Development Level

Tbio 968 | 11,445
Tchem 263 | 1,598
Tclin 122 | 613
Tdark 45 | 6,588

Collection

RFA-RM-18-021 12 | 328
Kinase: IDG Consortium (Target... 6 | 125
GPCR: IDG Consortium (Complete... 3 | 25
GPCR: IDG Consortium (Targets) 3 | 126
Ion Channel: IDG Consortium (T... 3 | 99
Kinase: IDG Consortium (Comple... 3 | 37

IMPC Phenotype

preweaning lethality, complete... 141 | 979
preweaning lethality, incomple... 68 | 499
abnormal embryo size 39 | 220
embryonic lethality prior to t... 39 | 278
enlarged heart 35 | 210
abnormal behavior 31 | 298
embryonic lethality prior to o... 29 | 239
increased total body fat amoun... 25 | 134
decreased vertical activity 24 | 208
abnormal heart morphology 22 | 162
abnormal bone structure 21 | 187
decreased lean body mass 21 | 135
decreased total body fat amoun... 21 | 207
edema 21 | 59
abnormal seminal vesicle morph... 20 | 114
hypoactivity 20 | 132
decreased bone mineral content 19 | 151
increased circulating alkaline... 19 | 122
decreased body weight 18 | 161
increased lean body mass 17 | 172
abnormal eye morphology 15 | 68
decreased bone mineral density 15 | 126
decreased circulating glucose ... 15 | 126
impaired glucose tolerance 15 | 75
increased startle reflex 15 | 112
abnormal craniofacial morpholo... 14 | 33
decreased lymphocyte cell numb... 13 | 83
embryonic growth retardation 13 | 106
improved glucose tolerance 13 | 79
small superior vagus ganglion 13 | 74
decreased circulating HDL chol... 12 | 68
decreased circulating choleste... 12 | 93
decreased grip strength 12 | 116
hyperactivity 12 | 148
short tibia 12 | 97
abnormal neural tube closure 11 | 46
anophthalmia 11 | 33
cataract 11 | 92
decreased circulating insulin ... 11 | 76
decreased circulating serum al... 11 | 82
decreased circulating triglyce... 11 | 79
decreased mean corpuscular vol... 11 | 79
increased or absent threshold ... 11 | 101
abnormal gait 10 | 69
abnormal retina morphology 10 | 71
decreased body length 10 | 101
decreased prepulse inhibition 10 | 82
decreased startle reflex 10 | 75
increased circulating choleste... 10 | 66
increased mean corpuscular vol... 10 | 92
increased neutrophil cell numb... 10 | 46
abnormal lens morphology 9 | 81
abnormal spleen morphology 9 | 55
abnormal testis morphology 9 | 43
decreased blood urea nitrogen ... 9 | 51
increased bone mineral content 9 | 108
increased grip strength 9 | 41
increased leukocyte cell numbe... 9 | 47
increased monocyte cell number 9 | 63
small testis 9 | 58
abnormal kidney morphology 8 | 65
decreased circulating alkaline... 8 | 46
decreased circulating total pr... 8 | 49
enlarged spleen 8 | 41
hemorrhage 8 | 23
increased circulating HDL chol... 8 | 80
increased mean corpuscular hem... 8 | 96
male infertility 8 | 123
microphthalmia 8 | 26
prenatal lethality prior to he... 8 | 87
tremors 8 | 39
abnormal cranium morphology 7 | 36
abnormal epididymis morphology 7 | 42
abnormal facial morphology 7 | 17
abnormal limb morphology 7 | 13
abnormal lung morphology 7 | 26
abnormal tail morphology 7 | 25
abnormal tooth morphology 7 | 24
cleft palate 7 | 8
decreased circulating amylase ... 7 | 28
decreased circulating aspartat... 7 | 34
decreased hemoglobin content 7 | 68
enlarged lymph nodes 7 | 37
hydrometra 7 | 53
increased blood urea nitrogen ... 7 | 48
mammalian phenotype 7 | 17
pale yolk sac 7 | 25
small thymus 7 | 16
thrombocytopenia 7 | 56
abnormal body wall morphology 6 | 9
abnormal bone mineralization 6 | 38
abnormal limb bud morphology 6 | 17
abnormal vibrissa morphology 6 | 25
increased body weight 6 | 25
increased bone mineral density 6 | 72
increased circulating triglyce... 6 | 42
increased fasted circulating g... 6 | 76
increased mean corpuscular hem... 6 | 36
pallor 6 | 34
vertebral fusion 6 | 23

Disease

Carcinoma 1,014 | 11,493
ovarian cancer 740 | 8,520
psoriasis 682 | 6,694
osteosarcoma 651 | 7,950
Cancer 546 | 2,499
lung cancer 533 | 4,740
glioblastoma 522 | 5,792
medulloblastoma, large-cell 495 | 6,241
atypical teratoid / rhabdoid tumor 443 | 5,112
Breast cancer 428 | 3,578
ependymoma 424 | 4,679
malignant mesothelioma 372 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 359 | 3,291
invasive ductal carcinoma 338 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 336 | 2,955
pancreatic cancer 333 | 2,398
intraductal papillary-mucinous carcinoma (IPMC) 332 | 2,989
non-small cell lung cancer 329 | 2,890
group 3 medulloblastoma 327 | 4,104
lung carcinoma 322 | 2,843
lung adenocarcinoma 315 | 2,716
Kidney cancer 311 | 2,613
adult high grade glioma 310 | 3,801
Astrocytoma, Pilocytic 307 | 3,081
interstitial cystitis 303 | 2,312
Autosomal recessive predisposition 262 | 1,442
ulcerative colitis 252 | 1,819
oligodendroglioma 248 | 2,850
cystic fibrosis 246 | 1,696
pituitary cancer 236 | 1,972
primitive neuroectodermal tumor 232 | 3,035
diabetes mellitus 229 | 1,728
tuberculosis 229 | 2,010
breast carcinoma 215 | 1,638
colon cancer 215 | 1,478
ductal carcinoma in situ 213 | 1,745
astrocytic glioma 209 | 2,597
subependymal giant cell astrocytoma 201 | 2,287
Schizophrenia 195 | 1,160
pancreatic ductal adenocarcinoma liver metastasis 187 | 1,962
group 4 medulloblastoma 173 | 1,855
adrenocortical carcinoma 172 | 1,428
Rheumatoid arthritis 159 | 1,191
primary pancreatic ductal adenocarcinoma 154 | 1,109
Intellectual disability 149 | 1,016
cutaneous lupus erythematosus 147 | 1,057
Obesity 146 | 678
Pick disease 143 | 1,894
astrocytoma 142 | 1,146
spina bifida 134 | 1,074
juvenile dermatomyositis 131 | 1,187
Short stature 128 | 531
acute quadriplegic myopathy 126 | 1,158
Dull intelligence 125 | 645
Low intelligence 125 | 645
Mental Retardation 125 | 645
Mental deficiency 125 | 645
Poor school performance 125 | 645
Liver Cirrhosis, Experimental 123 | 769
nasopharyngeal carcinoma 122 | 1,058
Cleft Palate 118 | 271
Epilepsy 118 | 792
active Crohn's disease 118 | 922
gastric carcinoma 115 | 807
Bipolar Disorder 111 | 666
Seizures 111 | 596
Breast Neoplasms 110 | 445
pediatric high grade glioma 109 | 1,064
Cognitive delay 107 | 608
Global developmental delay 107 | 608
Melanoma 107 | 711
Mental and motor retardation 107 | 608
active ulcerative colitis 107 | 764
Kidney disease 106 | 430
Mammary Neoplasms 106 | 425
Prostatic Neoplasms 105 | 495
Atopic dermatitis 100 | 952
esophageal adenocarcinoma 99 | 737
Hypertension 98 | 396
Hypertensive disease 97 | 292
Alzheimer's disease 96 | 658
Multiple myeloma 96 | 1,332
Asthma 94 | 385
Muscle hypotonia 94 | 571
dermatomyositis 91 | 966
primary Sjogren syndrome 90 | 735
Multiple Sclerosis 88 | 540
Liver cancer 87 | 604
Osteoporosis 87 | 363
medulloblastoma 87 | 720
Endometriosis 86 | 540
Hypoplastic mandible condyle 85 | 275
Mandibular hypoplasia 85 | 275
Micrognathism 85 | 275
Cryptorchidism 84 | 296
Depressive disorder 81 | 409
Orbital separation excessive 81 | 244
Small head 81 | 374
Arthritis 80 | 290
Duchenne muscular dystrophy 79 | 601

Tissue

Digestive Tract 1,358 | 17,369
Endocrine System 1,355 | 18,159
Skin and soft tissues 1,335 | 17,230
Female tissues 1,334 | 17,400
Male tissues 1,322 | 17,142
Liver and Pancreas 1,315 | 16,750
Blood and immune system 1,307 | 16,909
Urinary Tract 1,303 | 16,678
Nervous System 1,285 | 16,725
Respiratory system 1,271 | 16,393
Cardiovascular System 1,160 | 15,192

Target Family

Non-IDG 640 | 12,091
Enzyme 269 | 4,145
Transcription Factor 203 | 1,400
Kinase 93 | 634
Transporter 60 | 473
GPCR 57 | 408
Ion Channel 32 | 344
Epigenetic 21 | 242
Nuclear Receptor 19 | 48
TF/Epigenetic 4 | 38

MGI Phenotype

digestive-alimentary phenotype 1,398 | 1,398
mortality-aging 5,018 | 5,018
homeostasis-metabolism phenoty... 4,747 | 4,747
growth-size-body region phenot... 4,157 | 4,157
cellular phenotype 3,637 | 3,637
immune system phenotype 3,461 | 3,461
nervous system phenotype 3,447 | 3,447
behavior-neurological phenotyp... 3,401 | 3,401
hematopoietic system phenotype 3,383 | 3,383
cardiovascular system phenotyp... 2,660 | 2,660
endocrine-exocrine gland pheno... 2,293 | 2,293
skeleton phenotype 2,222 | 2,222
normal phenotype 1,999 | 1,999
reproductive system phenotype 1,999 | 1,999
integument phenotype 1,874 | 1,874
embryo phenotype 1,827 | 1,827
vision-eye phenotype 1,622 | 1,622
muscle phenotype 1,479 | 1,479
respiratory system phenotype 1,390 | 1,390
liver-biliary system phenotype 1,300 | 1,300
renal-urinary system phenotype 1,269 | 1,269
craniofacial phenotype 1,182 | 1,182
limbs-digits-tail phenotype 1,071 | 1,071
adipose tissue phenotype 992 | 992
neoplasm 975 | 975
hearing-vestibular-ear phenoty... 767 | 767
pigmentation phenotype 506 | 506
taste-olfaction phenotype 147 | 147
no phenotypic analysis 5 | 5

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Homeobox protein MSX-1 MSX1 Tbio Transcription Factor -2.59245 390.1 298
Leukemia inhibitory factor LIF Tbio Non-IDG -2.86943 538.7 413
Synaptotagmin-like protein 2 SYTL2 Tbio Non-IDG -1.27949 19.5 60
Choline O-acetyltransferase CHAT Tchem Enzyme -3.40175 2597.2 436
ATP-dependent DNA helicase Q4 RECQL4 Tbio Enzyme 0.00000 0
Solute carrier family 13 member 4 SLC13A4 Tbio Transporter -1.55886 37.5 50
Nucleoredoxin NXN Tbio Non-IDG -2.54390 345.4 96
TRAF2 and NCK-interacting protein kinase TNIK Tchem Kinase -1.33394 28.5 441
p21-activated protein kinase-interacting protein 1 PAK1IP1 Tbio Enzyme -1.02033 9.87 62
Transmembrane protein 248 TMEM248 Tdark Non-IDG 0.00000 47