Development Level

Tbio 881 | 11,445
Tchem 174 | 1,598
Tclin 68 | 613
Tdark 59 | 6,588

Collection

RFA-RM-18-021 10 | 328
Kinase: IDG Consortium (Target... 6 | 125
Kinase: IDG Consortium (Comple... 4 | 37
Ion Channel: IDG Consortium (T... 3 | 99
GPCR: IDG Consortium (Complete... 2 | 25
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 152 | 979
preweaning lethality, incomple... 79 | 499
abnormal embryo size 50 | 220
decreased body weight 42 | 161
embryonic lethality prior to t... 39 | 278
abnormal cranium morphology 35 | 36
abnormal behavior 34 | 298
decreased total body fat amoun... 32 | 207
enlarged heart 32 | 210
abnormal bone structure 31 | 187
decreased lean body mass 29 | 135
decreased body length 26 | 101
decreased bone mineral content 26 | 151
embryonic lethality prior to o... 26 | 239
abnormal craniofacial morpholo... 25 | 33
increased total body fat amoun... 24 | 134
embryonic growth retardation 22 | 106
abnormal heart morphology 21 | 162
abnormal snout morphology 21 | 23
abnormal tooth morphology 21 | 24
increased startle reflex 20 | 112
edema 19 | 59
increased lean body mass 19 | 172
abnormal seminal vesicle morph... 18 | 114
decreased circulating total pr... 17 | 49
hypoactivity 17 | 132
increased circulating alkaline... 17 | 122
short tibia 17 | 97
abnormal eye morphology 16 | 68
abnormal neural tube closure 16 | 46
decreased circulating glucose ... 16 | 126
decreased circulating serum al... 16 | 82
abnormal maxilla morphology 15 | 17
decreased bone mineral density 15 | 126
decreased circulating HDL chol... 14 | 68
decreased circulating choleste... 14 | 93
decreased prepulse inhibition 14 | 82
hyperactivity 14 | 148
abnormal coat-hair pigmentatio... 13 | 64
abnormal facial morphology 13 | 17
abnormal retina morphology 13 | 71
anophthalmia 13 | 33
abnormal tail morphology 12 | 25
decreased grip strength 12 | 116
decreased hemoglobin content 12 | 68
decreased lymphocyte cell numb... 12 | 83
decreased vertical activity 12 | 208
impaired glucose tolerance 12 | 75
increased circulating HDL chol... 12 | 80
increased circulating choleste... 12 | 66
increased mean corpuscular hem... 12 | 96
pallor 12 | 34
prenatal lethality prior to he... 12 | 87
abnormal limb morphology 11 | 13
abnormal vertebrae morphology 11 | 18
cataract 11 | 92
decreased circulating calcium ... 11 | 36
increased bone mineral density 11 | 72
abnormal lens morphology 10 | 81
corneal opacity 10 | 32
decreased caudal vertebrae num... 10 | 53
decreased circulating amylase ... 10 | 28
decreased circulating triglyce... 10 | 79
decreased erythrocyte cell num... 10 | 62
decreased hematocrit 10 | 46
decreased mean corpuscular vol... 10 | 79
hemorrhage 10 | 23
mammalian phenotype 10 | 17
small superior vagus ganglion 10 | 74
abnormal cornea morphology 9 | 31
abnormal head morphology 9 | 10
abnormal limb bud morphology 9 | 17
decreased blood urea nitrogen ... 9 | 51
increased bone mineral content 9 | 108
increased heart weight 9 | 62
increased neutrophil cell numb... 9 | 46
abnormal bone mineralization 8 | 38
abnormal embryo turning 8 | 31
abnormal joint morphology 8 | 23
abnormal kidney morphology 8 | 65
abnormal pericardium morpholog... 8 | 26
abnormal placenta size 8 | 20
decreased circulating aspartat... 8 | 34
decreased fasted circulating g... 8 | 65
decreased leukocyte cell numbe... 8 | 73
enlarged lymph nodes 8 | 37
increased blood urea nitrogen ... 8 | 48
increased circulating chloride... 8 | 41
increased mean corpuscular vol... 8 | 92
increased or absent threshold ... 8 | 101
pale yolk sac 8 | 25
persistence of hyaloid vascula... 8 | 33
vertebral fusion 8 | 23
decreased circulating LDL chol... 7 | 38
decreased circulating alkaline... 7 | 46
decreased circulating insulin ... 7 | 76
improved glucose tolerance 7 | 79
increased monocyte cell number 7 | 63
male infertility 7 | 123
small testis 7 | 58

Disease

Carcinoma 882 | 11,493
ovarian cancer 708 | 8,520
osteosarcoma 597 | 7,950
psoriasis 524 | 6,694
glioblastoma 484 | 5,792
medulloblastoma, large-cell 480 | 6,241
atypical teratoid / rhabdoid tumor 441 | 5,112
ependymoma 436 | 4,679
lung cancer 423 | 4,740
Cancer 407 | 2,499
Breast cancer 394 | 3,578
malignant mesothelioma 316 | 3,232
Kidney cancer 304 | 2,613
group 3 medulloblastoma 301 | 4,104
Astrocytoma, Pilocytic 294 | 3,081
invasive ductal carcinoma 279 | 2,951
adult high grade glioma 273 | 3,801
pancreatic cancer 267 | 2,398
oligodendroglioma 256 | 2,850
intraductal papillary-mucinous adenoma (IPMA) 250 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 250 | 3,291
non-small cell lung cancer 244 | 2,890
lung adenocarcinoma 243 | 2,716
primitive neuroectodermal tumor 243 | 3,035
lung carcinoma 239 | 2,843
intraductal papillary-mucinous carcinoma (IPMC) 232 | 2,989
astrocytic glioma 231 | 2,597
Autosomal recessive predisposition 228 | 1,442
interstitial cystitis 208 | 2,312
pituitary cancer 206 | 1,972
Intellectual disability 193 | 1,016
ulcerative colitis 184 | 1,819
cystic fibrosis 180 | 1,696
group 4 medulloblastoma 176 | 1,855
ductal carcinoma in situ 174 | 1,745
subependymal giant cell astrocytoma 170 | 2,287
tuberculosis 170 | 2,010
breast carcinoma 167 | 1,638
Short stature 165 | 531
Pick disease 150 | 1,894
Dull intelligence 149 | 645
Low intelligence 149 | 645
Mental Retardation 149 | 645
Mental deficiency 149 | 645
Poor school performance 149 | 645
pancreatic ductal adenocarcinoma liver metastasis 149 | 1,962
Schizophrenia 143 | 1,160
colon cancer 143 | 1,478
adrenocortical carcinoma 135 | 1,428
astrocytoma 133 | 1,146
primary pancreatic ductal adenocarcinoma 133 | 1,109
Cleft Palate 130 | 271
diabetes mellitus 130 | 1,728
Muscle hypotonia 123 | 571
Epilepsy 122 | 792
Cognitive delay 118 | 608
Global developmental delay 118 | 608
Mental and motor retardation 118 | 608
Seizures 118 | 596
juvenile dermatomyositis 115 | 1,187
Rheumatoid arthritis 113 | 1,191
acute quadriplegic myopathy 112 | 1,158
spina bifida 111 | 1,074
Hypoplastic mandible condyle 109 | 275
Mandibular hypoplasia 109 | 275
Micrognathism 109 | 275
pediatric high grade glioma 106 | 1,064
Craniofacial Abnormalities 104 | 151
nasopharyngeal carcinoma 104 | 1,058
Multiple myeloma 101 | 1,332
Orbital separation excessive 100 | 244
Obesity 99 | 678
Breast Neoplasms 98 | 445
Small head 97 | 374
Mammary Neoplasms 94 | 425
Cryptorchidism 93 | 296
gastric carcinoma 91 | 807
Strabismus 90 | 270
Liver cancer 88 | 604
medulloblastoma 88 | 720
Curvature of spine 86 | 282
Acquired scoliosis 85 | 281
Melanoma 85 | 711
dermatomyositis 84 | 966
Osteoporosis 82 | 363
cutaneous lupus erythematosus 82 | 1,057
Concave bridge of nose 80 | 195
Deafness 80 | 198
Depressed nasal bridge 80 | 195
Depressed nasal root/bridge 80 | 195
Brachydactyly 79 | 156
Atopic dermatitis 78 | 952
hearing impairment 78 | 199
Alzheimer's disease 77 | 658
Congenital deafness 77 | 185
Hearing Loss, Partial 77 | 185
Liver Cirrhosis, Experimental 77 | 769
autosomal dominant Emery-Dreifuss muscular dystrophy 77 | 510
Bipolar Disorder 75 | 666
Broad flat nasal bridge 73 | 236

Tissue

Endocrine System 1,157 | 18,159
Digestive Tract 1,128 | 17,369
Female tissues 1,122 | 17,400
Skin and soft tissues 1,122 | 17,230
Male tissues 1,114 | 17,142
Nervous System 1,110 | 16,725
Blood and immune system 1,103 | 16,909
Urinary Tract 1,098 | 16,678
Liver and Pancreas 1,093 | 16,750
Respiratory system 1,076 | 16,393
Cardiovascular System 1,014 | 15,192

Target Family

Non-IDG 546 | 12,091
Transcription Factor 227 | 1,400
Enzyme 214 | 4,145
Kinase 79 | 634
Epigenetic 39 | 242
Transporter 22 | 473
GPCR 18 | 408
Ion Channel 18 | 344
Nuclear Receptor 10 | 48
TF/Epigenetic 5 | 38
oGPCR 4 | 421

MGI Phenotype

craniofacial phenotype 1,182 | 1,182
mortality-aging 5,018 | 5,018
homeostasis-metabolism phenoty... 4,747 | 4,747
growth-size-body region phenot... 4,157 | 4,157
cellular phenotype 3,637 | 3,637
immune system phenotype 3,461 | 3,461
nervous system phenotype 3,447 | 3,447
behavior-neurological phenotyp... 3,401 | 3,401
hematopoietic system phenotype 3,383 | 3,383
cardiovascular system phenotyp... 2,660 | 2,660
endocrine-exocrine gland pheno... 2,293 | 2,293
skeleton phenotype 2,222 | 2,222
normal phenotype 1,999 | 1,999
reproductive system phenotype 1,999 | 1,999
integument phenotype 1,874 | 1,874
embryo phenotype 1,827 | 1,827
vision-eye phenotype 1,622 | 1,622
muscle phenotype 1,479 | 1,479
digestive-alimentary phenotype 1,398 | 1,398
respiratory system phenotype 1,390 | 1,390
liver-biliary system phenotype 1,300 | 1,300
renal-urinary system phenotype 1,269 | 1,269
limbs-digits-tail phenotype 1,071 | 1,071
adipose tissue phenotype 992 | 992
neoplasm 975 | 975
hearing-vestibular-ear phenoty... 767 | 767
pigmentation phenotype 506 | 506
taste-olfaction phenotype 147 | 147
no phenotypic analysis 5 | 5

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cat eye syndrome critical region protein 2 CECR2 Tchem Epigenetic -2.17030 147.0 44
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Transcription factor CP2-like protein 1 TFCP2L1 Tbio Transcription Factor -1.10701 12.4 231
Insulin-like growth factor 2 mRNA-binding protein 1 IGF2BP1 Tbio Non-IDG -1.85997 76.0 207
Pre-B-cell leukemia transcription factor 3 PBX3 Tbio Transcription Factor -1.58292 36.0 183
Pre-B-cell leukemia transcription factor 2 PBX2 Tbio Transcription Factor -1.90701 75.7 168
Lysine-specific demethylase hairless HR Tbio Enzyme -1.13301 12.4 99
Exportin-T XPOT Tbio Non-IDG -1.46210 29.6 86
A-kinase anchor protein 10, mitochondrial AKAP10 Tbio Enzyme -1.41570 26.7 202