumor 1,164 | 4,369
Cancer 1,103 | 2,346
malignant mesothelioma 973 | 3,162
Breast cancer 941 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 891 | 3,289
pilocytic astrocytoma 865 | 3,086
invasive ductal carcinoma 842 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 838 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 830 | 2,956
primitive neuroectodermal tumor 819 | 3,031
oligodendroglioma 808 | 2,849
non-small cell lung cancer 789 | 2,798
lung adenocarcinoma 778 | 2,713
lung carcinoma 775 | 2,844
pediatric high grade glioma 775 | 2,712
Carcinoma 755 | 2,147
pancreatic cancer 714 | 2,300
ependymoma 663 | 2,514
interstitial cystitis 632 | 2,299
subependymal giant cell astrocytoma 631 | 2,287
ulcerative colitis 607 | 2,087
pituitary cancer 597 | 1,972
astrocytic glioma 577 | 2,241
Pick disease 544 | 1,893
group 3 medulloblastoma 541 | 2,254
group 4 medulloblastoma 538 | 1,875
ductal carcinoma in situ 531 | 1,745
diabetes mellitus 520 | 1,663
adult high grade glioma 516 | 2,148
breast carcinoma 501 | 1,614
astrocytoma 500 | 1,493
colon cancer 491 | 1,475
cystic fibrosis 486 | 1,665
posterior fossa group A ependymoma 456 | 1,511
pancreatic ductal adenocarcinoma liver metastasis 454 | 1,795
primary pancreatic ductal adenocarcinoma 424 | 1,271
adrenocortical carcinoma 419 | 1,427
tuberculosis 413 | 1,557
sonic hedgehog group medulloblastoma 402 | 1,482
acute quadriplegic myopathy 390 | 1,157
medulloblastoma 385 | 1,524
Rheumatoid Arthritis 365 | 1,160
juvenile dermatomyositis 362 | 1,189
posterior fossa group B ependymoma 353 | 1,530
Obesity 338 | 616
Multiple myeloma 334 | 1,327
spina bifida 312 | 1,064
atypical teratoid/rhabdoid tumor 308 | 1,095
dermatomyositis 306 | 933
cutaneous lupus erythematosus 278 | 1,056
nasopharyngeal carcinoma 276 | 1,056
Intellectual disability 271 | 573
gastric carcinoma 270 | 832
Alzheimer's disease 268 | 644
Atopic dermatitis 265 | 944
Down syndrome 231 | 548
esophageal adenocarcinoma 228 | 737
Mammary Neoplasms 225 | 410
active Crohn's disease 225 | 918
Waldenstrons macroglobulinemia 218 | 765
Duchenne muscular dystrophy 214 | 602
autosomal dominant Emery-Dreifuss muscular dystrophy 210 | 499
Prostatic Neoplasms 207 | 471
Kidney disease 203 | 396
aldosterone-producing adenoma 202 | 664
acute myeloid leukemia 198 | 780
non primary Sjogren syndrome sicca 195 | 840
Schizophrenia 194 | 501
primary Sjogren syndrome 193 | 789
progressive supranuclear palsy 180 | 674
Endometriosis 176 | 535
Amyotrophic Lateral Sclerosis 172 | 431
Neurodegenerative disease 171 | 383
tuberculosis and treatment for 6 months 168 | 686
pancreatic carcinoma 163 | 567
fibroadenoma 162 | 557
Epilepsy 161 | 346
Parkinson's disease 157 | 364
Autistic Disorder 156 | 320
Heart disease 146 | 279
Hypertension 146 | 287
hepatocellular carcinoma 142 | 532
Vascular disease 138 | 281
chronic rhinosinusitis 138 | 512
Asthma 137 | 349
Multiple Sclerosis 136 | 498
non-small cell lung carcinoma 136 | 413
IGA Glomerulonephritis 132 | 454
Stomach Neoplasms 132 | 282
Atherosclerosis 130 | 275
active ulcerative colitis 126 | 477
Peripheral Neuropathy 123 | 303
Polycystic Ovary Syndrome 120 | 332
gastric cancer 120 | 430

Tissue

Nervous System 3,898 | 18,561
Female tissues 3,892 | 18,647
Digestive Tract 3,888 | 18,473
Endocrine System 3,886 | 18,512
Urinary Tract 3,867 | 18,444
Liver and Pancreas 3,863 | 18,136
Skin and soft tissues 3,845 | 18,115
Male tissues 3,840 | 17,969
Cardiovascular System 3,834 | 17,958
Blood and immune system 3,832 | 17,995
Respiratory system 3,770 | 17,484

Target Family

Non-IDG 1,837 | 11,971
Enzyme 875 | 4,146
Transcription Factor 464 | 1,400
Kinase 236 | 634
Transporter 118 | 473
GPCR 117 | 406
Epigenetic 106 | 242
Ion Channel 106 | 341
Nuclear Receptor 37 | 48
TF/Epigenetic 15 | 38
oGPCR 4 | 421

MGI Term

growth/size/body region phenot... 3,915 | 3,915
mortality/aging 4,850 | 4,850
homeostasis/metabolism phenoty... 4,454 | 4,454
cellular phenotype 3,348 | 3,348
nervous system phenotype 3,201 | 3,201
behavior/neurological phenotyp... 3,192 | 3,192
immune system phenotype 3,148 | 3,148
hematopoietic system phenotype 3,145 | 3,145
cardiovascular system phenotyp... 2,448 | 2,448
endocrine/exocrine gland pheno... 2,084 | 2,084
skeleton phenotype 2,058 | 2,058
normal phenotype 1,916 | 1,916
reproductive system phenotype 1,873 | 1,873
integument phenotype 1,748 | 1,748
embryo phenotype 1,674 | 1,674
vision/eye phenotype 1,478 | 1,478
muscle phenotype 1,385 | 1,385
digestive/alimentary phenotype 1,292 | 1,292
respiratory system phenotype 1,291 | 1,291
liver/biliary system phenotype 1,160 | 1,160
renal/urinary system phenotype 1,157 | 1,157
craniofacial phenotype 1,077 | 1,077
limbs/digits/tail phenotype 1,011 | 1,011
neoplasm 918 | 918
adipose tissue phenotype 901 | 901
hearing/vestibular/ear phenoty... 692 | 692
pigmentation phenotype 459 | 459
taste/olfaction phenotype 142 | 142
obsolete other phenotype 69 | 69

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.39907 258.0 359
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.11372 127.6 466
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788