Development Level

Tbio 83 | 11,445
Tclin 44 | 613
Tchem 32 | 1,598
Tdark 3 | 6,588

Collection

Ion Channel: IDG Consortium (T... 2 | 99
RFA-RM-18-021 2 | 328

IMPC Phenotype

preweaning lethality, complete... 9 | 979
preweaning lethality, incomple... 8 | 499
abnormal behavior 5 | 298
abnormal embryo size 4 | 220
decreased body weight 3 | 161
decreased prepulse inhibition 3 | 82
decreased total body fat amoun... 3 | 207
edema 3 | 59
embryonic lethality prior to t... 3 | 278
hyperactivity 3 | 148
improved glucose tolerance 3 | 79
increased circulating alkaline... 3 | 122
abnormal gait 2 | 69
decreased circulating amylase ... 2 | 28
decreased circulating calcium ... 2 | 36
decreased circulating chloride... 2 | 30
decreased circulating triglyce... 2 | 79
decreased hematocrit 2 | 46
decreased vertical activity 2 | 208
embryonic growth retardation 2 | 106
increased bone mineral content 2 | 108
increased circulating calcium ... 2 | 34
increased lean body mass 2 | 172
increased or absent threshold ... 2 | 101
increased startle reflex 2 | 112
male infertility 2 | 123
abnormal bone mineralization 1 | 38
abnormal duodenum morphology 1 | 4
abnormal epididymis morphology 1 | 42
abnormal facial morphology 1 | 17
abnormal forebrain development 1 | 20
abnormal gallbladder morpholog... 1 | 1
abnormal glucose homeostasis 1 | 4
abnormal hindbrain development 1 | 16
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal neural tube closure 1 | 46
abnormal placenta vasculature 1 | 2
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal sensory capabilities-... 1 | 8
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal vibrissa morphology 1 | 25
abnormal vocalization 1 | 21
absent vibrissae 1 | 12
cataract 1 | 92
cyanosis 1 | 7
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating phosphat... 1 | 27
decreased circulating total pr... 1 | 49
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased heart left ventricle... 1 | 28
decreased hemoglobin content 1 | 68
decreased mean platelet volume 1 | 25
decreased startle reflex 1 | 75
embryonic lethality prior to o... 1 | 239
enlarged epididymis 1 | 31
enlarged gallbladder 1 | 2
enlarged heart 1 | 210
enlarged spleen 1 | 41
hemorrhage 1 | 23
hydrometra 1 | 53
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
increased blood urea nitrogen ... 1 | 48
increased circulating LDL chol... 1 | 13
increased circulating choleste... 1 | 66
increased circulating sodium l... 1 | 71
increased fasted circulating g... 1 | 76
increased heart weight 1 | 62
increased total body fat amoun... 1 | 134
prenatal lethality 1 | 28
prolonged PR interval 1 | 15
respiratory system phenotype 1 | 2
short tibia 1 | 97
small epididymis 1 | 3
small superior vagus ganglion 1 | 74
thrombocytosis 1 | 27
vertebral fusion 1 | 23

Disease

Carcinoma 120 | 11,493
ovarian cancer 83 | 8,520
medulloblastoma, large-cell 80 | 6,241
psoriasis 74 | 6,694
osteosarcoma 72 | 7,950
atypical teratoid / rhabdoid tumor 71 | 5,112
glioblastoma 67 | 5,792
ependymoma 62 | 4,679
lung cancer 59 | 4,740
adult high grade glioma 57 | 3,801
Breast cancer 53 | 3,578
Kidney cancer 51 | 2,613
group 3 medulloblastoma 50 | 4,104
primitive neuroectodermal tumor 49 | 3,035
lung adenocarcinoma 43 | 2,716
oligodendroglioma 41 | 2,850
astrocytic glioma 40 | 2,597
Astrocytoma, Pilocytic 39 | 3,081
Cancer 39 | 2,499
Hypertension 38 | 396
invasive ductal carcinoma 37 | 2,951
non-small cell lung cancer 37 | 2,890
intraductal papillary-mucinous carcinoma (IPMC) 36 | 2,989
lung carcinoma 36 | 2,843
colon cancer 34 | 1,478
intraductal papillary-mucinous neoplasm (IPMN) 34 | 3,291
malignant mesothelioma 32 | 3,232
subependymal giant cell astrocytoma 32 | 2,287
intraductal papillary-mucinous adenoma (IPMA) 31 | 2,955
ulcerative colitis 31 | 1,819
Pick disease 28 | 1,894
Epilepsy 27 | 792
Bipolar Disorder 26 | 666
Obesity 26 | 678
breast carcinoma 26 | 1,638
diabetes mellitus 25 | 1,728
interstitial cystitis 25 | 2,312
pancreatic cancer 25 | 2,398
group 4 medulloblastoma 24 | 1,855
Heart disease 23 | 306
Hypertensive disease 23 | 292
Schizophrenia 23 | 1,160
cystic fibrosis 22 | 1,696
ductal carcinoma in situ 22 | 1,745
pituitary cancer 21 | 1,972
Atrial Fibrillation 20 | 124
Parkinson's disease 20 | 392
Autosomal recessive predisposition 19 | 1,442
Chronic heart failure 18 | 46
Depressive disorder 18 | 409
Asthma 17 | 385
Hypertensive disorder 17 | 56
Multiple myeloma 17 | 1,332
Rheumatoid arthritis 17 | 1,191
acute quadriplegic myopathy 17 | 1,158
tuberculosis 17 | 2,010
Melanoma 16 | 711
Mental Depression 16 | 333
Alzheimer's disease 15 | 658
Cerebrovascular disease 15 | 238
Coronary artery disease 15 | 268
Heart failure 15 | 162
Intellectual disability 15 | 1,016
Cardiomegaly 14 | 116
Seizures 14 | 596
Skin cancer 14 | 469
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,962
Mood Disorders 13 | 184
Myocardial Infarction 13 | 151
Vascular disease 13 | 319
Waldenstrons macroglobulinemia 13 | 765
astrocytoma 13 | 1,146
gastric carcinoma 13 | 807
spina bifida 13 | 1,074
Cognitive delay 12 | 608
Dull intelligence 12 | 645
Global developmental delay 12 | 608
Low intelligence 12 | 645
Mental Retardation 12 | 645
Mental and motor retardation 12 | 608
Mental deficiency 12 | 645
Poor school performance 12 | 645
dermatomyositis 12 | 966
medulloblastoma 12 | 720
Acute exacerbation of asthma 11 | 14
Asthma management 11 | 19
Bronchitis 11 | 43
Diabetes Mellitus, Non-Insulin-Dependent 11 | 145
Diabetes Mellitus, Type 2 11 | 142
Impotence 11 | 42
Liver Cirrhosis, Experimental 11 | 769
Liver cancer 11 | 604
Peripheral vascular disease 11 | 87
Pulmonary emphysema 11 | 48
adrenocortical carcinoma 11 | 1,428
cutaneous lupus erythematosus 11 | 1,057
fibroadenoma 11 | 559
juvenile dermatomyositis 11 | 1,187
non primary Sjogren syndrome sicca 11 | 891
primary Sjogren syndrome 10 | 735

Tissue

Endocrine System 162 | 18,159
Digestive Tract 159 | 17,369
Female tissues 158 | 17,400
Male tissues 158 | 17,142
Skin and soft tissues 158 | 17,230
Nervous System 157 | 16,725
Liver and Pancreas 156 | 16,750
Blood and immune system 155 | 16,909
Urinary Tract 153 | 16,678
Respiratory system 150 | 16,393
Cardiovascular System 147 | 15,192

Target Family

Enzyme 33 | 4,145
Non-IDG 31 | 12,091
Transcription Factor 22 | 1,400
Transporter 22 | 473
Kinase 21 | 634
Ion Channel 17 | 344
GPCR 16 | 408

KEGG Pathway

cGMP-PKG signaling pathway 162 | 162
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

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