Development Level

Tbio 171 | 11,651
Tchem 48 | 1,388
Tclin 22 | 612
Tdark 10 | 6,593

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, complete... 19 | 979
preweaning lethality, incomple... 9 | 499
embryonic lethality prior to t... 7 | 278
embryonic lethality prior to o... 6 | 239
short tibia 5 | 97
abnormal embryo size 4 | 220
abnormal retina morphology 4 | 71
hypoactivity 4 | 132
increased circulating alkaline... 4 | 122
abnormal lens morphology 3 | 81
abnormal neural tube closure 3 | 46
cataract 3 | 92
decreased bone mineral density 3 | 126
edema 3 | 59
increased circulating glucose ... 3 | 24
abnormal behavior 2 | 298
abnormal bone structure 2 | 187
abnormal craniofacial morpholo... 2 | 33
abnormal eye morphology 2 | 68
abnormal hindbrain morphology 2 | 10
abnormal midbrain morphology 2 | 10
abnormal placenta size 2 | 20
abnormal seminal vesicle morph... 2 | 114
abnormal testis morphology 2 | 43
decreased circulating creatini... 2 | 39
decreased circulating glucose ... 2 | 126
decreased lean body mass 2 | 135
decreased lymphocyte cell numb... 2 | 83
female infertility 2 | 60
impaired glucose tolerance 2 | 75
increased hemoglobin content 2 | 45
increased monocyte cell number 2 | 63
increased neutrophil cell numb... 2 | 46
increased spleen weight 2 | 10
increased total body fat amoun... 2 | 134
male infertility 2 | 123
small testis 2 | 58
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal epididymis morphology 1 | 42
abnormal femur morphology 1 | 14
abnormal forebrain development 1 | 20
abnormal forebrain morphology 1 | 10
abnormal gait 1 | 69
abnormal hindbrain development 1 | 16
abnormal joint morphology 1 | 23
abnormal kidney morphology 1 | 65
abnormal lung morphology 1 | 26
abnormal optic disc morphology 1 | 10
abnormal pericardium morpholog... 1 | 26
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal skin condition 1 | 6
abnormal skin morphology 1 | 50
abnormal spleen morphology 1 | 55
absent vibrissae 1 | 12
cardiovascular system phenotyp... 1 | 36
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased eosinophil cell numb... 1 | 24
decreased hemoglobin content 1 | 68
decreased mean corpuscular hem... 1 | 31
decreased spleen weight 1 | 10
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
enlarged heart 1 | 210
enlarged heart atrium 1 | 4
enlarged kidney 1 | 14
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
hyperactivity 1 | 148
increased anti-nuclear antigen... 1 | 19
increased blood urea nitrogen ... 1 | 48
increased body temperature 1 | 9
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating amylase ... 1 | 25
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating iron lev... 1 | 30
increased circulating sodium l... 1 | 71
increased fasted circulating g... 1 | 76
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased or absent threshold ... 1 | 101
microphthalmia 1 | 26
pale yolk sac 1 | 25
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
small seminal vesicle 1 | 10
small superior vagus ganglion 1 | 74
tremors 1 | 39

Disease

Cancer 171 | 2,499
Carcinoma 162 | 11,493
psoriasis 147 | 6,694
ovarian cancer 114 | 8,520
osteosarcoma 84 | 7,950
lung cancer 83 | 4,740
diabetes mellitus 82 | 1,728
glioblastoma 78 | 5,792
Ankylosing spondylitis 72 | 140
Behcet's disease 70 | 89
medulloblastoma, large-cell 68 | 6,241
Rheumatoid arthritis 67 | 1,191
Arthritis 65 | 290
Hypersensitivity reaction type II disease 61 | 253
dermatomyositis 61 | 966
Acquired immunodeficiency syndrome 60 | 197
Juvenile rheumatoid arthritis 58 | 111
Herpes zoster 57 | 68
Uveitis 57 | 103
atypical teratoid / rhabdoid tumor 54 | 5,112
Stevens-Johnson syndrome 52 | 92
Human immunodeficiency virus infectious disease 50 | 138
Psoriatic arthritis 49 | 86
Breast cancer 48 | 3,578
ependymoma 46 | 4,679
tuberculosis 46 | 2,010
Multiple myeloma 45 | 1,332
Schizophrenia 44 | 1,160
malignant mesothelioma 44 | 3,232
adult high grade glioma 42 | 3,801
pancreatic cancer 42 | 2,398
intraductal papillary-mucinous neoplasm (IPMN) 41 | 3,291
invasive ductal carcinoma 39 | 2,951
lung adenocarcinoma 38 | 2,716
Dermatitis 37 | 157
subependymal giant cell astrocytoma 37 | 2,287
Astrocytoma, Pilocytic 36 | 3,081
Nephritis 36 | 51
group 3 medulloblastoma 36 | 4,104
Behcet's syndrome 35 | 50
Congenital adrenal hyperplasia 35 | 73
Retinal vasculitis 35 | 36
Spondyloarthropathy, Susceptibility To, 1 35 | 35
Synovitis 35 | 78
Takayasu's arteritis 35 | 53
drug-induced hepatitis 35 | 44
oligodendroglioma 34 | 2,850
primitive neuroectodermal tumor 34 | 3,035
Anemia 33 | 365
Multiple Sclerosis 33 | 540
Kidney disease 31 | 430
intraductal papillary-mucinous carcinoma (IPMC) 31 | 2,989
astrocytic glioma 29 | 2,597
ulcerative colitis 29 | 1,819
Kidney cancer 28 | 2,613
astrocytoma 28 | 1,146
breast carcinoma 28 | 1,638
ductal carcinoma in situ 28 | 1,745
group 4 medulloblastoma 28 | 1,855
non-small cell lung cancer 28 | 2,890
Liver disease 27 | 237
juvenile dermatomyositis 27 | 1,187
colon cancer 25 | 1,478
lung carcinoma 25 | 2,843
Skin disease 24 | 66
intraductal papillary-mucinous adenoma (IPMA) 24 | 2,955
Breast Neoplasms 23 | 445
Mammary Neoplasms 23 | 425
cystic fibrosis 23 | 1,696
Hemochromatosis 22 | 54
Hepatitis B 22 | 108
Primary immunodeficiency disease 22 | 54
Birdshot chorioretinopathy 21 | 23
Leprosy 21 | 73
Stomach Neoplasms 21 | 300
pancreatic ductal adenocarcinoma liver metastasis 21 | 1,962
Prostatic Neoplasms 20 | 495
acute quadriplegic myopathy 20 | 1,158
adrenocortical carcinoma 20 | 1,428
Melanoma 19 | 711
cutaneous lupus erythematosus 19 | 1,057
interstitial cystitis 19 | 2,312
Intellectual disability 18 | 1,016
Pick disease 18 | 1,894
Waldenstrons macroglobulinemia 18 | 765
nasopharyngeal carcinoma 18 | 1,058
Carcinoma, Hepatocellular 17 | 228
Liver carcinoma 17 | 240
hepatocellular carcinoma 17 | 547
pituitary cancer 17 | 1,972
primary pancreatic ductal adenocarcinoma 17 | 1,109
Bipolar Disorder 16 | 666
Epilepsy 16 | 792
Lung Neoplasms 16 | 232
pancreatic carcinoma 16 | 562
primary Sjogren syndrome 16 | 735
Endometriosis 15 | 540
Short stature 15 | 531
Vascular disease 15 | 319
acute myeloid leukemia 15 | 783

Tissue

Endocrine System 182 | 18,159
Digestive Tract 179 | 17,369
Female tissues 179 | 17,400
Liver and Pancreas 179 | 16,750
Skin and soft tissues 178 | 17,230
Blood and immune system 177 | 16,909
Male tissues 177 | 17,142
Respiratory system 177 | 16,393
Urinary Tract 177 | 16,678
Nervous System 175 | 16,725
Cardiovascular System 172 | 15,192

Target Family

Non-IDG 152 | 12,091
Enzyme 27 | 4,145
Transcription Factor 27 | 1,400
Kinase 23 | 634
Epigenetic 17 | 242
GPCR 4 | 408
TF/Epigenetic 1 | 38

KEGG Pathway

Viral carcinogenesis 251 | 251
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, A-25 alpha chain HLA-A Tbio Non-IDG -2.41667 4123.8 0
HLA class I histocompatibility antigen, B-51 alpha chain HLA-B Tbio Non-IDG -1.88752 1613.5 0
General transcription factor IIH subunit 1 GTF2H1 Tbio Non-IDG -1.65323 46.0 231
Ran-specific GTPase-activating protein RANBP1 Tbio Enzyme -1.80548 64.8 193
Tyrosine-protein kinase SYK SYK Tchem Kinase -3.14835 1437.4 1136
Interleukin-6 receptor subunit beta IL6ST Tclin Non-IDG -1.72489 55.4 555
Tyrosine-protein kinase JAK3 JAK3 Tclin Kinase -2.64385 453.7 292
HLA class I histocompatibility antigen, B-37 alpha chain HLA-B Tbio Non-IDG -1.88752 1613.5 0
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
Transcription initiation factor IIB GTF2B Tbio Non-IDG -2.63302 410.1 286