Development Level

Tbio 1,862 | 11,651
Tchem 440 | 1,388
Tclin 226 | 612
Tdark 132 | 6,593

Collection

RFA-RM-18-021 21 | 328
Kinase: IDG Consortium (Target... 9 | 125
GPCR: IDG Consortium (Complete... 7 | 25
Ion Channel: IDG Consortium (T... 7 | 99
GPCR: IDG Consortium (Targets) 5 | 126
Kinase: IDG Consortium (Comple... 4 | 37

IMPC Phenotype

preweaning lethality, complete... 285 | 979
preweaning lethality, incomple... 155 | 499
enlarged heart 126 | 210
embryonic lethality prior to t... 104 | 278
abnormal heart morphology 80 | 162
decreased vertical activity 80 | 208
abnormal embryo size 79 | 220
abnormal behavior 78 | 298
abnormal bone structure 70 | 187
decreased total body fat amoun... 68 | 207
embryonic lethality prior to o... 58 | 239
decreased body weight 53 | 161
increased lean body mass 53 | 172
decreased bone mineral content 49 | 151
decreased lean body mass 47 | 135
abnormal seminal vesicle morph... 45 | 114
increased total body fat amoun... 42 | 134
hypoactivity 40 | 132
increased heart weight 40 | 62
increased circulating alkaline... 39 | 122
increased startle reflex 38 | 112
decreased grip strength 35 | 116
decreased mean corpuscular vol... 35 | 79
hyperactivity 35 | 148
decreased circulating glucose ... 34 | 126
embryonic growth retardation 34 | 106
decreased body length 33 | 101
decreased bone mineral density 31 | 126
decreased circulating choleste... 31 | 93
increased bone mineral content 31 | 108
abnormal eye morphology 30 | 68
cardiovascular system phenotyp... 30 | 36
decreased circulating serum al... 30 | 82
abnormal retina morphology 29 | 71
prenatal lethality prior to he... 29 | 87
short tibia 29 | 97
impaired glucose tolerance 28 | 75
cataract 26 | 92
abnormal gait 25 | 69
decreased circulating HDL chol... 25 | 68
decreased circulating triglyce... 25 | 79
decreased hemoglobin content 25 | 68
abnormal neural tube closure 24 | 46
decreased prepulse inhibition 24 | 82
edema 24 | 59
improved glucose tolerance 24 | 79
increased mean corpuscular vol... 24 | 92
abnormal lens morphology 23 | 81
abnormal sleep behavior 23 | 70
decreased fasted circulating g... 23 | 65
decreased lymphocyte cell numb... 23 | 83
male infertility 23 | 123
increased circulating HDL chol... 22 | 80
increased or absent threshold ... 22 | 101
decreased circulating insulin ... 21 | 76
decreased startle reflex 21 | 75
increased circulating sodium l... 21 | 71
increased fasted circulating g... 21 | 76
pale yolk sac 21 | 25
small superior vagus ganglion 21 | 74
abnormal retinal blood vessel ... 20 | 26
increased circulating choleste... 20 | 66
limb grasping 19 | 41
abnormal cranium morphology 18 | 36
decreased circulating alkaline... 18 | 46
decreased circulating total pr... 18 | 49
increased blood urea nitrogen ... 18 | 48
increased circulating triglyce... 18 | 42
pallor 18 | 34
abnormal pericardium morpholog... 17 | 26
abnormal retinal vasculature m... 17 | 27
abnormal testis morphology 17 | 43
corneal opacity 17 | 32
decreased blood urea nitrogen ... 17 | 51
decreased erythrocyte cell num... 17 | 62
enlarged spleen 17 | 41
hemorrhage 17 | 23
hydrometra 17 | 53
increased bone mineral density 17 | 72
increased circulating chloride... 17 | 41
increased mean corpuscular hem... 17 | 96
increased neutrophil cell numb... 17 | 46
tremors 17 | 39
abnormal behavioral response t... 16 | 66
abnormal kidney morphology 16 | 65
abnormal skin morphology 16 | 50
decreased mean corpuscular hem... 16 | 50
abnormal coat-hair pigmentatio... 15 | 64
decreased circulating calcium ... 15 | 36
decreased heart weight 15 | 27
decreased hematocrit 15 | 46
increased circulating calcium ... 15 | 34
increased circulating creatini... 15 | 38
prolonged QT interval 15 | 38
prolonged ST segment 15 | 36
small testis 15 | 58
abnormal bone mineralization 14 | 38
abnormal epididymis morphology 14 | 42
abnormal spleen morphology 14 | 55
increased prepulse inhibition 14 | 32

Disease

Carcinoma 1,891 | 11,493
ovarian cancer 1,509 | 8,520
osteosarcoma 1,317 | 7,950
psoriasis 1,212 | 6,694
glioblastoma 1,092 | 5,792
medulloblastoma, large-cell 1,074 | 6,241
lung cancer 1,010 | 4,740
atypical teratoid / rhabdoid tumor 909 | 5,112
Cancer 882 | 2,499
ependymoma 857 | 4,679
Breast cancer 793 | 3,578
malignant mesothelioma 709 | 3,232
group 3 medulloblastoma 674 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 670 | 3,291
invasive ductal carcinoma 660 | 2,951
adult high grade glioma 653 | 3,801
intraductal papillary-mucinous adenoma (IPMA) 647 | 2,955
non-small cell lung cancer 638 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 627 | 2,989
lung adenocarcinoma 626 | 2,716
lung carcinoma 617 | 2,843
Astrocytoma, Pilocytic 596 | 3,081
pancreatic cancer 588 | 2,398
Kidney cancer 582 | 2,613
primitive neuroectodermal tumor 532 | 3,035
oligodendroglioma 513 | 2,850
interstitial cystitis 489 | 2,312
Autosomal recessive predisposition 459 | 1,442
astrocytic glioma 439 | 2,597
ductal carcinoma in situ 416 | 1,745
subependymal giant cell astrocytoma 416 | 2,287
pituitary cancer 411 | 1,972
tuberculosis 410 | 2,010
ulcerative colitis 410 | 1,819
diabetes mellitus 406 | 1,728
breast carcinoma 402 | 1,638
pancreatic ductal adenocarcinoma liver metastasis 397 | 1,962
cystic fibrosis 394 | 1,696
colon cancer 388 | 1,478
group 4 medulloblastoma 355 | 1,855
Schizophrenia 345 | 1,160
adrenocortical carcinoma 331 | 1,428
Pick disease 325 | 1,894
Intellectual disability 294 | 1,016
juvenile dermatomyositis 286 | 1,187
primary pancreatic ductal adenocarcinoma 279 | 1,109
acute quadriplegic myopathy 278 | 1,158
Rheumatoid arthritis 277 | 1,191
astrocytoma 266 | 1,146
Obesity 246 | 678
Hypertension 234 | 396
Epilepsy 232 | 792
spina bifida 232 | 1,074
dermatomyositis 228 | 966
Multiple myeloma 219 | 1,332
pediatric high grade glioma 218 | 1,064
Dull intelligence 217 | 645
Low intelligence 217 | 645
Mental Retardation 217 | 645
Mental deficiency 217 | 645
Poor school performance 217 | 645
Bipolar Disorder 214 | 666
cutaneous lupus erythematosus 212 | 1,057
Liver Cirrhosis, Experimental 211 | 769
Seizures 210 | 596
gastric carcinoma 210 | 807
Short stature 203 | 531
Breast Neoplasms 197 | 445
Kidney disease 197 | 430
Hypertensive disease 195 | 292
Muscle hypotonia 194 | 571
Prostatic Neoplasms 193 | 495
Atopic dermatitis 192 | 952
Alzheimer's disease 189 | 658
Mammary Neoplasms 189 | 425
Cognitive delay 185 | 608
Global developmental delay 185 | 608
Mental and motor retardation 185 | 608
nasopharyngeal carcinoma 183 | 1,058
Melanoma 181 | 711
autosomal dominant Emery-Dreifuss muscular dystrophy 173 | 510
active Crohn's disease 172 | 922
Depressive disorder 171 | 409
active ulcerative colitis 171 | 764
Heart disease 170 | 306
Liver cancer 170 | 604
Duchenne muscular dystrophy 165 | 601
esophageal adenocarcinoma 162 | 737
aldosterone-producing adenoma 156 | 665
Atherosclerosis 151 | 291
Vascular disease 150 | 319
acute myeloid leukemia 147 | 783
Coronary artery disease 145 | 268
Down syndrome 144 | 499
medulloblastoma 144 | 720
primary Sjogren syndrome 141 | 735
non primary Sjogren syndrome sicca 140 | 891
Endometriosis 139 | 540
fibroadenoma 139 | 559
Waldenstrons macroglobulinemia 136 | 765

Tissue

Endocrine System 2,621 | 18,159
Digestive Tract 2,587 | 17,369
Female tissues 2,574 | 17,400
Skin and soft tissues 2,572 | 17,230
Male tissues 2,558 | 17,142
Urinary Tract 2,534 | 16,678
Liver and Pancreas 2,524 | 16,750
Blood and immune system 2,521 | 16,909
Nervous System 2,511 | 16,725
Respiratory system 2,486 | 16,393
Cardiovascular System 2,384 | 15,192

Target Family

Non-IDG 1,310 | 12,091
Enzyme 552 | 4,145
Transcription Factor 280 | 1,400
Kinase 179 | 634
GPCR 105 | 408
Ion Channel 74 | 344
Transporter 65 | 473
Epigenetic 51 | 242
Nuclear Receptor 30 | 48
TF/Epigenetic 13 | 38
oGPCR 1 | 421

MGI Phenotype

cardiovascular system phenotyp... 2,660 | 2,660
mortality-aging 5,018 | 5,018
homeostasis-metabolism phenoty... 4,747 | 4,747
growth-size-body region phenot... 4,157 | 4,157
cellular phenotype 3,637 | 3,637
immune system phenotype 3,461 | 3,461
nervous system phenotype 3,447 | 3,447
behavior-neurological phenotyp... 3,401 | 3,401
hematopoietic system phenotype 3,383 | 3,383
endocrine-exocrine gland pheno... 2,293 | 2,293
skeleton phenotype 2,222 | 2,222
normal phenotype 1,999 | 1,999
reproductive system phenotype 1,999 | 1,999
integument phenotype 1,874 | 1,874
embryo phenotype 1,827 | 1,827
vision-eye phenotype 1,622 | 1,622
muscle phenotype 1,479 | 1,479
digestive-alimentary phenotype 1,398 | 1,398
respiratory system phenotype 1,390 | 1,390
liver-biliary system phenotype 1,300 | 1,300
renal-urinary system phenotype 1,269 | 1,269
craniofacial phenotype 1,182 | 1,182
limbs-digits-tail phenotype 1,071 | 1,071
adipose tissue phenotype 992 | 992
neoplasm 975 | 975
hearing-vestibular-ear phenoty... 767 | 767
pigmentation phenotype 506 | 506
taste-olfaction phenotype 147 | 147
no phenotypic analysis 5 | 5

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Meckel syndrome type 1 protein MKS1 Tbio Non-IDG -1.31837 20.5 59
Epithelial membrane protein 2 EMP2 Tbio Non-IDG -2.30856 210.6 116
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Paired mesoderm homeobox protein 1 PRRX1 Tbio Transcription Factor -1.58479 38.8 304
Sphingomyelin phosphodiesterase 4 SMPD4 Tbio Enzyme -0.89678 7.05 66
A disintegrin and metalloproteinase with thrombospondin motifs 6 ADAMTS6 Tdark Enzyme -0.67364 4.37 40
Tyrosine-protein phosphatase non-receptor type 5 PTPN5 Tchem Enzyme -1.85420 70.8 225
Endothelin-converting enzyme 1 ECE1 Tchem Enzyme -2.56360 355.0 278
Myeloperoxidase MPO Tchem Enzyme -3.51470 3209.3 1255
ATP-binding cassette sub-family A member 1 ABCA1 Tclin Transporter -3.15111 1451.8 388