Development Level

Tbio 76 | 10,625
Tchem 43 | 1,890
Tclin 43 | 602
Tdark 3 | 7,003

Collection

Eligible Ion Channel Proteins 4 | 117

IMPC Term

preweaning lethality, complete... 6 | 633
preweaning lethality, incomple... 5 | 260
decreased body weight 4 | 174
increased circulating alkaline... 4 | 119
abnormal behavior 3 | 226
abnormal embryo size 3 | 112
decreased prepulse inhibition 3 | 52
embryonic lethality prior to t... 3 | 187
abnormal bone mineralization 2 | 55
abnormal forebrain development 2 | 18
abnormal hindbrain development 2 | 24
abnormal lens morphology 2 | 73
abnormal neural tube closure 2 | 37
abnormal retina morphology 2 | 100
abnormal spleen morphology 2 | 36
decreased bone mineral density 2 | 126
decreased circulating amylase ... 2 | 24
decreased circulating chloride... 2 | 32
decreased circulating creatini... 2 | 31
decreased circulating triglyce... 2 | 83
decreased hematocrit 2 | 25
decreased lean body mass 2 | 195
hypoactivity 2 | 89
improved glucose tolerance 2 | 56
increased circulating calcium ... 2 | 32
increased startle reflex 2 | 38
male infertility 2 | 62
abnormal epididymis morphology 1 | 31
abnormal facial morphology 1 | 9
abnormal gait 1 | 51
abnormal glucose homeostasis 1 | 5
abnormal midbrain development 1 | 22
abnormal placenta vasculature 1 | 2
abnormal respiratory quotient 1 | 9
abnormal seminal vesicle morph... 1 | 47
abnormal sensory capabilities/... 1 | 3
abnormal vibrissa morphology 1 | 17
abnormal vocalization 1 | 21
absent vibrissae 1 | 14
cataract 1 | 26
cyanosis 1 | 6
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased caudal vertebrae num... 1 | 49
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating bilirubi... 1 | 14
decreased circulating calcium ... 1 | 33
decreased circulating choleste... 1 | 85
decreased circulating glycerol... 1 | 19
decreased circulating insulin ... 1 | 75
decreased circulating iron lev... 1 | 25
decreased circulating magnesiu... 1 | 11
decreased circulating phosphat... 1 | 15
decreased circulating total pr... 1 | 41
decreased eosinophil cell numb... 1 | 41
decreased erythrocyte cell num... 1 | 43
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased hemoglobin content 1 | 53
decreased lumbar vertebrae num... 1 | 62
decreased macrophage cell numb... 1 | 4
decreased mean corpuscular vol... 1 | 50
decreased startle reflex 1 | 48
decreased total body fat amoun... 1 | 186
edema 1 | 11
enlarged epididymis 1 | 27
enlarged spleen 1 | 26
hemorrhage 1 | 12
hydrops fetalis 1 | 22
hyperactivity 1 | 108
impaired glucose tolerance 1 | 52
increased blood urea nitrogen ... 1 | 44
increased bone mineral content 1 | 92
increased caudal vertebrae num... 1 | 8
increased circulating LDL chol... 1 | 15
increased circulating choleste... 1 | 53
increased circulating phosphat... 1 | 24
increased circulating sodium l... 1 | 71
increased fasted circulating g... 1 | 68
increased heart weight 1 | 37
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 93
increased or absent threshold ... 1 | 128
prenatal lethality 1 | 16
respiratory system phenotype 1 | 2
short tibia 1 | 82
small epididymis 1 | 3
thrombocytosis 1 | 23
vertebral fusion 1 | 23

Disease

ovarian cancer 86 | 8,484
medulloblastoma, large-cell 83 | 6,234
psoriasis 77 | 6,685
osteosarcoma 73 | 7,933
glioblastoma 65 | 5,572
atypical teratoid / rhabdoid tumor 61 | 4,369
lung cancer 59 | 4,466
primitive neuroectodermal tumor 50 | 3,031
Breast cancer 48 | 3,094
Carcinoma 46 | 2,147
lung adenocarcinoma 44 | 2,713
oligodendroglioma 41 | 2,849
Cancer 40 | 2,346
invasive ductal carcinoma 40 | 2,950
pilocytic astrocytoma 40 | 3,086
ependymoma 37 | 2,514
intraductal papillary-mucinous carcinoma (IPMC) 37 | 2,988
lung carcinoma 36 | 2,844
adult high grade glioma 35 | 2,148
intraductal papillary-mucinous neoplasm (IPMN) 35 | 3,289
non-small cell lung cancer 35 | 2,798
colon cancer 34 | 1,475
ulcerative colitis 34 | 2,087
intraductal papillary-mucinous adenoma (IPMA) 33 | 2,956
malignant mesothelioma 33 | 3,162
astrocytic glioma 32 | 2,241
subependymal giant cell astrocytoma 32 | 2,287
medulloblastoma 31 | 1,524
pediatric high grade glioma 30 | 2,712
Pick disease 28 | 1,893
Hypertension 27 | 287
interstitial cystitis 27 | 2,299
breast carcinoma 26 | 1,614
pancreatic cancer 25 | 2,300
diabetes mellitus 24 | 1,663
ductal carcinoma in situ 24 | 1,745
group 4 medulloblastoma 24 | 1,875
Obesity 23 | 616
cystic fibrosis 23 | 1,665
pituitary cancer 22 | 1,972
Parkinson's disease 21 | 364
astrocytoma 21 | 1,493
posterior fossa group B ependymoma 21 | 1,530
Atrial Fibrillation 20 | 110
Heart disease 20 | 279
Hypertensive disease 19 | 193
Chronic heart failure 18 | 46
Epilepsy 18 | 346
Rheumatoid Arthritis 18 | 1,160
sonic hedgehog group medulloblastoma 18 | 1,482
Hypertensive disorder 17 | 58
Multiple myeloma 17 | 1,327
Schizophrenia 17 | 501
acute quadriplegic myopathy 17 | 1,157
group 3 medulloblastoma 17 | 2,254
Asthma 16 | 349
Waldenstrons macroglobulinemia 15 | 765
atypical teratoid/rhabdoid tumor 15 | 1,095
juvenile dermatomyositis 15 | 1,189
tuberculosis 15 | 1,557
Cerebrovascular disease 14 | 231
dermatomyositis 14 | 933
gastric carcinoma 14 | 832
posterior fossa group A ependymoma 14 | 1,511
Alzheimer's disease 13 | 644
spina bifida 13 | 1,064
Coronary artery disease 12 | 240
Heart failure 12 | 80
cutaneous lupus erythematosus 12 | 1,056
pancreatic carcinoma 12 | 567
primary pancreatic ductal adenocarcinoma 12 | 1,271
Acute exacerbation of asthma 11 | 14
Asthma management 11 | 20
Bronchitis 11 | 44
Cardiomegaly 11 | 66
Diabetes Mellitus, Non-Insulin-Dependent 11 | 157
Myocardial Infarction 11 | 126
Peripheral vascular disease 11 | 90
Prostatic Neoplasms 11 | 471
Pulmonary emphysema 11 | 34
Vascular disease 11 | 281
adrenocortical carcinoma 11 | 1,427
fibroadenoma 11 | 557
non primary Sjogren syndrome sicca 11 | 840
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,795
primary Sjogren syndrome 11 | 789
Angina pectoris 10 | 21
Cardiomyopathies 10 | 90
Duchenne muscular dystrophy 10 | 602
Impotence 10 | 45
Mammary Neoplasms 10 | 410
Congestive heart failure 9 | 30
Intellectual disability 9 | 573
Kidney disease 9 | 396
Myocardial Ischemia 9 | 169
Nasal congestion 9 | 24
Nasal discharge 9 | 26
Pulmonary hypertension 9 | 52
Stomach Neoplasms 9 | 282
non-small cell lung carcinoma 9 | 413

Tissue

Digestive Tract 164 | 18,473
Liver and Pancreas 164 | 18,136
Endocrine System 163 | 18,512
Male tissues 163 | 17,969
Nervous System 163 | 18,561
Blood and immune system 162 | 17,995
Female tissues 162 | 18,647
Urinary Tract 162 | 18,444
Skin and soft tissues 161 | 18,115
Cardiovascular System 160 | 17,958
Respiratory system 158 | 17,484

Target Family

Enzyme 34 | 4,146
Non-IDG 29 | 11,971
Kinase 25 | 634
Transcription Factor 22 | 1,400
Transporter 22 | 473
Ion Channel 17 | 341
GPCR 16 | 406

KEGG Pathway

cGMP-PKG signaling pathway 165 | 165
Metabolic pathways 1,254 | 1,254
Olfactory transduction 412 | 412
Pathways in cancer 402 | 402
HTLV-I infection 339 | 339
PI3K-Akt signaling pathway 338 | 338
Endocytosis 326 | 326
Epstein-Barr virus infection 279 | 279
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 262 | 262
Herpes simplex infection 262 | 262
MAPK signaling pathway 255 | 255
Viral carcinogenesis 253 | 253
Phagosome 231 | 231
Cell adhesion molecules (CAMs) 225 | 225
Ras signaling pathway 225 | 225
Rap1 signaling pathway 213 | 213
Regulation of actin cytoskelet... 213 | 213
Proteoglycans in cancer 202 | 202
cAMP signaling pathway 201 | 201
Focal adhesion 200 | 200
Natural killer cell mediated c... 199 | 199
Huntington's disease 194 | 194
Tuberculosis 187 | 187
Influenza A 184 | 184
Chemokine signaling pathway 182 | 182
Calcium signaling pathway 181 | 181
Axon guidance 176 | 176
Purine metabolism 171 | 171
Alzheimer's disease 169 | 169
Tight junction 169 | 169
NOD-like receptor signaling pa... 168 | 168
Protein processing in endoplas... 165 | 165
Transcriptional misregulation ... 165 | 165
RNA transport 164 | 164
Oxytocin signaling pathway 158 | 158
Jak-STAT signaling pathway 157 | 157
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
mTOR signaling pathway 153 | 153
Non-alcoholic fatty liver dise... 151 | 151
Adrenergic signaling in cardio... 150 | 150
MicroRNAs in cancer 150 | 150
Breast cancer 146 | 146
Alcoholism 145 | 145
Hepatitis B 145 | 145
Phospholipase D signaling path... 145 | 145
Parkinson's disease 142 | 142
Wnt signaling pathway 142 | 142
Signaling pathways regulating ... 141 | 141
Apoptosis 140 | 140
Insulin signaling pathway 138 | 138
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Measles 135 | 135
Ribosome 134 | 134
Oxidative phosphorylation 133 | 133
FoxO signaling pathway 132 | 132
Hepatitis C 132 | 132
Spliceosome 132 | 132
Dopaminergic synapse 131 | 131
Osteoclast differentiation 131 | 131
Autoimmune thyroid disease 130 | 130
Toxoplasmosis 130 | 130
Cell cycle 125 | 125
Platelet activation 124 | 124
AMPK signaling pathway 123 | 123
Lysosome 123 | 123
Type I diabetes mellitus 122 | 122
Vascular smooth muscle contrac... 121 | 121
Graft-versus-host disease 120 | 120
Sphingolipid signaling pathway 120 | 120
Neurotrophin signaling pathway 119 | 119
Oocyte meiosis 119 | 119
Th17 cell differentiation 119 | 119
Thyroid hormone signaling path... 118 | 118
Allograft rejection 116 | 116
Glutamatergic synapse 116 | 116
Leukocyte transendothelial mig... 116 | 116
Carbon metabolism 114 | 114
Serotonergic synapse 114 | 114
Cholinergic synapse 110 | 110
TNF signaling pathway 110 | 110
Insulin resistance 109 | 109
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
Chagas disease (American trypa... 106 | 106
T cell receptor signaling path... 104 | 104
Th1 and Th2 cell differentiati... 104 | 104
Glucagon signaling pathway 103 | 103
HIF-1 signaling pathway 103 | 103
Toll-like receptor signaling p... 103 | 103
Melanogenesis 102 | 102
Pyrimidine metabolism 102 | 102
AGE-RAGE signaling pathway in ... 101 | 101
Endocrine resistance 101 | 101
Estrogen signaling pathway 101 | 101
Retrograde endocannabinoid sig... 101 | 101
Amoebiasis 100 | 100
Rheumatoid arthritis 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A Tclin Enzyme -3.31593 2169.0 108
ADP/ATP translocase 3 SLC25A6 Tbio Transporter -2.06581 118.3 193
ADP/ATP translocase 1 SLC25A4 Tbio Transporter -2.05462 110.8 89
Cardiac phospholamban PLN Tbio Non-IDG -1.89899 84.7 326
Sodium/calcium exchanger 2 SLC8A2 Tbio Transporter -1.56223 31.9 51
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Cyclic AMP-responsive element-binding protein 3 CREB3 Tbio Transcription Factor -1.61736 42.0 159
Insulin INS Tbio Non-IDG -5.14691 141255.4 1549
Endothelin B receptor EDNRB Tclin GPCR -3.24561 1672.0 289
Adenylate cyclase type 1 ADCY1 Tchem Enzyme -1.58202 42.2 123