Development Level

Tbio 2,324 | 10,625
Tchem 679 | 1,890
Tclin 190 | 602
Tdark 155 | 7,003

Collection

Eligible Kinase Proteins 16 | 134
Eligible Ion Channel Proteins 7 | 117
Eligible non-olfactory GPCR Proteins 5 | 143

IMPC Term

preweaning lethality, complete... 171 | 633
preweaning lethality, incomple... 86 | 260
decreased lean body mass 60 | 195
embryonic lethality prior to t... 57 | 187
abnormal behavior 56 | 226
decreased body weight 49 | 174
decreased bone mineral content 48 | 157
decreased total body fat amoun... 45 | 186
abnormal bone structure 43 | 131
decreased bone mineral density 43 | 126
decreased body length 35 | 108
increased circulating alkaline... 34 | 119
abnormal embryo size 33 | 112
abnormal retina morphology 33 | 100
embryonic lethality prior to o... 31 | 148
hypoactivity 31 | 89
increased mean corpuscular hem... 30 | 93
enlarged heart 29 | 111
increased grip strength 29 | 83
increased mean corpuscular vol... 29 | 91
decreased grip strength 28 | 123
decreased circulating triglyce... 26 | 83
increased or absent threshold ... 26 | 128
decreased circulating glucose ... 25 | 121
decreased circulating choleste... 24 | 85
short tibia 22 | 82
increased bone mineral content 21 | 92
male infertility 21 | 62
abnormal bone mineralization 20 | 55
decreased circulating HDL chol... 20 | 77
increased lean body mass 20 | 107
decreased circulating insulin ... 19 | 75
decreased circulating serum al... 18 | 79
increased blood urea nitrogen ... 18 | 44
increased circulating HDL chol... 18 | 63
decreased hemoglobin content 17 | 53
decreased lumbar vertebrae num... 17 | 62
increased sacral vertebrae num... 17 | 62
increased total body fat amoun... 17 | 57
thrombocytopenia 17 | 46
decreased circulating alanine ... 16 | 53
increased body weight 16 | 42
small testis 16 | 37
abnormal lens morphology 15 | 73
abnormal retinal pigmentation 15 | 61
decreased rib number 15 | 59
hyperactivity 15 | 108
increased bone mineral density 15 | 52
increased circulating choleste... 15 | 53
increased exploration in new e... 15 | 56
prenatal lethality prior to he... 15 | 64
decreased prepulse inhibition 14 | 52
improved glucose tolerance 14 | 56
increased fasted circulating g... 14 | 68
increased heart weight 14 | 37
abnormal gait 13 | 51
decreased circulating alkaline... 13 | 41
decreased erythrocyte cell num... 13 | 43
decreased leukocyte cell numbe... 13 | 54
increased startle reflex 13 | 38
abnormal testis morphology 12 | 30
decreased caudal vertebrae num... 12 | 49
decreased circulating amylase ... 12 | 24
decreased circulating total pr... 12 | 41
decreased heart weight 12 | 44
decreased mean corpuscular vol... 12 | 50
impaired glucose tolerance 12 | 52
increased circulating sodium l... 12 | 71
abnormal eye morphology 11 | 38
abnormal spleen morphology 11 | 36
cataract 11 | 26
decreased circulating creatini... 11 | 31
decreased fasted circulating g... 11 | 49
increased hemoglobin content 11 | 45
limb grasping 11 | 35
tremors 11 | 34
abnormal behavioral response t... 10 | 52
abnormal sleep behavior 10 | 63
abnormal tooth morphology 10 | 24
decreased T cell number 10 | 31
decreased circulating LDL chol... 10 | 37
decreased circulating free fat... 10 | 39
decreased startle reflex 10 | 48
hydrops fetalis 10 | 22
increased circulating creatini... 10 | 29
increased circulating triglyce... 10 | 24
increased leukocyte cell numbe... 10 | 37
abnormal coat/hair pigmentatio... 9 | 54
abnormal cranium morphology 9 | 32
abnormal neural tube closure 9 | 37
abnormal seminal vesicle morph... 9 | 47
decreased circulating iron lev... 9 | 25
decreased neutrophil cell numb... 9 | 37
female infertility 9 | 34
increased circulating chloride... 9 | 43
increased circulating iron lev... 9 | 25
increased circulating phosphat... 9 | 24
persistence of hyaloid vascula... 9 | 22
increased circulating calcium ... 8 | 32
increased hematocrit 8 | 36

Disease

ovarian cancer 1,887 | 8,484
osteosarcoma 1,713 | 7,933
psoriasis 1,510 | 6,685
medulloblastoma, large-cell 1,372 | 6,234
glioblastoma 1,293 | 5,572
lung cancer 1,229 | 4,466
Cancer 1,092 | 2,346
atypical teratoid / rhabdoid tumor 938 | 4,369
malignant mesothelioma 844 | 3,162
Breast cancer 806 | 3,094
invasive ductal carcinoma 774 | 2,950
intraductal papillary-mucinous neoplasm (IPMN) 755 | 3,289
non-small cell lung cancer 735 | 2,798
pilocytic astrocytoma 716 | 3,086
intraductal papillary-mucinous carcinoma (IPMC) 713 | 2,988
intraductal papillary-mucinous adenoma (IPMA) 688 | 2,956
lung adenocarcinoma 686 | 2,713
pediatric high grade glioma 682 | 2,712
lung carcinoma 676 | 2,844
primitive neuroectodermal tumor 670 | 3,031
oligodendroglioma 643 | 2,849
pancreatic cancer 618 | 2,300
Carcinoma 596 | 2,147
interstitial cystitis 581 | 2,299
ulcerative colitis 563 | 2,087
ependymoma 551 | 2,514
subependymal giant cell astrocytoma 521 | 2,287
group 3 medulloblastoma 506 | 2,254
pituitary cancer 477 | 1,972
group 4 medulloblastoma 462 | 1,875
ductal carcinoma in situ 449 | 1,745
astrocytic glioma 443 | 2,241
breast carcinoma 438 | 1,614
diabetes mellitus 433 | 1,663
cystic fibrosis 430 | 1,665
colon cancer 426 | 1,475
astrocytoma 424 | 1,493
tuberculosis 420 | 1,557
Pick disease 418 | 1,893
adult high grade glioma 415 | 2,148
adrenocortical carcinoma 383 | 1,427
posterior fossa group A ependymoma 377 | 1,511
pancreatic ductal adenocarcinoma liver metastasis 365 | 1,795
primary pancreatic ductal adenocarcinoma 356 | 1,271
Rheumatoid Arthritis 349 | 1,160
medulloblastoma 335 | 1,524
juvenile dermatomyositis 328 | 1,189
acute quadriplegic myopathy 323 | 1,157
sonic hedgehog group medulloblastoma 323 | 1,482
Multiple myeloma 313 | 1,327
cutaneous lupus erythematosus 307 | 1,056
posterior fossa group B ependymoma 296 | 1,530
dermatomyositis 276 | 933
spina bifida 269 | 1,064
atypical teratoid/rhabdoid tumor 265 | 1,095
nasopharyngeal carcinoma 252 | 1,056
Atopic dermatitis 241 | 944
Obesity 234 | 616
Waldenstrons macroglobulinemia 223 | 765
gastric carcinoma 222 | 832
Alzheimer's disease 216 | 644
primary Sjogren syndrome 216 | 789
Mammary Neoplasms 205 | 410
Prostatic Neoplasms 205 | 471
active Crohn's disease 197 | 918
esophageal adenocarcinoma 197 | 737
Intellectual disability 195 | 573
Down syndrome 193 | 548
acute myeloid leukemia 186 | 780
Endometriosis 183 | 535
Duchenne muscular dystrophy 176 | 602
autosomal dominant Emery-Dreifuss muscular dystrophy 174 | 499
aldosterone-producing adenoma 173 | 664
non primary Sjogren syndrome sicca 168 | 840
Kidney disease 164 | 396
Neurodegenerative disease 162 | 383
Multiple Sclerosis 155 | 498
Amyotrophic Lateral Sclerosis 154 | 431
IGA Glomerulonephritis 151 | 454
progressive supranuclear palsy 150 | 674
pancreatic carcinoma 147 | 567
Asthma 145 | 349
Schizophrenia 142 | 501
Vascular disease 139 | 281
fibroadenoma 139 | 557
chronic rhinosinusitis 137 | 512
Parkinson's disease 132 | 364
mucosa-associated lymphoid tissue lymphoma 128 | 480
tuberculosis and treatment for 6 months 127 | 686
Heart disease 125 | 279
Stomach Neoplasms 124 | 282
non-small cell lung carcinoma 123 | 413
hepatocellular carcinoma 122 | 532
Atherosclerosis 121 | 275
Arthritis 113 | 248
Polycystic Ovary Syndrome 113 | 332
Autistic Disorder 112 | 320
Peripheral Neuropathy 111 | 303
gastric cancer 108 | 430
Hypertension 107 | 287

Tissue

Female tissues 3,327 | 18,647
Nervous System 3,327 | 18,561
Digestive Tract 3,325 | 18,473
Endocrine System 3,325 | 18,512
Urinary Tract 3,316 | 18,444
Liver and Pancreas 3,302 | 18,136
Blood and immune system 3,297 | 17,995
Male tissues 3,294 | 17,969
Cardiovascular System 3,288 | 17,958
Skin and soft tissues 3,283 | 18,115
Respiratory system 3,239 | 17,484

Target Family

Non-IDG 1,688 | 11,971
Enzyme 710 | 4,146
Transcription Factor 390 | 1,400
Kinase 227 | 634
Epigenetic 98 | 242
GPCR 81 | 406
Transporter 65 | 473
Ion Channel 41 | 341
Nuclear Receptor 32 | 48
TF/Epigenetic 14 | 38
oGPCR 2 | 421

MGI Term

cellular phenotype 3,348 | 3,348
mortality/aging 4,850 | 4,850
homeostasis/metabolism phenoty... 4,454 | 4,454
growth/size/body region phenot... 3,915 | 3,915
nervous system phenotype 3,201 | 3,201
behavior/neurological phenotyp... 3,192 | 3,192
immune system phenotype 3,148 | 3,148
hematopoietic system phenotype 3,145 | 3,145
cardiovascular system phenotyp... 2,448 | 2,448
endocrine/exocrine gland pheno... 2,084 | 2,084
skeleton phenotype 2,058 | 2,058
normal phenotype 1,916 | 1,916
reproductive system phenotype 1,873 | 1,873
integument phenotype 1,748 | 1,748
embryo phenotype 1,674 | 1,674
vision/eye phenotype 1,478 | 1,478
muscle phenotype 1,385 | 1,385
digestive/alimentary phenotype 1,292 | 1,292
respiratory system phenotype 1,291 | 1,291
liver/biliary system phenotype 1,160 | 1,160
renal/urinary system phenotype 1,157 | 1,157
craniofacial phenotype 1,077 | 1,077
limbs/digits/tail phenotype 1,011 | 1,011
neoplasm 918 | 918
adipose tissue phenotype 901 | 901
hearing/vestibular/ear phenoty... 692 | 692
pigmentation phenotype 459 | 459
taste/olfaction phenotype 142 | 142
obsolete other phenotype 69 | 69

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Signal transducer and activator of transcription 3 STAT3 Tchem Transcription Factor -3.71636 5706.6 1539
Cellular tumor antigen p53 TP53 Tchem Transcription Factor -4.67490 51004.8 5255
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN PTEN Tchem Enzyme -3.64373 4696.1 874
Retinoblastoma-associated protein RB1 Tchem Non-IDG -3.04645 1092.1 1858
Epidermal growth factor receptor EGFR Tclin Kinase -3.95948 9318.1 4989