Development Level

Tbio 98 | 11,445
Tchem 39 | 1,598
Tdark 6 | 6,588
Tclin 2 | 613

Collection

Kinase: IDG Consortium (Target... 3 | 125
Kinase: IDG Consortium (Comple... 2 | 37
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 12 | 979
decreased vertical activity 6 | 208
enlarged heart 6 | 210
abnormal heart morphology 5 | 162
preweaning lethality, incomple... 5 | 499
embryonic lethality prior to t... 4 | 278
increased bone mineral content 4 | 108
abnormal bone structure 3 | 187
decreased body weight 3 | 161
increased or absent threshold ... 3 | 101
mammalian phenotype 3 | 17
abnormal bone mineralization 2 | 38
abnormal limb morphology 2 | 13
abnormal snout morphology 2 | 23
abnormal tail movements 2 | 12
decreased body length 2 | 101
decreased bone mineral content 2 | 151
decreased bone mineral density 2 | 126
decreased circulating insulin ... 2 | 76
decreased circulating total pr... 2 | 49
decreased startle reflex 2 | 75
decreased total body fat amoun... 2 | 207
edema 2 | 59
embryonic lethality prior to o... 2 | 239
hydrometra 2 | 53
impaired glucose tolerance 2 | 75
increased blood urea nitrogen ... 2 | 48
increased fasted circulating g... 2 | 76
increased lean body mass 2 | 172
increased startle reflex 2 | 112
kinked tail 2 | 2
male infertility 2 | 123
microphthalmia 2 | 26
prenatal lethality prior to he... 2 | 87
small superior vagus ganglion 2 | 74
abnormal body wall morphology 1 | 9
abnormal brain morphology 1 | 13
abnormal cranium morphology 1 | 36
abnormal embryo development 1 | 7
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal eyelid fusion 1 | 3
abnormal facial morphology 1 | 17
abnormal forelimb morphology 1 | 2
abnormal gait 1 | 69
abnormal head morphology 1 | 10
abnormal head shape 1 | 10
abnormal iris morphology 1 | 13
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal maxilla morphology 1 | 17
abnormal response to tactile s... 1 | 17
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal tail morphology 1 | 25
abnormal vocalization 1 | 21
anophthalmia 1 | 33
cataract 1 | 92
corneal opacity 1 | 32
cyanosis 1 | 7
decreased CD4-positive, alpha ... 1 | 7
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased circulating HDL chol... 1 | 68
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating serum al... 1 | 82
decreased exploration in new e... 1 | 11
decreased heart left ventricle... 1 | 28
decreased lean body mass 1 | 135
decreased prepulse inhibition 1 | 82
hemorrhage 1 | 23
hydroencephaly 1 | 14
hyperactivity 1 | 148
hypoactivity 1 | 132
increased B cell number 1 | 9
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating alkaline... 1 | 122
increased circulating glucose ... 1 | 24
increased circulating insulin ... 1 | 3
increased circulating iron lev... 1 | 30
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased hematocrit 1 | 46
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased total body fat amoun... 1 | 134
polydactyly 1 | 7
prenatal lethality 1 | 28
protruding tongue 1 | 3
respiratory system phenotype 1 | 2
short tibia 1 | 97
small heart 1 | 10
syndactyly 1 | 23
thrombocytosis 1 | 27

Disease

Carcinoma 115 | 11,493
ovarian cancer 84 | 8,520
psoriasis 77 | 6,694
osteosarcoma 71 | 7,950
Cancer 63 | 2,499
glioblastoma 63 | 5,792
atypical teratoid / rhabdoid tumor 62 | 5,112
medulloblastoma, large-cell 60 | 6,241
ependymoma 55 | 4,679
Breast cancer 44 | 3,578
group 3 medulloblastoma 44 | 4,104
lung cancer 42 | 4,740
malignant mesothelioma 42 | 3,232
Astrocytoma, Pilocytic 41 | 3,081
adult high grade glioma 41 | 3,801
primitive neuroectodermal tumor 39 | 3,035
oligodendroglioma 34 | 2,850
Kidney cancer 31 | 2,613
interstitial cystitis 31 | 2,312
invasive ductal carcinoma 31 | 2,951
non-small cell lung cancer 31 | 2,890
astrocytic glioma 30 | 2,597
lung carcinoma 29 | 2,843
subependymal giant cell astrocytoma 29 | 2,287
intraductal papillary-mucinous neoplasm (IPMN) 28 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 27 | 2,989
intraductal papillary-mucinous adenoma (IPMA) 25 | 2,955
lung adenocarcinoma 25 | 2,716
pancreatic cancer 23 | 2,398
Schizophrenia 22 | 1,160
Pick disease 21 | 1,894
cystic fibrosis 21 | 1,696
pituitary cancer 21 | 1,972
ductal carcinoma in situ 20 | 1,745
breast carcinoma 19 | 1,638
colon cancer 19 | 1,478
diabetes mellitus 19 | 1,728
group 4 medulloblastoma 19 | 1,855
Colorectal Neoplasms 17 | 243
Osteoporosis 16 | 363
medulloblastoma 16 | 720
tuberculosis 16 | 2,010
ulcerative colitis 16 | 1,819
Autosomal recessive predisposition 15 | 1,442
Intellectual disability 15 | 1,016
Prostatic Neoplasms 15 | 495
Rheumatoid arthritis 15 | 1,191
astrocytoma 15 | 1,146
pediatric high grade glioma 15 | 1,064
Stomach Neoplasms 14 | 300
primary pancreatic ductal adenocarcinoma 14 | 1,109
Bipolar Disorder 13 | 666
Colonic Neoplasms 13 | 142
cutaneous lupus erythematosus 13 | 1,057
Breast Neoplasms 12 | 445
Multiple myeloma 12 | 1,332
Obesity 12 | 678
Orbital separation excessive 12 | 244
Short stature 12 | 531
Vascular disease 12 | 319
acute myeloid leukemia 12 | 783
adrenocortical carcinoma 12 | 1,428
non primary Sjogren syndrome sicca 12 | 891
Epilepsy 11 | 792
Hypoplastic mandible condyle 11 | 275
Mammary Neoplasms 11 | 425
Mandibular hypoplasia 11 | 275
Micrognathism 11 | 275
Waldenstrons macroglobulinemia 11 | 765
acute quadriplegic myopathy 11 | 1,158
gastric carcinoma 11 | 807
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
Adenoma 10 | 167
Depressive disorder 10 | 409
Parkinson's disease 10 | 392
aldosterone-producing adenoma 10 | 665
esophageal adenocarcinoma 10 | 737
spina bifida 10 | 1,074
Atopic dermatitis 9 | 952
Cell Transformation, Neoplastic 9 | 97
Cleft Palate 9 | 271
Cognitive delay 9 | 608
Dull intelligence 9 | 645
Global developmental delay 9 | 608
Low intelligence 9 | 645
Lymphoid leukemia 9 | 160
Melanoma 9 | 711
Mental Depression 9 | 333
Mental Retardation 9 | 645
Mental and motor retardation 9 | 608
Mental deficiency 9 | 645
Poor school performance 9 | 645
fibroadenoma 9 | 559
Acquired scoliosis 8 | 281
Broad flat nasal bridge 8 | 236
Chronic Lymphocytic Leukemia 8 | 262
Crohn's disease 8 | 321
Curvature of spine 8 | 282
Immune system cancer 8 | 140
Nasal bridge wide 8 | 236

Tissue

Endocrine System 142 | 18,159
Digestive Tract 141 | 17,369
Female tissues 141 | 17,400
Male tissues 140 | 17,142
Nervous System 139 | 16,725
Skin and soft tissues 139 | 17,230
Blood and immune system 137 | 16,909
Urinary Tract 137 | 16,678
Liver and Pancreas 134 | 16,750
Respiratory system 131 | 16,393
Cardiovascular System 124 | 15,192

Target Family

Non-IDG 73 | 12,091
Kinase 24 | 634
Enzyme 19 | 4,145
Transcription Factor 15 | 1,400
GPCR 10 | 408
Epigenetic 3 | 242
Nuclear Receptor 1 | 48

KEGG Pathway

Wnt signaling pathway 145 | 145
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Adenomatous polyposis coli protein 2 APC2 Tbio Non-IDG -1.50271 33.3 93
Protein Wnt-6 WNT6 Tbio Non-IDG -1.65830 46.6 186
Nuclear factor of activated T-cells, cytoplasmic 4 NFATC4 Tbio Transcription Factor -1.93766 88.3 358
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform PPP3CB Tbio Enzyme -1.53531 28.2 147
Calcium/calmodulin-dependent protein kinase type II subunit gamma CAMK2G Tchem Kinase -0.94556 7.03 308
Calcium/calmodulin-dependent protein kinase type II subunit beta CAMK2B Tchem Kinase -1.14550 13.6 344
Disheveled-associated activator of morphogenesis 1 DAAM1 Tbio Non-IDG -1.45166 30.8 269
Nuclear factor of activated T-cells, cytoplasmic 2 NFATC2 Tbio Transcription Factor -2.43207 259.4 365
Calcineurin subunit B type 1 PPP3R1 Tbio Non-IDG -2.60752 391.4 125