Development Level

Tbio 1,352 | 10,625
Tchem 462 | 1,890
Tclin 166 | 602
Tdark 104 | 7,003

Collection

Eligible Kinase Proteins 8 | 134
Eligible Ion Channel Proteins 6 | 117
Eligible non-olfactory GPCR Proteins 6 | 143

IMPC Term

preweaning lethality, complete... 92 | 633
preweaning lethality, incomple... 53 | 260
abnormal behavior 43 | 226
enlarged heart 40 | 111
decreased lean body mass 38 | 195
decreased body weight 37 | 174
abnormal seminal vesicle morph... 30 | 47
decreased bone mineral content 26 | 157
decreased grip strength 26 | 123
abnormal embryo size 25 | 112
decreased total body fat amoun... 25 | 186
small testis 25 | 37
embryonic lethality prior to t... 24 | 187
hypoactivity 24 | 89
decreased body length 22 | 108
decreased bone mineral density 22 | 126
decreased circulating triglyce... 22 | 83
increased circulating alkaline... 22 | 119
increased grip strength 22 | 83
abnormal bone structure 21 | 131
abnormal heart morphology 21 | 51
increased mean corpuscular hem... 21 | 93
abnormal testis morphology 20 | 30
male infertility 20 | 62
increased mean corpuscular vol... 19 | 91
decreased circulating HDL chol... 18 | 77
decreased circulating choleste... 18 | 85
decreased circulating glucose ... 18 | 121
abnormal bone mineralization 15 | 55
hyperactivity 15 | 108
impaired glucose tolerance 15 | 52
short tibia 15 | 82
abnormal retina morphology 14 | 100
increased bone mineral content 14 | 92
abnormal epididymis morphology 13 | 31
abnormal retinal pigmentation 13 | 61
decreased circulating serum al... 13 | 79
increased body weight 13 | 42
increased bone mineral density 13 | 52
increased or absent threshold ... 13 | 128
thrombocytopenia 13 | 46
abnormal behavioral response t... 12 | 52
abnormal cornea morphology 12 | 24
abnormal eye morphology 12 | 38
abnormal kidney morphology 12 | 30
abnormal lens morphology 12 | 73
decreased circulating insulin ... 12 | 75
female infertility 12 | 34
increased lean body mass 12 | 107
increased sacral vertebrae num... 12 | 62
decreased circulating total pr... 11 | 41
decreased lumbar vertebrae num... 11 | 62
increased circulating HDL chol... 11 | 63
abnormal gait 10 | 51
decreased T cell number 10 | 31
decreased circulating LDL chol... 10 | 37
decreased circulating alanine ... 10 | 53
decreased prepulse inhibition 10 | 52
embryonic lethality prior to o... 10 | 148
increased circulating choleste... 10 | 53
increased total body fat amoun... 10 | 57
abnormal neural tube closure 9 | 37
decreased CD8-positive, alpha-... 9 | 26
decreased fasted circulating g... 9 | 49
decreased heart weight 9 | 44
decreased hemoglobin content 9 | 53
decreased leukocyte cell numbe... 9 | 54
decreased startle reflex 9 | 48
enlarged epididymis 9 | 27
increased hematocrit 9 | 36
tremors 9 | 34
abnormal hindbrain development 8 | 24
abnormal spleen morphology 8 | 36
cataract 8 | 26
corneal opacity 8 | 25
hydrops fetalis 8 | 22
increased leukocyte cell numbe... 8 | 37
increased startle reflex 8 | 38
abnormal coat/hair pigmentatio... 7 | 54
abnormal forebrain development 7 | 18
abnormal midbrain development 7 | 22
abnormal tail morphology 7 | 17
abnormal tooth morphology 7 | 24
decreased circulating alkaline... 7 | 41
decreased circulating fructosa... 7 | 31
decreased erythrocyte cell num... 7 | 43
improved glucose tolerance 7 | 56
increased B cell number 7 | 23
increased blood urea nitrogen ... 7 | 44
increased circulating chloride... 7 | 43
increased circulating sodium l... 7 | 71
increased circulating triglyce... 7 | 24
increased hemoglobin content 7 | 45
limb grasping 7 | 35
narrow eye opening 7 | 15
abnormal sleep behavior 6 | 63
decreased circulating aspartat... 6 | 27
decreased rib number 6 | 59
increased circulating calcium ... 6 | 32
increased respiratory quotient 6 | 12

Disease

ovarian cancer 1,146 | 8,484
osteosarcoma 1,007 | 7,933
psoriasis 962 | 6,685
medulloblastoma, large-cell 838 | 6,234
Cancer 788 | 2,346
glioblastoma 777 | 5,572
lung cancer 745 | 4,466
atypical teratoid / rhabdoid tumor 569 | 4,369
malignant mesothelioma 526 | 3,162
Breast cancer 514 | 3,094
intraductal papillary-mucinous neoplasm (IPMN) 502 | 3,289
invasive ductal carcinoma 491 | 2,950
intraductal papillary-mucinous carcinoma (IPMC) 474 | 2,988
pilocytic astrocytoma 459 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 452 | 2,956
non-small cell lung cancer 447 | 2,798
lung carcinoma 443 | 2,844
lung adenocarcinoma 421 | 2,713
pancreatic cancer 412 | 2,300
primitive neuroectodermal tumor 411 | 3,031
pediatric high grade glioma 407 | 2,712
Carcinoma 388 | 2,147
interstitial cystitis 385 | 2,299
oligodendroglioma 384 | 2,849
ulcerative colitis 378 | 2,087
subependymal giant cell astrocytoma 340 | 2,287
ependymoma 323 | 2,514
pituitary cancer 323 | 1,972
ductal carcinoma in situ 318 | 1,745
diabetes mellitus 316 | 1,663
group 4 medulloblastoma 308 | 1,875
breast carcinoma 301 | 1,614
cystic fibrosis 295 | 1,665
adult high grade glioma 290 | 2,148
colon cancer 283 | 1,475
group 3 medulloblastoma 282 | 2,254
astrocytic glioma 272 | 2,241
tuberculosis 261 | 1,557
astrocytoma 258 | 1,493
posterior fossa group A ependymoma 250 | 1,511
primary pancreatic ductal adenocarcinoma 245 | 1,271
Pick disease 238 | 1,893
adrenocortical carcinoma 238 | 1,427
Rheumatoid Arthritis 232 | 1,160
pancreatic ductal adenocarcinoma liver metastasis 218 | 1,795
medulloblastoma 209 | 1,524
juvenile dermatomyositis 203 | 1,189
cutaneous lupus erythematosus 200 | 1,056
acute quadriplegic myopathy 194 | 1,157
Obesity 191 | 616
sonic hedgehog group medulloblastoma 187 | 1,482
Multiple myeloma 180 | 1,327
Mammary Neoplasms 169 | 410
atypical teratoid/rhabdoid tumor 166 | 1,095
Prostatic Neoplasms 163 | 471
gastric carcinoma 159 | 832
posterior fossa group B ependymoma 158 | 1,530
spina bifida 157 | 1,064
Atopic dermatitis 155 | 944
dermatomyositis 152 | 933
active Crohn's disease 150 | 918
primary Sjogren syndrome 149 | 789
Endometriosis 146 | 535
Alzheimer's disease 144 | 644
nasopharyngeal carcinoma 144 | 1,056
Down syndrome 129 | 548
Kidney disease 125 | 396
Waldenstrons macroglobulinemia 118 | 765
esophageal adenocarcinoma 118 | 737
aldosterone-producing adenoma 117 | 664
Duchenne muscular dystrophy 114 | 602
Intellectual disability 114 | 573
acute myeloid leukemia 114 | 780
autosomal dominant Emery-Dreifuss muscular dystrophy 114 | 499
Multiple Sclerosis 108 | 498
Asthma 107 | 349
fibroadenoma 105 | 557
Schizophrenia 103 | 501
Vascular disease 100 | 281
Amyotrophic Lateral Sclerosis 97 | 431
non primary Sjogren syndrome sicca 97 | 840
Stomach Neoplasms 96 | 282
Liver carcinoma 95 | 217
Adenoma 93 | 165
Lung Neoplasms 93 | 171
Polycystic Ovary Syndrome 92 | 332
Autistic Disorder 90 | 320
Arthritis 89 | 248
Hypertension 89 | 287
tuberculosis and treatment for 6 months 89 | 686
IGA Glomerulonephritis 88 | 454
non-small cell lung carcinoma 87 | 413
Peripheral Neuropathy 86 | 303
progressive supranuclear palsy 86 | 674
Heart disease 85 | 279
Infertility 85 | 163
pancreatic carcinoma 85 | 567
Diabetes Mellitus, Non-Insulin-Dependent 84 | 157
mucosa-associated lymphoid tissue lymphoma 84 | 480
active ulcerative colitis 81 | 477

Tissue

Female tissues 2,066 | 18,647
Nervous System 2,066 | 18,561
Digestive Tract 2,065 | 18,473
Endocrine System 2,064 | 18,512
Urinary Tract 2,061 | 18,444
Liver and Pancreas 2,054 | 18,136
Male tissues 2,040 | 17,969
Cardiovascular System 2,039 | 17,958
Skin and soft tissues 2,037 | 18,115
Blood and immune system 2,031 | 17,995
Respiratory system 1,995 | 17,484

Target Family

Non-IDG 961 | 11,971
Enzyme 408 | 4,146
Transcription Factor 305 | 1,400
Kinase 153 | 634
GPCR 78 | 406
Epigenetic 65 | 242
Transporter 44 | 473
Ion Channel 33 | 341
Nuclear Receptor 28 | 48
TF/Epigenetic 9 | 38

MGI Term

endocrine/exocrine gland pheno... 2,084 | 2,084
mortality/aging 4,850 | 4,850
homeostasis/metabolism phenoty... 4,454 | 4,454
growth/size/body region phenot... 3,915 | 3,915
cellular phenotype 3,348 | 3,348
nervous system phenotype 3,201 | 3,201
behavior/neurological phenotyp... 3,192 | 3,192
immune system phenotype 3,148 | 3,148
hematopoietic system phenotype 3,145 | 3,145
cardiovascular system phenotyp... 2,448 | 2,448
skeleton phenotype 2,058 | 2,058
normal phenotype 1,916 | 1,916
reproductive system phenotype 1,873 | 1,873
integument phenotype 1,748 | 1,748
embryo phenotype 1,674 | 1,674
vision/eye phenotype 1,478 | 1,478
muscle phenotype 1,385 | 1,385
digestive/alimentary phenotype 1,292 | 1,292
respiratory system phenotype 1,291 | 1,291
liver/biliary system phenotype 1,160 | 1,160
renal/urinary system phenotype 1,157 | 1,157
craniofacial phenotype 1,077 | 1,077
limbs/digits/tail phenotype 1,011 | 1,011
neoplasm 918 | 918
adipose tissue phenotype 901 | 901
hearing/vestibular/ear phenoty... 692 | 692
pigmentation phenotype 459 | 459
taste/olfaction phenotype 142 | 142
obsolete other phenotype 69 | 69

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Zinc finger and BTB domain-containing protein 1 ZBTB1 Tbio Transcription Factor -0.57513 5.01 57
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.39907 258.0 359
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
Glial cell line-derived neurotrophic factor GDNF Tbio Non-IDG -3.30206 2301.5 303
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851