Development Level

Tbio 1,358 | 11,445
Tchem 301 | 1,598
Tclin 97 | 613
Tdark 71 | 6,588

Collection

RFA-RM-18-021 7 | 328
Kinase: IDG Consortium (Comple... 6 | 37
Kinase: IDG Consortium (Target... 5 | 125
GPCR: IDG Consortium (Complete... 2 | 25
Ion Channel: IDG Consortium (T... 2 | 99

IMPC Phenotype

preweaning lethality, complete... 328 | 979
abnormal embryo size 141 | 220
embryonic lethality prior to t... 135 | 278
embryonic lethality prior to o... 90 | 239
preweaning lethality, incomple... 83 | 499
embryonic growth retardation 67 | 106
prenatal lethality prior to he... 34 | 87
abnormal behavior 33 | 298
abnormal neural tube closure 33 | 46
abnormal heart morphology 32 | 162
edema 31 | 59
enlarged heart 30 | 210
decreased body weight 29 | 161
abnormal craniofacial morpholo... 25 | 33
decreased vertical activity 25 | 208
pallor 25 | 34
abnormal bone structure 24 | 187
decreased lean body mass 23 | 135
increased startle reflex 23 | 112
increased lean body mass 22 | 172
pale yolk sac 22 | 25
abnormal embryo turning 21 | 31
abnormal eye morphology 21 | 68
decreased bone mineral content 21 | 151
decreased total body fat amoun... 21 | 207
hypoactivity 21 | 132
anophthalmia 20 | 33
increased total body fat amoun... 20 | 134
abnormal pericardium morpholog... 19 | 26
decreased circulating glucose ... 17 | 126
decreased prepulse inhibition 17 | 82
hemorrhage 17 | 23
abnormal limb bud morphology 16 | 17
cataract 16 | 92
decreased circulating serum al... 16 | 82
prenatal lethality 16 | 28
abnormal placenta size 15 | 20
hyperactivity 15 | 148
impaired glucose tolerance 15 | 75
abnormal retina morphology 14 | 71
decreased blood urea nitrogen ... 14 | 51
increased mean corpuscular hem... 14 | 96
microphthalmia 14 | 26
abnormal midbrain development 13 | 20
abnormal seminal vesicle morph... 13 | 114
decreased body length 13 | 101
decreased circulating triglyce... 13 | 79
increased circulating HDL chol... 13 | 80
abnormal forebrain development 12 | 20
abnormal hindbrain development 12 | 16
abnormal lens morphology 12 | 81
decreased circulating HDL chol... 12 | 68
decreased circulating choleste... 12 | 93
decreased grip strength 12 | 116
decreased mean corpuscular vol... 12 | 79
small superior vagus ganglion 12 | 74
abnormal neural tube morpholog... 11 | 12
decreased bone mineral density 11 | 126
increased blood urea nitrogen ... 11 | 48
increased circulating alkaline... 11 | 122
increased circulating choleste... 11 | 66
increased fasted circulating g... 11 | 76
increased monocyte cell number 11 | 63
abnormal facial morphology 10 | 17
abnormal limb morphology 10 | 13
decreased lymphocyte cell numb... 10 | 83
increased bone mineral density 10 | 72
increased circulating chloride... 10 | 41
increased circulating creatini... 10 | 38
increased grip strength 10 | 41
increased leukocyte cell numbe... 10 | 47
abnormal cranium morphology 9 | 36
abnormal gait 9 | 69
abnormal tail morphology 9 | 25
corneal opacity 9 | 32
decreased circulating alanine ... 9 | 47
decreased circulating total pr... 9 | 49
decreased fasted circulating g... 9 | 65
decreased startle reflex 9 | 75
enlarged lymph nodes 9 | 37
hydrometra 9 | 53
increased bone mineral content 9 | 108
increased or absent threshold ... 9 | 101
persistence of hyaloid vascula... 9 | 33
abnormal tooth morphology 8 | 24
decreased circulating alkaline... 8 | 46
decreased circulating aspartat... 8 | 34
decreased circulating chloride... 8 | 30
decreased red blood cell distr... 8 | 41
increased mean corpuscular vol... 8 | 92
increased neutrophil cell numb... 8 | 46
mammalian phenotype 8 | 17
abnormal kidney morphology 7 | 65
abnormal skin morphology 7 | 50
decreased circulating fructosa... 7 | 30
decreased circulating insulin ... 7 | 76
decreased hemoglobin content 7 | 68
improved glucose tolerance 7 | 79
increased mean platelet volume 7 | 45
small testis 7 | 58

Disease

Carcinoma 1,295 | 11,493
ovarian cancer 1,105 | 8,520
osteosarcoma 957 | 7,950
psoriasis 782 | 6,694
medulloblastoma, large-cell 719 | 6,241
glioblastoma 700 | 5,792
lung cancer 680 | 4,740
Cancer 663 | 2,499
atypical teratoid / rhabdoid tumor 635 | 5,112
Breast cancer 570 | 3,578
ependymoma 541 | 4,679
group 3 medulloblastoma 505 | 4,104
malignant mesothelioma 490 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 414 | 3,291
Kidney cancer 410 | 2,613
adult high grade glioma 400 | 3,801
non-small cell lung cancer 398 | 2,890
invasive ductal carcinoma 395 | 2,951
primitive neuroectodermal tumor 380 | 3,035
intraductal papillary-mucinous carcinoma (IPMC) 376 | 2,989
lung adenocarcinoma 373 | 2,716
oligodendroglioma 353 | 2,850
pancreatic cancer 344 | 2,398
Astrocytoma, Pilocytic 329 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 329 | 2,955
astrocytic glioma 312 | 2,597
lung carcinoma 280 | 2,843
interstitial cystitis 274 | 2,312
breast carcinoma 265 | 1,638
Autosomal recessive predisposition 245 | 1,442
ductal carcinoma in situ 244 | 1,745
pituitary cancer 243 | 1,972
subependymal giant cell astrocytoma 243 | 2,287
Intellectual disability 241 | 1,016
pancreatic ductal adenocarcinoma liver metastasis 240 | 1,962
ulcerative colitis 239 | 1,819
tuberculosis 231 | 2,010
diabetes mellitus 221 | 1,728
group 4 medulloblastoma 221 | 1,855
Pick disease 220 | 1,894
adrenocortical carcinoma 216 | 1,428
colon cancer 216 | 1,478
Multiple myeloma 201 | 1,332
cystic fibrosis 200 | 1,696
Schizophrenia 188 | 1,160
acute quadriplegic myopathy 188 | 1,158
astrocytoma 187 | 1,146
Short stature 185 | 531
Dull intelligence 180 | 645
Low intelligence 180 | 645
Mental Retardation 180 | 645
Mental deficiency 180 | 645
Poor school performance 180 | 645
juvenile dermatomyositis 176 | 1,187
Rheumatoid arthritis 174 | 1,191
primary pancreatic ductal adenocarcinoma 174 | 1,109
Cognitive delay 163 | 608
Global developmental delay 163 | 608
Mental and motor retardation 163 | 608
Breast Neoplasms 159 | 445
spina bifida 157 | 1,074
pediatric high grade glioma 156 | 1,064
dermatomyositis 155 | 966
Epilepsy 152 | 792
Mammary Neoplasms 147 | 425
Muscle hypotonia 145 | 571
nasopharyngeal carcinoma 140 | 1,058
Seizures 139 | 596
Small head 137 | 374
Waldenstrons macroglobulinemia 132 | 765
Cleft Palate 118 | 271
Liver cancer 116 | 604
acute myeloid leukemia 116 | 783
Atopic dermatitis 115 | 952
Prostatic Neoplasms 115 | 495
Cryptorchidism 111 | 296
Hypoplastic mandible condyle 111 | 275
Mandibular hypoplasia 111 | 275
Melanoma 111 | 711
Micrognathism 111 | 275
Obesity 110 | 678
medulloblastoma 110 | 720
Liver Cirrhosis, Experimental 109 | 769
Alzheimer's disease 108 | 658
Curvature of spine 108 | 282
Acquired scoliosis 107 | 281
autosomal dominant Emery-Dreifuss muscular dystrophy 106 | 510
Endometriosis 105 | 540
gastric carcinoma 104 | 807
Orbital separation excessive 102 | 244
cutaneous lupus erythematosus 100 | 1,057
Bipolar Disorder 98 | 666
non primary Sjogren syndrome sicca 95 | 891
esophageal adenocarcinoma 93 | 737
progressive supranuclear palsy 93 | 676
Duchenne muscular dystrophy 91 | 601
Strabismus 91 | 270
Down syndrome 89 | 499
active Crohn's disease 87 | 922
Kidney disease 86 | 430

Tissue

Endocrine System 1,802 | 18,159
Digestive Tract 1,776 | 17,369
Female tissues 1,772 | 17,400
Skin and soft tissues 1,771 | 17,230
Male tissues 1,757 | 17,142
Urinary Tract 1,743 | 16,678
Nervous System 1,740 | 16,725
Blood and immune system 1,738 | 16,909
Liver and Pancreas 1,735 | 16,750
Respiratory system 1,719 | 16,393
Cardiovascular System 1,649 | 15,192

Target Family

Non-IDG 881 | 12,091
Enzyme 358 | 4,145
Transcription Factor 294 | 1,400
Kinase 129 | 634
Epigenetic 66 | 242
Transporter 30 | 473
GPCR 28 | 408
Nuclear Receptor 17 | 48
Ion Channel 13 | 344
TF/Epigenetic 11 | 38

MGI Phenotype

embryo phenotype 1,827 | 1,827
mortality-aging 5,018 | 5,018
homeostasis-metabolism phenoty... 4,747 | 4,747
growth-size-body region phenot... 4,157 | 4,157
cellular phenotype 3,637 | 3,637
immune system phenotype 3,461 | 3,461
nervous system phenotype 3,447 | 3,447
behavior-neurological phenotyp... 3,401 | 3,401
hematopoietic system phenotype 3,383 | 3,383
cardiovascular system phenotyp... 2,660 | 2,660
endocrine-exocrine gland pheno... 2,293 | 2,293
skeleton phenotype 2,222 | 2,222
normal phenotype 1,999 | 1,999
reproductive system phenotype 1,999 | 1,999
integument phenotype 1,874 | 1,874
vision-eye phenotype 1,622 | 1,622
muscle phenotype 1,479 | 1,479
digestive-alimentary phenotype 1,398 | 1,398
respiratory system phenotype 1,390 | 1,390
liver-biliary system phenotype 1,300 | 1,300
renal-urinary system phenotype 1,269 | 1,269
craniofacial phenotype 1,182 | 1,182
limbs-digits-tail phenotype 1,071 | 1,071
adipose tissue phenotype 992 | 992
neoplasm 975 | 975
hearing-vestibular-ear phenoty... 767 | 767
pigmentation phenotype 506 | 506
taste-olfaction phenotype 147 | 147
no phenotypic analysis 5 | 5

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Homeobox protein MSX-1 MSX1 Tbio Transcription Factor -2.59245 390.1 298
Anaphase-promoting complex subunit 4 ANAPC4 Tbio Enzyme 0.43 0.13 156
Leukemia inhibitory factor LIF Tbio Non-IDG -2.86943 538.7 413
Protein pelota homolog PELO Tbio Non-IDG -1.33842 18.2 100
Zinc transporter ZIP3 SLC39A3 Tbio Transporter -0.52290 3.15 87
Peroxisome biogenesis factor 2 PEX2 Tbio Non-IDG -1.76849 57.3 170
ATP-dependent DNA helicase Q4 RECQL4 Tbio Enzyme 0.00000 0
Phosphate carrier protein, mitochondrial SLC25A3 Tbio Transporter -2.85426 703.4 33
Rapamycin-insensitive companion of mTOR RICTOR Tbio Non-IDG -2.79454 597.0 440
Cytochrome c oxidase assembly factor 5 COA5 Tdark Enzyme -0.77512 6.90 3