Development Level

Tbio 763 | 10,625
Tchem 203 | 1,890
Tclin 63 | 602
Tdark 48 | 7,003

Collection

Eligible Kinase Proteins 7 | 134
Eligible Ion Channel Proteins 3 | 117
Eligible non-olfactory GPCR Proteins 1 | 143

IMPC Term

preweaning lethality, complete... 83 | 633
decreased body weight 41 | 174
decreased lean body mass 38 | 195
preweaning lethality, incomple... 37 | 260
abnormal behavior 31 | 226
decreased bone mineral content 30 | 157
decreased total body fat amoun... 30 | 186
abnormal cranium morphology 28 | 32
decreased body length 24 | 108
embryonic lethality prior to t... 24 | 187
abnormal bone structure 23 | 131
decreased bone mineral density 23 | 126
abnormal tooth morphology 22 | 24
abnormal embryo size 19 | 112
abnormal bone mineralization 18 | 55
enlarged heart 18 | 111
increased circulating alkaline... 18 | 119
abnormal snout morphology 17 | 18
hypoactivity 16 | 89
abnormal maxilla morphology 15 | 16
decreased grip strength 15 | 123
abnormal retina morphology 14 | 100
decreased circulating choleste... 14 | 85
decreased circulating glucose ... 14 | 121
embryonic lethality prior to o... 14 | 148
decreased circulating serum al... 13 | 79
increased or absent threshold ... 13 | 128
abnormal eye morphology 12 | 38
decreased circulating HDL chol... 12 | 77
abnormal coat/hair pigmentatio... 11 | 54
decreased circulating total pr... 11 | 41
short tibia 11 | 82
decreased circulating calcium ... 10 | 33
decreased erythrocyte cell num... 10 | 43
decreased heart weight 10 | 44
decreased prepulse inhibition 10 | 52
decreased rib number 10 | 59
increased grip strength 10 | 83
increased lean body mass 10 | 107
increased mean corpuscular hem... 10 | 93
increased mean corpuscular vol... 10 | 91
decreased circulating amylase ... 9 | 24
decreased mean corpuscular vol... 9 | 50
increased bone mineral content 9 | 92
abnormal joint morphology 8 | 14
abnormal neural tube closure 8 | 37
abnormal tail morphology 8 | 17
corneal opacity 8 | 25
decreased circulating alkaline... 8 | 41
decreased circulating triglyce... 8 | 83
decreased hemoglobin content 8 | 53
hyperactivity 8 | 108
increased body weight 8 | 42
increased bone mineral density 8 | 52
increased circulating potassiu... 8 | 31
vertebral fusion 8 | 23
abnormal head morphology 7 | 10
abnormal startle reflex 7 | 14
abnormal vertebrae morphology 7 | 14
anophthalmia 7 | 20
craniofacial phenotype 7 | 9
decreased blood urea nitrogen ... 7 | 31
decreased hematocrit 7 | 25
decreased lumbar vertebrae num... 7 | 62
hydrops fetalis 7 | 22
increased blood urea nitrogen ... 7 | 44
increased circulating iron lev... 7 | 25
increased heart weight 7 | 37
increased total body fat amoun... 7 | 57
abnormal cornea morphology 6 | 24
abnormal femur morphology 6 | 14
abnormal gait 6 | 51
abnormal hindbrain development 6 | 24
abnormal lens morphology 6 | 73
abnormal locomotor activation 6 | 26
abnormal tibia morphology 6 | 14
cataract 6 | 26
decreased circulating LDL chol... 6 | 37
decreased circulating alanine ... 6 | 53
decreased circulating insulin ... 6 | 75
decreased eosinophil cell numb... 6 | 41
decreased leukocyte cell numbe... 6 | 54
narrow eye opening 6 | 15
small testis 6 | 37
abnormal eye size 5 | 11
abnormal rib morphology 5 | 28
abnormal seminal vesicle morph... 5 | 47
abnormal testis morphology 5 | 30
decreased circulating aspartat... 5 | 27
decreased circulating free fat... 5 | 39
decreased fasted circulating g... 5 | 49
decreased mean corpuscular hem... 5 | 34
impaired glucose tolerance 5 | 52
increased circulating HDL chol... 5 | 63
increased circulating chloride... 5 | 43
increased circulating choleste... 5 | 53
increased circulating sodium l... 5 | 71
increased sacral vertebrae num... 5 | 62
increased startle reflex 5 | 38
tremors 5 | 34

Disease

ovarian cancer 646 | 8,484
osteosarcoma 544 | 7,933
psoriasis 486 | 6,685
medulloblastoma, large-cell 439 | 6,234
glioblastoma 427 | 5,572
Cancer 367 | 2,346
lung cancer 365 | 4,466
atypical teratoid / rhabdoid tumor 345 | 4,369
Breast cancer 302 | 3,094
malignant mesothelioma 285 | 3,162
pilocytic astrocytoma 278 | 3,086
invasive ductal carcinoma 257 | 2,950
Carcinoma 253 | 2,147
oligodendroglioma 243 | 2,849
intraductal papillary-mucinous adenoma (IPMA) 231 | 2,956
pancreatic cancer 230 | 2,300
lung adenocarcinoma 227 | 2,713
intraductal papillary-mucinous neoplasm (IPMN) 226 | 3,289
lung carcinoma 224 | 2,844
primitive neuroectodermal tumor 223 | 3,031
ependymoma 220 | 2,514
non-small cell lung cancer 217 | 2,798
intraductal papillary-mucinous carcinoma (IPMC) 213 | 2,988
pediatric high grade glioma 211 | 2,712
interstitial cystitis 195 | 2,299
ulcerative colitis 189 | 2,087
pituitary cancer 188 | 1,972
group 4 medulloblastoma 182 | 1,875
astrocytic glioma 171 | 2,241
ductal carcinoma in situ 165 | 1,745
cystic fibrosis 164 | 1,665
astrocytoma 161 | 1,493
breast carcinoma 150 | 1,614
subependymal giant cell astrocytoma 150 | 2,287
primary pancreatic ductal adenocarcinoma 148 | 1,271
group 3 medulloblastoma 144 | 2,254
adult high grade glioma 141 | 2,148
Pick disease 140 | 1,893
posterior fossa group A ependymoma 139 | 1,511
colon cancer 137 | 1,475
sonic hedgehog group medulloblastoma 130 | 1,482
tuberculosis 124 | 1,557
adrenocortical carcinoma 123 | 1,427
medulloblastoma 119 | 1,524
posterior fossa group B ependymoma 117 | 1,530
diabetes mellitus 113 | 1,663
juvenile dermatomyositis 109 | 1,189
pancreatic ductal adenocarcinoma liver metastasis 108 | 1,795
acute quadriplegic myopathy 105 | 1,157
Rheumatoid Arthritis 103 | 1,160
Craniofacial Abnormalities 99 | 147
nasopharyngeal carcinoma 97 | 1,056
Intellectual disability 96 | 573
spina bifida 96 | 1,064
atypical teratoid/rhabdoid tumor 94 | 1,095
Multiple myeloma 87 | 1,327
gastric carcinoma 86 | 832
Mammary Neoplasms 81 | 410
dermatomyositis 80 | 933
Cleft palate 79 | 125
Obesity 79 | 616
cutaneous lupus erythematosus 78 | 1,056
autosomal dominant Emery-Dreifuss muscular dystrophy 73 | 499
Alzheimer's disease 72 | 644
Atopic dermatitis 71 | 944
esophageal adenocarcinoma 69 | 737
Duchenne muscular dystrophy 67 | 602
Down syndrome 64 | 548
Kidney disease 63 | 396
Prostatic Neoplasms 63 | 471
acute myeloid leukemia 58 | 780
Waldenstrons macroglobulinemia 57 | 765
Endometriosis 56 | 535
Osteoporosis 56 | 257
primary Sjogren syndrome 55 | 789
Amyotrophic Lateral Sclerosis 51 | 431
active Crohn's disease 51 | 918
progressive supranuclear palsy 51 | 674
fibroadenoma 50 | 557
non-small cell lung carcinoma 50 | 413
aldosterone-producing adenoma 49 | 664
non primary Sjogren syndrome sicca 49 | 840
Heart disease 48 | 279
Lung Neoplasms 48 | 171
chronic rhinosinusitis 48 | 512
pancreatic carcinoma 48 | 567
Cleft Lip 45 | 91
Polydactyly 44 | 93
tuberculosis and treatment for 6 months 43 | 686
Schizophrenia 42 | 501
Vascular disease 42 | 281
Autistic Disorder 41 | 320
Arthritis 40 | 248
Stomach Neoplasms 40 | 282
Parkinson's disease 39 | 364
Colorectal Neoplasms 38 | 217
Melanoma 38 | 261
Adenoma 37 | 165
IGA Glomerulonephritis 36 | 454
Multiple Sclerosis 35 | 498

Tissue

Nervous System 1,072 | 18,561
Digestive Tract 1,068 | 18,473
Endocrine System 1,068 | 18,512
Female tissues 1,068 | 18,647
Urinary Tract 1,063 | 18,444
Liver and Pancreas 1,058 | 18,136
Skin and soft tissues 1,057 | 18,115
Cardiovascular System 1,052 | 17,958
Male tissues 1,050 | 17,969
Blood and immune system 1,048 | 17,995
Respiratory system 1,031 | 17,484

Target Family

Non-IDG 482 | 11,971
Transcription Factor 219 | 1,400
Enzyme 191 | 4,146
Kinase 76 | 634
Epigenetic 36 | 242
Transporter 19 | 473
GPCR 18 | 406
Ion Channel 18 | 341
Nuclear Receptor 9 | 48
TF/Epigenetic 5 | 38
oGPCR 4 | 421

MGI Term

craniofacial phenotype 1,077 | 1,077
mortality/aging 4,850 | 4,850
homeostasis/metabolism phenoty... 4,454 | 4,454
growth/size/body region phenot... 3,915 | 3,915
cellular phenotype 3,348 | 3,348
nervous system phenotype 3,201 | 3,201
behavior/neurological phenotyp... 3,192 | 3,192
immune system phenotype 3,148 | 3,148
hematopoietic system phenotype 3,145 | 3,145
cardiovascular system phenotyp... 2,448 | 2,448
endocrine/exocrine gland pheno... 2,084 | 2,084
skeleton phenotype 2,058 | 2,058
normal phenotype 1,916 | 1,916
reproductive system phenotype 1,873 | 1,873
integument phenotype 1,748 | 1,748
embryo phenotype 1,674 | 1,674
vision/eye phenotype 1,478 | 1,478
muscle phenotype 1,385 | 1,385
digestive/alimentary phenotype 1,292 | 1,292
respiratory system phenotype 1,291 | 1,291
liver/biliary system phenotype 1,160 | 1,160
renal/urinary system phenotype 1,157 | 1,157
limbs/digits/tail phenotype 1,011 | 1,011
neoplasm 918 | 918
adipose tissue phenotype 901 | 901
hearing/vestibular/ear phenoty... 692 | 692
pigmentation phenotype 459 | 459
taste/olfaction phenotype 142 | 142
obsolete other phenotype 69 | 69

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.39907 258.0 359
Glypican-3 GPC3 Tbio Non-IDG -2.85848 794.8 523
POU domain, class 3, transcription factor 4 POU3F4 Tbio Transcription Factor -2.24459 179.3 55
High mobility group protein HMGI-C HMGA2 Tbio Transcription Factor -3.21092 1667.7 216
Methyl-CpG-binding protein 2 MECP2 Tchem Transcription Factor -3.22710 1827.6 567
Desmoplakin DSP Tbio Non-IDG -2.90088 786.5 167
Dymeclin DYM Tbio Non-IDG -1.45800 31.6 59