Development Level

Tbio 71 | 11,445
Tdark 11 | 6,588
Tchem 6 | 1,598

IMPC Phenotype

preweaning lethality, complete... 7 | 979
abnormal bone structure 5 | 187
abnormal behavior 3 | 298
decreased bone mineral density 3 | 126
embryonic lethality prior to o... 3 | 239
embryonic lethality prior to t... 3 | 278
male infertility 3 | 123
preweaning lethality, incomple... 3 | 499
abnormal embryo size 2 | 220
abnormal pericardium morpholog... 2 | 26
decreased body length 2 | 101
decreased bone mineral content 2 | 151
embryonic growth retardation 2 | 106
female infertility 2 | 60
hypoactivity 2 | 132
increased fasted circulating g... 2 | 76
increased mean corpuscular hem... 2 | 96
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal locomotor behavior 1 | 24
abnormal retina morphology 1 | 71
abnormal snout morphology 1 | 23
abnormal spine curvature 1 | 9
corneal opacity 1 | 32
decreased cardiac muscle contr... 1 | 11
decreased circulating HDL chol... 1 | 68
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating free fat... 1 | 31
decreased circulating potassiu... 1 | 20
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased heart weight 1 | 27
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
decreased total body fat amoun... 1 | 207
edema 1 | 59
impaired pupillary reflex 1 | 26
improved glucose tolerance 1 | 79
increased bone mineral density 1 | 72
increased cardiac muscle contr... 1 | 8
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating iron lev... 1 | 30
increased circulating total pr... 1 | 28
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased neutrophil cell numb... 1 | 46
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
thrombocytopenia 1 | 56
vertebral transformation 1 | 12

Disease

Carcinoma 57 | 11,493
ovarian cancer 52 | 8,520
osteosarcoma 39 | 7,950
medulloblastoma, large-cell 33 | 6,241
glioblastoma 29 | 5,792
psoriasis 27 | 6,694
lung cancer 25 | 4,740
atypical teratoid / rhabdoid tumor 23 | 5,112
ependymoma 22 | 4,679
group 3 medulloblastoma 22 | 4,104
Breast cancer 21 | 3,578
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,989
primitive neuroectodermal tumor 18 | 3,035
Kidney cancer 16 | 2,613
acute quadriplegic myopathy 16 | 1,158
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
malignant mesothelioma 15 | 3,232
Multiple myeloma 14 | 1,332
astrocytic glioma 14 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 14 | 2,955
lung adenocarcinoma 13 | 2,716
oligodendroglioma 13 | 2,850
adult high grade glioma 12 | 3,801
group 4 medulloblastoma 12 | 1,855
non-small cell lung cancer 12 | 2,890
subependymal giant cell astrocytoma 11 | 2,287
invasive ductal carcinoma 10 | 2,951
spina bifida 10 | 1,074
Pick disease 9 | 1,894
Waldenstrons macroglobulinemia 9 | 765
breast carcinoma 9 | 1,638
pediatric high grade glioma 9 | 1,064
Astrocytoma, Pilocytic 7 | 3,081
Cancer 7 | 2,499
Male infertility 7 | 206
astrocytoma 7 | 1,146
lung carcinoma 7 | 2,843
Intellectual disability 6 | 1,016
acute myeloid leukemia 6 | 783
dermatomyositis 6 | 966
pancreatic cancer 6 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 6 | 1,962
tuberculosis 6 | 2,010
Rheumatoid arthritis 5 | 1,191
adrenocortical carcinoma 5 | 1,428
aldosterone-producing adenoma 5 | 665
diabetes mellitus 5 | 1,728
ductal carcinoma in situ 5 | 1,745
juvenile dermatomyositis 5 | 1,187
pituitary cancer 5 | 1,972
primary pancreatic ductal adenocarcinoma 5 | 1,109
tuberculosis and treatment for 6 months 5 | 409
Amyotrophic lateral sclerosis 4 | 451
Autosomal recessive predisposition 4 | 1,442
Cognitive delay 4 | 608
Global developmental delay 4 | 608
Mental and motor retardation 4 | 608
colon cancer 4 | 1,478
hepatocellular carcinoma 4 | 547
interstitial cystitis 4 | 2,312
medulloblastoma 4 | 720
non primary Sjogren syndrome sicca 4 | 891
progressive supranuclear palsy 4 | 676
Atopic dermatitis 3 | 952
Chromosomal Instability 3 | 8
Dilated ventricles (finding) 3 | 121
Disease Progression 3 | 136
Dull intelligence 3 | 645
Emphysema 3 | 12
Epilepsy 3 | 792
Low intelligence 3 | 645
Mental Retardation 3 | 645
Mental deficiency 3 | 645
Microcephaly 3 | 166
Micronuclei, Chromosome-Defective 3 | 25
Pathological accumulation of air in tissues 3 | 10
Poor school performance 3 | 645
Schizophrenia 3 | 1,160
Seizures 3 | 596
Stomach Neoplasms 3 | 300
active ulcerative colitis 3 | 764
cystic fibrosis 3 | 1,696
hereditary spastic paraplegia 3 | 318
nasopharyngeal carcinoma 3 | 1,058
Alzheimer's disease 2 | 658
Anemia 2 | 365
Anteverted nostril 2 | 191
Bilateral fifth finger clinodactyly 2 | 110
Bipolar Disorder 2 | 666
Byzanthine arch palate 2 | 194
Curvature of little finger 2 | 110
Duchenne muscular dystrophy 2 | 601
Endometrial cancer 2 | 311
atypical teratoid/rhabdoid tumor 2 | 357
fibroadenoma 2 | 559
gastric carcinoma 2 | 807
mucosa-associated lymphoid tissue lymphoma 2 | 484
pancreatic carcinoma 2 | 562
substance-related disorder 2 | 162
ulcerative colitis 2 | 1,819

Tissue

Endocrine System 87 | 18,159
Male tissues 87 | 17,142
Blood and immune system 86 | 16,909
Digestive Tract 86 | 17,369
Liver and Pancreas 85 | 16,750
Nervous System 85 | 16,725
Respiratory system 85 | 16,393
Skin and soft tissues 85 | 17,230
Female tissues 84 | 17,400
Urinary Tract 84 | 16,678
Cardiovascular System 82 | 15,192

Target Family

Non-IDG 56 | 12,091
Enzyme 31 | 4,145
Kinase 1 | 634

KEGG Pathway

mRNA surveillance pathway 88 | 88
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A GSPT1 Tbio Enzyme -1.35573 22.8 99
Protein pelota homolog PELO Tbio Non-IDG -1.33842 18.2 100
Polyadenylate-binding protein 2 PABPN1 Tbio Non-IDG -2.48757 316.4 120
Serine/threonine-protein kinase SMG1 SMG1 Tchem Kinase -1.61615 60.9 195
Polyadenylate-binding protein 4-like PABPC4L Tdark Non-IDG 0.00000 1.00 49
Embryonic polyadenylate-binding protein 2 PABPN1L Tdark Non-IDG -0.16137 1.83 53
RNA-binding protein 8A RBM8A Tbio Non-IDG -3.16448 1415.1 94
NTF2-related export protein 1 NXT1 Tbio Non-IDG -1.49831 29.4 91
Apoptotic chromatin condensation inducer in the nucleus ACIN1 Tbio Non-IDG -1.51987 31.1 429
Telomerase-binding protein EST1A SMG6 Tbio Enzyme -1.48788 32.6 37