Development Level

Tbio 1,565 | 10,625
Tchem 547 | 1,890
Tclin 215 | 602
Tdark 121 | 7,003

Collection

Eligible Ion Channel Proteins 10 | 117
Eligible Kinase Proteins 10 | 134
Eligible non-olfactory GPCR Proteins 7 | 143

IMPC Term

preweaning lethality, complete... 164 | 633
preweaning lethality, incomple... 84 | 260
enlarged heart 79 | 111
decreased lean body mass 66 | 195
embryonic lethality prior to t... 65 | 187
abnormal behavior 63 | 226
decreased bone mineral content 59 | 157
decreased total body fat amoun... 59 | 186
abnormal bone structure 48 | 131
decreased body weight 46 | 174
decreased bone mineral density 40 | 126
abnormal embryo size 39 | 112
abnormal retina morphology 39 | 100
decreased body length 37 | 108
abnormal heart morphology 34 | 51
decreased heart weight 34 | 44
embryonic lethality prior to o... 34 | 148
increased circulating alkaline... 34 | 119
increased lean body mass 34 | 107
decreased grip strength 33 | 123
decreased circulating glucose ... 32 | 121
increased heart weight 32 | 37
increased or absent threshold ... 32 | 128
hypoactivity 31 | 89
increased bone mineral content 28 | 92
short tibia 28 | 82
abnormal lens morphology 27 | 73
decreased circulating choleste... 25 | 85
abnormal bone mineralization 24 | 55
decreased hemoglobin content 24 | 53
hyperactivity 24 | 108
decreased circulating triglyce... 23 | 83
cardiovascular system phenotyp... 22 | 35
decreased circulating HDL chol... 22 | 77
increased blood urea nitrogen ... 21 | 44
increased grip strength 21 | 83
increased mean corpuscular vol... 21 | 91
increased total body fat amoun... 21 | 57
abnormal eye morphology 19 | 38
decreased circulating insulin ... 19 | 75
decreased circulating serum al... 19 | 79
decreased mean corpuscular vol... 19 | 50
increased startle reflex 19 | 38
prenatal lethality prior to he... 19 | 64
abnormal behavioral response t... 18 | 52
abnormal gait 18 | 51
decreased circulating alanine ... 18 | 53
decreased prepulse inhibition 18 | 52
improved glucose tolerance 18 | 56
increased circulating HDL chol... 18 | 63
abnormal neural tube closure 17 | 37
abnormal retinal blood vessel ... 17 | 18
abnormal retinal pigmentation 17 | 61
abnormal sleep behavior 17 | 63
impaired glucose tolerance 17 | 52
increased bone mineral density 17 | 52
increased fasted circulating g... 17 | 68
increased mean corpuscular hem... 17 | 93
abnormal QRS complex 16 | 25
increased body weight 16 | 42
increased circulating choleste... 16 | 53
abnormal heart left ventricle ... 15 | 20
abnormal retinal vasculature m... 15 | 15
abnormal seminal vesicle morph... 15 | 47
decreased fasted circulating g... 15 | 49
increased circulating calcium ... 15 | 32
increased circulating sodium l... 15 | 71
shortened RR interval 15 | 19
increased heart rate 14 | 17
abnormal cranium morphology 13 | 32
decreased circulating alkaline... 13 | 41
decreased leukocyte cell numbe... 13 | 54
decreased rib number 13 | 59
decreased startle reflex 13 | 48
increased leukocyte cell numbe... 13 | 37
tremors 13 | 34
cataract 12 | 26
decreased caudal vertebrae num... 12 | 49
decreased erythrocyte cell num... 12 | 43
decreased hematocrit 12 | 25
increased circulating potassiu... 12 | 31
increased hemoglobin content 12 | 45
straub tail 12 | 26
thrombocytopenia 12 | 46
abnormal hindbrain development 11 | 24
abnormal midbrain development 11 | 22
anophthalmia 11 | 20
corneal opacity 11 | 25
decreased blood urea nitrogen ... 11 | 31
decreased circulating calcium ... 11 | 33
decreased circulating total pr... 11 | 41
female infertility 11 | 34
increased circulating creatini... 11 | 29
increased circulating triglyce... 11 | 24
increased hematocrit 11 | 36
increased prepulse inhibition 11 | 21
limb grasping 11 | 35
increased circulating chloride... 10 | 43
male infertility 10 | 62
small testis 10 | 37

Disease

ovarian cancer 1,383 | 8,484
osteosarcoma 1,200 | 7,933
psoriasis 1,122 | 6,685
medulloblastoma, large-cell 984 | 6,234
glioblastoma 977 | 5,572
lung cancer 893 | 4,466
Cancer 811 | 2,346
atypical teratoid / rhabdoid tumor 722 | 4,369
malignant mesothelioma 639 | 3,162
invasive ductal carcinoma 629 | 2,950
intraductal papillary-mucinous neoplasm (IPMN) 626 | 3,289
Breast cancer 618 | 3,094
intraductal papillary-mucinous adenoma (IPMA) 612 | 2,956
lung adenocarcinoma 594 | 2,713
intraductal papillary-mucinous carcinoma (IPMC) 591 | 2,988
non-small cell lung cancer 576 | 2,798
lung carcinoma 571 | 2,844
pilocytic astrocytoma 566 | 3,086
pancreatic cancer 519 | 2,300
primitive neuroectodermal tumor 494 | 3,031
Carcinoma 490 | 2,147
pediatric high grade glioma 488 | 2,712
oligodendroglioma 476 | 2,849
interstitial cystitis 455 | 2,299
ulcerative colitis 443 | 2,087
ependymoma 421 | 2,514
ductal carcinoma in situ 400 | 1,745
subependymal giant cell astrocytoma 385 | 2,287
pituitary cancer 375 | 1,972
colon cancer 368 | 1,475
cystic fibrosis 366 | 1,665
breast carcinoma 364 | 1,614
diabetes mellitus 352 | 1,663
group 4 medulloblastoma 339 | 1,875
astrocytic glioma 332 | 2,241
group 3 medulloblastoma 329 | 2,254
adult high grade glioma 322 | 2,148
tuberculosis 321 | 1,557
pancreatic ductal adenocarcinoma liver metastasis 317 | 1,795
astrocytoma 314 | 1,493
adrenocortical carcinoma 309 | 1,427
primary pancreatic ductal adenocarcinoma 304 | 1,271
posterior fossa group A ependymoma 300 | 1,511
Pick disease 293 | 1,893
juvenile dermatomyositis 267 | 1,189
acute quadriplegic myopathy 263 | 1,157
medulloblastoma 249 | 1,524
sonic hedgehog group medulloblastoma 248 | 1,482
Rheumatoid Arthritis 244 | 1,160
posterior fossa group B ependymoma 240 | 1,530
dermatomyositis 216 | 933
gastric carcinoma 206 | 832
Multiple myeloma 202 | 1,327
Obesity 202 | 616
spina bifida 201 | 1,064
atypical teratoid/rhabdoid tumor 196 | 1,095
cutaneous lupus erythematosus 195 | 1,056
Kidney disease 183 | 396
Atopic dermatitis 177 | 944
Prostatic Neoplasms 176 | 471
Mammary Neoplasms 175 | 410
nasopharyngeal carcinoma 174 | 1,056
Alzheimer's disease 167 | 644
Hypertension 164 | 287
active Crohn's disease 162 | 918
Duchenne muscular dystrophy 159 | 602
autosomal dominant Emery-Dreifuss muscular dystrophy 159 | 499
esophageal adenocarcinoma 158 | 737
Heart disease 153 | 279
aldosterone-producing adenoma 147 | 664
Atherosclerosis 139 | 275
Down syndrome 139 | 548
primary Sjogren syndrome 139 | 789
Intellectual disability 138 | 573
Vascular disease 137 | 281
Endometriosis 135 | 535
acute myeloid leukemia 134 | 780
fibroadenoma 133 | 557
pancreatic carcinoma 130 | 567
Hypertensive disease 128 | 193
Waldenstrons macroglobulinemia 128 | 765
Coronary artery disease 122 | 240
Amyotrophic Lateral Sclerosis 119 | 431
Asthma 119 | 349
Cerebrovascular disease 118 | 231
Multiple Sclerosis 118 | 498
Schizophrenia 118 | 501
non primary Sjogren syndrome sicca 114 | 840
non-small cell lung carcinoma 110 | 413
mucosa-associated lymphoid tissue lymphoma 109 | 480
Autistic Disorder 105 | 320
Parkinson's disease 104 | 364
Stomach Neoplasms 101 | 282
progressive supranuclear palsy 99 | 674
Arthritis 98 | 248
IGA Glomerulonephritis 98 | 454
Neurodegenerative disease 97 | 383
active ulcerative colitis 97 | 477
chronic rhinosinusitis 97 | 512
hepatocellular carcinoma 94 | 532

Tissue

Digestive Tract 2,429 | 18,473
Nervous System 2,429 | 18,561
Endocrine System 2,428 | 18,512
Female tissues 2,428 | 18,647
Urinary Tract 2,421 | 18,444
Liver and Pancreas 2,413 | 18,136
Male tissues 2,409 | 17,969
Cardiovascular System 2,406 | 17,958
Skin and soft tissues 2,403 | 18,115
Blood and immune system 2,400 | 17,995
Respiratory system 2,389 | 17,484

Target Family

Non-IDG 1,187 | 11,971
Enzyme 499 | 4,146
Transcription Factor 272 | 1,400
Kinase 174 | 634
GPCR 100 | 406
Ion Channel 70 | 341
Transporter 56 | 473
Epigenetic 48 | 242
Nuclear Receptor 29 | 48
TF/Epigenetic 13 | 38

MGI Term

cardiovascular system phenotyp... 2,448 | 2,448
mortality/aging 4,850 | 4,850
homeostasis/metabolism phenoty... 4,454 | 4,454
growth/size/body region phenot... 3,915 | 3,915
cellular phenotype 3,348 | 3,348
nervous system phenotype 3,201 | 3,201
behavior/neurological phenotyp... 3,192 | 3,192
immune system phenotype 3,148 | 3,148
hematopoietic system phenotype 3,145 | 3,145
endocrine/exocrine gland pheno... 2,084 | 2,084
skeleton phenotype 2,058 | 2,058
normal phenotype 1,916 | 1,916
reproductive system phenotype 1,873 | 1,873
integument phenotype 1,748 | 1,748
embryo phenotype 1,674 | 1,674
vision/eye phenotype 1,478 | 1,478
muscle phenotype 1,385 | 1,385
digestive/alimentary phenotype 1,292 | 1,292
respiratory system phenotype 1,291 | 1,291
liver/biliary system phenotype 1,160 | 1,160
renal/urinary system phenotype 1,157 | 1,157
craniofacial phenotype 1,077 | 1,077
limbs/digits/tail phenotype 1,011 | 1,011
neoplasm 918 | 918
adipose tissue phenotype 901 | 901
hearing/vestibular/ear phenoty... 692 | 692
pigmentation phenotype 459 | 459
taste/olfaction phenotype 142 | 142
obsolete other phenotype 69 | 69

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
C-reactive protein CRP Tbio Non-IDG -4.51399 33883.5 1160
Retinaldehyde-binding protein 1 RLBP1 Tbio Non-IDG -2.12314 137.8 95
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
Erythropoietin EPO Tbio Non-IDG -3.90053 8755.8 628
Histone deacetylase 5 HDAC5 Tclin Epigenetic -2.11372 127.6 466
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788