Development Level

Tbio 1,169 | 10,625
Tchem 349 | 1,890
Tclin 90 | 602
Tdark 66 | 7,003

Collection

Eligible Kinase Proteins 6 | 134
Eligible Ion Channel Proteins 3 | 117

IMPC Term

preweaning lethality, complete... 184 | 633
embryonic lethality prior to t... 77 | 187
abnormal embryo size 63 | 112
embryonic lethality prior to o... 45 | 148
preweaning lethality, incomple... 35 | 260
decreased lean body mass 30 | 195
abnormal neural tube closure 24 | 37
decreased body weight 24 | 174
abnormal behavior 22 | 226
decreased bone mineral content 22 | 157
abnormal hindbrain development 17 | 24
abnormal midbrain development 16 | 22
decreased total body fat amoun... 16 | 186
embryonic growth retardation 16 | 28
prenatal lethality prior to he... 16 | 64
abnormal retina morphology 14 | 100
decreased body length 14 | 108
enlarged heart 14 | 111
increased mean corpuscular hem... 14 | 93
increased or absent threshold ... 14 | 128
abnormal forebrain development 13 | 18
anophthalmia 13 | 20
decreased bone mineral density 13 | 126
decreased grip strength 13 | 123
increased grip strength 13 | 83
abnormal embryo turning 12 | 15
increased total body fat amoun... 12 | 57
abnormal bone structure 11 | 131
abnormal eye morphology 11 | 38
decreased circulating choleste... 11 | 85
hypoactivity 11 | 89
increased circulating HDL chol... 11 | 63
pale yolk sac 11 | 12
abnormal bone mineralization 10 | 55
decreased circulating HDL chol... 10 | 77
decreased circulating triglyce... 10 | 83
decreased prepulse inhibition 10 | 52
hydrops fetalis 10 | 22
increased lean body mass 10 | 107
increased mean corpuscular vol... 10 | 91
abnormal lens morphology 9 | 73
abnormal limb bud morphology 9 | 15
abnormal pericardium morpholog... 9 | 11
decreased circulating glucose ... 9 | 121
decreased circulating serum al... 9 | 79
impaired glucose tolerance 9 | 52
increased body weight 9 | 42
increased circulating alkaline... 9 | 119
increased fasted circulating g... 9 | 68
microphthalmia 9 | 15
pallor 9 | 13
abnormal heart morphology 8 | 51
decreased circulating alanine ... 8 | 53
decreased rib number 8 | 59
increased blood urea nitrogen ... 8 | 44
prenatal lethality 8 | 16
abnormal neural tube morpholog... 7 | 8
abnormal placenta size 7 | 10
abnormal retinal pigmentation 7 | 61
abnormal tooth morphology 7 | 24
craniofacial phenotype 7 | 9
decreased fasted circulating g... 7 | 49
decreased hemoglobin content 7 | 53
enlarged lymph nodes 7 | 27
female infertility 7 | 34
hyperactivity 7 | 108
increased leukocyte cell numbe... 7 | 37
increased startle reflex 7 | 38
abnormal gait 6 | 51
corneal opacity 6 | 25
decreased blood urea nitrogen ... 6 | 31
decreased circulating alkaline... 6 | 41
decreased circulating fructosa... 6 | 31
decreased circulating insulin ... 6 | 75
decreased circulating total pr... 6 | 41
decreased eosinophil cell numb... 6 | 41
decreased lumbar vertebrae num... 6 | 62
decreased mean corpuscular vol... 6 | 50
edema 6 | 11
improved glucose tolerance 6 | 56
increased sacral vertebrae num... 6 | 62
persistence of hyaloid vascula... 6 | 22
abnormal craniofacial morpholo... 5 | 12
abnormal eye size 5 | 11
abnormal facial morphology 5 | 9
abnormal snout morphology 5 | 18
abnormal startle reflex 5 | 14
abnormal tail bud morphology 5 | 6
cardiovascular system phenotyp... 5 | 35
decreased circulating LDL chol... 5 | 37
decreased circulating aspartat... 5 | 27
decreased circulating chloride... 5 | 32
decreased circulating iron lev... 5 | 25
decreased spleen weight 5 | 13
increased bone mineral content 5 | 92
increased circulating choleste... 5 | 53
increased circulating creatini... 5 | 29
increased hemoglobin content 5 | 45
male infertility 5 | 62
thrombocytopenia 5 | 46

Disease

ovarian cancer 1,007 | 8,484
osteosarcoma 876 | 7,933
psoriasis 724 | 6,685
medulloblastoma, large-cell 666 | 6,234
glioblastoma 633 | 5,572
lung cancer 618 | 4,466
Cancer 609 | 2,346
atypical teratoid / rhabdoid tumor 508 | 4,369
Breast cancer 453 | 3,094
malignant mesothelioma 442 | 3,162
intraductal papillary-mucinous neoplasm (IPMN) 388 | 3,289
invasive ductal carcinoma 375 | 2,950
non-small cell lung cancer 369 | 2,798
primitive neuroectodermal tumor 361 | 3,031
intraductal papillary-mucinous carcinoma (IPMC) 357 | 2,988
lung adenocarcinoma 357 | 2,713
Carcinoma 343 | 2,147
pediatric high grade glioma 333 | 2,712
oligodendroglioma 331 | 2,849
pilocytic astrocytoma 320 | 3,086
intraductal papillary-mucinous adenoma (IPMA) 307 | 2,956
pancreatic cancer 302 | 2,300
ependymoma 291 | 2,514
group 3 medulloblastoma 269 | 2,254
lung carcinoma 265 | 2,844
interstitial cystitis 259 | 2,299
ulcerative colitis 245 | 2,087
breast carcinoma 238 | 1,614
astrocytic glioma 234 | 2,241
ductal carcinoma in situ 231 | 1,745
subependymal giant cell astrocytoma 228 | 2,287
group 4 medulloblastoma 227 | 1,875
astrocytoma 224 | 1,493
pituitary cancer 217 | 1,972
adrenocortical carcinoma 205 | 1,427
colon cancer 203 | 1,475
Pick disease 200 | 1,893
diabetes mellitus 198 | 1,663
pancreatic ductal adenocarcinoma liver metastasis 192 | 1,795
cystic fibrosis 190 | 1,665
adult high grade glioma 187 | 2,148
primary pancreatic ductal adenocarcinoma 187 | 1,271
Multiple myeloma 185 | 1,327
sonic hedgehog group medulloblastoma 181 | 1,482
acute quadriplegic myopathy 177 | 1,157
posterior fossa group A ependymoma 177 | 1,511
tuberculosis 176 | 1,557
juvenile dermatomyositis 171 | 1,189
Rheumatoid Arthritis 161 | 1,160
medulloblastoma 155 | 1,524
dermatomyositis 147 | 933
spina bifida 138 | 1,064
Mammary Neoplasms 137 | 410
atypical teratoid/rhabdoid tumor 137 | 1,095
nasopharyngeal carcinoma 134 | 1,056
posterior fossa group B ependymoma 134 | 1,530
Intellectual disability 123 | 573
Waldenstrons macroglobulinemia 123 | 765
Atopic dermatitis 104 | 944
Prostatic Neoplasms 104 | 471
gastric carcinoma 104 | 832
Endometriosis 103 | 535
acute myeloid leukemia 102 | 780
Alzheimer's disease 100 | 644
autosomal dominant Emery-Dreifuss muscular dystrophy 100 | 499
Obesity 97 | 616
cutaneous lupus erythematosus 97 | 1,056
esophageal adenocarcinoma 92 | 737
Duchenne muscular dystrophy 90 | 602
progressive supranuclear palsy 88 | 674
Down syndrome 86 | 548
non primary Sjogren syndrome sicca 85 | 840
primary Sjogren syndrome 84 | 789
Kidney disease 82 | 396
aldosterone-producing adenoma 82 | 664
active Crohn's disease 81 | 918
Craniofacial Abnormalities 76 | 147
Amyotrophic Lateral Sclerosis 73 | 431
pancreatic carcinoma 72 | 567
Heart disease 69 | 279
IGA Glomerulonephritis 69 | 454
Vascular disease 66 | 281
non-small cell lung carcinoma 66 | 413
Stomach Neoplasms 65 | 282
Melanoma 63 | 261
Schizophrenia 63 | 501
fibroadenoma 63 | 557
tuberculosis and treatment for 6 months 63 | 686
chronic rhinosinusitis 62 | 512
Cleft palate 61 | 125
Lung Neoplasms 61 | 171
Autistic Disorder 60 | 320
Colorectal Neoplasms 60 | 217
Liver carcinoma 59 | 217
Parkinson's disease 57 | 364
Neurodegenerative disease 54 | 383
Renal Cell Carcinoma 53 | 199
Neoplasm Invasiveness 52 | 127
gastric cancer 51 | 430
mucosa-associated lymphoid tissue lymphoma 50 | 480

Tissue

Endocrine System 1,664 | 18,512
Nervous System 1,663 | 18,561
Digestive Tract 1,662 | 18,473
Female tissues 1,661 | 18,647
Male tissues 1,650 | 17,969
Liver and Pancreas 1,648 | 18,136
Urinary Tract 1,648 | 18,444
Skin and soft tissues 1,646 | 18,115
Cardiovascular System 1,643 | 17,958
Blood and immune system 1,640 | 17,995
Respiratory system 1,628 | 17,484

Target Family

Non-IDG 798 | 11,971
Enzyme 315 | 4,146
Transcription Factor 289 | 1,400
Kinase 124 | 634
Epigenetic 58 | 242
GPCR 27 | 406
Transporter 24 | 473
Nuclear Receptor 17 | 48
Ion Channel 12 | 341
TF/Epigenetic 10 | 38

MGI Term

embryo phenotype 1,674 | 1,674
mortality/aging 4,850 | 4,850
homeostasis/metabolism phenoty... 4,454 | 4,454
growth/size/body region phenot... 3,915 | 3,915
cellular phenotype 3,348 | 3,348
nervous system phenotype 3,201 | 3,201
behavior/neurological phenotyp... 3,192 | 3,192
immune system phenotype 3,148 | 3,148
hematopoietic system phenotype 3,145 | 3,145
cardiovascular system phenotyp... 2,448 | 2,448
endocrine/exocrine gland pheno... 2,084 | 2,084
skeleton phenotype 2,058 | 2,058
normal phenotype 1,916 | 1,916
reproductive system phenotype 1,873 | 1,873
integument phenotype 1,748 | 1,748
vision/eye phenotype 1,478 | 1,478
muscle phenotype 1,385 | 1,385
digestive/alimentary phenotype 1,292 | 1,292
respiratory system phenotype 1,291 | 1,291
liver/biliary system phenotype 1,160 | 1,160
renal/urinary system phenotype 1,157 | 1,157
craniofacial phenotype 1,077 | 1,077
limbs/digits/tail phenotype 1,011 | 1,011
neoplasm 918 | 918
adipose tissue phenotype 901 | 901
hearing/vestibular/ear phenoty... 692 | 692
pigmentation phenotype 459 | 459
taste/olfaction phenotype 142 | 142
obsolete other phenotype 69 | 69

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Erythropoietin EPO Tbio Non-IDG -3.90053 8755.8 628
Endoplasmin HSP90B1 Tchem Non-IDG -2.72785 604.5 748
Teratocarcinoma-derived growth factor 1 TDGF1 Tbio Non-IDG 156.3 371
Basic helix-loop-helix transcription factor scleraxis SCX Tbio Transcription Factor -2.80657 344.1 42
Zinc finger protein 148 ZNF148 Tbio Transcription Factor -1.71996 60.7 178
Glypican-3 GPC3 Tbio Non-IDG -2.85848 794.8 523
Cyclin-dependent kinase 8 CDK8 Tchem Kinase -1.96301 102.7 307
Histone-lysine N-methyltransferase SETD1B SETD1B Tbio Epigenetic -1.20916 14.6 78