Development Level

Tbio 2,101 | 10,625
Tchem 579 | 1,890
Tclin 287 | 602
Tdark 225 | 7,003

Collection

Eligible Ion Channel Proteins 29 | 117
Eligible non-olfactory GPCR Proteins 27 | 143
Eligible Kinase Proteins 21 | 134

IMPC Term

abnormal behavior 204 | 226
preweaning lethality, complete... 200 | 633
preweaning lethality, incomple... 108 | 260
decreased lean body mass 104 | 195
decreased total body fat amoun... 102 | 186
decreased grip strength 99 | 123
hyperactivity 96 | 108
decreased bone mineral content 91 | 157
hypoactivity 81 | 89
abnormal bone structure 79 | 131
decreased bone mineral density 76 | 126
increased circulating alkaline... 76 | 119
decreased body weight 75 | 174
increased grip strength 75 | 83
decreased body length 66 | 108
increased or absent threshold ... 62 | 128
embryonic lethality prior to t... 57 | 187
abnormal sleep behavior 54 | 63
increased lean body mass 53 | 107
abnormal retina morphology 50 | 100
abnormal gait 49 | 51
decreased circulating glucose ... 49 | 121
abnormal behavioral response t... 47 | 52
decreased circulating triglyce... 47 | 83
increased mean corpuscular vol... 46 | 91
increased bone mineral content 44 | 92
decreased startle reflex 43 | 48
short tibia 43 | 82
decreased circulating choleste... 40 | 85
decreased prepulse inhibition 40 | 52
enlarged heart 39 | 111
decreased circulating HDL chol... 38 | 77
abnormal embryo size 35 | 112
decreased circulating serum al... 34 | 79
increased circulating sodium l... 34 | 71
increased mean corpuscular hem... 34 | 93
limb grasping 34 | 35
decreased hemoglobin content 33 | 53
increased startle reflex 33 | 38
abnormal bone mineralization 32 | 55
abnormal lens morphology 32 | 73
tremors 32 | 34
embryonic lethality prior to o... 30 | 148
increased circulating HDL chol... 30 | 63
decreased fasted circulating g... 29 | 49
increased exploration in new e... 29 | 56
increased total body fat amoun... 29 | 57
male infertility 29 | 62
decreased circulating insulin ... 28 | 75
impaired glucose tolerance 28 | 52
decreased heart weight 27 | 44
increased circulating choleste... 27 | 53
increased fasted circulating g... 27 | 68
increased blood urea nitrogen ... 26 | 44
increased circulating chloride... 26 | 43
decreased leukocyte cell numbe... 25 | 54
increased bone mineral density 25 | 52
thrombocytopenia 25 | 46
abnormal coat/hair pigmentatio... 24 | 54
abnormal locomotor activation 24 | 26
increased hemoglobin content 24 | 45
prenatal lethality prior to he... 24 | 64
straub tail 24 | 26
abnormal retinal pigmentation 23 | 61
decreased erythrocyte cell num... 23 | 43
decreased rib number 22 | 59
cataract 21 | 26
decreased mean corpuscular vol... 21 | 50
increased circulating triglyce... 21 | 24
abnormal eye morphology 20 | 38
decreased circulating amylase ... 20 | 24
abnormal spleen morphology 19 | 36
decreased caudal vertebrae num... 19 | 49
decreased circulating alanine ... 19 | 53
decreased vertical activity 19 | 22
improved glucose tolerance 19 | 56
increased circulating potassiu... 19 | 31
increased hematocrit 19 | 36
increased leukocyte cell numbe... 19 | 37
abnormal seminal vesicle morph... 18 | 47
decreased circulating alkaline... 18 | 41
decreased circulating free fat... 18 | 39
decreased circulating total pr... 18 | 41
increased heart weight 18 | 37
increased sacral vertebrae num... 18 | 62
abnormal tooth morphology 17 | 24
decreased circulating LDL chol... 17 | 37
decreased lumbar vertebrae num... 17 | 62
abnormal kidney morphology 16 | 30
decreased circulating chloride... 16 | 32
decreased circulating fructosa... 16 | 31
increased circulating calcium ... 16 | 32
abnormal heart morphology 15 | 51
abnormal vocalization 15 | 21
decreased T cell number 15 | 31
female infertility 15 | 34
increased body weight 15 | 42
increased circulating creatini... 15 | 29
abnormal cornea morphology 14 | 24
vertebral fusion 14 | 23

Disease

ovarian cancer 1,621 | 8,484
medulloblastoma, large-cell 1,413 | 6,234
osteosarcoma 1,413 | 7,933
psoriasis 1,342 | 6,685
glioblastoma 1,317 | 5,572
atypical teratoid / rhabdoid tumor 1,065 | 4,369
lung cancer 990 | 4,466
pilocytic astrocytoma 842 | 3,086
oligodendroglioma 791 | 2,849
primitive neuroectodermal tumor 762 | 3,031
Cancer 742 | 2,346
malignant mesothelioma 735 | 3,162
Breast cancer 708 | 3,094
pediatric high grade glioma 689 | 2,712
intraductal papillary-mucinous neoplasm (IPMN) 679 | 3,289
lung carcinoma 667 | 2,844
invasive ductal carcinoma 657 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 639 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 633 | 2,988
ependymoma 616 | 2,514
Carcinoma 611 | 2,147
non-small cell lung cancer 597 | 2,798
subependymal giant cell astrocytoma 595 | 2,287
lung adenocarcinoma 582 | 2,713
astrocytic glioma 562 | 2,241
pituitary cancer 553 | 1,972
adult high grade glioma 521 | 2,148
pancreatic cancer 507 | 2,300
Pick disease 497 | 1,893
interstitial cystitis 473 | 2,299
ulcerative colitis 465 | 2,087
group 4 medulloblastoma 464 | 1,875
astrocytoma 429 | 1,493
group 3 medulloblastoma 429 | 2,254
cystic fibrosis 413 | 1,665
ductal carcinoma in situ 409 | 1,745
posterior fossa group A ependymoma 391 | 1,511
colon cancer 381 | 1,475
breast carcinoma 380 | 1,614
diabetes mellitus 379 | 1,663
medulloblastoma 372 | 1,524
sonic hedgehog group medulloblastoma 355 | 1,482
adrenocortical carcinoma 331 | 1,427
tuberculosis 329 | 1,557
pancreatic ductal adenocarcinoma liver metastasis 318 | 1,795
primary pancreatic ductal adenocarcinoma 305 | 1,271
posterior fossa group B ependymoma 293 | 1,530
atypical teratoid/rhabdoid tumor 275 | 1,095
juvenile dermatomyositis 263 | 1,189
Obesity 256 | 616
acute quadriplegic myopathy 254 | 1,157
Rheumatoid Arthritis 253 | 1,160
Schizophrenia 237 | 501
Intellectual disability 235 | 573
Alzheimer's disease 234 | 644
cutaneous lupus erythematosus 228 | 1,056
Multiple myeloma 212 | 1,327
spina bifida 212 | 1,064
Epilepsy 211 | 346
Neurodegenerative disease 209 | 383
dermatomyositis 207 | 933
Atopic dermatitis 205 | 944
gastric carcinoma 204 | 832
nasopharyngeal carcinoma 194 | 1,056
Down syndrome 187 | 548
Parkinson's disease 184 | 364
active Crohn's disease 184 | 918
Autistic Disorder 177 | 320
Duchenne muscular dystrophy 172 | 602
non primary Sjogren syndrome sicca 166 | 840
esophageal adenocarcinoma 165 | 737
Prostatic Neoplasms 157 | 471
autosomal dominant Emery-Dreifuss muscular dystrophy 156 | 499
Kidney disease 155 | 396
aldosterone-producing adenoma 153 | 664
progressive supranuclear palsy 150 | 674
Mammary Neoplasms 149 | 410
fibroadenoma 146 | 557
primary Sjogren syndrome 146 | 789
Multiple Sclerosis 144 | 498
Amyotrophic Lateral Sclerosis 140 | 431
Endometriosis 135 | 535
acute myeloid leukemia 133 | 780
Waldenstrons macroglobulinemia 126 | 765
Bipolar Disorder 124 | 266
Vascular disease 121 | 281
Neuropathy 120 | 210
Heart disease 115 | 279
tuberculosis and treatment for 6 months 112 | 686
Hypertension 111 | 287
non-small cell lung carcinoma 111 | 413
Asthma 108 | 349
chronic rhinosinusitis 107 | 512
active ulcerative colitis 106 | 477
pancreatic carcinoma 105 | 567
Arthritis 104 | 248
hepatocellular carcinoma 101 | 532
glioblastoma multiforme 100 | 347
Stomach Neoplasms 97 | 282
mucosa-associated lymphoid tissue lymphoma 97 | 480

Tissue

Nervous System 3,157 | 18,561
Endocrine System 3,147 | 18,512
Digestive Tract 3,145 | 18,473
Female tissues 3,145 | 18,647
Urinary Tract 3,131 | 18,444
Liver and Pancreas 3,117 | 18,136
Skin and soft tissues 3,105 | 18,115
Cardiovascular System 3,104 | 17,958
Male tissues 3,093 | 17,969
Blood and immune system 3,083 | 17,995
Respiratory system 3,041 | 17,484

Target Family

Non-IDG 1,498 | 11,971
Enzyme 677 | 4,146
Transcription Factor 312 | 1,400
Kinase 170 | 634
GPCR 167 | 406
Ion Channel 156 | 341
Transporter 104 | 473
Epigenetic 65 | 242
Nuclear Receptor 33 | 48
TF/Epigenetic 10 | 38

MGI Term

behavior/neurological phenotyp... 3,192 | 3,192
mortality/aging 4,850 | 4,850
homeostasis/metabolism phenoty... 4,454 | 4,454
growth/size/body region phenot... 3,915 | 3,915
cellular phenotype 3,348 | 3,348
nervous system phenotype 3,201 | 3,201
immune system phenotype 3,148 | 3,148
hematopoietic system phenotype 3,145 | 3,145
cardiovascular system phenotyp... 2,448 | 2,448
endocrine/exocrine gland pheno... 2,084 | 2,084
skeleton phenotype 2,058 | 2,058
normal phenotype 1,916 | 1,916
reproductive system phenotype 1,873 | 1,873
integument phenotype 1,748 | 1,748
embryo phenotype 1,674 | 1,674
vision/eye phenotype 1,478 | 1,478
muscle phenotype 1,385 | 1,385
digestive/alimentary phenotype 1,292 | 1,292
respiratory system phenotype 1,291 | 1,291
liver/biliary system phenotype 1,160 | 1,160
renal/urinary system phenotype 1,157 | 1,157
craniofacial phenotype 1,077 | 1,077
limbs/digits/tail phenotype 1,011 | 1,011
neoplasm 918 | 918
adipose tissue phenotype 901 | 901
hearing/vestibular/ear phenoty... 692 | 692
pigmentation phenotype 459 | 459
taste/olfaction phenotype 142 | 142
obsolete other phenotype 69 | 69

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Mitochondrial 2-oxodicarboxylate carrier SLC25A21 Tbio Transporter -0.46900 2.68 102
HLA class I histocompatibility antigen, A-3 alpha chain HLA-A Tbio Non-IDG -3.60614 4042.7 585
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
D(2) dopamine receptor DRD2 Tclin GPCR -3.24474 1775.2 248
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
F-box only protein 47 FBXO47 Tdark Non-IDG 0.08 0.95 47
Syntaxin-1B STX1B Tbio Non-IDG -1.74488 52.6 27
Achaete-scute homolog 1 ASCL1 Tbio Transcription Factor -2.39907 258.0 359
Lumican LUM Tbio Non-IDG -2.67820 509.4 209
Apolipoprotein E APOE Tbio Non-IDG -4.17470 15380.4 788