Development Level

Tbio 840 | 10,625
Tchem 298 | 1,890
Tclin 119 | 602
Tdark 35 | 7,003

Collection

Eligible Ion Channel Proteins 5 | 117
Eligible Kinase Proteins 4 | 134
Eligible non-olfactory GPCR Proteins 3 | 143

IMPC Term

preweaning lethality, complete... 83 | 633
preweaning lethality, incomple... 40 | 260
embryonic lethality prior to t... 25 | 187
abnormal behavior 24 | 226
decreased body weight 21 | 174
abnormal embryo size 20 | 112
decreased lean body mass 20 | 195
decreased bone mineral content 19 | 157
enlarged heart 18 | 111
increased circulating alkaline... 17 | 119
abnormal retina morphology 15 | 100
abnormal bone structure 13 | 131
decreased bone mineral density 13 | 126
decreased grip strength 13 | 123
decreased total body fat amoun... 13 | 186
increased or absent threshold ... 13 | 128
decreased circulating triglyce... 12 | 83
embryonic lethality prior to o... 12 | 148
hypoactivity 12 | 89
abnormal eye morphology 11 | 38
increased grip strength 11 | 83
decreased circulating HDL chol... 10 | 77
decreased circulating choleste... 10 | 85
increased lean body mass 10 | 107
decreased body length 9 | 108
decreased circulating alkaline... 9 | 41
decreased circulating glucose ... 9 | 121
decreased circulating insulin ... 9 | 75
impaired glucose tolerance 9 | 52
increased body weight 9 | 42
increased circulating choleste... 9 | 53
increased total body fat amoun... 9 | 57
abnormal neural tube closure 8 | 37
abnormal retinal pigmentation 8 | 61
abnormal seminal vesicle morph... 8 | 47
abnormal testis morphology 8 | 30
decreased circulating serum al... 8 | 79
decreased prepulse inhibition 8 | 52
hydrops fetalis 8 | 22
hyperactivity 8 | 108
improved glucose tolerance 8 | 56
increased circulating HDL chol... 8 | 63
increased mean corpuscular vol... 8 | 91
short tibia 8 | 82
small testis 8 | 37
abnormal bone mineralization 7 | 55
abnormal heart morphology 7 | 51
abnormal tooth morphology 7 | 24
decreased blood urea nitrogen ... 7 | 31
increased bone mineral content 7 | 92
increased circulating triglyce... 7 | 24
increased mean corpuscular hem... 7 | 93
increased startle reflex 7 | 38
male infertility 7 | 62
tremors 7 | 34
abnormal gait 6 | 51
abnormal hindbrain development 6 | 24
cataract 6 | 26
decreased heart weight 6 | 44
decreased rib number 6 | 59
abnormal cornea morphology 5 | 24
abnormal epididymis morphology 5 | 31
abnormal forebrain development 5 | 18
abnormal lens morphology 5 | 73
abnormal midbrain development 5 | 22
abnormal spleen morphology 5 | 36
abnormal tail morphology 5 | 17
absent vibrissae 5 | 14
anophthalmia 5 | 20
corneal opacity 5 | 25
craniofacial phenotype 5 | 9
decreased circulating amylase ... 5 | 24
decreased circulating free fat... 5 | 39
decreased lumbar vertebrae num... 5 | 62
decreased mean corpuscular vol... 5 | 50
decreased startle reflex 5 | 48
female infertility 5 | 34
increased circulating glucose ... 5 | 16
increased circulating sodium l... 5 | 71
increased hemoglobin content 5 | 45
abnormal kidney morphology 4 | 30
abnormal locomotor activation 4 | 26
abnormal sleep behavior 4 | 63
decreased T cell number 4 | 31
decreased circulating aspartat... 4 | 27
decreased circulating glycerol... 4 | 19
increased blood urea nitrogen ... 4 | 44
increased bone mineral density 4 | 52
increased circulating aspartat... 4 | 17
increased circulating calcium ... 4 | 32
increased circulating glycerol... 4 | 11
increased circulating iron lev... 4 | 25
increased circulating serum al... 4 | 25
increased exploration in new e... 4 | 56
increased mean corpuscular hem... 4 | 25
microphthalmia 4 | 15
persistence of hyaloid vascula... 4 | 22
small thymus 4 | 11
thrombocytopenia 4 | 46
vertebral fusion 4 | 23

Disease

ovarian cancer 681 | 8,484
psoriasis 643 | 6,685
osteosarcoma 601 | 7,933
Cancer 505 | 2,346
lung cancer 488 | 4,466
glioblastoma 461 | 5,572
medulloblastoma, large-cell 459 | 6,234
Breast cancer 341 | 3,094
atypical teratoid / rhabdoid tumor 340 | 4,369
intraductal papillary-mucinous neoplasm (IPMN) 339 | 3,289
malignant mesothelioma 336 | 3,162
intraductal papillary-mucinous adenoma (IPMA) 320 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 318 | 2,988
invasive ductal carcinoma 317 | 2,950
lung carcinoma 307 | 2,844
lung adenocarcinoma 301 | 2,713
non-small cell lung cancer 301 | 2,798
pancreatic cancer 298 | 2,300
pilocytic astrocytoma 295 | 3,086
interstitial cystitis 289 | 2,299
ulcerative colitis 285 | 2,087
Carcinoma 275 | 2,147
oligodendroglioma 236 | 2,849
pediatric high grade glioma 233 | 2,712
cystic fibrosis 230 | 1,665
pituitary cancer 216 | 1,972
primitive neuroectodermal tumor 214 | 3,031
colon cancer 210 | 1,475
diabetes mellitus 209 | 1,663
ductal carcinoma in situ 204 | 1,745
ependymoma 197 | 2,514
breast carcinoma 192 | 1,614
subependymal giant cell astrocytoma 188 | 2,287
group 4 medulloblastoma 185 | 1,875
tuberculosis 182 | 1,557
posterior fossa group A ependymoma 169 | 1,511
primary pancreatic ductal adenocarcinoma 168 | 1,271
astrocytoma 166 | 1,493
group 3 medulloblastoma 162 | 2,254
astrocytic glioma 161 | 2,241
adrenocortical carcinoma 157 | 1,427
adult high grade glioma 156 | 2,148
pancreatic ductal adenocarcinoma liver metastasis 149 | 1,795
Rheumatoid Arthritis 146 | 1,160
cutaneous lupus erythematosus 140 | 1,056
Pick disease 133 | 1,893
Obesity 126 | 616
juvenile dermatomyositis 126 | 1,189
sonic hedgehog group medulloblastoma 123 | 1,482
acute quadriplegic myopathy 121 | 1,157
spina bifida 121 | 1,064
medulloblastoma 118 | 1,524
gastric carcinoma 114 | 832
nasopharyngeal carcinoma 112 | 1,056
posterior fossa group B ependymoma 112 | 1,530
active Crohn's disease 109 | 918
Kidney disease 102 | 396
atypical teratoid/rhabdoid tumor 101 | 1,095
Prostatic Neoplasms 98 | 471
esophageal adenocarcinoma 98 | 737
Mammary Neoplasms 97 | 410
Atopic dermatitis 96 | 944
primary Sjogren syndrome 93 | 789
Alzheimer's disease 91 | 644
Multiple myeloma 90 | 1,327
dermatomyositis 87 | 933
Endometriosis 84 | 535
Asthma 82 | 349
Cleft palate 80 | 125
Multiple Sclerosis 79 | 498
Duchenne muscular dystrophy 78 | 602
Craniofacial Abnormalities 75 | 147
Schizophrenia 74 | 501
Vascular disease 74 | 281
Down syndrome 72 | 548
Atherosclerosis 71 | 275
Hypertension 71 | 287
autosomal dominant Emery-Dreifuss muscular dystrophy 71 | 499
Arthritis 69 | 248
non-small cell lung carcinoma 69 | 413
Waldenstrons macroglobulinemia 67 | 765
Lung Neoplasms 66 | 171
Heart disease 65 | 279
Inflammatory bowel disease 64 | 142
Intellectual disability 64 | 573
Stomach Neoplasms 64 | 282
acute myeloid leukemia 63 | 780
aldosterone-producing adenoma 63 | 664
pancreatic carcinoma 63 | 567
fibroadenoma 61 | 557
Adenoma 60 | 165
Autistic Disorder 60 | 320
IGA Glomerulonephritis 60 | 454
Hypersensitivity reaction type II disease 57 | 235
Hypertensive disease 57 | 193
Liver disease 57 | 219
non primary Sjogren syndrome sicca 57 | 840
Coronary artery disease 56 | 240
Crohn's disease 56 | 304
chronic rhinosinusitis 56 | 512

Tissue

Nervous System 1,284 | 18,561
Digestive Tract 1,283 | 18,473
Endocrine System 1,280 | 18,512
Female tissues 1,278 | 18,647
Urinary Tract 1,277 | 18,444
Liver and Pancreas 1,274 | 18,136
Skin and soft tissues 1,266 | 18,115
Male tissues 1,264 | 17,969
Blood and immune system 1,258 | 17,995
Cardiovascular System 1,258 | 17,958
Respiratory system 1,247 | 17,484

Target Family

Non-IDG 584 | 11,971
Enzyme 241 | 4,146
Transcription Factor 199 | 1,400
Kinase 87 | 634
Transporter 55 | 473
GPCR 54 | 406
Ion Channel 30 | 341
Epigenetic 19 | 242
Nuclear Receptor 19 | 48
TF/Epigenetic 4 | 38

MGI Term

digestive/alimentary phenotype 1,292 | 1,292
mortality/aging 4,850 | 4,850
homeostasis/metabolism phenoty... 4,454 | 4,454
growth/size/body region phenot... 3,915 | 3,915
cellular phenotype 3,348 | 3,348
nervous system phenotype 3,201 | 3,201
behavior/neurological phenotyp... 3,192 | 3,192
immune system phenotype 3,148 | 3,148
hematopoietic system phenotype 3,145 | 3,145
cardiovascular system phenotyp... 2,448 | 2,448
endocrine/exocrine gland pheno... 2,084 | 2,084
skeleton phenotype 2,058 | 2,058
normal phenotype 1,916 | 1,916
reproductive system phenotype 1,873 | 1,873
integument phenotype 1,748 | 1,748
embryo phenotype 1,674 | 1,674
vision/eye phenotype 1,478 | 1,478
muscle phenotype 1,385 | 1,385
respiratory system phenotype 1,291 | 1,291
liver/biliary system phenotype 1,160 | 1,160
renal/urinary system phenotype 1,157 | 1,157
craniofacial phenotype 1,077 | 1,077
limbs/digits/tail phenotype 1,011 | 1,011
neoplasm 918 | 918
adipose tissue phenotype 901 | 901
hearing/vestibular/ear phenoty... 692 | 692
pigmentation phenotype 459 | 459
taste/olfaction phenotype 142 | 142
obsolete other phenotype 69 | 69

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788
Forkhead box protein M1 FOXM1 Tbio Transcription Factor -3.09305 1275.4 345
Glial cell line-derived neurotrophic factor GDNF Tbio Non-IDG -3.30206 2301.5 303
Mucin-1 MUC1 Tbio Non-IDG -3.49560 3532.0 1851
Transmembrane protease serine 6 TMPRSS6 Tchem Enzyme -1.99222 118.1 102
Zinc finger protein 148 ZNF148 Tbio Transcription Factor -1.71996 60.7 178
Class A basic helix-loop-helix protein 15 BHLHA15 Tbio Transcription Factor -1.24086 19.1 70
V(D)J recombination-activating protein 1 RAG1 Tbio Non-IDG -3.00063 1061.1 65