Development Level

Tbio 2,724 | 11,651
Tchem 552 | 1,388
Tclin 206 | 612
Tdark 155 | 6,593

Collection

RFA-RM-18-021 27 | 328
Kinase: IDG Consortium (Target... 14 | 125
Kinase: IDG Consortium (Comple... 13 | 37
GPCR: IDG Consortium (Targets) 7 | 126
Ion Channel: IDG Consortium (T... 6 | 99
GPCR: IDG Consortium (Complete... 4 | 25

IMPC Phenotype

preweaning lethality, complete... 293 | 979
preweaning lethality, incomple... 156 | 499
embryonic lethality prior to t... 94 | 278
abnormal embryo size 80 | 220
abnormal behavior 79 | 298
embryonic lethality prior to o... 67 | 239
abnormal bone structure 65 | 187
decreased vertical activity 61 | 208
enlarged heart 60 | 210
decreased body weight 54 | 161
hypoactivity 51 | 132
male infertility 49 | 123
increased total body fat amoun... 48 | 134
decreased total body fat amoun... 47 | 207
abnormal seminal vesicle morph... 42 | 114
decreased bone mineral content 42 | 151
decreased lean body mass 40 | 135
increased circulating alkaline... 40 | 122
abnormal heart morphology 39 | 162
increased lean body mass 39 | 172
increased startle reflex 39 | 112
decreased bone mineral density 38 | 126
decreased circulating glucose ... 32 | 126
increased mean corpuscular hem... 32 | 96
embryonic growth retardation 31 | 106
decreased body length 30 | 101
decreased lymphocyte cell numb... 30 | 83
increased bone mineral content 30 | 108
hyperactivity 28 | 148
increased mean corpuscular vol... 28 | 92
abnormal eye morphology 26 | 68
edema 26 | 59
cataract 25 | 92
decreased mean corpuscular vol... 25 | 79
prenatal lethality prior to he... 25 | 87
short tibia 25 | 97
small superior vagus ganglion 25 | 74
decreased circulating choleste... 24 | 93
decreased circulating triglyce... 23 | 79
decreased prepulse inhibition 23 | 82
improved glucose tolerance 23 | 79
small testis 23 | 58
abnormal retina morphology 22 | 71
abnormal gait 21 | 69
abnormal lens morphology 21 | 81
increased bone mineral density 21 | 72
increased monocyte cell number 21 | 63
female infertility 20 | 60
impaired glucose tolerance 20 | 75
increased fasted circulating g... 20 | 76
increased heart weight 20 | 62
decreased circulating serum al... 19 | 82
decreased grip strength 19 | 116
increased circulating HDL chol... 19 | 80
increased neutrophil cell numb... 19 | 46
abnormal kidney morphology 18 | 65
decreased circulating HDL chol... 18 | 68
decreased circulating insulin ... 18 | 76
decreased leukocyte cell numbe... 18 | 73
increased circulating choleste... 18 | 66
decreased circulating alkaline... 17 | 46
decreased hemoglobin content 17 | 68
increased blood urea nitrogen ... 17 | 48
increased grip strength 17 | 41
increased leukocyte cell numbe... 17 | 47
thrombocytopenia 17 | 56
abnormal neural tube closure 16 | 46
abnormal testis morphology 16 | 43
anophthalmia 16 | 33
decreased erythrocyte cell num... 16 | 62
abnormal craniofacial morpholo... 15 | 33
decreased blood urea nitrogen ... 15 | 51
decreased startle reflex 15 | 75
hydrometra 15 | 53
increased or absent threshold ... 15 | 101
abnormal bone mineralization 14 | 38
abnormal skin morphology 14 | 50
abnormal spleen morphology 14 | 55
decreased circulating alanine ... 14 | 47
decreased circulating total pr... 14 | 49
decreased fasted circulating g... 14 | 65
hemorrhage 14 | 23
increased circulating sodium l... 14 | 71
increased mean platelet volume 14 | 45
limb grasping 14 | 41
persistence of hyaloid vascula... 14 | 33
decreased circulating amylase ... 13 | 28
decreased circulating calcium ... 13 | 36
decreased circulating creatini... 13 | 39
increased circulating triglyce... 13 | 42
increased hemoglobin content 13 | 45
tremors 13 | 39
abnormal cranium morphology 12 | 36
decreased mean corpuscular hem... 12 | 50
decreased neutrophil cell numb... 12 | 42
increased circulating creatini... 12 | 38
prenatal lethality 12 | 28
abnormal coat-hair pigmentatio... 11 | 64
corneal opacity 11 | 32
increased circulating chloride... 11 | 41

Disease

Carcinoma 2,513 | 11,493
ovarian cancer 2,053 | 8,520
osteosarcoma 1,851 | 7,950
psoriasis 1,625 | 6,694
medulloblastoma, large-cell 1,497 | 6,241
glioblastoma 1,459 | 5,792
lung cancer 1,362 | 4,740
atypical teratoid / rhabdoid tumor 1,217 | 5,112
Cancer 1,191 | 2,499
ependymoma 1,107 | 4,679
group 3 medulloblastoma 1,029 | 4,104
Breast cancer 1,006 | 3,578
malignant mesothelioma 924 | 3,232
adult high grade glioma 888 | 3,801
invasive ductal carcinoma 827 | 2,951
non-small cell lung cancer 814 | 2,890
intraductal papillary-mucinous neoplasm (IPMN) 801 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 759 | 2,989
Astrocytoma, Pilocytic 758 | 3,081
Kidney cancer 737 | 2,613
lung adenocarcinoma 733 | 2,716
primitive neuroectodermal tumor 731 | 3,035
intraductal papillary-mucinous adenoma (IPMA) 727 | 2,955
lung carcinoma 716 | 2,843
pancreatic cancer 690 | 2,398
oligodendroglioma 689 | 2,850
interstitial cystitis 621 | 2,312
astrocytic glioma 580 | 2,597
Autosomal recessive predisposition 561 | 1,442
subependymal giant cell astrocytoma 558 | 2,287
tuberculosis 544 | 2,010
ulcerative colitis 536 | 1,819
pituitary cancer 506 | 1,972
diabetes mellitus 493 | 1,728
breast carcinoma 485 | 1,638
ductal carcinoma in situ 482 | 1,745
cystic fibrosis 467 | 1,696
pancreatic ductal adenocarcinoma liver metastasis 451 | 1,962
Pick disease 446 | 1,894
colon cancer 444 | 1,478
group 4 medulloblastoma 441 | 1,855
Schizophrenia 419 | 1,160
Intellectual disability 413 | 1,016
adrenocortical carcinoma 413 | 1,428
Rheumatoid arthritis 383 | 1,191
astrocytoma 356 | 1,146
juvenile dermatomyositis 350 | 1,187
acute quadriplegic myopathy 349 | 1,158
Multiple myeloma 339 | 1,332
primary pancreatic ductal adenocarcinoma 330 | 1,109
cutaneous lupus erythematosus 324 | 1,057
Dull intelligence 298 | 645
Low intelligence 298 | 645
Mental Retardation 298 | 645
Mental deficiency 298 | 645
Poor school performance 298 | 645
dermatomyositis 293 | 966
spina bifida 293 | 1,074
pediatric high grade glioma 291 | 1,064
Obesity 283 | 678
Epilepsy 278 | 792
Short stature 275 | 531
nasopharyngeal carcinoma 267 | 1,058
Atopic dermatitis 261 | 952
Cognitive delay 260 | 608
Global developmental delay 260 | 608
Mental and motor retardation 260 | 608
Liver Cirrhosis, Experimental 249 | 769
Muscle hypotonia 242 | 571
Bipolar Disorder 241 | 666
Seizures 241 | 596
Alzheimer's disease 237 | 658
Waldenstrons macroglobulinemia 236 | 765
Breast Neoplasms 229 | 445
Melanoma 227 | 711
gastric carcinoma 227 | 807
Prostatic Neoplasms 225 | 495
Mammary Neoplasms 220 | 425
active Crohn's disease 217 | 922
primary Sjogren syndrome 215 | 735
esophageal adenocarcinoma 208 | 737
non primary Sjogren syndrome sicca 208 | 891
acute myeloid leukemia 206 | 783
Endometriosis 199 | 540
Down syndrome 195 | 499
Liver cancer 195 | 604
Small head 192 | 374
aldosterone-producing adenoma 186 | 665
autosomal dominant Emery-Dreifuss muscular dystrophy 185 | 510
Duchenne muscular dystrophy 184 | 601
Neurodegenerative disease 182 | 414
medulloblastoma 182 | 720
Depressive disorder 181 | 409
active ulcerative colitis 180 | 764
Kidney disease 175 | 430
Multiple Sclerosis 173 | 540
progressive supranuclear palsy 168 | 676
Amyotrophic lateral sclerosis 167 | 451
Hypertension 163 | 396
Hypertensive disease 160 | 292

Tissue

Endocrine System 3,570 | 18,159
Digestive Tract 3,501 | 17,369
Female tissues 3,481 | 17,400
Skin and soft tissues 3,470 | 17,230
Male tissues 3,455 | 17,142
Blood and immune system 3,433 | 16,909
Nervous System 3,433 | 16,725
Liver and Pancreas 3,422 | 16,750
Urinary Tract 3,417 | 16,678
Respiratory system 3,359 | 16,393
Cardiovascular System 3,214 | 15,192

Target Family

Non-IDG 1,839 | 12,091
Enzyme 781 | 4,145
Transcription Factor 411 | 1,400
Kinase 241 | 634
Epigenetic 105 | 242
GPCR 87 | 408
Transporter 74 | 473
Ion Channel 48 | 344
Nuclear Receptor 35 | 48
TF/Epigenetic 14 | 38
oGPCR 2 | 421

MGI Phenotype

cellular phenotype 3,637 | 3,637
mortality-aging 5,018 | 5,018
homeostasis-metabolism phenoty... 4,747 | 4,747
growth-size-body region phenot... 4,157 | 4,157
immune system phenotype 3,461 | 3,461
nervous system phenotype 3,447 | 3,447
behavior-neurological phenotyp... 3,401 | 3,401
hematopoietic system phenotype 3,383 | 3,383
cardiovascular system phenotyp... 2,660 | 2,660
endocrine-exocrine gland pheno... 2,293 | 2,293
skeleton phenotype 2,222 | 2,222
normal phenotype 1,999 | 1,999
reproductive system phenotype 1,999 | 1,999
integument phenotype 1,874 | 1,874
embryo phenotype 1,827 | 1,827
vision-eye phenotype 1,622 | 1,622
muscle phenotype 1,479 | 1,479
digestive-alimentary phenotype 1,398 | 1,398
respiratory system phenotype 1,390 | 1,390
liver-biliary system phenotype 1,300 | 1,300
renal-urinary system phenotype 1,269 | 1,269
craniofacial phenotype 1,182 | 1,182
limbs-digits-tail phenotype 1,071 | 1,071
adipose tissue phenotype 992 | 992
neoplasm 975 | 975
hearing-vestibular-ear phenoty... 767 | 767
pigmentation phenotype 506 | 506
taste-olfaction phenotype 147 | 147
no phenotypic analysis 5 | 5

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Signal transducer and activator of transcription 3 STAT3 Tchem Transcription Factor -3.81500 6459.7 1749
Cellular tumor antigen p53 TP53 Tchem Transcription Factor -4.74112 54026.3 6298
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN PTEN Tbio Enzyme -3.70874 5099.6 916
Retinoblastoma-associated protein RB1 Tchem Non-IDG -3.07052 1137.4 2150
Catenin beta-1 CTNNB1 Tchem Non-IDG -3.99948 9786.0 3058
Epidermal growth factor receptor EGFR Tclin Kinase -4.02650 10013.1 6418
Mitogen-activated protein kinase 1 MAPK1 Tchem Kinase -3.18822 1239.4 1248
Glycogen synthase kinase-3 beta GSK3B Tclin Kinase -3.00390 610.8 955
Transcription factor AP-1 JUN Tchem Transcription Factor -3.83935 6236.4 2664
Breast cancer type 1 susceptibility protein BRCA1 Tchem Non-IDG -3.76784 6081.3 1542