Development Level

Tbio 1,608 | 11,651
Tchem 388 | 1,388
Tclin 173 | 612
Tdark 124 | 6,593

Collection

RFA-RM-18-021 23 | 328
Kinase: IDG Consortium (Target... 13 | 125
Kinase: IDG Consortium (Comple... 6 | 37
GPCR: IDG Consortium (Targets) 5 | 126
Ion Channel: IDG Consortium (T... 5 | 99
GPCR: IDG Consortium (Complete... 1 | 25

IMPC Phenotype

preweaning lethality, complete... 184 | 979
preweaning lethality, incomple... 111 | 499
enlarged heart 66 | 210
decreased vertical activity 64 | 208
abnormal behavior 61 | 298
abnormal seminal vesicle morph... 60 | 114
embryonic lethality prior to t... 53 | 278
abnormal embryo size 52 | 220
abnormal heart morphology 45 | 162
male infertility 44 | 123
abnormal bone structure 40 | 187
decreased total body fat amoun... 38 | 207
hypoactivity 38 | 132
small testis 38 | 58
decreased lean body mass 34 | 135
embryonic lethality prior to o... 34 | 239
decreased body weight 33 | 161
increased circulating alkaline... 33 | 122
decreased bone mineral content 32 | 151
abnormal testis morphology 30 | 43
increased total body fat amoun... 30 | 134
decreased circulating choleste... 27 | 93
increased bone mineral content 27 | 108
increased lean body mass 27 | 172
decreased bone mineral density 26 | 126
impaired glucose tolerance 26 | 75
small superior vagus ganglion 26 | 74
decreased circulating glucose ... 23 | 126
female infertility 23 | 60
improved glucose tolerance 23 | 79
increased mean corpuscular hem... 23 | 96
increased mean corpuscular vol... 23 | 92
increased startle reflex 23 | 112
short tibia 23 | 97
abnormal kidney morphology 22 | 65
decreased body length 22 | 101
embryonic growth retardation 22 | 106
abnormal eye morphology 21 | 68
decreased grip strength 21 | 116
hyperactivity 21 | 148
increased bone mineral density 21 | 72
decreased circulating HDL chol... 19 | 68
cataract 18 | 92
increased circulating HDL chol... 18 | 80
increased circulating choleste... 18 | 66
increased or absent threshold ... 18 | 101
abnormal epididymis morphology 17 | 42
abnormal lens morphology 17 | 81
abnormal retina morphology 17 | 71
decreased lymphocyte cell numb... 17 | 83
decreased mean corpuscular vol... 17 | 79
decreased circulating insulin ... 16 | 76
decreased circulating serum al... 16 | 82
increased grip strength 16 | 41
decreased circulating total pr... 15 | 49
decreased circulating triglyce... 15 | 79
decreased fasted circulating g... 15 | 65
decreased prepulse inhibition 15 | 82
edema 15 | 59
increased leukocyte cell numbe... 15 | 47
prenatal lethality prior to he... 15 | 87
small adrenal glands 15 | 16
abnormal spleen morphology 14 | 55
anophthalmia 14 | 33
thrombocytopenia 14 | 56
abnormal gait 13 | 69
abnormal skin morphology 13 | 50
hydrometra 13 | 53
increased fasted circulating g... 13 | 76
abnormal cornea morphology 12 | 31
abnormal locomotor behavior 12 | 24
abnormal neural tube closure 12 | 46
decreased startle reflex 12 | 75
increased circulating sodium l... 12 | 71
increased circulating triglyce... 12 | 42
increased hemoglobin content 12 | 45
small thymus 12 | 16
abnormal coat-hair pigmentatio... 11 | 64
decreased leukocyte cell numbe... 11 | 73
enlarged epididymis 11 | 31
increased neutrophil cell numb... 11 | 46
limb grasping 11 | 41
small spleen 11 | 19
abnormal behavioral response t... 10 | 66
abnormal craniofacial morpholo... 10 | 33
abnormal cranium morphology 10 | 36
corneal opacity 10 | 32
decreased circulating LDL chol... 10 | 38
decreased circulating alanine ... 10 | 47
decreased erythrocyte cell num... 10 | 62
enlarged lymph nodes 10 | 37
increased circulating chloride... 10 | 41
increased monocyte cell number 10 | 63
tremors 10 | 39
abnormal bone mineralization 9 | 38
decreased circulating calcium ... 9 | 36
decreased circulating fructosa... 9 | 30
decreased hemoglobin content 9 | 68
decreased mean corpuscular hem... 9 | 50
increased circulating total pr... 9 | 28

Disease

Carcinoma 1,582 | 11,493
ovarian cancer 1,252 | 8,520
osteosarcoma 1,102 | 7,950
psoriasis 1,036 | 6,694
medulloblastoma, large-cell 920 | 6,241
glioblastoma 900 | 5,792
Cancer 883 | 2,499
lung cancer 848 | 4,740
atypical teratoid / rhabdoid tumor 748 | 5,112
ependymoma 662 | 4,679
Breast cancer 640 | 3,578
group 3 medulloblastoma 596 | 4,104
malignant mesothelioma 588 | 3,232
adult high grade glioma 583 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 543 | 3,291
invasive ductal carcinoma 520 | 2,951
intraductal papillary-mucinous carcinoma (IPMC) 510 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 490 | 2,955
non-small cell lung cancer 490 | 2,890
Astrocytoma, Pilocytic 486 | 3,081
lung carcinoma 474 | 2,843
pancreatic cancer 460 | 2,398
lung adenocarcinoma 456 | 2,716
primitive neuroectodermal tumor 452 | 3,035
Kidney cancer 437 | 2,613
oligodendroglioma 422 | 2,850
interstitial cystitis 407 | 2,312
diabetes mellitus 375 | 1,728
Autosomal recessive predisposition 367 | 1,442
astrocytic glioma 365 | 2,597
subependymal giant cell astrocytoma 364 | 2,287
tuberculosis 364 | 2,010
ulcerative colitis 358 | 1,819
pituitary cancer 357 | 1,972
breast carcinoma 334 | 1,638
ductal carcinoma in situ 331 | 1,745
cystic fibrosis 317 | 1,696
Schizophrenia 298 | 1,160
colon cancer 296 | 1,478
group 4 medulloblastoma 286 | 1,855
pancreatic ductal adenocarcinoma liver metastasis 276 | 1,962
Pick disease 266 | 1,894
Rheumatoid arthritis 261 | 1,191
adrenocortical carcinoma 259 | 1,428
Intellectual disability 252 | 1,016
primary pancreatic ductal adenocarcinoma 231 | 1,109
astrocytoma 222 | 1,146
Obesity 217 | 678
juvenile dermatomyositis 217 | 1,187
cutaneous lupus erythematosus 209 | 1,057
acute quadriplegic myopathy 205 | 1,158
Multiple myeloma 203 | 1,332
Short stature 194 | 531
Dull intelligence 191 | 645
Low intelligence 191 | 645
Mental Retardation 191 | 645
Mental deficiency 191 | 645
Poor school performance 191 | 645
Cognitive delay 186 | 608
Global developmental delay 186 | 608
Mental and motor retardation 186 | 608
Prostatic Neoplasms 185 | 495
Epilepsy 183 | 792
Breast Neoplasms 182 | 445
spina bifida 178 | 1,074
Mammary Neoplasms 177 | 425
pediatric high grade glioma 175 | 1,064
Liver Cirrhosis, Experimental 173 | 769
Atopic dermatitis 167 | 952
Bipolar Disorder 165 | 666
Seizures 164 | 596
dermatomyositis 162 | 966
active Crohn's disease 159 | 922
gastric carcinoma 158 | 807
Kidney disease 156 | 430
Melanoma 154 | 711
Alzheimer's disease 153 | 658
nasopharyngeal carcinoma 151 | 1,058
Endometriosis 149 | 540
Muscle hypotonia 143 | 571
Multiple Sclerosis 142 | 540
primary Sjogren syndrome 141 | 735
Depressive disorder 139 | 409
Hypertension 138 | 396
Anemia 133 | 365
active ulcerative colitis 132 | 764
acute myeloid leukemia 129 | 783
Down syndrome 128 | 499
Cryptorchidism 126 | 296
Liver cancer 126 | 604
Arthritis 124 | 290
non primary Sjogren syndrome sicca 124 | 891
Duchenne muscular dystrophy 123 | 601
Osteoporosis 123 | 363
Waldenstrons macroglobulinemia 123 | 765
aldosterone-producing adenoma 123 | 665
esophageal adenocarcinoma 123 | 737
medulloblastoma 123 | 720
Asthma 121 | 385
autosomal dominant Emery-Dreifuss muscular dystrophy 121 | 510

Tissue

Endocrine System 2,229 | 18,159
Digestive Tract 2,173 | 17,369
Female tissues 2,153 | 17,400
Skin and soft tissues 2,142 | 17,230
Male tissues 2,140 | 17,142
Blood and immune system 2,105 | 16,909
Liver and Pancreas 2,103 | 16,750
Nervous System 2,102 | 16,725
Urinary Tract 2,097 | 16,678
Respiratory system 2,068 | 16,393
Cardiovascular System 1,918 | 15,192

Target Family

Non-IDG 1,083 | 12,091
Enzyme 455 | 4,145
Transcription Factor 310 | 1,400
Kinase 164 | 634
GPCR 79 | 408
Epigenetic 69 | 242
Transporter 57 | 473
Ion Channel 38 | 344
Nuclear Receptor 28 | 48
TF/Epigenetic 10 | 38

MGI Phenotype

endocrine-exocrine gland pheno... 2,293 | 2,293
mortality-aging 5,018 | 5,018
homeostasis-metabolism phenoty... 4,747 | 4,747
growth-size-body region phenot... 4,157 | 4,157
cellular phenotype 3,637 | 3,637
immune system phenotype 3,461 | 3,461
nervous system phenotype 3,447 | 3,447
behavior-neurological phenotyp... 3,401 | 3,401
hematopoietic system phenotype 3,383 | 3,383
cardiovascular system phenotyp... 2,660 | 2,660
skeleton phenotype 2,222 | 2,222
normal phenotype 1,999 | 1,999
reproductive system phenotype 1,999 | 1,999
integument phenotype 1,874 | 1,874
embryo phenotype 1,827 | 1,827
vision-eye phenotype 1,622 | 1,622
muscle phenotype 1,479 | 1,479
digestive-alimentary phenotype 1,398 | 1,398
respiratory system phenotype 1,390 | 1,390
liver-biliary system phenotype 1,300 | 1,300
renal-urinary system phenotype 1,269 | 1,269
craniofacial phenotype 1,182 | 1,182
limbs-digits-tail phenotype 1,071 | 1,071
adipose tissue phenotype 992 | 992
neoplasm 975 | 975
hearing-vestibular-ear phenoty... 767 | 767
pigmentation phenotype 506 | 506
taste-olfaction phenotype 147 | 147
no phenotypic analysis 5 | 5

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
Elongation of very long chain fatty acids protein 2 ELOVL2 Tbio Non-IDG -1.99271 91.8 122
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
A disintegrin and metalloproteinase with thrombospondin motifs 6 ADAMTS6 Tdark Enzyme -0.67364 4.37 40
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Meiosis-specific protein MEI4 MEI4 Tdark Non-IDG 0.00000 7
GDH/6PGL endoplasmic bifunctional protein H6PD Tbio Non-IDG -2.24806 169.7 207
ATP-binding cassette sub-family A member 1 ABCA1 Tclin Transporter -3.15111 1451.8 388
Integrin alpha-2 ITGA2 Tbio Non-IDG -2.58423 335.9 895
Neuroendocrine secretory protein 55 GNAS Tbio Non-IDG -2.63356 1389.7 509